Gene

KWMTBOMO06553  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011651

Annotation

PREDICTED:_anamorsin_homolog_[Plutella_xylostella]

Location

Bomo_Chr11(+):10323975-10329919      View in EpiBrowser

Full name

Anamorsin homolog       + More
Anamorsin      

Alternative Name

Fe-S cluster assembly protein DRE2 homolog
Cytokine-induced apoptosis inhibitor 1

Location in the cell

Nuclear   Reliability : 2.65

CDS

ATGGACAACTTGAAAAACGGAGACAATGTTCTTATTATTTGGAAGAACGACAGTCAAGGAAACATTACGAGCCTAATAGAAGACGTAAAAAAAGTAATTCAAAGTGATACTGTGGTTCTGGAAAACTCCGACATGATCACTGAAGGTTCCCGTGAGCATTCATCATTTGATGTTGTTCTCTCAAACTGGTTACCTCCCCACAGTGTCTCACATTCTGATAAACTATTGGCAATAATCATTAAATTACTCAAACCAAATGGTAAACTTATACTCAAAGATCTCAACAAATTGACCAGTACACTTAAATTAAATGGTTTTGTAAATGTCACTGAATTGGAGAATAACAGATATGTTGCGGAGAAACCAAAGTTTGAGGTTGGTTCAAAGTCATCTCTGAAATTAAATGGAAAAGCCACAGTCTGGAAGTTGGACAGCACAGTTGAGGAAGCTTGGGCCAGCACTAACAACGATGATATTATTGATGAGAACGAACTATTGGATGAAAATGACCTTAAAAAGCCAGATAAAGAAGCTTTGAGTGTTTGTGCAACAACAGGCAAGAGAAAAGCGTGCGTGGACTGCACCTGTGGCCTCGCCGAGGAACTAAGGGGCGAGACAAAAGAAACTCCAAAATCGTCGTGTGGAAGTTGTTACTTGGGCGATGCGTTCCGATGCGCGACCTGCCCGTACCTCGGCATGCCAGCCTTCAAGCCCGGCGAGAAAGTGATGTTAGATCTCAAGGCCGATATATGA

Protein

MDNLKNGDNVLIIWKNDSQGNITSLIEDVKKVIQSDTVVLENSDMITEGSREHSSFDVVLSNWLPPHSVSHSDKLLAIIIKLLKPNGKLILKDLNKLTSTLKLNGFVNVTELENNRYVAEKPKFEVGSKSSLKLNGKATVWKLDSTVEEAWASTNNDDIIDENELLDENDLKKPDKEALSVCATTGKRKACVDCTCGLAEELRGETKETPKSSCGSCYLGDAFRCATCPYLGMPAFKPGEKVMLDLKADI

Description

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.

Cofactor

[2Fe-2S] cluster
[4Fe-4S] cluster

Subunit

Monomer.
Monomer. Interacts with NDOR1. Interacts with CHCHD4.

Similarity

Belongs to the anamorsin family.

Keywords

2Fe-2S   4Fe-4S   Complete proteome   Cytoplasm   Iron   Iron-sulfur   Metal-binding   Mitochondrion   Reference proteome  

Feature

chain  Anamorsin homolog

Uniprot

H9JQ45   A0A2W1BP47   A0A2A4JAH4   A0A2H1WPT8   I4DLD1   I4DMN8   + More
A0A3S2L842   A0A194QUM9   S4PBA6   A0A336MID5   A0A336L2I2   A0A182H5V0   A0A023ENN9   Q17L24   U5EZP7   A0A1L8DJE0   A0A182JL34   R4G435   A0A0P4VK93   A0A1L8DJ86   A0A224XTC9   A0A2J7PDG1   A0A182VUA7   A0A084VYN7   A0A1Q3FHC1   A0A182Y932   A0A182P675   E0VVV1   B0WQ75   A0A164U5S6   A0A182M6Q8   A0A2M3ZAR1   A0A2M3ZIR8   A0A182JSP8   A0A182QA31   A0A182NGL8   W5JDU4   A0A182RUQ0   A0A182F5S4   A0A182VLU3   Q7PWQ6   A0A0P6BHU6   A0A2M4AL90   T1GFK3   A0A182XDC5   A0A182LMX8   A0A182UKD8   A0A182I776   A0A2M4BY03   A0A2M4BY08   A0A2M4ALW0   A0A067RKU9   A0A0T6B1T1   A0A2M4ANS4   A0A1J1HRV3   A0A0K8TA45   A0A0A9Z9I8   A0A3B4DTP7   A0A2D0RE45   A0A1B0CE17   E9G038   E3TGJ0   A0A212ENS5   A0A091HPD0   A0A1B6HMY8   A0A2M4AMY9   A0A093QT01   A0A2D0RF89   A0A1V9XF13   A0A093DLM5   A0A0L7R1C9   K7IZS4   A0A0L0C6D9   A0A1A7XQD0   D6WCU7   W5L046   A0A3B1JES3   A0A093JDV6   A0A232FFP7   R0JU51   A0A093HBM5   A0A091MPX2   A0A0P6I6S5   A0A1B6G9N3   A0A093C8X6   A0A091WN69   A0A091FLL3   A0A315VZG0   K1PUR4   A0A093NG25   A0A087QN74   A0A3Q3IMV3   A0A1V4K0U4   B4NYT3   B4HXL7   M4ANG0   A0A091R1B5   A0A2I4D9Y4   A0A087VLS0   A0A0L7LGC4  

Pubmed

19121390    28756777    22651552    26354079    23622113    26483478    + More
24945155    17510324    27129103    24438588    25244985    20566863    20920257    23761445    12364791    20966253    24845553    25401762    21292972    20634964    22118469    28327890    20075255    26108605    18362917    19820115    25329095    28648823    29703783    22992520    17994087    23542700    26227816   

EMBL

BABH01012138    BABH01012139    KZ149971    PZC76051.1    NWSH01002125    PCG69085.1    + More
ODYU01010147    SOQ55048.1    AK402099    KQ459590    BAM18721.1    KPI97282.1    AK402556    BAM19178.1    RSAL01000094    RVE47875.1    KQ461190    KPJ07261.1    GAIX01006007    JAA86553.1    UFQT01001355    SSX30182.1    UFQS01000874    UFQT01000874    UFQT01004235    SSX07420.1    SSX27762.1    SSX35586.1    JXUM01026690    KQ560764    KXJ80974.1    GAPW01003554    JAC10044.1    CH477219    GANO01000396    JAB59475.1    GFDF01007543    JAV06541.1    ACPB03012557    GAHY01001136    JAA76374.1    GDKW01001124    JAI55471.1    GFDF01007545    JAV06539.1    GFTR01004644    JAW11782.1    NEVH01026387    PNF14370.1    ATLV01018382    KE525231    KFB43081.1    GFDL01008097    JAV26948.1    DS235815    EEB17507.1    DS232036    LRGB01001581    KZS11086.1    AXCM01000336    GGFM01004868    MBW25619.1    GGFM01007648    MBW28399.1    AXCN02002086    ADMH02001840    ETN60954.1    AAAB01008984    GDIP01015677    JAM88038.1    GGFK01008234    MBW41555.1    CAQQ02395050    APCN01003368    GGFJ01008751    MBW57892.1    GGFJ01008752    MBW57893.1    GGFK01008440    MBW41761.1    KK852567    KDR21215.1    LJIG01016192    KRT81340.1    GGFK01009061    MBW42382.1    CVRI01000020    CRK90707.1    GBRD01003540    JAG62281.1    GBHO01001662    JAG41942.1    AJWK01008508    GL732528    EFX87463.1    GU589476    ADO29426.1    AGBW02013617    OWR43129.1    KL519666    KFO89178.1    GECU01031680    JAS76026.1    GGFK01008832    MBW42153.1    KL431080    KFW91641.1    MNPL01013003    OQR71948.1    KN127047    KFU94711.1    KQ414668    KOC64647.1    JRES01000940    KNC26989.1    HADW01018649    HADX01011977    SBP20049.1    KQ971311    EEZ99063.1    KK575366    KFW10037.1    NNAY01000319    OXU29259.1    KB743139    EOB01001.1    KL205902    KFV76367.1    KK834474    KFP79010.1    GDIQ01009701    JAN85036.1    GECZ01022160    GECZ01010627    JAS47609.1    JAS59142.1    KL455283    KFV08747.1    KL411055    KFR02951.1    KL447260    KFO71365.1    NHOQ01001396    PWA24856.1    JH815838    EKC25468.1    KL224535    KFW60965.1    KL225750    KFM02678.1    LSYS01005191    OPJ78024.1    CM000157    CH480818    KK711337    KFQ33565.1    KL497913    KFO13562.1    JTDY01001239    KOB74439.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000283053    UP000053240    UP000069940    + More
UP000249989    UP000008820    UP000075880    UP000015103    UP000235965    UP000075920    UP000030765    UP000076408    UP000075885    UP000009046    UP000002320    UP000076858    UP000075883    UP000075881    UP000075886    UP000075884    UP000000673    UP000075900    UP000069272    UP000075903    UP000007062    UP000015102    UP000076407    UP000075882    UP000075902    UP000075840    UP000027135    UP000183832    UP000261440    UP000221080    UP000092461    UP000000305    UP000007151    UP000192247    UP000053825    UP000002358    UP000037069    UP000007266    UP000018467    UP000215335    UP000053584    UP000053283    UP000053760    UP000005408    UP000054081    UP000053286    UP000261600    UP000190648    UP000002282    UP000001292    UP000002852    UP000192220    UP000037510   

PRIDE

H9JQ45    B0WQ75   

Pfam

PF05093   CIAPIN1        + More
PF16803   DRE2_N
PF08241   Methyltransf_11
PF13847   Methyltransf_31

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR007785   Anamorsin       
IPR031838   Dre2_N       
IPR013216   Methyltransf_11       
IPR025714   Methyltranfer_dom       
IPR036388   WH-like_DNA-bd_sf       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF53335   SSF53335        + More
SSF46689   SSF46689       

Gene 3D

1.10.10.10    

ProteinModelPortal

H9JQ45   A0A2W1BP47   A0A2A4JAH4   A0A2H1WPT8   I4DLD1   I4DMN8   + More
A0A3S2L842   A0A194QUM9   S4PBA6   A0A336MID5   A0A336L2I2   A0A182H5V0   A0A023ENN9   Q17L24   U5EZP7   A0A1L8DJE0   A0A182JL34   R4G435   A0A0P4VK93   A0A1L8DJ86   A0A224XTC9   A0A2J7PDG1   A0A182VUA7   A0A084VYN7   A0A1Q3FHC1   A0A182Y932   A0A182P675   E0VVV1   B0WQ75   A0A164U5S6   A0A182M6Q8   A0A2M3ZAR1   A0A2M3ZIR8   A0A182JSP8   A0A182QA31   A0A182NGL8   W5JDU4   A0A182RUQ0   A0A182F5S4   A0A182VLU3   Q7PWQ6   A0A0P6BHU6   A0A2M4AL90   T1GFK3   A0A182XDC5   A0A182LMX8   A0A182UKD8   A0A182I776   A0A2M4BY03   A0A2M4BY08   A0A2M4ALW0   A0A067RKU9   A0A0T6B1T1   A0A2M4ANS4   A0A1J1HRV3   A0A0K8TA45   A0A0A9Z9I8   A0A3B4DTP7   A0A2D0RE45   A0A1B0CE17   E9G038   E3TGJ0   A0A212ENS5   A0A091HPD0   A0A1B6HMY8   A0A2M4AMY9   A0A093QT01   A0A2D0RF89   A0A1V9XF13   A0A093DLM5   A0A0L7R1C9   K7IZS4   A0A0L0C6D9   A0A1A7XQD0   D6WCU7   W5L046   A0A3B1JES3   A0A093JDV6   A0A232FFP7   R0JU51   A0A093HBM5   A0A091MPX2   A0A0P6I6S5   A0A1B6G9N3   A0A093C8X6   A0A091WN69   A0A091FLL3   A0A315VZG0   K1PUR4   A0A093NG25   A0A087QN74   A0A3Q3IMV3   A0A1V4K0U4   B4NYT3   B4HXL7   M4ANG0   A0A091R1B5   A0A2I4D9Y4   A0A087VLS0   A0A0L7LGC4  

PDB

2YUI     E-value=0.00100534,     Score=98

KEGG

101735486    K22746 anamorsin | (RefSeq) anamorsin homolog

GO

GO:0051539   GO:0009055   GO:0005758   GO:0016226   GO:0051537   GO:0046872   GO:0008168   GO:0005737   GO:0005634   GO:0043066   GO:0006915   GO:0030097   GO:0051536   GO:0003677   GO:0005730   GO:0005654   GO:0030707   GO:0016791   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0006260  

PANTHER

PTHR13273  

Subcellular location

Cytoplasm  
Mitochondrion intermembrane space  
Nucleus  

Length:

250

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00337

Exp number, first 60 AAs:

0

Total prob of N-in:

0.08975

outside

1  -  250

 

 

Pi

200.597813

Theta

173.09774

Tajima's D

0.648275

CLR

0

CSRT

0.56177191140443

Interpretation

Uncertain