Gene

KWMTBOMO06535  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011646

Annotation

PREDICTED:_beta-N-acetylglucosaminidase_1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(+):9963920-9986523      View in EpiBrowser

Full name

Beta-hexosaminidase      

Location in the cell

Cytoplasmic   Reliability : 1.073

CDS

ATGGCGCTTCATGGGCTGTTGGCGTTGATGACGACCATGCATTTGGCAGGTGTACTATGCAATGTAGAAAGTACATTTGACGAAATCACCCCTCAAATTTACGAACCATCATGGATGTATAAGTGCGTGCCAGATGAAGGATGTCAGCGTAGTGAACATCCTAGGCCGACATTGTCCGACAATTCAACGTCAGCTTTCTTCGATTCACTTGACGTGTGCCGTATAGTCTGCGGAAGGTTCGGCGGAATCTGGCCTAAGCCGGTTACAGCAGCACTGAGCTCGCAGACTGTGAAGATCCACCCTAATTATTTGAGATATGATCTGCTCAACGTGCCTGCAGAAACTAGGGAGCTATTAGTGGAAATGACGCAAGTGATAAGCAATAACTTGTTGGCTGAGTGCGGAGGACACGTCACTGAGGTGGTGGACACTCAGGTCGTTGTCATCATCGTGGTGAAGACCGCCATCACTTCGTTGAATTGGAACACTGACGAACAATACATGCTGGACGTACAAACTAGAGGAGGAGAAGTCTCTGTCCATATAGAAGCAGAAACCATTTACGGAGCTCGTCACGGCTTAGAGACCTTCTCTCAATTAATATCATCAGACAAACGTGACTTTTCTGATGTGGAACATTGCGGTTTGGTCCTCGTGTCCGGTGCAAAGATTCGTGACAGACCGATCTACAAACATAGAGGCTTAGTTCTAGATACTTCTAGACATTTCATACCGATGGTCGACATTAAAAGAACTATCGATGGTATGGCGACAACAAAAATGAATGTCTTTCATTGGCATGCCACCGATTCTCACAGTTTTCCTTTGGAAGCGAGTCGGGTGCCTCAGTTTACAAGATATGGCGCCTACTCGGGCAGCGAAATGTACACGACGGAAGAAATACGAGAGTTGATACATTACGCGAAGGTACGCGGCATCCGAGTCGTCATTGAAATAGACGCGCCGGCGCATTCAGGAAACGGATGGCAATGGGGAAGGGAATACGGCTTAGGTGATTTAGCGGTATGCGTTAACGCTTACCCCTGGAGACATCTTTGCATCGAACCTCCTTGTGGTCAACTGAATCCAGCGAACCCTAATATGTACCGGGTGCTGAGGAACTTGTACCAAGATGTTGCGGATCTGTTGAATTCACCGCCATTGCTACACATGGGAGGAGACGAGGTTTACTTCGGGTGCTGGAACTCGAGCCAAGAAATTATCTCGTACATGAAGGACCAAGGATACGATACGACGGAAGAAGGTTTCATGAAGTTGTGGGGTGAATTCCATAACAAAGCCCTTCAAATTTGGGACGAAGAGATTTCCGCGAAAGGACTGGACCCACAGCCCGTGATGTTATGGTCTTCGCAACTGACACAGGCTCAGAGGATCTCACAACACTTGGACAAAGAAAGATACATCATTGAAGTTTGGGAGCCTTTGAACAGCCCATTATTGACTCAACTCTTGAGGCTCGGCTATAGAACTGTTTCAGTACCGAAGGACATTTGGTATTTGGATCATGGCTTCTGGGGCAGAACGGTATATTCCAATTGGAGAAGGATGTATGCTCACACTCTACCACGGGACGAAGGCGTGTTAGGCGGTGAAGTGGCCATGTGGACGGAGTATTGCGACGCTCAGGCCCTAGACACCCGAGTATGGCCGAGAGCGGCTGCAGTGGCGGAGAGGCTGTGGTCAGACCCGACGTCCACAGTGTACAGCGCAGAGCCGAGGCTGCAGAGGCTCCGGACGAGACTGATAGCTCGGGGCCTGAGGCCCGACGCCATGTCCCCGGCGTGGTGCTCCCAGCACGACAGCAAATGTCTTTGA

Protein

MALHGLLALMTTMHLAGVLCNVESTFDEITPQIYEPSWMYKCVPDEGCQRSEHPRPTLSDNSTSAFFDSLDVCRIVCGRFGGIWPKPVTAALSSQTVKIHPNYLRYDLLNVPAETRELLVEMTQVISNNLLAECGGHVTEVVDTQVVVIIVVKTAITSLNWNTDEQYMLDVQTRGGEVSVHIEAETIYGARHGLETFSQLISSDKRDFSDVEHCGLVLVSGAKIRDRPIYKHRGLVLDTSRHFIPMVDIKRTIDGMATTKMNVFHWHATDSHSFPLEASRVPQFTRYGAYSGSEMYTTEEIRELIHYAKVRGIRVVIEIDAPAHSGNGWQWGREYGLGDLAVCVNAYPWRHLCIEPPCGQLNPANPNMYRVLRNLYQDVADLLNSPPLLHMGGDEVYFGCWNSSQEIISYMKDQGYDTTEEGFMKLWGEFHNKALQIWDEEISAKGLDPQPVMLWSSQLTQAQRISQHLDKERYIIEVWEPLNSPLLTQLLRLGYRTVSVPKDIWYLDHGFWGRTVYSNWRRMYAHTLPRDEGVLGGEVAMWTEYCDAQALDTRVWPRAAAVAERLWSDPTSTVYSAEPRLQRLRTRLIARGLRPDAMSPAWCSQHDSKCL

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Similarity

Belongs to the glycosyl hydrolase 20 family.

Feature

chain  Beta-hexosaminidase

Uniprot

A4PHN6   H9JQ40   A8IDA5   A0A212EXD1   A0A2W1BL06   A0A2A4K369   + More
A0A194PW86   A0A2H1WAB3   A0A194QQN5   A0A0L7LUX1   A0A1Y1L8L6   A0A1Y1LDC0   A0A2J7QLP0   A0A2J7QLN5   A0A2J7QLQ5   A0A1B0CCX8   A0A1W4XJ86   A0A1W4XUF0   A0A1W4XU97   A0A1W4XTD2   A0A0C5C9K5   A0A1B6ED71   A0A182FQH0   A0A2P0P9N4   A0A2R7W0Q5   A0A1A9ZA56   A0A1B0FD25   A0A1J1IPT6   A0A1B0C609   A0A1A9XAV1   A0A2P8YWA3   A0A1Q3FIK6   A0A1I8N7F0   A0A1A9V5G4   A0A224XGY4   T1PAH1   A0A0M4EIH8   A0A0L0CIG2   A0A182GFT8   B4M1A8   A0A3B0KPR4   Q170Q1   E0VGG8   A0A1W4XJ90   A0A0Q9WD14   A0A067RNC2   B0W1X6   A5YVX4   Q29GS4   A0A1A9X5F5   B3MZG5   B4L3B1   B4JLT4   B4MJ44   T1HH13   A0A0A1WXP1   W8BGT9   A0A0K8UL98   Q7QKY7   A0A2H8TX73   Q9W3C4   B3NUL2   A0A1W4UQS0   A0A182MUW2   B4Q014   B4IK00   J9KAK0   A0A232F251   A0A336MD78   A0A1B0DGZ0   A0A1I8P8U7   K7IXT8   B4GV37   A0A182VPZ9   B5DN57   B4GUV2   A0A0A9Y3Z2   A0A0K8SIH6   A0A2K8JRH0   A0A0A9Y9Z5   A0A146KMB2   R4G8V6   A0A1Q1NPB5   A0A2S2NQI9   A0A1B6KVW3   A0A2H8U0P4   A0A182IRJ1   A0A182NN29   A0A3B0JXI5   A0A182G6N2   J9JVG2   A0A1A9WED7   A0A1A9ZAI9   A0A182QJ60   A0A1B6JM15   A0A1B0AU47   A0A1B0FRG6   A0A226F3N7   U4USN2  

EC Number

3.2.1.52

Pubmed

17617724    19121390    22118469    28756777    26354079    26227816    + More
28004739    25224926    29403074    25315136    26108605    26483478    17994087    17510324    20566863    24845553    18342252    18362917    19820115    15632085    25830018    24495485    9087549    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    28648823    20075255    25401762    26823975    28130397    23537049   

EMBL

AB286957    BAF52531.1    BABH01012162    BABH01012163    EU158179    ABV79901.1    + More
AGBW02011808    OWR46107.1    KZ149984    PZC75719.1    NWSH01000214    PCG78344.1    KQ459590    KPI97263.1    ODYU01007035    SOQ49424.1    KQ461190    KPJ07280.1    JTDY01000039    KOB79240.1    GEZM01062226    JAV69944.1    GEZM01062225    GEZM01062224    JAV69945.1    NEVH01013243    PNF29505.1    PNF29504.1    PNF29506.1    AJWK01007208    KM217123    AJO25048.1    GEDC01001410    JAS35888.1    KU739385    ARA90562.1    KK854169    PTY12510.1    CCAG010013058    CVRI01000055    CRL01556.1    JXJN01024611    JXJN01026390    PYGN01000323    PSN48529.1    GFDL01007625    JAV27420.1    GFTR01007348    JAW09078.1    KA645732    KA649460    AFP60361.1    CP012528    ALC48704.1    JRES01000348    KNC32035.1    JXUM01060403    KQ562100    KXJ76695.1    CH940651    EDW65462.1    OUUW01000015    SPP88609.1    CH477470    EAT40440.1    DS235142    EEB12474.1    KRF82242.1    KK852567    KDR21204.1    DS231824    EDS27412.1    EF592537    KQ971319    ABQ95983.1    EFA11380.2    CH379064    EAL32035.1    CH902635    EDV33766.1    CH933810    EDW07039.1    CH916371    EDV91695.1    CH963738    EDW72133.1    ACPB03022325    ACPB03022326    GBXI01012067    GBXI01010881    GBXI01005670    GBXI01005108    JAD02225.1    JAD03411.1    JAD08622.1    JAD09184.1    GAMC01010352    JAB96203.1    GDHF01024835    GDHF01014117    GDHF01013427    GDHF01003974    JAI27479.1    JAI38197.1    JAI38887.1    JAI48340.1    AAAB01008181    EAA03285.4    GFXV01007088    MBW18893.1    AE014298    AY118361    AAF46406.1    AAM48390.1    CH954180    EDV46335.1    AXCM01000572    CM000162    EDX02220.2    CH480850    EDW51356.1    ABLF02023225    ABLF02023226    NNAY01001235    OXU24662.1    UFQS01000959    UFQT01000959    SSX07952.1    SSX28186.1    AJVK01060576    CH479192    EDW26574.1    EDY72864.1    EDW26489.1    GBHO01017248    JAG26356.1    GBRD01012892    JAG52934.1    MF683372    ATU82513.1    GBHO01017249    JAG26355.1    GDHC01021744    JAP96884.1    GAHY01000307    JAA77203.1    KX459597    AQM58348.1    GGMR01006397    MBY19016.1    GEBQ01024365    GEBQ01023473    JAT15612.1    JAT16504.1    GFXV01007173    MBW18978.1    OUUW01000003    SPP78479.1    JXUM01046409    JXUM01046410    KQ561475    KXJ78479.1    ABLF02020377    AXCN02002216    GECU01007405    JAT00302.1    JXJN01003514    CCAG010017058    LNIX01000001    OXA63801.1    KB632432    ERL95528.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053268    UP000053240    UP000037510    + More
UP000235965    UP000092461    UP000192223    UP000069272    UP000092445    UP000092444    UP000183832    UP000092460    UP000092443    UP000245037    UP000095301    UP000078200    UP000092553    UP000037069    UP000069940    UP000249989    UP000008792    UP000268350    UP000008820    UP000009046    UP000027135    UP000002320    UP000007266    UP000001819    UP000091820    UP000007801    UP000009192    UP000001070    UP000007798    UP000015103    UP000007062    UP000000803    UP000008711    UP000192221    UP000075883    UP000002282    UP000001292    UP000007819    UP000215335    UP000092462    UP000095300    UP000002358    UP000008744    UP000075920    UP000075880    UP000075884    UP000075886    UP000198287    UP000030742   

PRIDE

A4PHN6    H9JQ40    Q9W3C4   

Pfam

PF00728   Glyco_hydro_20        + More
PF14845   Glycohydro_20b2
PF00046   Homeodomain

Interpro

IPR029019   HEX_eukaryotic_N        + More
IPR015883   Glyco_hydro_20_cat       
IPR029018   Hex-like_dom2       
IPR025705   Beta_hexosaminidase_sua/sub       
IPR017853   Glycoside_hydrolase_SF       
IPR017970   Homeobox_CS       
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF51445   SSF51445        + More
SSF55545   SSF55545       
SSF46689   SSF46689       
SSF56112   SSF56112       

Gene 3D

3.30.379.10    

CDD

cd00086  homeodomain

ProteinModelPortal

A4PHN6   H9JQ40   A8IDA5   A0A212EXD1   A0A2W1BL06   A0A2A4K369   + More
A0A194PW86   A0A2H1WAB3   A0A194QQN5   A0A0L7LUX1   A0A1Y1L8L6   A0A1Y1LDC0   A0A2J7QLP0   A0A2J7QLN5   A0A2J7QLQ5   A0A1B0CCX8   A0A1W4XJ86   A0A1W4XUF0   A0A1W4XU97   A0A1W4XTD2   A0A0C5C9K5   A0A1B6ED71   A0A182FQH0   A0A2P0P9N4   A0A2R7W0Q5   A0A1A9ZA56   A0A1B0FD25   A0A1J1IPT6   A0A1B0C609   A0A1A9XAV1   A0A2P8YWA3   A0A1Q3FIK6   A0A1I8N7F0   A0A1A9V5G4   A0A224XGY4   T1PAH1   A0A0M4EIH8   A0A0L0CIG2   A0A182GFT8   B4M1A8   A0A3B0KPR4   Q170Q1   E0VGG8   A0A1W4XJ90   A0A0Q9WD14   A0A067RNC2   B0W1X6   A5YVX4   Q29GS4   A0A1A9X5F5   B3MZG5   B4L3B1   B4JLT4   B4MJ44   T1HH13   A0A0A1WXP1   W8BGT9   A0A0K8UL98   Q7QKY7   A0A2H8TX73   Q9W3C4   B3NUL2   A0A1W4UQS0   A0A182MUW2   B4Q014   B4IK00   J9KAK0   A0A232F251   A0A336MD78   A0A1B0DGZ0   A0A1I8P8U7   K7IXT8   B4GV37   A0A182VPZ9   B5DN57   B4GUV2   A0A0A9Y3Z2   A0A0K8SIH6   A0A2K8JRH0   A0A0A9Y9Z5   A0A146KMB2   R4G8V6   A0A1Q1NPB5   A0A2S2NQI9   A0A1B6KVW3   A0A2H8U0P4   A0A182IRJ1   A0A182NN29   A0A3B0JXI5   A0A182G6N2   J9JVG2   A0A1A9WED7   A0A1A9ZAI9   A0A182QJ60   A0A1B6JM15   A0A1B0AU47   A0A1B0FRG6   A0A226F3N7   U4USN2  

PDB

3OZP     E-value=1.08525e-104,     Score=973

KEGG

100038345    K12373 hexosaminidase [EC:3.2.1.52] | (RefSeq) GlcNAcase1, BmGlcNAcase1; beta-N-acetylglucosaminidas

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00603    Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
00604    Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0004563   GO:0102148   GO:0016021   GO:0044130   GO:0016231   GO:0005886   GO:0005634   GO:0043565   GO:0006355   GO:0008375   GO:0005615   GO:0032504   GO:0004553   GO:0020037   GO:0006259   GO:0004813   GO:0006419   GO:0015923   GO:0006260  

Subcellular location

Nucleus  

SignalP

Position:   1 - 20,         Likelihood:  0.978534

 

 

Length:

611

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0234

Exp number, first 60 AAs:

0.02269

Total prob of N-in:

0.00118

outside

1  -  611

 

 

Pi

253.15854

Theta

201.607175

Tajima's D

1.10069

CLR

0.248388

CSRT

0.688015599220039

Interpretation

Uncertain