Gene

KWMTBOMO06541

Pre Gene Modal

BGIBMGA011834

Annotation

methionine_sulfoxide_reductase_[Bombyx_mori]

Location

Bomo_Chr11(-):10096727-10106624      View in EpiBrowser

Full name

Peptide methionine sulfoxide reductase      

Alternative Name

Ecdysone-induced protein 28/29 kDa
Methionine-S-sulfoxide reductase
Peptide-methionine (S)-S-oxide reductase

Location in the cell

Cytoplasmic   Reliability : 1.169 Mitochondrial   Reliability : 1.651

CDS

ATGAAGCCACCAGTTAACAACACCCTTTTGCACGATGTGGACATTCCCACGAAGAAGGCGACTTTTGGTATGGGCTGCTTCTGGTCAAACGATTCTCTTTTCGGCGCCACGCTCGGTGTCATACGCACTCGTGTGGGATACGCCGGTGGCACGACCAAGAATCCGCATTACAGAAGCATCGGGGACCACACAGAAGTTATAGAGATCGATTATGATCCGAAAACTGTTACCTATGAGGAGCTTCTCGAAATTTTCTGGGCTAACCACGAGTACGGACTAACCACCAAATTAAAGAGACAGTATCAGTCAATGATTCTGTACCACGATGATGAACAACGTTTAGTGGCTGAAGCCTCGCACAGAGCCGTGCAGAGCCGCTGTAACGAGACCTTACGCACTGAGATAGCGAAGGCTGACGTTTTCTATCCAGCTGAAGACTACCATCAGAAATACAGACTTCAAGGCCACAAAGACTTCTGCCGCAGTATCGGGCTCGATTCCTCTAAGCTACAGACTTCTCATTTGGCCGCCAGACTCAACGGTTACCTGGTCGGTGTTGGAGGAATGAATCAATTCGACCAGGAACTGCCGAAACTAGGCCTCAACGAGAAACAAGCTGAATACGTGAGGAGGGAGCTTGAACGCAACGAAGGCGGCGGTCTGGCTTGCTAA

Protein

MKPPVNNTLLHDVDIPTKKATFGMGCFWSNDSLFGATLGVIRTRVGYAGGTTKNPHYRSIGDHTEVIEIDYDPKTVTYEELLEIFWANHEYGLTTKLKRQYQSMILYHDDEQRLVAEASHRAVQSRCNETLRTEIAKADVFYPAEDYHQKYRLQGHKDFCRSIGLDSSKLQTSHLAARLNGYLVGVGGMNQFDQELPKLGLNEKQAEYVRRELERNEGGGLAC

Description

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Catalytic Activity

[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide

Similarity

Belongs to the MsrA Met sulfoxide reductase family.

Keywords

Alternative splicing   Complete proteome   Oxidoreductase   Reference proteome   Ubl conjugation  

Feature

chain  Peptide methionine sulfoxide reductase
splice variant  In isoform Eip29.

Uniprot

Q1HQ83   H9JQM8   S4PTD2   A0A2A4IZQ8   A0A212EQP4   I4DKF1   + More
A0A2H1VK86   A0A3S2LZV9   A0A194PWY0   I4DS31   A0A0L7LBI5   A0A084WIV9   A0A182J992   A0A1B0CT88   A0A1L8DU60   A0A2M3YZ62   A0A2C9GQY1   Q7PVA0   A0A182Q1P8   A0A2M4BZV0   A0A182KSB4   A0A2M4BYD7   Q7Q0D3   Q1HRN8   D6WWX6   Q17NK7   A0A023EKL0   A0A2M4CUY5   A0A182TB04   A0A0K8TLT4   A0A2M4A5T9   A0A182Y1I0   V5H0U7   A0A182FBD2   A0A1Q3FKK8   A0A1J1J3M2   B0XGG5   A0A182P5W1   A0A1L8EEL7   A0A0L0C8I9   A0A1L8EEI9   U5ESG1   A0A1L8EEP9   A0A1L8EJ87   A0A1L8EEL4   A0A1L8EEW3   A0A1L8EEK2   A0A1L8E9B6   A0A1L8E9M4   A0A1Q3FJ24   A0A1L8EAE8   A0A034VIH8   A0A1W4VPE2   A0A182GKA0   A0A1W4VNS0   A0A1W4VB12   W8BSG7   Q17NK6   A0A194QPJ4   W8C9F0   A0A1I8MSM3   A0A1I8MSM1   Q6NLA4   B0XGG4   B0WFN8   A0A1I8MSP1   A0A182KSA9   D3TL12   A0A182P5W2   A0A1B0F9B2   A0A1A9ZDP0   A0A0A1X6Q3   B4HI85   B4QL24   A0A1A9Y1K7   A0A1B0BPV4   A0A1A9UM08   B5X0L2   P08761   A0A0J9RW08   A0A0R1E8A1   B3NI28   Q7KUM8   A0A1I8PSG9   A0A1I8PSH0   A0A0R1ECT8   A0A0J9ULI0   A0A1I8PSD3   B4NLV9   M9PI66   M9PCL6   A0A1I8PSH7   B4GUB8   A0A1Y1L9S4   A0A0R3P7U0   A0A1Y1LAT4   B3M707   A0A1I8PSD2   A0A026W992   A0A1A9W4D9  

EC Number

1.8.4.11

Pubmed

19121390    23622113    22118469    22651552    26354079    26227816    + More
24438588    12364791    14747013    17210077    20966253    17204158    18362917    19820115    17510324    24945155    26483478    26369729    25244985    26108605    25348373    24495485    25315136    20353571    25830018    17994087    22936249    3097323    12145281    10731132    12537572    28953965    17550304    12537568    12537573    12537574    16110336    17569856    17569867    28004739    15632085    24508170    30249741   

EMBL

DQ443169    ABF51258.1    BABH01012156    GAIX01012243    JAA80317.1    NWSH01004534    + More
PCG64976.1    AGBW02013253    OWR43812.1    AK401769    BAM18391.1    ODYU01003010    SOQ41233.1    RSAL01000094    RVE47866.1    KQ459590    KPI97269.1    AK405394    BAM20721.1    JTDY01001838    KOB72754.1    ATLV01023950    KE525347    KFB50153.1    AJWK01027294    GFDF01004134    JAV09950.1    GGFM01000802    MBW21553.1    APCN01003307    AAAB01008986    EAA00184.4    AXCN02001024    GGFJ01009270    MBW58411.1    GGFJ01008956    MBW58097.1    EAA00212.3    DQ440056    ABF18089.1    KQ971361    EFA08080.1    CH477198    EAT48308.1    JXUM01069649    GAPW01003903    GAPW01003902    KQ562562    JAC09696.1    KXJ75615.1    GGFL01004921    MBW69099.1    GDAI01002505    JAI15098.1    GGFK01002846    MBW36167.1    GALX01002013    JAB66453.1    GFDL01006905    JAV28140.1    CVRI01000069    CRL07045.1    DS233029    EDS27596.1    GFDG01001668    JAV17131.1    JRES01000760    KNC28560.1    GFDG01001667    JAV17132.1    GANO01002372    JAB57499.1    GFDG01001674    JAV17125.1    GFDG01000110    JAV18689.1    GFDG01001671    JAV17128.1    GFDG01001670    JAV17129.1    GFDG01001669    JAV17130.1    GFDG01003515    JAV15284.1    GFDG01003514    JAV15285.1    GFDL01007435    JAV27610.1    GFDG01003224    JAV15575.1    GAKP01015856    JAC43096.1    KXJ75616.1    GAMC01006707    JAB99848.1    EAT48309.1    KQ461190    KPJ07274.1    GAMC01006708    GAMC01006706    JAB99849.1    BT012430    AAS93701.1    EDS27595.1    DS231920    EDS26382.1    EZ422103    ADD18307.1    CCAG010023097    GBXI01007974    JAD06318.1    CH480815    EDW41581.1    CM000363    CM002912    EDX10549.1    KMY99748.1    JXJN01018237    BT044581    ACI16543.1    X58286    X04024    X04521    AF541958    AE014296    BT004857    KMY99752.1    CH891752    KRK05263.1    CH954178    EDV52114.2    AAS64994.2    KRK05265.1    KMY99750.1    CH964278    EDW85411.1    AGB94571.1    AGB94572.1    CH479191    EDW26201.1    GEZM01064621    JAV68685.1    CH379069    KRT07504.1    GEZM01064620    JAV68686.1    CH902618    EDV40872.2    KK107321    QOIP01000002    EZA52657.1    RLU25906.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053268    UP000037510    + More
UP000030765    UP000075880    UP000092461    UP000075840    UP000007062    UP000075886    UP000075882    UP000007266    UP000008820    UP000069940    UP000249989    UP000075901    UP000076408    UP000069272    UP000183832    UP000002320    UP000075885    UP000037069    UP000192221    UP000053240    UP000095301    UP000092444    UP000092445    UP000001292    UP000000304    UP000092443    UP000092460    UP000078200    UP000000803    UP000002282    UP000008711    UP000095300    UP000007798    UP000008744    UP000001819    UP000007801    UP000053097    UP000279307    UP000091820   

PRIDE

Q1HQ83    H9JQM8    Q6NLA4    P08761    Q7KUM8   

Pfam

PF01625   PMSR        + More
PF12796   Ank_2

Interpro

IPR036509   Met_Sox_Rdtase_MsrA_sf        + More
IPR002569   Met_Sox_Rdtase_MsrA       
IPR020845   AMP-binding_CS       
IPR002110   Ankyrin_rpt       
IPR020683   Ankyrin_rpt-contain_dom       
IPR036770   Ankyrin_rpt-contain_sf       

SUPFAM

SSF55068   SSF55068        + More
SSF48403   SSF48403       

Gene 3D

3.30.1060.10     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

Q1HQ83   H9JQM8   S4PTD2   A0A2A4IZQ8   A0A212EQP4   I4DKF1   + More
A0A2H1VK86   A0A3S2LZV9   A0A194PWY0   I4DS31   A0A0L7LBI5   A0A084WIV9   A0A182J992   A0A1B0CT88   A0A1L8DU60   A0A2M3YZ62   A0A2C9GQY1   Q7PVA0   A0A182Q1P8   A0A2M4BZV0   A0A182KSB4   A0A2M4BYD7   Q7Q0D3   Q1HRN8   D6WWX6   Q17NK7   A0A023EKL0   A0A2M4CUY5   A0A182TB04   A0A0K8TLT4   A0A2M4A5T9   A0A182Y1I0   V5H0U7   A0A182FBD2   A0A1Q3FKK8   A0A1J1J3M2   B0XGG5   A0A182P5W1   A0A1L8EEL7   A0A0L0C8I9   A0A1L8EEI9   U5ESG1   A0A1L8EEP9   A0A1L8EJ87   A0A1L8EEL4   A0A1L8EEW3   A0A1L8EEK2   A0A1L8E9B6   A0A1L8E9M4   A0A1Q3FJ24   A0A1L8EAE8   A0A034VIH8   A0A1W4VPE2   A0A182GKA0   A0A1W4VNS0   A0A1W4VB12   W8BSG7   Q17NK6   A0A194QPJ4   W8C9F0   A0A1I8MSM3   A0A1I8MSM1   Q6NLA4   B0XGG4   B0WFN8   A0A1I8MSP1   A0A182KSA9   D3TL12   A0A182P5W2   A0A1B0F9B2   A0A1A9ZDP0   A0A0A1X6Q3   B4HI85   B4QL24   A0A1A9Y1K7   A0A1B0BPV4   A0A1A9UM08   B5X0L2   P08761   A0A0J9RW08   A0A0R1E8A1   B3NI28   Q7KUM8   A0A1I8PSG9   A0A1I8PSH0   A0A0R1ECT8   A0A0J9ULI0   A0A1I8PSD3   B4NLV9   M9PI66   M9PCL6   A0A1I8PSH7   B4GUB8   A0A1Y1L9S4   A0A0R3P7U0   A0A1Y1LAT4   B3M707   A0A1I8PSD2   A0A026W992   A0A1A9W4D9  

PDB

4U66     E-value=1.16474e-36,     Score=381

KEGG

732898    K07304 peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] | (RefSeq) methionine sulfoxide reduct

GO

GO:0008113   GO:0005737   GO:0034599   GO:0036456   GO:0016021   GO:0000096   GO:0006979   GO:0008340   GO:0006355   GO:0043565   GO:0020037   GO:0006259   GO:0004813   GO:0006419   GO:0015923   GO:0005634   GO:0006260   GO:0055114  

Length:

223

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.686700000000001

Exp number, first 60 AAs:

0.68465

Total prob of N-in:

0.03465

outside

1  -  223

 

 

Pi

153.6538

Theta

136.844355

Tajima's D

-1.047374

CLR

114.829506

CSRT

0.124443777811109

Interpretation

Possibly Positive selection