Gene

KWMTBOMO06487

Pre Gene Modal

BGIBMGA011856

Annotation

putative_ankyrin_repeat_domain_54_[Danaus_plexippus]

Location

Bomo_Chr11(-):8711206-8712270      View in EpiBrowser

Full name

Ankyrin repeat domain-containing protein 54      

Alternative Name

Lyn-interacting ankyrin repeat protein

Location in the cell

Nuclear   Reliability : 3.284

CDS

ATGACAGACTCTGGAGTCGACACTGGAAATGAGAGCAGCGATAATCCTGTGTTTGATCATTCGAAATGTGTTTTGGAATTTAATCTTCCAGCAATTCCTATAACCCAATCTGGTCAGCCAATGCCAGTAGAGTTTTTAGATGAGCCACATGATCATGTCGGAAAAATTAAATGCTCCACAAAAGCAAGACACTGCCGTCTTAAGCATAGATACGGTGGAACAGTTTGCGCATCCAGGAATCACAAGTTGCGGTTCGCGGCTTCCACGAATAACACAGAACTCGTTGAACGATTATTAAAAGCTGGAGCGGATCCTAATTGTTCAGATGAGCACAAAAGAAGCCCATTGCATTTAGCAGCTTGCCGTGGCTATGTCGATGTAGTGAGAATACTTCTGCGTCACGGTGCTAACCCTAACAATAAAGACACACTTGGAAACACACCTCTTCATTTGGCTGCATGTACTAATCACATAACAGTTGTCATTGAACTATTAGATGCTGGAACTGATGTCAGTTCACATGACAGAAATGGCCGCAATCCCATACAATTAGCACAAAGTAAATTAAAGATAATACAAATGCGTCCCAGTGGTGTGGGGCATTTTGAAGTGACTCGTCAATTGATTAGTGAAATTTGCCAAGTTGTAGAAATGATGCTGAAATATATGAAAATGCAGAAGGCTGATGCAGGTGAGCTGGAATCTTTGCGACTGAGGTTGGAGCAAGTGAGTACACGGGAACAAGTTGACTCAGAAGTACAAAATCTACTCGACAGCCTGGACTCACTGAAACTTAGATAA

Protein

MTDSGVDTGNESSDNPVFDHSKCVLEFNLPAIPITQSGQPMPVEFLDEPHDHVGKIKCSTKARHCRLKHRYGGTVCASRNHKLRFAASTNNTELVERLLKAGADPNCSDEHKRSPLHLAACRGYVDVVRILLRHGANPNNKDTLGNTPLHLAACTNHITVVIELLDAGTDVSSHDRNGRNPIQLAQSKLKIIQMRPSGVGHFEVTRQLISEICQVVEMMLKYMKMQKADAGELESLRLRLEQVSTREQVDSEVQNLLDSLDSLKLR

Description

Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

Subunit

Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.

Keywords

Acetylation   Alternative splicing   ANK repeat   Complete proteome   Cytoplasm   Nucleus   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Ankyrin repeat domain-containing protein 54
splice variant  In isoform 2.

Uniprot

H9JQQ0   A0A2W1BE37   A0A2A4JMH1   S4P148   A0A2H1VCY2   A0A0L7LUT4   + More
A0A0N1PGN8   A0A212FN38   I4DKF2   A0A194PUZ1   A0A2S2PR59   A0A2S2Q8X3   J9JY15   A0A1I8NGK4   A0A1I8NQP8   T1PKJ3   A0A2H8THK6   A0A067QZM4   A0A226EFY6   A0A1A9WG43   A0A1A9Z343   A0A1E1XEP4   A0A232EQ91   A0A0A9WBK5   A0A0K8VRJ6   W8BUF2   A0A034WAU2   A0A1S3IDJ6   A0A0A1WVQ3   A0A224XXE3   K7IX54   A0A1D2N5H5   A0A1A9VAT3   A0A1B0B943   A0A0M4F040   B4QNQ3   B3NGM9   A0A0J9RSZ6   B4HLQ6   Q9VT59   A0A224YT69   A0A1W4UMJ5   B4PDX3   A0A131XN07   A0A2T7PWQ9   A0A1B0FGK9   B4J225   B4LCC3   A0A088AH50   B4L923   A0A131YZY5   B3MA58   A0A2A3ETS7   V9L5C1   A0A1Z5LCI9   A0A3Q7Q7L9   B4MN14   L5M9H6   A0A2Y9GVR3   K9IX63   A0A2U3YBB5   S7NLD8   A0A2U3WP12   A0A1B6F4M5   A0A293MR29   G7N3T6   G7PFE1   A0A1A8REN4   A0A1A8QLV6   U6D2K4   E2AN12   A0A3Q0T2T6   M1EEA7   H9H799   H9GMB2   A0A195BSK0   A0A195DI55   H9FA25   G1PPQ7   E9J423   A0A384DA99   L5KI94   A0A2J8UWC2   K7C930   Q6NXT1   A0A087TKK3   A0A2K5VZQ7   A0A0D9R3L9   A0A2K5M662   I2CWG3   A0A2Y9KM81   W5PY71   A0A341CST1   A0A2K6NBW8   A0A3P4KHP0   M3YNA7   E2QSJ6   A0A3Q7VC82  

Pubmed

19121390    28756777    23622113    26227816    26354079    22118469    + More
22651552    25315136    24845553    28503490    28648823    25401762    26823975    24495485    25348373    25830018    20075255    27289101    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28797301    17550304    28049606    18057021    26830274    24402279    28528879    22002653    20798317    23236062    17495919    21881562    25319552    21993624    21282665    23258410    15164055    16136131    15461802    14702039    10591208    15489334    18691976    19413330    19369195    20068231    21406692    24275569    20809919    25362486    16341006   

EMBL

BABH01012275    KZ150297    PZC71557.1    NWSH01000980    PCG73275.1    GAIX01009061    + More
JAA83499.1    ODYU01001870    SOQ38675.1    JTDY01000052    KOB79154.1    KQ461161    KPJ08020.1    AGBW02007611    OWR55148.1    AK401770    BAM18392.1    KQ459590    KPI97226.1    GGMR01019179    MBY31798.1    GGMS01004817    MBY74020.1    ABLF02030504    KA648615    AFP63244.1    GFXV01001705    MBW13510.1    KK852854    KDR14976.1    LNIX01000004    OXA55721.1    GFAC01001451    JAT97737.1    NNAY01002826    OXU20487.1    GBHO01041369    GBHO01041368    GBHO01041367    GBHO01041366    GBHO01041365    GBHO01034967    GDHC01019025    GDHC01013409    JAG02235.1    JAG02236.1    JAG02237.1    JAG02238.1    JAG02239.1    JAG08637.1    JAP99603.1    JAQ05220.1    GDHF01010812    JAI41502.1    GAMC01013801    JAB92754.1    GAKP01008030    GAKP01008029    JAC50923.1    GBXI01011692    JAD02600.1    GFTR01003236    JAW13190.1    AAZX01008221    LJIJ01000206    ODN00472.1    JXJN01010264    CP012525    ALC44082.1    CM000363    EDX09920.1    CH954178    EDV51265.1    CM002912    KMY98782.1    CH480815    EDW40938.1    AE014296    BT023914    AAF50195.1    ABA81848.1    GFPF01006038    MAA17184.1    CM000159    EDW93969.1    GEFH01001071    JAP67510.1    PZQS01000001    PVD37871.1    CCAG010013633    CH916366    EDV95950.1    CH940647    EDW68768.1    KRF84010.1    CH933816    EDW17198.1    GEDV01004455    JAP84102.1    CH902618    EDV39072.1    KZ288189    PBC34682.1    JW874681    AFP07198.1    GFJQ02002236    JAW04734.1    CH963847    EDW73570.1    KB102787    ELK35001.1    GABZ01007204    JAA46321.1    KE164518    EPQ18306.1    GECZ01024645    JAS45124.1    GFWV01018596    MAA43324.1    CM001262    EHH20218.1    CM001285    EHH65825.1    HAEH01003551    HAEI01008241    SBS04496.1    HAEF01008300    HAEG01013116    SBR94099.1    HAAF01004293    CCP76118.1    GL441034    EFN65170.1    JP005631    AER94228.1    AAWZ02028380    KQ976419    KYM89275.1    KQ980824    KYN12517.1    JU327728    AFE71484.1    AAPE02044881    GL768069    EFZ12435.1    KB030755    ELK10243.1    NDHI03003442    PNJ49547.1    AACZ04068050    GABC01010058    GABE01005663    NBAG03000283    JAA01280.1    JAA39076.1    PNI49000.1    CR456471    AK127583    Z97630    BC014641    BC066909    KK115653    KFM65642.1    AQIA01007032    AQIB01136613    AQIB01136614    AQIB01136615    AQIB01136616    AQIB01136617    JV635958    AFJ71298.1    AMGL01083896    AMGL01083897    CYRY02000473    VCW50000.1    AEYP01012683    AAEX03007325   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000007151    UP000053268    + More
UP000007819    UP000095301    UP000095300    UP000027135    UP000198287    UP000091820    UP000092445    UP000215335    UP000085678    UP000002358    UP000094527    UP000078200    UP000092460    UP000092553    UP000000304    UP000008711    UP000001292    UP000000803    UP000192221    UP000002282    UP000245119    UP000092444    UP000001070    UP000008792    UP000005203    UP000009192    UP000007801    UP000242457    UP000286641    UP000007798    UP000248481    UP000245341    UP000245340    UP000009130    UP000000311    UP000261340    UP000002280    UP000001646    UP000078540    UP000078492    UP000001074    UP000261680    UP000010552    UP000002277    UP000005640    UP000054359    UP000233100    UP000029965    UP000233060    UP000248482    UP000002356    UP000252040    UP000233200    UP000000715    UP000002254    UP000286642   

PRIDE

H9JQQ0    Q9VT59    Q6NXT1   

Pfam

PF12796   Ank_2        + More
PF00023   Ank

Interpro

IPR036770   Ankyrin_rpt-contain_sf        + More
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       
IPR009551   Wntless       
IPR039323   ANKRD60       

SUPFAM

SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9JQQ0   A0A2W1BE37   A0A2A4JMH1   S4P148   A0A2H1VCY2   A0A0L7LUT4   + More
A0A0N1PGN8   A0A212FN38   I4DKF2   A0A194PUZ1   A0A2S2PR59   A0A2S2Q8X3   J9JY15   A0A1I8NGK4   A0A1I8NQP8   T1PKJ3   A0A2H8THK6   A0A067QZM4   A0A226EFY6   A0A1A9WG43   A0A1A9Z343   A0A1E1XEP4   A0A232EQ91   A0A0A9WBK5   A0A0K8VRJ6   W8BUF2   A0A034WAU2   A0A1S3IDJ6   A0A0A1WVQ3   A0A224XXE3   K7IX54   A0A1D2N5H5   A0A1A9VAT3   A0A1B0B943   A0A0M4F040   B4QNQ3   B3NGM9   A0A0J9RSZ6   B4HLQ6   Q9VT59   A0A224YT69   A0A1W4UMJ5   B4PDX3   A0A131XN07   A0A2T7PWQ9   A0A1B0FGK9   B4J225   B4LCC3   A0A088AH50   B4L923   A0A131YZY5   B3MA58   A0A2A3ETS7   V9L5C1   A0A1Z5LCI9   A0A3Q7Q7L9   B4MN14   L5M9H6   A0A2Y9GVR3   K9IX63   A0A2U3YBB5   S7NLD8   A0A2U3WP12   A0A1B6F4M5   A0A293MR29   G7N3T6   G7PFE1   A0A1A8REN4   A0A1A8QLV6   U6D2K4   E2AN12   A0A3Q0T2T6   M1EEA7   H9H799   H9GMB2   A0A195BSK0   A0A195DI55   H9FA25   G1PPQ7   E9J423   A0A384DA99   L5KI94   A0A2J8UWC2   K7C930   Q6NXT1   A0A087TKK3   A0A2K5VZQ7   A0A0D9R3L9   A0A2K5M662   I2CWG3   A0A2Y9KM81   W5PY71   A0A341CST1   A0A2K6NBW8   A0A3P4KHP0   M3YNA7   E2QSJ6   A0A3Q7VC82  

PDB

1N0R     E-value=4.01532e-22,     Score=257

KEGG

101741646    K21442 ankyrin repeat domain-containing protein 54 | (RefSeq) ankyrin repeat domain-containing prote

GO

GO:0017147   GO:0016055   GO:0016021   GO:0045859   GO:0019887   GO:0005634   GO:0005737   GO:1902531   GO:0045648   GO:0030496   GO:0044877   GO:0006913   GO:0005515   GO:0005622   GO:0005840   GO:0006412   GO:0006259   GO:0004813   GO:0006419   GO:0015923   GO:0006260  

PANTHER

PTHR13449   PTHR22677  

Subcellular location

Nucleus   Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity).   With evidence from 7 publications.
Cytoplasm   Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity).   With evidence from 7 publications.
Midbody   Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity).   With evidence from 7 publications.

Length:

266

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00207

Exp number, first 60 AAs:

0

Total prob of N-in:

0.05928

outside

1  -  266

 

 

Pi

179.783713

Theta

236.475835

Tajima's D

-0.755072

CLR

1131.869712

CSRT

0.185690715464227

Interpretation

Uncertain