Gene

KWMTBOMO06575

Pre Gene Modal

BGIBMGA011811

Annotation

Dmc1_homolog_[Bombyx_mori]

Location

Bomo_Chr11(-):10821577-10827641      View in EpiBrowser

Full name

Meiotic recombination protein DMC1/LIM15 homolog      

Location in the cell

Cytoplasmic   Reliability : 1.898

CDS

ATGTCTATAGACTCCGACAGGCTAAGGCCCATCGCGGACAGATTCAATTTAGATCAGAATGCAGTTTTAGACAATGTTTTATACGCAAGAGCCTACACGTCAGAGCATCAGGCTGAGCTTCTAGACTACGTCGCGGCAAAGTTTCACGAAGAGGCCGGCGTTTTCAAGCTGCTCATCATAGACTCCATCATGGCACTGTTCAGGGTAGACTTCTCAGGACGAGGCGAACTTGCCGACAGACAGCAAAAACTAGCGCAAGTGCTGTCACGTTTGCAAAAGATATCGGAAGAATATAATGTAGCAGTCTTCATAACAAATCAAATGACTGCGGATCCAGGAGCGACTCTTACTTTTCAAGCCGATCCCAAGAAACCTATAGGAGGAAATATTTTAGCTCACGCATCAACCACAAGAATATCACTAAGAAAAGGGCGAGGGGACAACAGAATCGCAAAGATATATGATTCACCGGATTTACCTGAGAGCGAAGCTACATTTGCTATTACGAACGGAGGTGTTGCCGATGCAAAAGATTAA

Protein

MSIDSDRLRPIADRFNLDQNAVLDNVLYARAYTSEHQAELLDYVAAKFHEEAGVFKLLIIDSIMALFRVDFSGRGELADRQQKLAQVLSRLQKISEEYNVAVFITNQMTADPGATLTFQADPKKPIGGNILAHASTTRISLRKGRGDNRIAKIYDSPDLPESEATFAITNGGVADAKD

Description

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Subunit

Double stacked ring-shaped homooctamer (By similarity). Interacts with the MND1-PSMC3IP heterodimer. Interacts with BRCA2 (By similarity).
Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.

Similarity

Belongs to the RecA family.
Belongs to the RecA family. DMC1 subfamily.

Keywords

ATP-binding   Cell cycle   Chromosome   Complete proteome   DNA-binding   Meiosis   Nucleotide-binding   Nucleus   Reference proteome   3D-structure   Alternative splicing   Polymorphism  

Feature

chain  Meiotic recombination protein DMC1/LIM15 homolog
splice variant  In isoform 2.
sequence variant  In dbSNP:rs58396845.

Uniprot

O01680   A0A3S2LTS6   A0A2H1V702   A0A2W1BHH7   A0A2A4K2Q3   A0A194PVH7   + More
A0A212ENU8   A0A1B6GPJ8   A0A067QS12   A0A1B6LH26   A0A1W5BH02   A0A210R4F7   F6QSA2   H0ZYI8   L5KFW1   T1IRE9   H2YAG9   A0A2K5K156   T1HJR2   G1LVW5   A0A1U7TGC3   F1N1D2   A0A1S2ZHC2   L8IC18   M3YNY3   A0A091H6V0   W5Q1Y7   A0A091PJP6   A0A091S4F8   A0A091HL99   R4LAY2   D3ZJ85   A0A091UMH6   G5AYT3   H0VQJ0   A0A2I3N2M6   Q14AN8   Q61880   A0A0X9R761   A0A091QAA2   A0A2I2YI99   A0A2R9BVM5   A0A2I3S418   H0WMD4   A0A384AP04   A0A1B6C4V9   A0A2Y9H1P8   A0A2U3YUS6   A0A2I2UWH9   A0A3Q7R3Z6   A0A3P4RUE9   A0A091RLI2   F7DIK7   A0A2K5VU11   G3R6H9   A0A0D9R2Q2   A0A2R9BW93   A0A096NK25   A0A1D5QFF0   H2P4D8   H2QLN6   Q14565   G3T477   R7VMW0   A0A093GQ24   A0A2Y9DGF9   A0A384DAG7   G1PM66   A0A3Q7UXJ4   F6TA35   U3KDJ2   A0A091W6D4   A0A091KBT8   H0ZJE4   G1SMY5   K7D4W1   A0A091IS36   A0A091LQE7   A0A0A0A9G4   E2RK50   F1SKQ1   I3N691   A0A091ETS4   G1RYR6   A0A094KS92   A0A3Q2GWH3   A0A1S3FVA0   F1NI95   A0A3Q2PRP9   A0A1B2INM8   A0A2K6GGT0   A0A2I0MJT6   A0A1D8DGN9   A0A093FKU3   A0A093QTP8   A0A2K6MXA7   A0A2K6RE75   K7F8T6   A0A2Y9KM11   A0A2I0USM2  

Pubmed

28756777    26354079    22118469    24845553    28812685    17495919    + More
20360741    23258410    20010809    19393038    22751099    20809919    15057822    15632090    21993625    21993624    12040188    15489334    21183079    8581742    8602360    15834424    17639081    22549958    22398555    22722832    15164055    16136131    17975172    19892987    17431167    8590282    15461802    14702039    10591208    20729832    15125839    23371554    18464734    16341006    30723633    15592404    27581082    25362486    17381049   

EMBL

U94994    AAB53331.1    RSAL01000209    RVE44253.1    ODYU01001000    SOQ36601.1    + More
KZ150089    PZC73721.1    NWSH01000215    PCG78329.1    KQ459590    KPI97327.1    AGBW02013617    OWR43154.1    GECZ01005486    JAS64283.1    KK852999    KDR12654.1    GEBQ01016970    JAT23007.1    NEDP02000449    OWF55907.1    ABQF01074324    KB030755    ELK10227.1    JH431357    ACPB03023528    ACPB03023529    ACTA01001545    ACTA01009545    ACTA01017545    JH881533    ELR53728.1    AEYP01012705    KL525922    KFO91174.1    AMGL01083932    KL391276    KFP91710.1    KK942198    KFQ51562.1    KL217503    KFO95969.1    KC119408    AGL11959.1    AABR07058506    AABR07058507    AABR07058508    CH473950    EDM15796.1    KK457929    KFQ77495.1    JH167581    GEBF01001546    EHB02203.1    JAO02087.1    AAKN02031255    AHZZ02001242    AHZZ02001243    AHZZ02001244    AHZZ02001245    BC116767    BC119081    CH466550    AAI16768.1    EDL04643.1    D58419    D64107    KR935226    AMA07374.1    KK692748    KFQ22494.1    CABD030121110    CABD030121111    CABD030121112    CABD030121113    CABD030121114    AJFE02074289    AJFE02074290    AJFE02074291    AJFE02074292    AJFE02074293    AJFE02074294    AACZ04068046    AAQR03016224    AAQR03016225    AAQR03016226    AAQR03016227    AAQR03016228    AAQR03016229    GEDC01031028    GEDC01028750    JAS06270.1    JAS08548.1    AANG04003655    CYRY02043058    VCX37178.1    KK801876    KFQ29352.1    AQIA01006986    AQIA01006987    AQIA01006988    AQIA01006989    AQIB01136568    AQIB01136569    JSUE03005514    JSUE03005515    JSUE03005516    JSUE03005517    JSUE03005518    ABGA01199590    ABGA01199591    ABGA01199592    ABGA01268147    ABGA01268148    ABGA01268149    ABGA01268150    ABGA01268151    ABGA01268152    ABGA01268153    NDHI03003442    PNJ49646.1    NBAG03000283    PNI48894.1    D63882    D64108    CR456486    AK292617    AK297664    AY520538    AL022320    BC125163    BC125164    KB376266    EMC76815.1    KL216282    KFV68879.1    AAPE02044911    AGTO01000070    KK734814    KFR10999.1    KK738778    KFP38019.1    ABQF01015971    AAGW02071788    GABE01003802    GABE01003801    GABE01003800    JAA40938.1    KK500774    KFP10245.1    KK503707    KFP60604.1    KL871143    KGL90701.1    AAEX03007314    AEMK02000027    MF461414    DQIR01029080    AWO67521.1    HCZ84555.1    AGTP01024198    KK719069    KFO61288.1    ADFV01024571    ADFV01024572    ADFV01024573    ADFV01024574    ADFV01024575    ADFV01024576    ADFV01024577    ADFV01024578    ADFV01024579    KL262261    KFZ60192.1    AADN05000523    KT598032    ANZ54964.1    AKCR02000009    PKK29935.1    KU975604    AOS89616.1    KK395771    KFV57205.1    KL672898    KFW87327.1    AGCU01057936    AGCU01057937    AGCU01057938    AGCU01057939    AGCU01057940    AGCU01057941    KZ505643    PKU49030.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000007151    UP000027135    UP000242188    + More
UP000002280    UP000007754    UP000010552    UP000007875    UP000233080    UP000015103    UP000008912    UP000189704    UP000009136    UP000079721    UP000000715    UP000002356    UP000054308    UP000002494    UP000006813    UP000005447    UP000028761    UP000000589    UP000001519    UP000240080    UP000002277    UP000005225    UP000261681    UP000248481    UP000245341    UP000011712    UP000286640    UP000002281    UP000233100    UP000029965    UP000006718    UP000001595    UP000005640    UP000007646    UP000053875    UP000248480    UP000261680    UP000001074    UP000286642    UP000002279    UP000016665    UP000053605    UP000001811    UP000053119    UP000053858    UP000002254    UP000008227    UP000005215    UP000052976    UP000001073    UP000081671    UP000000539    UP000265000    UP000233160    UP000053872    UP000053258    UP000233180    UP000233200    UP000007267    UP000248482   

PRIDE

O01680    F1N1D2    D3ZJ85    Q61880    Q14565   

Pfam

PF08423   Rad51

Interpro

IPR011940   Dmc1        + More
IPR003593   AAA+_ATPase       
IPR033925   Rad51_DMC1_RadA       
IPR027417   P-loop_NTPase       
IPR020587   RecA_monomer-monomer_interface       
IPR016467   DNA_recomb/repair_RecA-like       
IPR010995   DNA_repair_Rad51/TF_NusA_a-hlx       
IPR013632   DNA_recomb/repair_Rad51_C       
IPR020588   RecA_ATP-bd       

SUPFAM

SSF52540   SSF52540        + More
SSF47794   SSF47794       

CDD

cd01123  Rad51_DMC1_radA

ProteinModelPortal

O01680   A0A3S2LTS6   A0A2H1V702   A0A2W1BHH7   A0A2A4K2Q3   A0A194PVH7   + More
A0A212ENU8   A0A1B6GPJ8   A0A067QS12   A0A1B6LH26   A0A1W5BH02   A0A210R4F7   F6QSA2   H0ZYI8   L5KFW1   T1IRE9   H2YAG9   A0A2K5K156   T1HJR2   G1LVW5   A0A1U7TGC3   F1N1D2   A0A1S2ZHC2   L8IC18   M3YNY3   A0A091H6V0   W5Q1Y7   A0A091PJP6   A0A091S4F8   A0A091HL99   R4LAY2   D3ZJ85   A0A091UMH6   G5AYT3   H0VQJ0   A0A2I3N2M6   Q14AN8   Q61880   A0A0X9R761   A0A091QAA2   A0A2I2YI99   A0A2R9BVM5   A0A2I3S418   H0WMD4   A0A384AP04   A0A1B6C4V9   A0A2Y9H1P8   A0A2U3YUS6   A0A2I2UWH9   A0A3Q7R3Z6   A0A3P4RUE9   A0A091RLI2   F7DIK7   A0A2K5VU11   G3R6H9   A0A0D9R2Q2   A0A2R9BW93   A0A096NK25   A0A1D5QFF0   H2P4D8   H2QLN6   Q14565   G3T477   R7VMW0   A0A093GQ24   A0A2Y9DGF9   A0A384DAG7   G1PM66   A0A3Q7UXJ4   F6TA35   U3KDJ2   A0A091W6D4   A0A091KBT8   H0ZJE4   G1SMY5   K7D4W1   A0A091IS36   A0A091LQE7   A0A0A0A9G4   E2RK50   F1SKQ1   I3N691   A0A091ETS4   G1RYR6   A0A094KS92   A0A3Q2GWH3   A0A1S3FVA0   F1NI95   A0A3Q2PRP9   A0A1B2INM8   A0A2K6GGT0   A0A2I0MJT6   A0A1D8DGN9   A0A093FKU3   A0A093QTP8   A0A2K6MXA7   A0A2K6RE75   K7F8T6   A0A2Y9KM11   A0A2I0USM2  

PDB

2ZJB     E-value=5.75853e-85,     Score=796

KEGG

693117    K10872 meiotic recombination protein DMC1 | (RefSeq) Dmc1, Dmc1h; Dmc1 homolog

GO

GO:0005524   GO:0006281   GO:0000150   GO:0005634   GO:0007131   GO:0008094   GO:0003677   GO:0001541   GO:0042148   GO:0003697   GO:0007141   GO:0000781   GO:0006312   GO:0007286   GO:0007129   GO:0000794   GO:0003690   GO:0001556   GO:0000730   GO:0016887   GO:0007283   GO:0007276   GO:0005694   GO:0005654   GO:0007292   GO:0051321   GO:0006259   GO:0015299   GO:0006419   GO:0015923   GO:0006260  

Subcellular location

Nucleus  
Chromosome  

Length:

178

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05448

Exp number, first 60 AAs:

0.02383

Total prob of N-in:

0.11091

outside

1  -  178

 

 

Pi

170.913946

Theta

148.102803

Tajima's D

0.446139

CLR

0

CSRT

0.501824908754562

Interpretation

Uncertain