Gene

KWMTBOMO06524  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011844

Annotation

protein_disulfide_isomerase_precursor_[Bombyx_mori]

Location

Bomo_Chr11(-):9776551-9792719      View in EpiBrowser

Full name

Protein disulfide-isomerase      

Location in the cell

ER   Reliability : 4.553

CDS

ATGCGTGTTTTAATTTTCACGGCTATAGCCCTGCTAGGGCTCGCTCTCGGAGATGAAGTGCCCACTGAAGAAAATGTGCTCGTTTTGAGTAAAGCTAACTTTGAAACTGTAATTACAACCACGGAGTACATTTTAGTTGAATTCTATGCTCCATGGTGCGGCCACTGCAAATCTCTGGCACCGGAATACGCCAAGGCAGCAACAAAGCTGGCTGAAGAAGAATCTCCTATCAAACTAGCGAAAGTTGACGCAACTCAAGAACAGGATCTCGCCGAGAGCTACGGTGTACGAGGATACCCGACTCTCAAATTCTTCAGGAATGGCAGTCCTATCGACTATTCAGGTGGTCGTCAAGCTGATGACATCATCAGTTGGCTGAAGAAGAAGACTGGCCCCCCTGCTGTTGAGGTCACCTCTGCTGAACAGGCTAAAGAACTTATCGATGCCAATACTGTTATTGTATTTGGTTTCTTTTCGGACCAGAGCTCAGCCAGAGCCAAAACTTTCCTTTCAACTGCTCAAGTTGTTGATGACCAAGTATTTGCTATTGTCAGCGATGAGAAAGTGATCAAGGAGTTGGAGGCTGAAGATGAAGATGTTGTGCTTTTCAAGAACTTCGAAGAGAAACGTGTCAAATATGAAGATGAAGAAATCACTGAGGATCTGCTCAATGCTTGGGTGTTTGTCCAGAGCATGCCTACTATCGTTGAATTCTCGCATGAAACTGCTTCCAAGATCTTTGGTGGAAAGATCAAATACCACCTTCTTATCTTCTTATCCAAGAAAAATGGCGATTTCGAGAAATACCTTGAGGATTTGAAGCCGGTCGCGAAGACCTACCGCGACAGGATCATGACCGTCGCCATCGATGCCGACGAAGATGAACACCAAAGGATCTTGGAGTTCTTCGGCATGAAGAAGGATGAGGTTCCATCTGCCCGTCTGATCGCCCTTGAACAAGACATGGCCAAATACAAGCCCAGCAGTAATGAGCTGTCGCCTAACGCTATTGAGGAATTCGTTCAATCGTTCTTCGACGGCACCCTGAAGCAGCATCTGCTGAGCGAGGACCTGCCCTCGGACTGGGCCGCCAAACCCGTCAAAGTGCTCGTCGCCGCCAACTTCGACGAAGTCGTCTTCGACACAACTAAGAAGGTCCTCGTCGAATTCTACGCTCCTTGGTGCGGCCACTGCAAACAGCTGGTCCCTATCTACGACAAGCTCGGCGAGCACTTTGAGAACGACGATGACGTCATCATTGCCAAAATCGACGCCACCGCCAACGAACTGGAACACACCAAGATCACGTCCTTCCCAACGATCAAACTTTACAGCAAGGACAACCAGGTCCACGACTACAACGGCGAGAGGACACTGGCCGGCCTCACCAAGTTCGTTGAGACCGACGGTGAAGGCGCCGAGCCAGGACCTTCTGTGACCGAATTCGAAGAGGAGGAAGATGTGCCTGCCAGAGACGAGTTATAA

Protein

MRVLIFTAIALLGLALGDEVPTEENVLVLSKANFETVITTTEYILVEFYAPWCGHCKSLAPEYAKAATKLAEEESPIKLAKVDATQEQDLAESYGVRGYPTLKFFRNGSPIDYSGGRQADDIISWLKKKTGPPAVEVTSAEQAKELIDANTVIVFGFFSDQSSARAKTFLSTAQVVDDQVFAIVSDEKVIKELEAEDEDVVLFKNFEEKRVKYEDEEITEDLLNAWVFVQSMPTIVEFSHETASKIFGGKIKYHLLIFLSKKNGDFEKYLEDLKPVAKTYRDRIMTVAIDADEDEHQRILEFFGMKKDEVPSARLIALEQDMAKYKPSSNELSPNAIEEFVQSFFDGTLKQHLLSEDLPSDWAAKPVKVLVAANFDEVVFDTTKKVLVEFYAPWCGHCKQLVPIYDKLGEHFENDDDVIIAKIDATANELEHTKITSFPTIKLYSKDNQVHDYNGERTLAGLTKFVETDGEGAEPGPSVTEFEEEEDVPARDEL

Description

Participates in the folding of proteins containing disulfide bonds.

Catalytic Activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subunit

Homodimer.

Similarity

Belongs to the protein disulfide isomerase family.

Keywords

Alternative splicing   Complete proteome   Disulfide bond   Endoplasmic reticulum   Isomerase   Redox-active center   Reference proteome   Repeat   Signal  

Feature

chain  Protein disulfide-isomerase
splice variant  In isoform D.

Uniprot

H9JQN8   Q9GPH2   I4DIQ3   A0A2A4J7L8   I4DLY7   A0A0U1VTU3   + More
A0A2H1VU96   S4NP33   G9D554   A0A212FP73   A0A2W1BSJ9   V5GZ61   A0A1J1I589   A0A1L8DUD1   A0A0P4WI78   A0A1L8DUB0   U5EV80   A0A1L8DUB3   A0A182Y1G6   B0WFQ4   A0A182MYS9   A0A034VQH7   B0X3M7   A0A0K8TWH4   A0A336M5N1   G9JKY3   A0A182TD69   Q5TMX9   A0A1S4HAB3   A0A182KS99   A0A182HQD4   A0A182RD13   A0A182WZT9   A0A182UP09   A0A0P4WLN5   A0A182P5V3   A0A182MG57   A0A1I8MXQ8   A0A2J7R328   A0A1L8EF87   T1PF58   A0A1L8EFE1   A0A182WEX4   W8BHI2   A0A182QYN8   U5EXV6   A0A1I8P5Q9   A0A182J8G7   A0A084WIX0   A0A1L8EFM8   D6WHD6   A0A182FBC4   A0A067RBI3   T1E8D6   A0A2M3ZYI7   A0A2M4BL90   A0A1Q3FFI6   A0A1B6KDW2   A0A2M3ZYQ1   W5JK16   A0A2M3ZYG2   A0A2M4BLF1   A0A1B6IVK8   A0A0A9YM47   A0A1Y1KS02   A0A226ECT4   C0JBY4   R4WQK3   A0A0N8EAP0   A0A182GFX8   Q1HR78   B4L127   A0A3G5ART5   A0A3G5ANU4   B4PIY3   B4QKK6   A0A1W7R9Z2   A0A3B0J7U5   B4HI55   A0A1W4VP72   B3NHN4   T1L2F7   Q2M1A2   X2JGP4   A0A2I9LPF6   P54399   A0A2M3ZE69   B3M733   A0A1Q3FFB3   B4GUE5   E2BG03   B4N522   D3TRE3   B4LGU3   A0A1A9V3N0   B4IXK8   A0A0J7L6A5   A0A2Z5WPU1   A0A0P4VT63  

EC Number

5.3.4.1

Pubmed

19121390    11892983    22651552    26354079    23622113    21967427    + More
22118469    28756777    25244985    25348373    12364791    20966253    25315136    24495485    24438588    18362917    19820115    24845553    20920257    23761445    25401762    28004739    23691247    26483478    17204158    17510324    17994087    17550304    22936249    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    29248469    7787847    12537569    20798317    20353571    27129103   

EMBL

BABH01012177    AF325211    AAG45936.1    AK401171    KQ459590    BAM17793.1    + More
KPI97250.1    NWSH01002655    PCG67756.1    AK402305    BAM18927.1    JX183988    AGF69546.1    ODYU01004447    SOQ44326.1    GAIX01012014    JAA80546.1    JF777457    AEU11802.1    AGBW02003612    OWR55527.1    KZ149984    PZC75730.1    GALX01002703    JAB65763.1    CVRI01000042    CRK95503.1    GFDF01004054    JAV10030.1    GDRN01036013    JAI67374.1    GFDF01004053    JAV10031.1    GANO01001143    JAB58728.1    GFDF01004052    JAV10032.1    DS231920    EDS26398.1    GAKP01014585    JAC44367.1    DS232318    EDS39919.1    GDHF01033678    JAI18636.1    UFQT01000187    SSX21338.1    JN863961    AEW66914.1    AAAB01008986    EAL38666.3    APCN01003309    GDRN01036014    JAI67373.1    AXCM01006744    NEVH01007823    PNF35251.1    GFDG01001402    JAV17397.1    KA647381    AFP62010.1    GFDG01001401    JAV17398.1    GAMC01017431    GAMC01017428    JAB89124.1    AXCN02001026    GANO01000727    JAB59144.1    ATLV01023952    KE525347    KFB50164.1    GFDG01001400    JAV17399.1    KQ971321    EFA00647.1    KK852567    KDR21216.1    GAMD01002863    JAA98727.1    GGFK01000221    MBW33542.1    GGFJ01004696    MBW53837.1    GFDL01008773    JAV26272.1    GEBQ01030325    JAT09652.1    GGFK01000217    MBW33538.1    ADMH02001279    ETN63240.1    GGFK01000273    MBW33594.1    GGFJ01004734    MBW53875.1    GECU01021031    GECU01016836    GECU01003704    JAS86675.1    JAS90870.1    JAT04003.1    GBHO01009502    GBHO01009500    GBRD01012827    JAG34102.1    JAG34104.1    JAG52999.1    GEZM01077735    JAV63191.1    LNIX01000004    OXA55402.1    FJ179395    ACN89260.1    AK416967    BAN20182.1    GDIQ01045348    JAN49389.1    JXUM01060637    JXUM01060638    KQ562111    KXJ76669.1    DQ440216    CH477198    ABF18249.1    EAT48285.1    CH933809    EDW18184.1    MH979838    AYV89293.1    MH990459    AYV89006.1    CM000159    EDW94574.1    CM000363    CM002912    EDX10517.1    KMY99709.1    GFAH01000417    JAV47972.1    OUUW01000002    SPP76002.1    CH480815    EDW41551.1    CH954178    EDV51829.1    CAEY01000947    CH379069    EAL30673.1    AE014296    AHN58095.1    GFWZ01000275    MBW20265.1    U18973    BT001544    BT003181    BT011488    BT012439    GGFM01006048    MBW26799.1    CH902618    EDV40898.1    GFDL01008799    JAV26246.1    CH479191    EDW26228.1    GL448096    EFN85405.1    CH964101    EDW79461.1    CCAG010000249    EZ423995    ADD20271.1    CH940647    EDW70558.1    CH916366    EDV97470.1    LBMM01000553    KMQ98073.1    LC164244    BBC20867.1    GDKW01002455    JAI54140.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000183832    UP000076408    + More
UP000002320    UP000075884    UP000075902    UP000007062    UP000075882    UP000075840    UP000075900    UP000076407    UP000075903    UP000075885    UP000075883    UP000095301    UP000235965    UP000075920    UP000075886    UP000095300    UP000075880    UP000030765    UP000007266    UP000069272    UP000027135    UP000000673    UP000198287    UP000069940    UP000249989    UP000008820    UP000009192    UP000002282    UP000000304    UP000268350    UP000001292    UP000192221    UP000008711    UP000015104    UP000001819    UP000000803    UP000007801    UP000008744    UP000008237    UP000007798    UP000092444    UP000008792    UP000078200    UP000001070    UP000036403   

PRIDE

H9JQN8    Q9GPH2    C0JBY4    X2JGP4    P54399   

Pfam

PF00085   Thioredoxin

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR017937   Thioredoxin_CS       
IPR005792   Prot_disulphide_isomerase       
IPR013766   Thioredoxin_domain       
IPR005788   Disulphide_isomerase       

SUPFAM

SSF52833   SSF52833       

ProteinModelPortal

H9JQN8   Q9GPH2   I4DIQ3   A0A2A4J7L8   I4DLY7   A0A0U1VTU3   + More
A0A2H1VU96   S4NP33   G9D554   A0A212FP73   A0A2W1BSJ9   V5GZ61   A0A1J1I589   A0A1L8DUD1   A0A0P4WI78   A0A1L8DUB0   U5EV80   A0A1L8DUB3   A0A182Y1G6   B0WFQ4   A0A182MYS9   A0A034VQH7   B0X3M7   A0A0K8TWH4   A0A336M5N1   G9JKY3   A0A182TD69   Q5TMX9   A0A1S4HAB3   A0A182KS99   A0A182HQD4   A0A182RD13   A0A182WZT9   A0A182UP09   A0A0P4WLN5   A0A182P5V3   A0A182MG57   A0A1I8MXQ8   A0A2J7R328   A0A1L8EF87   T1PF58   A0A1L8EFE1   A0A182WEX4   W8BHI2   A0A182QYN8   U5EXV6   A0A1I8P5Q9   A0A182J8G7   A0A084WIX0   A0A1L8EFM8   D6WHD6   A0A182FBC4   A0A067RBI3   T1E8D6   A0A2M3ZYI7   A0A2M4BL90   A0A1Q3FFI6   A0A1B6KDW2   A0A2M3ZYQ1   W5JK16   A0A2M3ZYG2   A0A2M4BLF1   A0A1B6IVK8   A0A0A9YM47   A0A1Y1KS02   A0A226ECT4   C0JBY4   R4WQK3   A0A0N8EAP0   A0A182GFX8   Q1HR78   B4L127   A0A3G5ART5   A0A3G5ANU4   B4PIY3   B4QKK6   A0A1W7R9Z2   A0A3B0J7U5   B4HI55   A0A1W4VP72   B3NHN4   T1L2F7   Q2M1A2   X2JGP4   A0A2I9LPF6   P54399   A0A2M3ZE69   B3M733   A0A1Q3FFB3   B4GUE5   E2BG03   B4N522   D3TRE3   B4LGU3   A0A1A9V3N0   B4IXK8   A0A0J7L6A5   A0A2Z5WPU1   A0A0P4VT63  

PDB

4EL1     E-value=1.82176e-136,     Score=1246

KEGG

692673    K09580 protein disulfide-isomerase A1 [EC:5.3.4.1] | (RefSeq) Pdi; protein disulfide isomerase

GO

GO:0005623   GO:0045454   GO:0003756   GO:0016853   GO:0034976   GO:0006457   GO:0005783   GO:0043025   GO:0005635   GO:0045169   GO:0005791   GO:0070732   GO:0060187   GO:0048471   GO:0005615   GO:0016021   GO:0005737   GO:0012505   GO:0015037   GO:0005788   GO:0020037   GO:0006259   GO:0004813   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

Subcellular location

Endoplasmic reticulum lumen  

SignalP

Position:   1 - 17,         Likelihood:  0.999395

 

 

Length:

494

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07015

Exp number, first 60 AAs:

0.06996

Total prob of N-in:

0.00530

outside

1  -  494

 

 

Pi

279.48187

Theta

190.171513

Tajima's D

2.14643

CLR

0.167676

CSRT

0.904904754762262

Interpretation

Uncertain