Gene

KWMTBOMO06549

Pre Gene Modal

BGIBMGA011827

Annotation

PREDICTED:_cell_division_cycle_protein_27_homolog?_partial_[Bombyx_mori]

Location

Bomo_Chr11(-):10228745-10232354      View in EpiBrowser

Full name

Cell division cycle protein 27 homolog      

Alternative Name

Anaphase-promoting complex subunit 3
CDC27 homolog
H-NUC

Location in the cell

Nuclear   Reliability : 1.471

CDS

ATGATTGTGCAAGAACCTATCCAGGTTATCGTTTGGGATTGCCTCAACAATTATGAATTCGAAAACGCTATATTTTTGGCAGAAAGATTGTATGCGGAAGTTGGCTCAGAAGAAGCTGCGTTTTTGTTGGGAACATGTTATTATAGGTCAGGGCGAATTAATGAAGCACATCATTTACTTCAAAATAAAACCCTTGCATTACCACAAGCAAGGTTTTTATTAGCCAAATGTTCAGCTGACTTGAAATCCTACAAAGATGCAGAAATTGCACTGGGCTCCAACCTTGATATAATAGCTTCTGAATTTGGAGAGCAGGCGCCATACGCTTTACAGCTTCTTGCCAAAGTATACATCAGCACAGGAAGAAGGAATGAAGCCGCTGAAGCCCATCGGAAAGCACTATCTCTTAACCCATTTATGTGGAAATCATTTGCACAGCTCTGTAATATGGGTGAGAAAGTTGACCCCCAACAAGTTTTCCAAATAAACAACTCTGAGTTCACATTTGGTGTTACAACATTAGTCAATCTAGTCAGCAATTCAGAAAATATATCATTTGTTAACTGTAATATTCATAATAACAGCAGCATGAATACAAATGTAACACCTAATAATGTTGCCACACGTACACCCATGGCTATGTCGACAAGTATAACTCCTGAGACACAAGCCCCAATGAAGCGAATGCATAGTGTTTTTAGTGGTATGGCACCTATTCCATTTTCACCATCATTTGGAATGCTTACAATGGAAGAATCTCCTGTATTATATACTCCAACATTGACAGATTCAAATGAACAGAAAGCAATTCCTAAAATAGTTAATTCTCTACGTGCACAAATGGGACAACTTAAGGATGCAGTATTTAGCCCAGCTCCAAGATGTACACTTGGCCCTGCCCCACGTAGATCATCAAGACTATTCAGTAATAATAATAGTAGTTATTCAGTAAAGGAAAATAATAAATCACCTAGTAGGAAATTTGCAGCACCAAAGAGTCCCTCAAGAAAAAATAAACAGAGAACTGCTAAAAATATTAAATCTAATACAATAGATTCAAATAAAAGTATAGAAACTGTCACTCCAACCATACCTCCAAAGAATTCAAATGGAGTAGCATTGTTGAGTCTTATGAAAGAAATAGGAGAAGCTTATAAATATCTTGCATTTTTAGACTGTAAAAATGCAATAAAATCCTTTCAAGAGTTACCTCCAAAACAATTGGCTTCACCTTGGGTACAAACCATGATCGCACGTAGCCATTATGAATTGGCTCAATATGAGGCAGCTGCTAAAATATTTTCAGAAATAAGAAAACAGTATCCAAGTCGTACTGAAGGGATGGAAATTTACAGTACCTGTCTATGGCATCTTCAGCGTGAAGCACAGTTATCAGCCTTAGCACAAGAATTAGTAGAATTAAACAGAACTAATCCAATTGCTTGGTTAGTTGCAGGAAACTGTTTTTCTCTTCATAAGGAACGTGAAACTGCATTAAAGTTCTTCAGACGTGCAGTTCAGCTAAATCCAGATGCTGCTTATGCACATGCATTATTAGGGCACGAATACGCCGTAGCAGAAGAAACTGATAAAGCTCTTGCTAGCTTCAGGTTAGCTGTTAGTATTGATCCACGAAATTACGTTGCATGGTTTGGTATAGCTACAGTTTACGCACGACAAGAACGTTGGAAAGCATCAGAAGTTCACATACGCCGTGCTCTCAGTATACATCCACTTTCAGGAGTGTTGAGATGTCAGTTAGGTCTGGCACAGTCTGCTCTCGGAAAAATGGAAAGAGCTTTATCCACATTAGAAAAAGCTGTAGCATTAGATACAGAGAATCCCTTATGTCGTTTCCATAGAGCTTCTGTATTGTTAAGAGCAGGAAGACCGCAAGATGCATTAGCAGATCTACATCACTTAAAGGACATAGCCCCTAGAGAGTCATTAGTTTATTATTTACTGGGAAAAGTTCACAATAAATTAGGTAATGCTCATTTGGCATTAATGCACTTTAGTTGGGCTACAGATTTAGATCCTAAAGGAACTGGAGGTCACATAAAAGAAGGATTCGATCCATCAAAACAGGAAGATCCACCTGAGAGATCAACCTAA

Protein

MIVQEPIQVIVWDCLNNYEFENAIFLAERLYAEVGSEEAAFLLGTCYYRSGRINEAHHLLQNKTLALPQARFLLAKCSADLKSYKDAEIALGSNLDIIASEFGEQAPYALQLLAKVYISTGRRNEAAEAHRKALSLNPFMWKSFAQLCNMGEKVDPQQVFQINNSEFTFGVTTLVNLVSNSENISFVNCNIHNNSSMNTNVTPNNVATRTPMAMSTSITPETQAPMKRMHSVFSGMAPIPFSPSFGMLTMEESPVLYTPTLTDSNEQKAIPKIVNSLRAQMGQLKDAVFSPAPRCTLGPAPRRSSRLFSNNNSSYSVKENNKSPSRKFAAPKSPSRKNKQRTAKNIKSNTIDSNKSIETVTPTIPPKNSNGVALLSLMKEIGEAYKYLAFLDCKNAIKSFQELPPKQLASPWVQTMIARSHYELAQYEAAAKIFSEIRKQYPSRTEGMEIYSTCLWHLQREAQLSALAQELVELNRTNPIAWLVAGNCFSLHKERETALKFFRRAVQLNPDAAYAHALLGHEYAVAEETDKALASFRLAVSIDPRNYVAWFGIATVYARQERWKASEVHIRRALSIHPLSGVLRCQLGLAQSALGKMERALSTLEKAVALDTENPLCRFHRASVLLRAGRPQDALADLHHLKDIAPRESLVYYLLGKVHNKLGNAHLALMHFSWATDLDPKGTGGHIKEGFDPSKQEDPPERST

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Subunit

Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (By similarity). Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1 (By similarity).
Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (By similarity). Interacts with RB. Interacts with FAM168B/MANI (PubMed:20716133). Interacts with MCPH1 (By similarity).
Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1 (PubMed:22139841).

Similarity

Belongs to the APC3/CDC27 family.

Keywords

Complete proteome   Nucleus   Phosphoprotein   Reference proteome   Repeat   TPR repeat   Ubl conjugation pathway   Alternative splicing   3D-structure   Polymorphism  

Feature

chain  Cell division cycle protein 27 homolog
splice variant  In isoform 2 and isoform 3.
sequence variant  In a breast cancer sample; somatic mutation.

Uniprot

H9JQM1   A0A2A4JM55   A0A2W1BS94   A0A2H1V9T5   A0A212EQP9   A0A194QUN4   + More
A0A194PVC8   A0A0L7L5F9   S4PBX1   A0A067QMT7   A0A2J7Q745   A0A1B6CI21   A0A1B6CA75   A0A2J7Q753   A0A1Y1KFQ5   A0A158NCH3   A0A026X3Q2   A0A151WMU1   A0A0L7QNT1   A0A146LB22   A0A0K8SSP0   A0A0K8SS92   A0A0A9W3T4   A0A0A9WC99   D6WE80   A0A1B6JB13   A0A232EWT7   A0A1W4WJJ2   E2BBZ1   A0A2A3E6H6   A0A1B6EIM3   A0A2P6KSE5   A0A087UYA4   A0A154NZW1   C3YYK3   A0A069DXI8   A0A2R5LMU0   T1I1S9   A0A1L8DX52   A0A1L8DX40   A0A1S3HBY8   A0A224XJM2   A0A1S3HBU9   Q4V8A2   G1TVC8   A0A2U3XSH4   A0A3Q7S7G7   A0A3P4RU91   A0A3Q7WTH3   A0A384CAF5   A0A2Y9KPK0   A0A3Q7SG91   A0A2U3ZRH1   A0A3Q7XNQ4   A0A3Q7QH60   A0A2Y9G554   A0A2K5F6T3   A0A384CA94   F1Q3E7   A0A2Y9L2F3   A0A3Q7T5D6   A0A2U3WPP9   M3Y9M5   A0A3Q7X265   A2A6Q5   A0A341CPA6   A0A2U4C3K3   A0A2Y9PFY0   G5EA36   A0A2K6URD5   A0A0M8ZRF7   F6RN71   A0A287DBJ2   U3CSN8   A2A6Q5-2   P30260   A0A1S3GIV6   W5PPV6   A2A6Q5-3   A0A1S3GL51   A0A2J8J9M7   K9IMX3   F1RRT1   K7DMX4   A0A2K5SAZ2   S7NZ57   L5KTD9   A0A2J8UZ56   A0A3Q7QJE6   A0A383ZLW9   G3T800   U3E8G7   A0A0D9QUY6   H9EPL4   A0A2J8UZ51   G1M7Z1   A0A2U3WPY4   A0A3Q7QUN4   A0A2U4C3K8  

Pubmed

19121390    28756777    22118469    26354079    26227816    23622113    + More
24845553    28004739    21347285    24508170    30249741    26823975    25401762    18362917    19820115    28648823    20798317    18563158    26334808    15489334    21993624    24813606    16341006    19468303    20716133    11181995    16964243    16625196    18669648    19413330    19690332    20068231    21269460    23186163    19892987    25243066    8234252    7756179    14657031    18485873    21307936    16364912    22139841    25043029    26083744    16959974    20809919    23258410    17431167    25319552    20010809   

EMBL

BABH01012147    NWSH01001010    PCG73137.1    KZ149971    PZC76057.1    ODYU01001414    + More
SOQ37561.1    AGBW02013252    OWR43820.1    KQ461190    KPJ07266.1    KQ459590    KPI97277.1    JTDY01002785    KOB70733.1    GAIX01005722    JAA86838.1    KK853239    KDR09515.1    NEVH01017447    PNF24399.1    GEDC01024184    JAS13114.1    GEDC01027049    JAS10249.1    PNF24398.1    GEZM01087841    JAV58445.1    ADTU01011886    KK107034    QOIP01000008    EZA62024.1    RLU19609.1    KQ982934    KYQ49189.1    KQ414843    KOC60280.1    GDHC01013111    JAQ05518.1    GBRD01009635    JAG56189.1    GBRD01009636    JAG56188.1    GBHO01041110    JAG02494.1    GBHO01041109    JAG02495.1    KQ971325    EEZ99466.1    GECU01037849    GECU01011369    JAS69857.1    JAS96337.1    NNAY01001823    OXU22808.1    GL447175    EFN86815.1    KZ288377    PBC26651.1    GECZ01031992    JAS37777.1    MWRG01005995    PRD29260.1    KK122254    KFM82343.1    KQ434786    KZC05133.1    GG666565    EEN54643.1    GBGD01000487    JAC88402.1    GGLE01006698    MBY10824.1    ACPB03014726    GFDF01003053    JAV11031.1    GFDF01003054    JAV11030.1    GFTR01008093    JAW08333.1    BC097475    AAGW02039889    AAGW02039890    AAGW02039891    CYRY02043393    VCX37755.1    AAEX03006341    AAEX03006342    AEYP01079234    AEYP01079235    AL603709    CH466558    BC157955    BC172100    AC002558    CH471231    EAW57688.1    KQ435955    KOX68019.1    AGTP01052477    AGTP01052478    AGTP01052479    AGTP01052480    GAMS01001687    JAB21449.1    U00001    S78234    AY518321    BC011656    AMGL01018839    AMGL01018840    AMGL01018841    NBAG03000498    PNI19464.1    GABZ01004370    JAA49155.1    AEMK02000080    GABC01002557    GABF01006682    GABE01000570    JAA08781.1    JAA15463.1    JAA44169.1    PNI19459.1    KE161298    EPQ02948.1    KB030578    ELK14211.1    NDHI03003438    PNJ50550.1    GAMQ01003397    JAB38454.1    AQIB01117874    AQIB01117875    JSUE03016688    JU320566    JU320567    JU478102    AFE64323.1    AFH34906.1    PNJ50545.1    ACTA01000109    ACTA01008109    ACTA01144106    ACTA01152105    ACTA01160104    ACTA01168102    ACTA01176100    ACTA01184098    ACTA01192096   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000027135    UP000235965    UP000005205    UP000053097    UP000279307    UP000075809    UP000053825    UP000007266    UP000215335    UP000192223    UP000008237    UP000242457    UP000054359    UP000076502    UP000001554    UP000015103    UP000085678    UP000002494    UP000001811    UP000245341    UP000286640    UP000286642    UP000261680    UP000248482    UP000245340    UP000286641    UP000248481    UP000233020    UP000291021    UP000002254    UP000000715    UP000000589    UP000252040    UP000245320    UP000248483    UP000005640    UP000233220    UP000053105    UP000002281    UP000005215    UP000081671    UP000002356    UP000008227    UP000233040    UP000010552    UP000261681    UP000007646    UP000029965    UP000006718    UP000008912   

PRIDE

H9JQM1    Q4V8A2    A2A6Q5    G5EA36    P30260    F1RRT1    + More

Pfam

PF13174   TPR_6        + More
PF13181   TPR_8
PF00515   TPR_1
PF00804   Syntaxin
PF05721   PhyH
PF13176   TPR_7
PF07719   TPR_2

Interpro

IPR013026   TPR-contain_dom        + More
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR001440   TPR_1       
IPR010989   SNARE       
IPR006011   Syntaxin_N       
IPR000727   T_SNARE_dom       
IPR008775   Phytyl_CoA_dOase       
IPR013105   TPR_2       

SUPFAM

SSF48452   SSF48452        + More
SSF47661   SSF47661       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9JQM1   A0A2A4JM55   A0A2W1BS94   A0A2H1V9T5   A0A212EQP9   A0A194QUN4   + More
A0A194PVC8   A0A0L7L5F9   S4PBX1   A0A067QMT7   A0A2J7Q745   A0A1B6CI21   A0A1B6CA75   A0A2J7Q753   A0A1Y1KFQ5   A0A158NCH3   A0A026X3Q2   A0A151WMU1   A0A0L7QNT1   A0A146LB22   A0A0K8SSP0   A0A0K8SS92   A0A0A9W3T4   A0A0A9WC99   D6WE80   A0A1B6JB13   A0A232EWT7   A0A1W4WJJ2   E2BBZ1   A0A2A3E6H6   A0A1B6EIM3   A0A2P6KSE5   A0A087UYA4   A0A154NZW1   C3YYK3   A0A069DXI8   A0A2R5LMU0   T1I1S9   A0A1L8DX52   A0A1L8DX40   A0A1S3HBY8   A0A224XJM2   A0A1S3HBU9   Q4V8A2   G1TVC8   A0A2U3XSH4   A0A3Q7S7G7   A0A3P4RU91   A0A3Q7WTH3   A0A384CAF5   A0A2Y9KPK0   A0A3Q7SG91   A0A2U3ZRH1   A0A3Q7XNQ4   A0A3Q7QH60   A0A2Y9G554   A0A2K5F6T3   A0A384CA94   F1Q3E7   A0A2Y9L2F3   A0A3Q7T5D6   A0A2U3WPP9   M3Y9M5   A0A3Q7X265   A2A6Q5   A0A341CPA6   A0A2U4C3K3   A0A2Y9PFY0   G5EA36   A0A2K6URD5   A0A0M8ZRF7   F6RN71   A0A287DBJ2   U3CSN8   A2A6Q5-2   P30260   A0A1S3GIV6   W5PPV6   A2A6Q5-3   A0A1S3GL51   A0A2J8J9M7   K9IMX3   F1RRT1   K7DMX4   A0A2K5SAZ2   S7NZ57   L5KTD9   A0A2J8UZ56   A0A3Q7QJE6   A0A383ZLW9   G3T800   U3E8G7   A0A0D9QUY6   H9EPL4   A0A2J8UZ51   G1M7Z1   A0A2U3WPY4   A0A3Q7QUN4   A0A2U4C3K8  

PDB

5LCW     E-value=5.90127e-148,     Score=1346

KEGG

101736244    K03350 anaphase-promoting complex subunit 3 | (RefSeq) cell division cycle protein 27 homolog

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0051301   GO:0016020   GO:0016192   GO:0003677   GO:0007091   GO:0005680   GO:0005876   GO:0005654   GO:0005737   GO:0019903   GO:0005813   GO:0070979   GO:0005634   GO:0031145   GO:1901990   GO:0005829   GO:0006511   GO:0005515   GO:0000166   GO:0015385   GO:0016021   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0006260  

Subcellular location

Nucleus  

Length:

704

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01969

Exp number, first 60 AAs:

0.00025

Total prob of N-in:

0.00103

outside

1  -  704

 

 

Pi

5.620587

Theta

7.144782

Tajima's D

-0.734999

CLR

0.749679

CSRT

0.19974001299935

Interpretation

Uncertain