Silkworm Genome Informatics Database

Gene

KWMTBOMO06488 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011623

Annotation

PREDICTED:_armadillo_repeat-containing_protein_8-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(+):8713051-8726978 View in EpiBrowser

Full name

Armadillo repeat-containing protein 8

Location in the cell

Cytoplasmic Reliability : 1.529

CDS

ATGCAACAGTTTACAGTATTCATGGATATCGAAAGCTCCCGCTCGTATATCGACGAGTTGTATTCTTCGGATGCGGTGAAGGTAATGGAAGCTTTGGTAACGCTGAAGAACTCGGTAATAGGGAGCAACAGACAGAAGAGTTCAGTGATCAGTCAAGGGGTAGTTCCAAGGCTGCTACAATTGATGTCTGAAGAATCACTGGATCCGAACATTAGACTAGAGGCAACTATTACAATAGGTTCACTTGCAAAAGGCACACCAGAAAATATAGACTCTCTAATTGAAAAAGGAACAGCTACAGCATTAGTGGAAATGCTTAAGACGGTACCACTTGGTTCAAAACTTGCGGAGGCAGCTCTGTGTGCCTTAAGGAGTATATTCTCGCATAAACCTGCACCAGTTGATGCCTTACCGGCTGACATGAGGTTGCTCACAAGATTAACACAGATTGCGCGGGAAGACTCTCAGGAAGCGCGCACTAGTGTGATACGTGTGCTGGCTGTATGGTGCAGCGGCACTGTAGAACAAGAAGCCTTGACGTGTGCGGGAGCGTGCTCGGCCGCCGCCGCGATGCTCGTGGTGCCGCCCCGCTCGGTGCCTTCGCCCTCGCGACTGGTGCCAGCCCTGGAATTACTAGCCGCCATGTGCTTCAAGAATCCCAATGTTGCACAGGTCGCTTTGAATACAAGGCACGGTGATAAATCAATACCGGAATTACTAATGTGCCTGGTGTCTCGCGACAAGCCTCTCGTAGTGGCGTTGAAAGCTGCCAAATGTCTCACTTTCTTACAGAGGGCCGGCGCTCTGCCAGCCGACGACAGCAGGATCGTTTTCGGAGCTCTTCCGTGTCTGGCGCGTTTGTGTACCAAAGAGAACACGGAAGACATCCGAGCGTCCGCCGCCGAGGTGCTCGCCTATTTGACCGAGGTCGACACGTCCCTCCAGCGTTTAGCGGCGATATCGAATCACTTGATGAGTTCCCTGGCGGACATCGTGAACTGTCAGTCCGCGGCCGCCAAGCAAGGCGCGTTCAAATGTTTCGCTTCGCTCGGAGCGAACGACGAGGACATCAGGAAAATGATCATCGAAACCCACGGCCTGATGGTGCACGTCGTCAACGGACTGAACAATCCTGATCCCTGTGTGAGTCTAGCGGCCGTGCGGTGCTTGCATTCGTTGTCAAGATCGGTTCAACAGCTGCGAACGACTTTTCAGGACCACGCGGTGTGGAAGCCTCTCATGCAGCTGCTGAACGATTCTCCGGGCCCTGAACTATTGAACGTCGGTTCGTCGACCTTGTGCAATCTGTTGCTCGAATTCTCACCGGCCAAAGAACCGATGCTCGATCAAGGTGCAGTTGAGATGCTGTGTAATTTGACAAAAATGTCGGATCCCGCGTTGAGATTGAACGGGATTTGGGCGTTAATGAACATGGCTTTTCAGGCGGAACAGAAGGTGAAGCAGCGCATCCTGTGCTGCCTGGGCACGGAGCAGATGTTCCGTCTGCTGGGCGACAGCGACACGCGCGTCATCATGAAGATGCTGGGCCTGCTGCGCAACCTGCTCTCCACCAGGCAGCACATCGACGCCATCATGAGCGAGTACTCGTCGCAGGTCATGCAGGCAGTAATAGTGGTGCTGGAGGGTTCGTATCCAGCGGAGGTGAAGGAGCAAGCCTTGTGTATACTGGGGAATATCGGCGACGGTGAAAAATCGAAAGATCTGATAATGGCCAACGAAGACGTGCTCCGGAAACTTGTTGATTATTTGGCGCACCCGGAGAGCAAGTTGCAGGAGGCGGCGCTGTTCGTGGCCGGCAACCTGGTGTGGCGCGGGGAGGCGGGCGCCGCCGCGCGACAGCAGCGCCTCGCCGAGCTGGGCTTGCTGCGCGCGCTCAAGCTGCTGCGTGCCTCGCACCACGCCGCGCACCTGCACGACAAGGTGAAGACCGCTCTGGCGCAATTCAATGAGTTCACATAA

Protein

MQQFTVFMDIESSRSYIDELYSSDAVKVMEALVTLKNSVIGSNRQKSSVISQGVVPRLLQLMSEESLDPNIRLEATITIGSLAKGTPENIDSLIEKGTATALVEMLKTVPLGSKLAEAALCALRSIFSHKPAPVDALPADMRLLTRLTQIAREDSQEARTSVIRVLAVWCSGTVEQEALTCAGACSAAAAMLVVPPRSVPSPSRLVPALELLAAMCFKNPNVAQVALNTRHGDKSIPELLMCLVSRDKPLVVALKAAKCLTFLQRAGALPADDSRIVFGALPCLARLCTKENTEDIRASAAEVLAYLTEVDTSLQRLAAISNHLMSSLADIVNCQSAAAKQGAFKCFASLGANDEDIRKMIIETHGLMVHVVNGLNNPDPCVSLAAVRCLHSLSRSVQQLRTTFQDHAVWKPLMQLLNDSPGPELLNVGSSTLCNLLLEFSPAKEPMLDQGAVEMLCNLTKMSDPALRLNGIWALMNMAFQAEQKVKQRILCCLGTEQMFRLLGDSDTRVIMKMLGLLRNLLSTRQHIDAIMSEYSSQVMQAVIVVLEGSYPAEVKEQALCILGNIGDGEKSKDLIMANEDVLRKLVDYLAHPESKLQEAALFVAGNLVWRGEAGAAARQQRLAELGLLRALKLLRASHHAAHLHDKVKTALAQFNEFT

Description

Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

Subunit

Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).

Keywords

Acetylation Alternative splicing Complete proteome Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Reference proteome Repeat

Feature

chain Armadillo repeat-containing protein 8
splice variant In isoform 3.

Uniprot

H9JQ17 A0A2H1VD14 A0A194PV80 A0A2A4JNB4 A0A2W1B7Z2 A0A0L7LUM3 + More
E0VGJ9 A0A1B0CMB5 A0A0C9Q3S1 A0A182Y2I1 A0A1Q3F2H7 A0A1Q3F2F3 A0A1Q3F2L6 B0WVZ1 Q16LL6 K7IY42 U5ETQ8 A0A182R974 A0A1W4XWE9 A0A182VFV8 W5J8D2 A0A2M4ALW6 A0A1Q3F2G3 A0A2M4ALN0 A0A2M4AJJ7 A0A1W4XVI7 A0A158P0X5 F4WTW0 A0A1B6GLL6 A0A1W4XWJ6 E2BR23 E1ZZW8 D6WDP7 E9JCP7 A0A151WWU6 A0A1W4XLE6 A0A1Y1LBT6 A0A1Y1LBZ4 A0A195CZA6 A0A026VXP0 A0A1Y1LBT3 A0A1Y1LE15 A0A131YPZ0 A0A2A3ETL4 A0A131XHS7 A0A0M9ADY7 A0A0A9W9U1 A0A224YTW1 A0A182QUM3 L7LZ47 A0A131YFQ9 A0A3L8DDK0 N6UAC7 A0A224YHV4 T1J6L0 A0A224YHW0 A0A131YR10 A0A147BSN7 A0A224YND7 A0A023FN44 L7LUA5 A0A023F360 U4UA46 T1HV19 A0A2R5LD91 A0A2S2R0L9 A0A023GFP2 A0A182NI80 Q7Q557 A0A182X4K9 A0A182JU18 A0A084VW76 A0A182WBP0 A0A0P5JLR3 A0A162NUU9 A0A0P6GY49 A0A0P5JQM0 A0A0P6FMW1 A0A1S3D8H5 A0A182M6K8 A0A0P5M9V5 A0A0N7ZRL4 A0A0N7ZKX0 A0A0P5Z2D5 A0A151NHH9 A0A2H8TZJ4 A0A182TT75 A0A2S2P9N0 J9JVL8 G3HEX6 Q8IUR7-2 A0A091EBT8 A0A2K6DG88 A0A2K6DGA2 A0A2K6K9Y3 A0A2K6KA48 A0A2K5W3L1 A0A2K5W3E8 G3S7U5 G3RV63

Pubmed

19121390 26354079 28756777 26227816 20566863 25244985 + More
17510324 20075255 20920257 23761445 21347285 21719571 20798317 18362917 19820115 21282665 28004739 24508170 26830274 28049606 25401762 28797301 25576852 30249741 23537049 29652888 25474469 12364791 24438588 22293439 21804562 14702039 16641997 15489334 17974005 17467196 21269460 23186163 29911972 22398555

EMBL

BABH01012275 ODYU01001870 SOQ38676.1 KQ459590 KPI97227.1 NWSH01000980 + More
PCG73276.1 KZ150297 PZC71558.1 JTDY01000052 KOB79152.1 DS235148 EEB12505.1 AJWK01018549 AJWK01018550 AJWK01018551 AJWK01018552 AJWK01018553 GBYB01008713 JAG78480.1 GFDL01013281 JAV21764.1 GFDL01013305 JAV21740.1 GFDL01013245 JAV21800.1 DS232134 EDS35823.1 CH477901 EAT35212.1 GANO01001793 JAB58078.1 ADMH02002104 ETN59049.1 GGFK01008416 MBW41737.1 GFDL01013326 JAV21719.1 GGFK01008197 MBW41518.1 GGFK01007635 MBW40956.1 ADTU01005894 GL888345 EGI62317.1 GECZ01006478 JAS63291.1 GL449898 EFN81829.1 GL435530 EFN73279.1 KQ971322 EFA00811.2 GL771854 EFZ09413.1 KQ982691 KYQ52135.1 GEZM01060275 JAV71132.1 GEZM01060274 JAV71133.1 KQ977141 KYN05454.1 KK107622 EZA48445.1 GEZM01060277 JAV71129.1 GEZM01060278 JAV71128.1 GEDV01007530 JAP81027.1 KZ288191 PBC34489.1 GEFH01002514 JAP66067.1 KQ435687 KOX81363.1 GBHO01040316 GBRD01000577 JAG03288.1 JAG65244.1 GFPF01006114 MAA17260.1 AXCN02000483 GACK01007673 JAA57361.1 GEDV01011247 JAP77310.1 QOIP01000009 RLU18242.1 APGK01043063 APGK01043064 KB741011 ENN75562.1 GFPF01006112 MAA17258.1 JH431878 GFPF01006111 MAA17257.1 GEDV01007529 JAP81028.1 GEGO01001616 JAR93788.1 GFPF01006113 MAA17259.1 GBBK01002187 JAC22295.1 GACK01009639 JAA55395.1 GBBI01002877 JAC15835.1 KB631957 ERL87456.1 ACPB03017450 GGLE01003375 MBY07501.1 GGMS01014117 MBY83320.1 GBBM01003630 JAC31788.1 AAAB01008960 EAA11301.4 ATLV01017495 KE525170 KFB42220.1 GDIQ01198001 JAK53724.1 LRGB01000531 KZS18280.1 GDIQ01027658 JAN67079.1 GDIQ01196554 JAK55171.1 GDIQ01057101 JAN37636.1 AXCM01002234 GDIQ01170669 JAK81056.1 GDIP01219425 JAJ03977.1 GDIP01235377 JAI88024.1 GDIP01051000 JAM52715.1 AKHW03003018 KYO36099.1 GFXV01007879 MBW19684.1 GGMR01013540 MBY26159.1 ABLF02031954 JH000322 EGV98748.1 AF109184 AK001721 AK001882 AK289577 AK296757 AK296837 AC022337 AC068777 CH471052 BC013424 BC032661 BC041699 AL096748 KN122133 KFO32751.1 AQIA01038048 AQIA01038049 CABD030024400 CABD030024401 CABD030024402 CABD030024403 CABD030024404 CABD030024405 CABD030024406 CABD030024407 CABD030024408

Proteomes

UP000005204 UP000053268 UP000218220 UP000037510 UP000009046 UP000092461 + More
UP000076408 UP000002320 UP000008820 UP000002358 UP000075900 UP000192223 UP000075903 UP000000673 UP000005205 UP000007755 UP000008237 UP000000311 UP000007266 UP000075809 UP000078542 UP000053097 UP000242457 UP000053105 UP000075886 UP000279307 UP000019118 UP000030742 UP000015103 UP000075884 UP000007062 UP000076407 UP000075881 UP000030765 UP000075920 UP000076858 UP000079169 UP000075883 UP000050525 UP000075902 UP000007819 UP000001075 UP000005640 UP000028990 UP000233120 UP000233180 UP000233100 UP000001519

PRIDE

H9JQ17 G3HEX6 Q8IUR7

Pfam

PF00514 Arm + More
PF02985 HEAT

Interpro

IPR011989   ARM-like        + More
IPR038739   ARMC8/Vid28
IPR000225   Armadillo
IPR016024   ARM-type_fold
IPR021133   HEAT_type_2
IPR000357   HEAT

SUPFAM

SSF48371 SSF48371

Gene 3D

1.25.10.10

ProteinModelPortal

H9JQ17 A0A2H1VD14 A0A194PV80 A0A2A4JNB4 A0A2W1B7Z2 A0A0L7LUM3 + More
E0VGJ9 A0A1B0CMB5 A0A0C9Q3S1 A0A182Y2I1 A0A1Q3F2H7 A0A1Q3F2F3 A0A1Q3F2L6 B0WVZ1 Q16LL6 K7IY42 U5ETQ8 A0A182R974 A0A1W4XWE9 A0A182VFV8 W5J8D2 A0A2M4ALW6 A0A1Q3F2G3 A0A2M4ALN0 A0A2M4AJJ7 A0A1W4XVI7 A0A158P0X5 F4WTW0 A0A1B6GLL6 A0A1W4XWJ6 E2BR23 E1ZZW8 D6WDP7 E9JCP7 A0A151WWU6 A0A1W4XLE6 A0A1Y1LBT6 A0A1Y1LBZ4 A0A195CZA6 A0A026VXP0 A0A1Y1LBT3 A0A1Y1LE15 A0A131YPZ0 A0A2A3ETL4 A0A131XHS7 A0A0M9ADY7 A0A0A9W9U1 A0A224YTW1 A0A182QUM3 L7LZ47 A0A131YFQ9 A0A3L8DDK0 N6UAC7 A0A224YHV4 T1J6L0 A0A224YHW0 A0A131YR10 A0A147BSN7 A0A224YND7 A0A023FN44 L7LUA5 A0A023F360 U4UA46 T1HV19 A0A2R5LD91 A0A2S2R0L9 A0A023GFP2 A0A182NI80 Q7Q557 A0A182X4K9 A0A182JU18 A0A084VW76 A0A182WBP0 A0A0P5JLR3 A0A162NUU9 A0A0P6GY49 A0A0P5JQM0 A0A0P6FMW1 A0A1S3D8H5 A0A182M6K8 A0A0P5M9V5 A0A0N7ZRL4 A0A0N7ZKX0 A0A0P5Z2D5 A0A151NHH9 A0A2H8TZJ4 A0A182TT75 A0A2S2P9N0 J9JVL8 G3HEX6 Q8IUR7-2 A0A091EBT8 A0A2K6DG88 A0A2K6DGA2 A0A2K6K9Y3 A0A2K6KA48 A0A2K5W3L1 A0A2K5W3E8 G3S7U5 G3RV63

PDB

5MFD E-value=3.16611e-07, Score=133

KEGG

101742313 K23336 armadillo repeat-containing protein 8 | (RefSeq) armadillo repeat-containing protein 8-like

GO

GO:0034657 GO:0043161 GO:0005737 GO:0005634 GO:0000151 GO:1904724 GO:0005576 GO:0035580 GO:0043312 GO:0005515 GO:0005488 GO:0005840 GO:0006412 GO:0006259 GO:0004813 GO:0006419 GO:0015923 GO:0006260

PANTHER

PTHR15651

Subcellular location

Nucleus
Cytoplasm

Length:

659

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00423999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00037

outside

1 - 659

Pi

285.324898

Theta

189.719622

Tajima's D

1.514215

CLR

0.096294

CSRT

0.791510424478776

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics