Gene

KWMTBOMO06565

Pre Gene Modal

BGIBMGA011820

Annotation

glutathione_S-transferase_omega_4_[Bombyx_mori]

Location

Bomo_Chr11(-):10570089-10573424      View in EpiBrowser

Full name

Pyrimidodiazepine synthase      

Alternative Name

Protein sepia

Location in the cell

Cytoplasmic   Reliability : 2.712

CDS

ATGGTCTCACCAAAAATTAACTTTAACACGAAGCATTTGGGAAAAGGCGATCCTTTACCACCTTGGAGCGGAAAGTTGCGAGTCTATAACATGCGTTTATGTCCCTTTGCACAGAGAACAATATTAACGTTAAACGCAAAGCAAATCGATTACGAAGTGATAAATATTGATCTCGTTAATAAACCAGAATGGTTGCCGACAAAAAGTATATTCGGTAAAGTACCTACAATTGAGGTGGAAGATGGAGTATGTATCTGCGAAAGTCTTATCATCGCAGAGTACTTAGAGGAGGTATACCCCGAAATACCTTTAATTTCAAAGGATCCAATAAAGAAAGCGTATGAAAAAATAATTATTGAAGCTTCCGAGCCTATATTTGTAATGTATTTCAAAGTTATGAGAACGCCCGATACGATCAACGATGAAACGTTAATGAGTTATCACAAAGCTCTTACATTTTTCGAGGGACAGTTAAGGAATCGTGGCACAAGATTTCTCGGCGGCGAAAAGCCTGGATTCGCAGACTACATGATCTGGCCGTGGTTCGAGAGAATTCAATCGATGAACGATGAAAAACTCAAAATTAAATCCGCAAAATTCGACTTACTGGTTGCCTACATAGAAAACATGTACAAGGATCCCGCCGTCAGTCAATACCTACTACCTAAAGATGTCATGGATAAATTACACGCCGAATATAAGACAGGGAAGTTCGAAGTACAATCGATTGAAGATCTGTTGTAA

Protein

MVSPKINFNTKHLGKGDPLPPWSGKLRVYNMRLCPFAQRTILTLNAKQIDYEVINIDLVNKPEWLPTKSIFGKVPTIEVEDGVCICESLIIAEYLEEVYPEIPLISKDPIKKAYEKIIIEASEPIFVMYFKVMRTPDTINDETLMSYHKALTFFEGQLRNRGTRFLGGEKPGFADYMIWPWFERIQSMNDEKLKIKSAKFDLLVAYIENMYKDPAVSQYLLPKDVMDKLHAEYKTGKFEVQSIEDLL

Description

Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8-tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.

Catalytic Activity

2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione

Subunit

Homodimer.

Similarity

Belongs to the GST superfamily.
Belongs to the GST superfamily. Omega family.

Keywords

Complete proteome   Oxidoreductase   Reference proteome  

Feature

chain  Pyrimidodiazepine synthase

Uniprot

B0LKP6   A0A1W6I4L7   Q003U5   A8R5V3   Q2I0J6   Q2F5R1   + More
A0A0K8TVL8   A0A077DB46   A0A212ENT1   V5QRD7   A0A075X8Z3   A0A3G1ZLD4   A0A194QP05   S4PRM5   X5CYG0   A0A194PWB9   A0A2W1BKA7   A0A2A4K3U4   A0A0K0XRN2   A0A1P8L0S8   A0A3G1RJ69   A0A0A7BZ19   A0A0K0XRU9   A0A2H1WZL7   A0A0L7LIF7   A0A1P8L0S5   L0AUY5   A0A212ENR8   A0A0K8TUF6   Q2F689   H9JQL3   A0A1P8L0T2   I3QKS2   A0A2W1BLG9   S4PGW2   X5CHK3   A0A194QNZ4   A0A067RSS2   A0A2A4K3H8   A0A3G1ZLC9   F6KX45   A0A2H1WH63   M1F1J2   I4DLE0   A0A0K8WLV7   A0A0A1XFW9   B4N5B2   A0A0K8UJP0   A0A3G1RJ80   A0A034VXM9   A0A2S0E490   A0A067R995   W8DRC1   U5EVI8   A0A3G2JSG2   A0A3G2JSH3   A0A182JDY0   A0A0L7LJG6   A0A0C9RE60   A0A0K0XRR4   A0A034W067   A0A2J7REL7   A0A077D9Z1   A0A3M7TAC4   A0A3G2JSD7   W8C7W1   W8BVG5   F4MI62   A0A224XIY6   Q9VSL3   A0A151I9P5   A0A336KBC7   B4QM37   A0A2M3Z5Z3   A0A0A1WK06   A0A1W4USE1   A0A1W6L1J4   A0A0A1X6C0   F4WQF7   A0A182QF29   A0A0A1XS43   A0A034W064   M1F3Z9   A0A0A7RE47   B4PG13   B1GS90   A0A0V0GCL5   A0A232ENR6   A0A2M4BXD7   A0A182RS14   B4PG14   A0A2M4AJK6   B4LFS6   A0A226EFL0   B5DPX2   E9GI93   A0A084WJL4   A0A0C9RF10   A0A182FZL3  

EC Number

1.5.4.1

Pubmed

19121390    19022397    23939046    26017144    22118469    30319435    + More
26354079    23622113    28756777    26198868    29912411    26227816    24845553    21605564    22651552    25830018    17994087    25348373    29149030    30290366    30375419    24495485    21276481    10731132    12537572    12537569    19608790    6438092    16712527    22936249    21719571    17550304    18348209    28648823    15632085    21292972    24438588   

EMBL

BABH01012121    BABH01012122    EU216544    ABY66601.1    KX500039    ARM39009.1    + More
DQ978378    ABJ15788.1    BABH01012119    AB365127    BAF91356.1    DQ355373    ABC79689.1    DQ311362    ABD36306.1    GCVX01000115    JAI18115.1    KM099187    AIL29317.1    AGBW02013617    OWR43143.1    KF595079    AHB18379.1    KF482977    AIH07601.1    MH177601    AYM01173.1    KQ461190    KPJ07247.1    GAIX01000690    JAA91870.1    KF929209    AHW45907.1    KQ459590    KPI97298.1    KZ150089    PZC73707.1    NWSH01000215    PCG78322.1    KP938867    AKS40348.1    KX229713    APW77574.1    MG879011    AWX68891.1    KC966935    AHV85209.1    KP938865    AKS40346.1    ODYU01012248    SOQ58457.1    JTDY01000943    KOB75343.1    KX229712    APW77573.1    JX915905    AFZ78680.1    OWR43142.1    GCVX01000106    JAI18124.1    DQ311183    ABD36128.1    BABH01012120    KX229715    APW77576.1    JQ750592    KF680499    AFK10494.1    AHC08061.1    PZC73706.1    GAIX01003477    JAA89083.1    KF929208    AHW45906.1    KPJ07248.1    KK852482    KDR22869.1    PCG78323.1    MH177600    AYM01172.1    HQ667939    AEG75845.1    ODYU01008647    SOQ52411.1    JQ690094    AFJ05097.1    AK402108    BAM18730.1    KPI97297.1    GDHF01000474    JAI51840.1    GBXI01004889    JAD09403.1    CH964101    EDW79551.1    GDHF01025387    JAI26927.1    MG879010    AWX68890.1    GAKP01010876    JAC48076.1    KY997068    ATY49608.1    KK852612    KDR20250.1    KC700029    KF855315    AHE13884.1    AIT99311.1    GANO01001860    JAB58011.1    MH189347    AYN44515.1    MH189370    AYN44538.1    KOB75341.1    GBYB01006640    JAG76407.1    KP938864    AKS40345.1    GAKP01010873    JAC48079.1    NEVH01004959    PNF39266.1    KM099186    AIL29316.1    REGN01000043    RNA44949.1    MH189327    AYN44495.1    GAMC01003374    JAC03182.1    GAMC01003373    JAC03183.1    EZ966124    ADK66966.1    GFTR01003971    JAW12455.1    AE014296    AY070667    GQ351317    GQ351318    AAF50405.1    KQ978273    KYM95783.1    UFQS01000264    UFQT01000264    SSX02186.1    SSX22563.1    CM000363    CM002912    EDX09720.1    KMY98399.1    GGFM01003179    MBW23930.1    GBXI01014923    JAC99368.1    KX609439    ARN17846.1    GBXI01007861    JAD06431.1    GL888273    EGI63557.1    AXCN02000521    GBXI01000491    JAD13801.1    GAKP01010878    JAC48074.1    JQ690095    GAKP01010875    AFJ05098.1    JAC48077.1    KM657434    AJA33435.1    CM000159    EDW93157.1    AM492670    CAM34501.1    GECL01000398    JAP05726.1    NNAY01003100    OXU19978.1    GGFJ01008552    MBW57693.1    EDW93158.1    GGFK01007630    MBW40951.1    CH940647    EDW69303.1    LNIX01000004    OXA56160.1    CH379069    EDY73696.2    GL732546    EFX80638.1    ATLV01024038    KE525348    KFB50408.1    GBYB01005576    JAG75343.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000218220    UP000037510    + More
UP000027135    UP000007798    UP000075880    UP000235965    UP000276133    UP000000803    UP000078542    UP000000304    UP000192221    UP000007755    UP000075886    UP000002282    UP000215335    UP000075900    UP000008792    UP000198287    UP000001819    UP000000305    UP000030765    UP000069272   

PRIDE

B0LKP6    A8R5V3    Q2I0J6    Q2F5R1    Q2F689    H9JQL3    + More
Q9VSL3   

Pfam

PF13417   GST_N_3        + More
PF14497   GST_C_3
PF00043   GST_C

Interpro

IPR004046   GST_C        + More
IPR005442   GST_omega       
IPR036249   Thioredoxin-like_sf       
IPR036282   Glutathione-S-Trfase_C_sf       
IPR004045   Glutathione_S-Trfase_N       
IPR010987   Glutathione-S-Trfase_C-like       
IPR040079   Glutathione_S-Trfase       

SUPFAM

SSF47616   SSF47616        + More
SSF52833   SSF52833       

ProteinModelPortal

B0LKP6   A0A1W6I4L7   Q003U5   A8R5V3   Q2I0J6   Q2F5R1   + More
A0A0K8TVL8   A0A077DB46   A0A212ENT1   V5QRD7   A0A075X8Z3   A0A3G1ZLD4   A0A194QP05   S4PRM5   X5CYG0   A0A194PWB9   A0A2W1BKA7   A0A2A4K3U4   A0A0K0XRN2   A0A1P8L0S8   A0A3G1RJ69   A0A0A7BZ19   A0A0K0XRU9   A0A2H1WZL7   A0A0L7LIF7   A0A1P8L0S5   L0AUY5   A0A212ENR8   A0A0K8TUF6   Q2F689   H9JQL3   A0A1P8L0T2   I3QKS2   A0A2W1BLG9   S4PGW2   X5CHK3   A0A194QNZ4   A0A067RSS2   A0A2A4K3H8   A0A3G1ZLC9   F6KX45   A0A2H1WH63   M1F1J2   I4DLE0   A0A0K8WLV7   A0A0A1XFW9   B4N5B2   A0A0K8UJP0   A0A3G1RJ80   A0A034VXM9   A0A2S0E490   A0A067R995   W8DRC1   U5EVI8   A0A3G2JSG2   A0A3G2JSH3   A0A182JDY0   A0A0L7LJG6   A0A0C9RE60   A0A0K0XRR4   A0A034W067   A0A2J7REL7   A0A077D9Z1   A0A3M7TAC4   A0A3G2JSD7   W8C7W1   W8BVG5   F4MI62   A0A224XIY6   Q9VSL3   A0A151I9P5   A0A336KBC7   B4QM37   A0A2M3Z5Z3   A0A0A1WK06   A0A1W4USE1   A0A1W6L1J4   A0A0A1X6C0   F4WQF7   A0A182QF29   A0A0A1XS43   A0A034W064   M1F3Z9   A0A0A7RE47   B4PG13   B1GS90   A0A0V0GCL5   A0A232ENR6   A0A2M4BXD7   A0A182RS14   B4PG14   A0A2M4AJK6   B4LFS6   A0A226EFL0   B5DPX2   E9GI93   A0A084WJL4   A0A0C9RF10   A0A182FZL3  

PDB

3WD6     E-value=1.37973e-76,     Score=726

KEGG

100141441    K00310 pyrimidodiazepine synthase [EC:1.5.4.1] | (RefSeq) GSTo4, GST13; glutathione S-transferase om

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0004364   GO:0006749   GO:0016782   GO:0045174   GO:0016740   GO:0042803   GO:0006728   GO:0006726   GO:0004734   GO:0055114   GO:0005515   GO:0008152   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

Length:

247

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00168

Exp number, first 60 AAs:

0

Total prob of N-in:

0.05334

outside

1  -  247

 

 

Pi

158.937428

Theta

141.624046

Tajima's D

-0.708042

CLR

0.210789

CSRT

0.194490275486226

Interpretation

Uncertain