Gene

KWMTBOMO06567  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011658

Annotation

glutathione_S-transferase_omega_2_[Bombyx_mori]

Location

Bomo_Chr11(+):10580645-10585659      View in EpiBrowser

Full name

Pyrimidodiazepine synthase      

Alternative Name

Protein sepia

Location in the cell

Cytoplasmic   Reliability : 2.155

CDS

ATGTCTGCAATTAAGGACAGCAGAAATATCAACTTTAACACAAAGCATTTAAGGAAAGGTGATCCTTTACCGCCTTTCAATGGAAAATTGCGAGTGTACAACATGAGGTATTGCCCCTACGCTCAGCGAACCATTCTAGCTCTTAACGCGAAACAAATTGACTATGAGGTTGTAAATATTGATCTGATCGACAAACCTGAGTGGCTGACAACTAAAAGTGCCTTCGCAAAAGTTCCAGCGATAGAAATAGCAGAAGATGTGACCATTTACGAAAGCTTAGTGACAGTTGAATATTTAGATGAGGTCTATCCGAAAAGGCCTTTACTGCCGCAAGATCCTTTGAAGAAAGCATTGGACAAAATTATTGTAGAAGCATCGGCGCCTATTCAGTCGCTTTTTATAAAGATTCTAAAATTCTCCGACACTGTCAATGAGGAGCATGTTGCTGCGTACCACAAGGCTTTAGATTTCATCCAGGAACAGTTGAAAAACCGAGGCACTGTGTTCTTGGACGGAAGTGAACCTGGATACGCTGATTATATGATATGGCCTTGGTTCGAGAGGCTTAGGGCATTTGCACATGATGAAAGAGTGAGACTTGAACCGTCTAAGTATTCTTTACTGTTGGAGTACATAGACAACATGTTGAAGGACTCTGCCGTGAGCCAGTACTTAATTCCGCTGGAGATTTTGGCCAAATTTCATGAAGCCTACACCAAAAAAGAGAGACCGAACTATGAATTGTTAAATGAATGTTTGAAATCATTTTAA

Protein

MSAIKDSRNINFNTKHLRKGDPLPPFNGKLRVYNMRYCPYAQRTILALNAKQIDYEVVNIDLIDKPEWLTTKSAFAKVPAIEIAEDVTIYESLVTVEYLDEVYPKRPLLPQDPLKKALDKIIVEASAPIQSLFIKILKFSDTVNEEHVAAYHKALDFIQEQLKNRGTVFLDGSEPGYADYMIWPWFERLRAFAHDERVRLEPSKYSLLLEYIDNMLKDSAVSQYLIPLEILAKFHEAYTKKERPNYELLNECLKSF

Description

Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8-tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.

Catalytic Activity

2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione

Subunit

Homodimer.

Similarity

Belongs to the GST superfamily.
Belongs to the GST superfamily. Omega family.

Keywords

Complete proteome   Oxidoreductase   Reference proteome  

Feature

chain  Pyrimidodiazepine synthase

Uniprot

Q2F5R1   Q003U5   A8R5V3   Q2I0J6   A0A212ENT1   V5QRD7   + More
A0A075X8Z3   A0A3G1ZLD4   A0A1W6I4L7   A0A0K8TVL8   X5CYG0   A0A077DB46   A0A194QP05   A0A2W1BKA7   A0A2A4K3U4   A0A3G1RJ69   S4PRM5   A0A194PWB9   A0A0K0XRU9   B0LKP6   A0A0K0XRN2   A0A1P8L0S8   A0A2H1WZL7   A0A0L7LIF7   I3QKS2   A0A3G1RJ80   A0A077D9Z1   X5CHK3   A0A212ENR8   A0A1P8L0S5   A0A194QNZ4   H9JQL3   A0A0K8TUF6   A0A182JDY0   Q2F689   A0A2H1WH63   I4DLE0   F6KX45   A0A3G1ZLC9   A0A0Q9WHJ5   A0A023EL34   A0A0K0XRR4   A0A2C9GUK0   A0A1Y9IVR3   A0A1P8L0T2   A0A0A7RE47   A0A2W1BLG9   A0A182RS14   B4N5B2   B4KXF3   A0A084WJL4   M1F1J2   B3M699   A0A182QF29   B4LFS6   A0A182PSE3   L0AUY5   A0A0L7LJG6   A0A0C9RE60   U5EVI8   A0A1Y9H2D0   A0A182FZL3   A0A1S4G560   Q86D85   A0A2M4BXD7   A0A1D2NGH4   Q9VSL2   A0A2A4K3H8   A0A2M4AJK6   A0A034VXM9   A0A034W067   D1MAK0   S4PGW2   B4QM37   Q1HQK1   A0A182K8V1   A0A182HWJ3   T1DH03   A0A182XMN5   A0A1Y9IRT7   A0A182L340   A0A182TF70   A0A2S0E494   A0A1W4USE1   A0A2M4AKA9   A0A182T4F7   Q9VSL3   A0A2J7REL7   A0A2M3Z5Z3   A0A1J1INK6   B4PG14   A0A067RSS2   B4IX23   A0A0P6J0T5   A0A2S0E490   B4IX25   A0A087ZEB4   W5JCP5  

EC Number

1.5.4.1

Pubmed

19121390    19022397    23939046    22118469    30319435    26017144    + More
26354079    28756777    29912411    23622113    26198868    26227816    22651552    21605564    17994087    24945155    24438588    12364791    12914673    14747013    17210077    27289101    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19608790    26109357    26109356    25348373    20380296    22936249    17204158    20966253    29149030    12537569    6438092    16712527    17550304    24845553    26999592    20920257   

EMBL

DQ311362    ABD36306.1    DQ978378    ABJ15788.1    BABH01012119    AB365127    + More
BAF91356.1    DQ355373    ABC79689.1    AGBW02013617    OWR43143.1    KF595079    AHB18379.1    KF482977    AIH07601.1    MH177601    AYM01173.1    KX500039    ARM39009.1    GCVX01000115    JAI18115.1    KF929209    AHW45907.1    KM099187    AIL29317.1    KQ461190    KPJ07247.1    KZ150089    PZC73707.1    NWSH01000215    PCG78322.1    MG879011    AWX68891.1    GAIX01000690    JAA91870.1    KQ459590    KPI97298.1    KP938865    AKS40346.1    BABH01012121    BABH01012122    EU216544    ABY66601.1    KP938867    AKS40348.1    KX229713    APW77574.1    ODYU01012248    SOQ58457.1    JTDY01000943    KOB75343.1    JQ750592    KF680499    AFK10494.1    AHC08061.1    MG879010    AWX68890.1    KM099186    AIL29316.1    KF929208    AHW45906.1    OWR43142.1    KX229712    APW77573.1    KPJ07248.1    BABH01012120    GCVX01000106    JAI18124.1    DQ311183    ABD36128.1    ODYU01008647    SOQ52411.1    AK402108    BAM18730.1    KPI97297.1    HQ667939    AEG75845.1    MH177600    AYM01172.1    CH940647    KRF84316.1    GAPW01003688    GEHC01000037    JAC09910.1    JAV47608.1    KP938864    AKS40345.1    AXCM01015401    KX229715    APW77576.1    KM657434    AJA33435.1    PZC73706.1    CH964101    EDW79551.1    CH933809    EDW18639.1    ATLV01024038    KE525348    KFB50408.1    JQ690094    AFJ05097.1    CH902618    EDV39719.2    AXCN02000521    EDW69303.1    JX915905    AFZ78680.1    KOB75341.1    GBYB01006640    JAG76407.1    GANO01001860    JAB58011.1    AY255856    AAAB01008960    AAP13482.1    EAA11710.2    GGFJ01008552    MBW57693.1    LJIJ01000052    ODN04195.1    AE014296    AY071484    GQ351317    GQ351318    AAF50406.1    AAL49106.1    ACZ02424.1    ACZ02429.1    PCG78323.1    GGFK01007630    MBW40951.1    GAKP01010876    JAC48076.1    GAKP01010873    JAC48079.1    GU128144    ACY95464.1    GAIX01003477    JAA89083.1    CM000363    CM002912    EDX09720.1    KMY98399.1    DQ440443    ABF18476.1    APCN01001494    GAMD01002566    JAA99024.1    KY997066    ATY49606.1    GGFK01007890    MBW41211.1    AY070667    AAF50405.1    NEVH01004959    PNF39266.1    GGFM01003179    MBW23930.1    CVRI01000054    CRL00065.1    CM000159    EDW93158.1    KK852482    KDR22869.1    CH916366    EDV96329.1    GDUN01000336    JAN95583.1    KY997068    ATY49608.1    EDV96331.1    ADMH02001883    ETN60650.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000053268    UP000037510    + More
UP000075880    UP000008792    UP000075883    UP000075920    UP000075900    UP000007798    UP000009192    UP000030765    UP000007801    UP000075886    UP000075885    UP000075884    UP000069272    UP000007062    UP000094527    UP000000803    UP000000304    UP000075881    UP000075840    UP000076407    UP000075903    UP000075882    UP000075902    UP000192221    UP000075901    UP000235965    UP000183832    UP000002282    UP000027135    UP000001070    UP000000673   

PRIDE

Q2F5R1    A8R5V3    Q2I0J6    B0LKP6    H9JQL3    Q2F689    + More
Q9VSL2    Q9VSL3   

Pfam

PF13417   GST_N_3        + More
PF14497   GST_C_3
PF00043   GST_C

Interpro

IPR004045   Glutathione_S-Trfase_N        + More
IPR010987   Glutathione-S-Trfase_C-like       
IPR040079   Glutathione_S-Trfase       
IPR005442   GST_omega       
IPR036249   Thioredoxin-like_sf       
IPR036282   Glutathione-S-Trfase_C_sf       
IPR004046   GST_C       

SUPFAM

SSF47616   SSF47616        + More
SSF52833   SSF52833       

ProteinModelPortal

Q2F5R1   Q003U5   A8R5V3   Q2I0J6   A0A212ENT1   V5QRD7   + More
A0A075X8Z3   A0A3G1ZLD4   A0A1W6I4L7   A0A0K8TVL8   X5CYG0   A0A077DB46   A0A194QP05   A0A2W1BKA7   A0A2A4K3U4   A0A3G1RJ69   S4PRM5   A0A194PWB9   A0A0K0XRU9   B0LKP6   A0A0K0XRN2   A0A1P8L0S8   A0A2H1WZL7   A0A0L7LIF7   I3QKS2   A0A3G1RJ80   A0A077D9Z1   X5CHK3   A0A212ENR8   A0A1P8L0S5   A0A194QNZ4   H9JQL3   A0A0K8TUF6   A0A182JDY0   Q2F689   A0A2H1WH63   I4DLE0   F6KX45   A0A3G1ZLC9   A0A0Q9WHJ5   A0A023EL34   A0A0K0XRR4   A0A2C9GUK0   A0A1Y9IVR3   A0A1P8L0T2   A0A0A7RE47   A0A2W1BLG9   A0A182RS14   B4N5B2   B4KXF3   A0A084WJL4   M1F1J2   B3M699   A0A182QF29   B4LFS6   A0A182PSE3   L0AUY5   A0A0L7LJG6   A0A0C9RE60   U5EVI8   A0A1Y9H2D0   A0A182FZL3   A0A1S4G560   Q86D85   A0A2M4BXD7   A0A1D2NGH4   Q9VSL2   A0A2A4K3H8   A0A2M4AJK6   A0A034VXM9   A0A034W067   D1MAK0   S4PGW2   B4QM37   Q1HQK1   A0A182K8V1   A0A182HWJ3   T1DH03   A0A182XMN5   A0A1Y9IRT7   A0A182L340   A0A182TF70   A0A2S0E494   A0A1W4USE1   A0A2M4AKA9   A0A182T4F7   Q9VSL3   A0A2J7REL7   A0A2M3Z5Z3   A0A1J1INK6   B4PG14   A0A067RSS2   B4IX23   A0A0P6J0T5   A0A2S0E490   B4IX25   A0A087ZEB4   W5JCP5  

PDB

3WD6     E-value=1.71675e-140,     Score=1277

KEGG

692941    K00310 pyrimidodiazepine synthase [EC:1.5.4.1] | (RefSeq) GSTo2, GST6, Gsto; glutathione S-transfera

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0004364   GO:0006749   GO:0016782   GO:0045174   GO:0055114   GO:0004734   GO:0006726   GO:0006728   GO:0042803   GO:0008152   GO:0005515   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

Length:

256

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00174

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.12568

outside

1  -  256

 

 

Pi

323.117903

Theta

206.935763

Tajima's D

1.553439

CLR

0.001808

CSRT

0.796010199490025

Interpretation

Uncertain