Gene

KWMTBOMO06543

Pre Gene Modal

BGIBMGA011831

Annotation

PREDICTED:_sodium/hydrogen_exchanger_3_[Bombyx_mori]

Location

Bomo_Chr11(-):10156478-10199374      View in EpiBrowser

Full name

Sodium/hydrogen exchanger      

Location in the cell

PlasmaMembrane   Reliability : 4.502

CDS

ATGACGTCATTGAAGCACGGAGTGAACTTGAGCAGACGCGCTTGCAGGCAAGCCTTCGCTTTGGTCGCTGTGAGCACGATACTGCACGCCGTACAATGTTCACCTGTCGAAACTACCACGAAAACGAATCCGTCCATGACAGTCGATGGTATATCGACGTACCCTGGTCTAGGGTTCGGACCAATGGGTCCTGTGGAGCCCTTACCCGGAGAGCCACCAGGCACACAGCTACGCCAGAACCAAGACACTACAACTGAATTACCGACAACTGAGAAAACCAAGAAGGAGAGGACCTTCGTGATAGCAGCGTTTGAGTTCCATCGAGTGGAGACGCCATTTTTGATCGGACTTTGGATATTTTTTGCCAGTCTCGCGAAGATAGGGTTCCACATGGCTCCGAAACTATCACGAATGTTACCTGAGTCATGTCTCCTTGTCTTCGTTGGTGTGTTGATAGGTGCATTACTTCTAAGTACTCACAGTGTACACGTTCAACCACTCACACCGGATACCTTCTTTTTGTATATGCTTCCACCTATAATATTGGATGCGGGATATTTTATGCCAAACAGGCTATTCTTTGATCATTTGGGTACCATTTTATTGTTTGCTGTTGTTGGGACTGTATTCAACACTTTGACTATTGGTGCTTCATTGTGGGCTTGCGGCCAGACTGGCATGTTCGGGTGTACAACACCGTTATTAGATATGCTGTTGTTCGGGGCTTTAATATCAGCCGTGGATCCGGTGGCGGTATTGGCGGTGTTCGAAGAAATTCACGTTGACGAAGTTTTGTATATTGTTGTTTTCGGTGAATCCTTACTTAACGATGCCGTTACTGTTGTATTGTATCACATGTTCGAAGCATACACGGAAATGGGACCGTCGCGTCTAGTCTACACGGATATTCTGGCCGGCCTGGCTTCGTTCCTGGTCGTAGCAGTAGGGGGAACGTGTATTGGAGTTGTGTGGGGCTTCGCGACGGGTCTCGTAACTCGCTTCACCAACGAAGTCAGGGTCATAGAGCCGATCTTCATATTCGTAATGGCGTATTTAGCATATTTGAACGCGGAAATGTTTCACATGAGCGGGATATTAGCCATAACATTTTGCGGTATTACAATGAAGAATTATGTTGAAGCGAATATTTCACATAAATCACACACCACAATCAAATACACTATGAAGATGCTATCGTCTTCGTCTGAGACCATTATATTCATGTTTCTCGGTGTCGCAACAGTGAATAACACCCACGTTTGGAATACGTGGTTCGTACTGTTAACCATTGTGTTCTGCTCAATATTCCGGATTATAGGAGTATACATATTTAGCGCTGTAGCAAATAAGTTTCGTCTGCACAAATTGAATAGAGTTGAGAAATTCGTCATGTCTTATGGAGGTCTCCGAGGCGCAGTGGCTTTCGCACTTGTTCTACTTATAGATCCAACGGTAGTAAATCTGCAGCCCATGTTTGTTACAACGACAATAGCTGTGATATACTTTACGGTTTTCATACAAGGCATCACGATCAAGCCCCTGGTCAAGATACTGAATGTGAAGACGGCGGAAAAACGGAAACCCACTATGAACGAGAGGATCCATGAGAGGTGCATGGATCACTTGATGGCAGGCATTGAAGATATTCTCGGCAAACATGGCAATCATCATATGCGTGATAAATTTAAAAGATTCGACAATAGATTTATCAGGCCATTCCTTTTGAGAAATTATCAGGGAGCGGAACCGAAGATTTTGGAGACTTATTCGAAATTAGCTATGAGAGACGCCATAGAATATATGCAAAGAAATGCTTCTACGATCGGTAACATTTCCGGAGCTGAATCCATGTCGGCGATTTTCAAAAATTACACAAACACAAACTTTAATGGAAGTCCAAGTTTTAGTCAAATAGATACATCGACTTGGAACATAGACATGCAGGAACTAGAATATAACCCCTCTAAGAAAGATCTCACTGATGCAAAAATCCATCATCTGCTCGCTGAAGAATTGTGCAAGCCTTTTAGACGGCATCGTCGCCTAAGCTACAGCCGGCATGCCGTAAACGAACGAGATCTCGGTATACAAGTCAACTACAAGACCCACATGAACATACGCAGACGGGTCGGTGACAGGAAACATCATCATAAAAGGAGCAAACGTGGAAAACAGGACGGAAAAAATCACGTTACTTTCCCGGAATTCCAGCAAAACGGTTCGGCTAAACAGTTCACGCACGATTATATCGACGAGGTACTTCAGGAGGACGGCGAAGAGCGGGAAGTCAGACGGGACGGCGACGACGGCGGTATTACATTCACTGCCAAATCCCCGCCCGGCTACAAAGAAGTCAGTCCAACGTCTTCGCATAAAGAAAATAGTAGTTCACTTTTAAACCAGTTGGCTAACCTGCCCGGATTTAATCCTCTTAAGGCGAGGATAATAAAGCAGTACGTTAAAACGCCCGAAGAGATACTACCGACAGCTGTTGAGAAATCCTTACCGTGGAGAAGGGACAGATCCACGTATAACTTTGTTCCCAACGAAGACATTCTAGAAGAAGACGAAAGAAGATTGTCCGATGACAACGATAACTACAACATGATCGTGGCTGAGCAAGCTCGAGTGGCGACGCCAACAGCAACGGAGACAATGTTGCCATGGAAACGAGAAGAAGCTGAAGGATCTGGTGCCCTCAAGCAATCAGAATTTCCTTCATGGGCTTCAAACAAAGAATATCTAGCCTATAATTCTCCTTCCTCTACTTTCTTAGGTCTATTCCGAAGAGAAAGCTCTAGTTCGACCCAAGGCGCTGCTGAAGCTGTAGTGCTATCTGATTCCGAGGGGCACAGAGAGAGTACCAGTAAAGGCGAAGCGTCCTCAAAAGACGGTGGTGTACGTCAAGGTCCTAGCTTATTATCGAAACGAAGCACAAGCCTGGGTGGTCCGTCTGTGTTGTTGATGGAGGACGTGGCCCATTCAGATCCTCTGGGTGCATCTAGCAGACCAGCTAGTATTATGCAAGGACCGCAACGAGGACAATGCCGGCGAGGTTCCATGATGGAGTTGACAGGTTCAATGTCGCGTGATGCAATAACAGAAGAGAAGTGTTGTAAATCGTTGCCAGAAAGTGAAAGGATGGGCGTCAGGCGTCTTCCCCTAGGTCAGAGTCTGGGACGGGAGCCGTTCATTCGACAGCTAACTTTAGCTTCGAGCCTTACGACTAGCTCATCATCAGAGGACTCATCGGACGAAAACACCTGA

Protein

MTSLKHGVNLSRRACRQAFALVAVSTILHAVQCSPVETTTKTNPSMTVDGISTYPGLGFGPMGPVEPLPGEPPGTQLRQNQDTTTELPTTEKTKKERTFVIAAFEFHRVETPFLIGLWIFFASLAKIGFHMAPKLSRMLPESCLLVFVGVLIGALLLSTHSVHVQPLTPDTFFLYMLPPIILDAGYFMPNRLFFDHLGTILLFAVVGTVFNTLTIGASLWACGQTGMFGCTTPLLDMLLFGALISAVDPVAVLAVFEEIHVDEVLYIVVFGESLLNDAVTVVLYHMFEAYTEMGPSRLVYTDILAGLASFLVVAVGGTCIGVVWGFATGLVTRFTNEVRVIEPIFIFVMAYLAYLNAEMFHMSGILAITFCGITMKNYVEANISHKSHTTIKYTMKMLSSSSETIIFMFLGVATVNNTHVWNTWFVLLTIVFCSIFRIIGVYIFSAVANKFRLHKLNRVEKFVMSYGGLRGAVAFALVLLIDPTVVNLQPMFVTTTIAVIYFTVFIQGITIKPLVKILNVKTAEKRKPTMNERIHERCMDHLMAGIEDILGKHGNHHMRDKFKRFDNRFIRPFLLRNYQGAEPKILETYSKLAMRDAIEYMQRNASTIGNISGAESMSAIFKNYTNTNFNGSPSFSQIDTSTWNIDMQELEYNPSKKDLTDAKIHHLLAEELCKPFRRHRRLSYSRHAVNERDLGIQVNYKTHMNIRRRVGDRKHHHKRSKRGKQDGKNHVTFPEFQQNGSAKQFTHDYIDEVLQEDGEEREVRRDGDDGGITFTAKSPPGYKEVSPTSSHKENSSSLLNQLANLPGFNPLKARIIKQYVKTPEEILPTAVEKSLPWRRDRSTYNFVPNEDILEEDERRLSDDNDNYNMIVAEQARVATPTATETMLPWKREEAEGSGALKQSEFPSWASNKEYLAYNSPSSTFLGLFRRESSSSTQGAAEAVVLSDSEGHRESTSKGEASSKDGGVRQGPSLLSKRSTSLGGPSVLLMEDVAHSDPLGASSRPASIMQGPQRGQCRRGSMMELTGSMSRDAITEEKCCKSLPESERMGVRRLPLGQSLGREPFIRQLTLASSLTTSSSSEDSSDENT

Similarity

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Feature

chain  Sodium/hydrogen exchanger

Uniprot

A0A2H1VK81   A0A212EQT5   A0A194PV44   A0A194QP30   A0A2A4JNX1   A0A2A4JNZ4   + More
H9JQM5   A0A067R6I4   E0VVV0   A0A139WKN9   A0A139WKX4   A0A1S4H0P3   A0A139WKQ1   E2AT05   A0A310SUC0   A0A151X1K5   A0A158NEZ9   T1HLN6   A0A195EUA9   F4W456   A0A182Q8W0   A0A224XJ56   A0A1W6EVP8   A0A1I8JU83   A0A195CKH5   A0A1Y1M429   E2B6P9   A0A026WMV2   A0A1Y1M586   A0A154PCL4   A0A034VTN8   V9I7M5   A0A0L7QSZ7   W8AZ23   V9I6L7   A0A182IQG8   V9I6M0   A0A1Y1M1Z0   W8AV39   A0A087ZVR0   Q5TNB1   A0A084VYE0   V9I6L4   Q6Y8G3   A0A2M3ZYK3   A0A1I8Q7V1   B4KGP5   Q17L17   A0A1Q3G3S6   A0A1I8Q7Y4   Q7Z0L7   A0A195E5H0   A0A0Q9X5Y7   A0A1B6CUX3   Q9NCQ0   A0A1W4UHX1   A0A0C9PZD1   A0A0Q9X8H4   A0A2M4BBH5   A0A0Q9XFZ5   Q9VIF9   A0A2M3YX91   A0A0Q9X659   M9NDU7   A0A2M3ZF79   A0A182UBY0   A0A1W4UVN6   A0A1I8Q7U8   A0A1I8Q7W5   B4IFK5   B3NKU7   B4P6Z7   A0A1I8Q7Z7   B4MDP3   A0A1A9XW14   A0A0Q5VYS2   A0A1I8Q7U3   A0A1W4UX32   A0A0R1DNH7   A0A1Q3G3Q3   A0A1I8Q7W0   A0A1Q3G2W6   A0A0Q9WXB3   A0A1Q3G3K3   A0A0C9REV7   A0A1W4UHV5   A0A1A9ZK74   A0A2C9GPC7   A0A1Q3G3J1   A0A2M4CJH9   A0A2M4CJ94   B3MU54   A0A2M4CIY5   A0A0P8Y5P0   A0A1Q3G2Y7   A0A2M3YX89   A0A0Q9X5Z9   A0A2M3ZYE4  

Pubmed

22118469    26354079    19121390    24845553    20566863    18362917    + More
19820115    12364791    20798317    21347285    21719571    28004739    24508170    30249741    25348373    24495485    14747013    17210077    24438588    16943493    17994087    17510324    12386840    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18057021    17550304   

EMBL

ODYU01003010    SOQ41230.1    AGBW02013252    OWR43814.1    KQ459590    KPI97271.1    + More
KQ461190    KPJ07272.1    NWSH01001010    PCG73143.1    PCG73142.1    BABH01012152    KK852854    KDR14983.1    DS235815    EEB17506.1    KQ971326    KYB28463.1    KYB28465.1    AAAB01008984    KYB28464.1    GL442439    EFN63440.1    KQ760208    OAD61382.1    KQ982585    KYQ54282.1    ADTU01001496    ADTU01001497    ADTU01001498    ADTU01001499    ACPB03012053    KQ981979    KYN31487.1    GL887491    EGI71052.1    AXCN02000627    GFTR01008365    JAW08061.1    KY563394    ARK19803.1    KQ977642    KYN00957.1    GEZM01043497    JAV79055.1    GL446000    EFN88633.1    KK107153    QOIP01000012    EZA56981.1    RLU15809.1    GEZM01043496    JAV79056.1    KQ434870    KZC09527.1    GAKP01013470    JAC45482.1    JR035716    JR035718    JR035721    JR035722    AEY56626.1    AEY56628.1    AEY56631.1    AEY56632.1    KQ414755    KOC61745.1    GAMC01016437    JAB90118.1    JR035709    JR035712    JR035715    JR035719    AEY56619.1    AEY56622.1    AEY56625.1    AEY56629.1    JR035711    JR035714    JR035717    JR035720    AEY56621.1    AEY56624.1    AEY56627.1    AEY56630.1    GEZM01043494    JAV79058.1    GAMC01016443    JAB90112.1    EAL39028.2    ATLV01018359    ATLV01018360    KE525231    KFB42984.1    JR035707    JR035708    JR035710    JR035713    AEY56617.1    AEY56618.1    AEY56620.1    AEY56623.1    AY170874    AAO34131.1    GGFK01000325    MBW33646.1    CH933807    EDW13245.2    CH477219    EAT47410.1    GFDL01000587    JAV34458.1    AY122621    AAM63432.1    KQ979609    KYN20147.1    KRG03638.1    GEDC01020016    JAS17282.1    AF187723    AAF80554.1    GBYB01006891    GBYB01006893    GBYB01006894    GBYB01006897    JAG76658.1    JAG76660.1    JAG76661.1    JAG76664.1    KRG03641.1    GGFJ01001263    MBW50404.1    KRG03646.1    AE014134    AAF53960.2    GGFM01000119    MBW20870.1    KRG03644.1    AFH03790.1    GGFM01006377    MBW27128.1    CH480833    EDW46427.1    CH954179    EDV54470.1    CM000158    EDW89966.1    CH940661    EDW71304.2    KQS61807.1    KRJ98837.1    GFDL01000615    JAV34430.1    GFDL01000902    JAV34143.1    KRF85646.1    GFDL01000658    JAV34387.1    GBYB01006895    JAG76662.1    APCN01005847    GFDL01000670    JAV34375.1    GGFL01001143    MBW65321.1    GGFL01001141    MBW65319.1    CH902624    EDV33383.1    GGFL01001142    MBW65320.1    KPU74447.1    GFDL01000882    JAV34163.1    GGFM01000120    MBW20871.1    KRG03654.1    GGFK01000253    MBW33574.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000218220    UP000005204    UP000027135    + More
UP000009046    UP000007266    UP000000311    UP000075809    UP000005205    UP000015103    UP000078541    UP000007755    UP000075886    UP000075900    UP000078542    UP000008237    UP000053097    UP000279307    UP000076502    UP000053825    UP000075880    UP000005203    UP000007062    UP000030765    UP000095300    UP000009192    UP000008820    UP000078492    UP000192221    UP000000803    UP000075902    UP000001292    UP000008711    UP000002282    UP000008792    UP000092443    UP000092445    UP000075840    UP000007801   

PRIDE

H9JQM5    Q9VIF9   

Pfam

PF00999   Na_H_Exchanger        + More
PF00375   SDF
PF00069   Pkinase

Interpro

IPR018422   Cation/H_exchanger_CPA1        + More
IPR006153   Cation/H_exchanger       
IPR004709   NaH_exchanger       
IPR018410   Na/H_exchanger_3/5       
IPR036458   Na:dicarbo_symporter_sf       
IPR001991   Na-dicarboxylate_symporter       
IPR018107   Na-dicarboxylate_symporter_CS       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       
IPR020846   MFS_dom       

SUPFAM

SSF118215   SSF118215        + More
SSF56112   SSF56112       

CDD

cd06174  MFS

ProteinModelPortal

A0A2H1VK81   A0A212EQT5   A0A194PV44   A0A194QP30   A0A2A4JNX1   A0A2A4JNZ4   + More
H9JQM5   A0A067R6I4   E0VVV0   A0A139WKN9   A0A139WKX4   A0A1S4H0P3   A0A139WKQ1   E2AT05   A0A310SUC0   A0A151X1K5   A0A158NEZ9   T1HLN6   A0A195EUA9   F4W456   A0A182Q8W0   A0A224XJ56   A0A1W6EVP8   A0A1I8JU83   A0A195CKH5   A0A1Y1M429   E2B6P9   A0A026WMV2   A0A1Y1M586   A0A154PCL4   A0A034VTN8   V9I7M5   A0A0L7QSZ7   W8AZ23   V9I6L7   A0A182IQG8   V9I6M0   A0A1Y1M1Z0   W8AV39   A0A087ZVR0   Q5TNB1   A0A084VYE0   V9I6L4   Q6Y8G3   A0A2M3ZYK3   A0A1I8Q7V1   B4KGP5   Q17L17   A0A1Q3G3S6   A0A1I8Q7Y4   Q7Z0L7   A0A195E5H0   A0A0Q9X5Y7   A0A1B6CUX3   Q9NCQ0   A0A1W4UHX1   A0A0C9PZD1   A0A0Q9X8H4   A0A2M4BBH5   A0A0Q9XFZ5   Q9VIF9   A0A2M3YX91   A0A0Q9X659   M9NDU7   A0A2M3ZF79   A0A182UBY0   A0A1W4UVN6   A0A1I8Q7U8   A0A1I8Q7W5   B4IFK5   B3NKU7   B4P6Z7   A0A1I8Q7Z7   B4MDP3   A0A1A9XW14   A0A0Q5VYS2   A0A1I8Q7U3   A0A1W4UX32   A0A0R1DNH7   A0A1Q3G3Q3   A0A1I8Q7W0   A0A1Q3G2W6   A0A0Q9WXB3   A0A1Q3G3K3   A0A0C9REV7   A0A1W4UHV5   A0A1A9ZK74   A0A2C9GPC7   A0A1Q3G3J1   A0A2M4CJH9   A0A2M4CJ94   B3MU54   A0A2M4CIY5   A0A0P8Y5P0   A0A1Q3G2Y7   A0A2M3YX89   A0A0Q9X5Z9   A0A2M3ZYE4  

PDB

2MDF     E-value=1.43678e-16,     Score=215

KEGG

101740608    K12040 solute carrier family 9 (sodium/hydrogen exchanger), member 3 | (RefSeq) sodium/hydrogen exch

GO

GO:0015385   GO:0006885   GO:0016021   GO:0015386   GO:0098719   GO:0015293   GO:0071805   GO:0051453   GO:0005886   GO:0004672   GO:0005524   GO:0030641   GO:0001745   GO:0005623   GO:0006873   GO:0051454   GO:0006814   GO:0006812   GO:0015299   GO:0006419   GO:0015923   GO:0005634   GO:0006260   GO:0055085  

PANTHER

PTHR10110  

SignalP

Position:   1 - 33,         Likelihood:  0.828202

 

 

Length:

1088

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

260.888699999999

Exp number, first 60 AAs:

2.68255

Total prob of N-in:

0.19130

outside

1  -  110

TMhelix

111  -  130

inside

131  -  142

TMhelix

143  -  162

outside

163  -  171

TMhelix

172  -  194

inside

195  -  200

TMhelix

201  -  223

outside

224  -  237

TMhelix

238  -  257

inside

258  -  263

TMhelix

264  -  283

outside

284  -  302

TMhelix

303  -  325

inside

326  -  337

TMhelix

338  -  355

outside

356  -  359

TMhelix

360  -  379

inside

380  -  424

TMhelix

425  -  447

outside

448  -  461

TMhelix

462  -  481

inside

482  -  487

TMhelix

488  -  510

outside

511  -  1088

 

 

Pi

227.239083

Theta

184.644448

Tajima's D

0.818786

CLR

0.293288

CSRT

0.605969701514924

Interpretation

Uncertain