Gene

KWMTBOMO06571

Pre Gene Modal

BGIBMGA011817

Annotation

PREDICTED:_heparan_sulfate_2-O-sulfotransferase_pipe_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):10672562-10696744      View in EpiBrowser

Full name

Heparan sulfate 2-O-sulfotransferase pipe      

Location in the cell

Cytoplasmic   Reliability : 1.929 Mitochondrial   Reliability : 1.468

CDS

ATGGTGCTTTTTGAGAATAAAGAAATGTACCTCATACAGGAAAACTTTGGTGTTCATACTGACCAGACGGAGCACACGCTGGGAACTGCGCAGGAGTACAAAGGTGGTCTTCAGGCCTTACGCAGACACAGCGGTGCTGAGCGCAATAAGCCCCAAAGGACATTAGAAGCGGAACCAAGCGAAGCGGACGCATCTCAAGAGCAAATAGAACAAGAATACTTAGACAAAGAACTAATTCCTGAACCGTGGGAACTAAACAACACAGCCCGAGCCGGCAGAGAGATGCTTTTCTTCAACAGGGTGCCCAAGGTCGGAAGTCAGACCTTCATGGAACTATTAAGACGACTGGCCATCAGAAATCAATTTGGTTTCCACCGTGACGCGGTGCAGCGTGTAGAAACGATTCGTCTGGCCCCCGCAGACCAGCAGCTCCTCGTGAGTCTTGTATCGGCTCACGCGCCGCCCGCTTCCTACATCAAACACGTCTGCTATACAAACTTTACAAGGTTTGGGTTCCCATCGCCGATATATGTGAACGTGGTAAGGGACCCCGTGGAGCGCGTCATCTCTTGGTACTACTACGTGCGCGCGCCGTGGTACTACGTGGAGAGGAAGAGAGCCTTCCCAGATCTGCCGTTACCCGACCCAGCCTGGCTGAAAAAGGATTTTGAAACCTGCGTATTGAGCGGAGATCGCGAGTGTCAGTACATCGAAGGCGAAACGCACGAAGGCATCGGGGACCATCGTCGACAAACCCTGTTCTTCTGCGGACACGAGGCCCAGTGCACGCCGTTTAATAGTGTTGGGGCGTTGCAAAGAGCGAAACGTGTTGTTGAAGAGCAGTATGCAGTCGTCGGCGTACTAGAAGATATGAACTCAACTCTGTTGGCGTTCGAACGCTACGTACCGAGATTTTTCACAGGCGCTTCGCGTTTGTATTGGGAAGAGTTGAACACTTTCAATCGCATTAATCGAAACGCGTTCAAGCCTCCGGTCTCCGAAGCCGTCAAGCAAATCGTTCGAGCGAACTTCACAAGAGAAATAGAATTCTACGAATTCTGCAAACAGAGGCTGCACATGCAACTGAAGGCGTTGCGAGATCCGACTATAACATTGCCGACACCGACCAGAAGTTGGAGGCGGAAGAGGGAATCCAAAATAAATGACTTCAATTGA

Protein

MVLFENKEMYLIQENFGVHTDQTEHTLGTAQEYKGGLQALRRHSGAERNKPQRTLEAEPSEADASQEQIEQEYLDKELIPEPWELNNTARAGREMLFFNRVPKVGSQTFMELLRRLAIRNQFGFHRDAVQRVETIRLAPADQQLLVSLVSAHAPPASYIKHVCYTNFTRFGFPSPIYVNVVRDPVERVISWYYYVRAPWYYVERKRAFPDLPLPDPAWLKKDFETCVLSGDRECQYIEGETHEGIGDHRRQTLFFCGHEAQCTPFNSVGALQRAKRVVEEQYAVVGVLEDMNSTLLAFERYVPRFFTGASRLYWEELNTFNRINRNAFKPPVSEAVKQIVRANFTREIEFYEFCKQRLHMQLKALRDPTITLPTPTRSWRRKRESKINDFN

Description

Sulfotransferase involved in dorsoventral axis patterning in early embryos. Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell. Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade.

Subunit

Interacts directly with windbeutel (wbl).

Similarity

Belongs to the sulfotransferase 3 family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Glycoprotein   Golgi apparatus   Membrane   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Heparan sulfate 2-O-sulfotransferase pipe
splice variant  In isoform 11.

Uniprot

A0A3S2P879   A0A194QP00   A0A212ENT7   A0A194PX14   A0A2H1VMM8   A0A2A4K336   + More
A0A2W1BJ33   I4DR77   A0A1L7RU15   A0A2P8Y9Q1   A0A067R7J8   A0A146KNK8   D7EHP6   A0A2J7Q8P0   A0A1Y1M8Q4   E0VV10   A0A336LCZ8   A0A2R7VS42   A0A336LIS7   E2BCU5   A0A2A3EI03   A0A1B6E882   E2A932   A0A1B6GFM1   A0A1B0D5Q7   A0A1B6KC91   A0A1W4WSE3   A0A088A8I5   A0A151J0V9   U4UKT8   A0A026WRM4   A0A151X1C5   A0A0L7R0X3   N6TQW6   A0A1B6JPQ9   F4WMH3   A0A195EW88   A0A3L8DEG2   A0A158NAD4   A0A151I113   A0A1B0Y0B9   A0A310SUZ4   A0A182PZL2   A0A182YR06   A0A182T5B8   A0A182GZ95   A0A182PJS5   A0A182NKG6   A0A195CQ64   A0A182KP99   E9IF14   Q176Y4   A0A182XM47   A0A182I1L7   A0A182WHP2   B0VZJ9   Q7Q640   A0A182R720   A0A182TLQ5   A0A182V4J0   A0A182FD43   A0A084W453   A0A182IV48   A0A182MSG2   A0A154PMX4   A0A1J1I3E8   J9K6F3   A0A2H8TDX1   W8BUX2   A0A2S2PNE4   A0A1A9VWD2   A0A1A9ZA28   A0A1I8MXX1   A0A0Q9XR00   A0A0A1XMC8   A0A0M4F269   B4J193   A0A034WHE8   A0A0Q9WJ91   B4MXI7   A0A1B0GD33   A0A0Q9XMA2   B5DRU2   B4IG18   B4ITL7   A0A1A9Y3C9   A0A1B0BCI2   A0A0P8XVW6   A0A1I8P2M4   A0A1W4UBX0   Q86BJ3-4   B3NIC5   A0A0J9RZA5   A0A1A9WGB5   B4QQF4   B4H966   A0A3B0JT91   A0A1B0CBD4  

EC Number

2.8.2.-

Pubmed

26354079    22118469    28756777    22651552    29403074    24845553    + More
26823975    18362917    19820115    28004739    20566863    20798317    23537049    24508170    21719571    30249741    21347285    25244985    26483478    20966253    21282665    17510324    12364791    14747013    17210077    24438588    24495485    25315136    17994087    25830018    25348373    15632085    17550304    9827800    11169845    10731132    12537572    9568717    11076773    12050143    15252019    22936249   

EMBL

RSAL01000209    RVE44257.1    KQ461190    KPJ07242.1    AGBW02013617    OWR43148.1    + More
KQ459590    KPI97304.1    ODYU01003386    SOQ42081.1    NWSH01000215    PCG78338.1    KZ150089    PZC73715.1    AK404982    BAM20417.1    LN623705    CEG62433.1    PYGN01000773    PSN40983.1    KK852654    KDR19341.1    GDHC01020611    JAP98017.1    DS497665    EFA12172.1    NEVH01016949    PNF24960.1    GEZM01037791    JAV81931.1    DS235798    EEB17216.1    UFQS01002845    UFQT01002845    SSX14731.1    SSX34125.1    KK854049    PTY10266.1    UFQS01000010    UFQT01000010    SSW97129.1    SSX17515.1    GL447393    EFN86485.1    KZ288254    PBC30902.1    GEDC01003158    JAS34140.1    GL437711    EFN70017.1    GECZ01008656    GECZ01001548    JAS61113.1    JAS68221.1    AJVK01025532    GEBQ01030910    JAT09067.1    KQ980629    KYN14977.1    KB632254    ERL90620.1    KK107119    EZA58667.1    KQ982585    KYQ54197.1    KQ414669    KOC64492.1    APGK01055188    APGK01055189    KB741261    ENN71600.1    GECU01006460    JAT01247.1    GL888217    EGI64584.1    KQ981954    KYN32157.1    QOIP01000009    RLU18867.1    ADTU01010246    ADTU01010247    ADTU01010248    ADTU01010249    KQ976600    KYM79490.1    KT000408    ANI86006.1    KQ759894    OAD62035.1    AXCN02000399    JXUM01099118    KQ564470    KXJ72224.1    KQ977440    KYN02775.1    GL762758    EFZ20839.1    CH477380    EAT42225.1    APCN01000067    APCN01000068    APCN01000069    DS231814    EDS31736.1    AAAB01008960    EAA11659.4    ATLV01020277    ATLV01020278    ATLV01020279    KE525297    KFB44997.1    AXCM01006151    AXCM01006152    AXCM01006153    AXCM01006154    KQ434996    KZC13231.1    CVRI01000040    CRK94723.1    ABLF02035623    ABLF02035628    GFXV01000491    MBW12296.1    GAMC01009464    JAB97091.1    GGMR01018361    MBY30980.1    CH933809    KRG06435.1    GBXI01011164    GBXI01002180    JAD03128.1    JAD12112.1    CP012525    ALC45170.1    CH916366    EDV97962.1    GAKP01005377    JAC53575.1    CH940647    KRF84611.1    CH963876    EDW76756.1    CCAG010002298    KRG06436.1    CH379070    EDY74203.2    CH480834    EDW46605.1    CH891717    CM000159    EDW99730.1    KRK02388.1    JXJN01012007    CH902618    KPU78851.1    AF102135    AF102136    AF263993    AE014296    BT010278    BT058012    BT125816    BT125857    BT126134    BT126392    CH954178    EDV52350.2    CM002912    KMZ00525.1    CM000363    EDX11060.1    CH479227    EDW35290.1    OUUW01000002    SPP76576.1    AJWK01005056    AJWK01005057   

Proteomes

UP000283053    UP000053240    UP000007151    UP000053268    UP000218220    UP000245037    + More
UP000027135    UP000007266    UP000235965    UP000009046    UP000008237    UP000242457    UP000000311    UP000092462    UP000192223    UP000005203    UP000078492    UP000030742    UP000053097    UP000075809    UP000053825    UP000019118    UP000007755    UP000078541    UP000279307    UP000005205    UP000078540    UP000075886    UP000076408    UP000075901    UP000069940    UP000249989    UP000075885    UP000075884    UP000078542    UP000075882    UP000008820    UP000076407    UP000075840    UP000075920    UP000002320    UP000007062    UP000075900    UP000075902    UP000075903    UP000069272    UP000030765    UP000075880    UP000075883    UP000076502    UP000183832    UP000007819    UP000078200    UP000092445    UP000095301    UP000009192    UP000092553    UP000001070    UP000008792    UP000007798    UP000092444    UP000001819    UP000001292    UP000002282    UP000092443    UP000092460    UP000007801    UP000095300    UP000192221    UP000000803    UP000008711    UP000091820    UP000000304    UP000008744    UP000268350    UP000092461   

PRIDE

Q86BJ3   

Pfam

PF03567   Sulfotransfer_2

Interpro

IPR005331   Sulfotransferase        + More
IPR027417   P-loop_NTPase       
IPR007734   Heparan_SO4_2-O-STrfase       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

A0A3S2P879   A0A194QP00   A0A212ENT7   A0A194PX14   A0A2H1VMM8   A0A2A4K336   + More
A0A2W1BJ33   I4DR77   A0A1L7RU15   A0A2P8Y9Q1   A0A067R7J8   A0A146KNK8   D7EHP6   A0A2J7Q8P0   A0A1Y1M8Q4   E0VV10   A0A336LCZ8   A0A2R7VS42   A0A336LIS7   E2BCU5   A0A2A3EI03   A0A1B6E882   E2A932   A0A1B6GFM1   A0A1B0D5Q7   A0A1B6KC91   A0A1W4WSE3   A0A088A8I5   A0A151J0V9   U4UKT8   A0A026WRM4   A0A151X1C5   A0A0L7R0X3   N6TQW6   A0A1B6JPQ9   F4WMH3   A0A195EW88   A0A3L8DEG2   A0A158NAD4   A0A151I113   A0A1B0Y0B9   A0A310SUZ4   A0A182PZL2   A0A182YR06   A0A182T5B8   A0A182GZ95   A0A182PJS5   A0A182NKG6   A0A195CQ64   A0A182KP99   E9IF14   Q176Y4   A0A182XM47   A0A182I1L7   A0A182WHP2   B0VZJ9   Q7Q640   A0A182R720   A0A182TLQ5   A0A182V4J0   A0A182FD43   A0A084W453   A0A182IV48   A0A182MSG2   A0A154PMX4   A0A1J1I3E8   J9K6F3   A0A2H8TDX1   W8BUX2   A0A2S2PNE4   A0A1A9VWD2   A0A1A9ZA28   A0A1I8MXX1   A0A0Q9XR00   A0A0A1XMC8   A0A0M4F269   B4J193   A0A034WHE8   A0A0Q9WJ91   B4MXI7   A0A1B0GD33   A0A0Q9XMA2   B5DRU2   B4IG18   B4ITL7   A0A1A9Y3C9   A0A1B0BCI2   A0A0P8XVW6   A0A1I8P2M4   A0A1W4UBX0   Q86BJ3-4   B3NIC5   A0A0J9RZA5   A0A1A9WGB5   B4QQF4   B4H966   A0A3B0JT91   A0A1B0CBD4  

PDB

4NDZ     E-value=1.41515e-26,     Score=297

KEGG

101745735    no KO assigned | (RefSeq) heparan sulfate 2-O-sulfotransferase pipe

GO

GO:0016021   GO:0008146   GO:0005794   GO:0030173   GO:1900005   GO:0005694   GO:0009880   GO:0005634   GO:0045752   GO:0009950   GO:0040014   GO:0006468   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0006260  

PANTHER

PTHR12129  

Subcellular location

Golgi apparatus membrane  

Length:

391

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00278

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00686

outside

1  -  391

 

 

Pi

230.310041

Theta

159.572862

Tajima's D

0.955106

CLR

0.088289

CSRT

0.641717914104295

Interpretation

Uncertain