Silkworm Genome Informatics Database

Gene

KWMTBOMO06485 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011857

Annotation

DNA_cytosine-5_methyltransferase_[Bombyx_mori]

Location

Bomo_Chr11(-):8675578-8677610 View in EpiBrowser

Full name

Cytosine-specific methyltransferase + More
tRNA (cytosine(38)-C(5))-methyltransferase

Alternative Name

DNA (cytosine-5)-methyltransferase-like protein 2
DNA methyltransferase homolog HsaIIP
PuMet

Location in the cell

Cytoplasmic Reliability : 1.315 Nuclear Reliability : 1.732

CDS

ATGGAGGAAAAAATGGAACACAGAATATTAGAACTTTACAGCGGTATTGGTGGCATGCATTGTGCCTGGAATGAAAGCACAATCAAAGGGAAAGTTGTAGCCGCTATAGATATAAACACCGTCGCAAATGACGTTTACAAGTACAACTTTCCTGAGACACTATTATTCACCAAAAATATACAATCTTTAACACCGATAGAAATAGAAAAGTATAAAATTGACACAGTTCTCATGTCACCACCTTGCCAGCCTTTTACTCGCAATGGAAAAAATTTGGATGAAAATGATCCAAGAACCAACTCATTTTTATATTTCATAGATATATTAGACAAATTAAATACCCTTCAATATATTTTAATGGAAAATGTTAAAGGGTTTGAATGTTCTACTGTTCGAAATTTATTTGTTGAAAAGTTGACTTACTGTGGATTTGTCTATCAAGAGTTTATGTTGAGTCCTGTAAGTGTTGGAGTGCCTAATTCAAGATTGAGGTATTATTGTATAGCTAAAAGGAATAATACATGGAACTTTAAAAGAAAAGATGAGCTTATTACATGTCTTCCAAAAACCTTTGCAAAACCTCATTGCCTTAAGGATATTATTGAAAATAATGTGCCTGATGATTACTTGGTGCCAGACAAGATGTTAAGGAAAGCAAATATATTTGACATTTGTTATGCAGATTCTAACAGGTCATGTTGTTTTACTAAAGCATACACACATTATGTAGAAGGTACAGGCTCTGTGTTCACTGAAACAAGTTATGACATAGTACAGAAGTATTTAAAATTGGCTAATTATTTCGAAGTAGGTAGTGATGAATTTCTGCAAACCTTAAAAAAGCTTAAACTTAGGTTCTTTACGTCTAAAGAAATCTTGCAGTTAATGTCATTTCCTAGTGAGTATAGTTTTCCTAAGACTGTTACAAGGAAACAATGTTATAGGCTTCTTGGAAATAGTGTAAATGTTAAAGTTATCAGTGAATTATTACAAATTTTGTTTGATGAATAA

Protein

MEEKMEHRILELYSGIGGMHCAWNESTIKGKVVAAIDINTVANDVYKYNFPETLLFTKNIQSLTPIEIEKYKIDTVLMSPPCQPFTRNGKNLDENDPRTNSFLYFIDILDKLNTLQYILMENVKGFECSTVRNLFVEKLTYCGFVYQEFMLSPVSVGVPNSRLRYYCIAKRNNTWNFKRKDELITCLPKTFAKPHCLKDIIENNVPDDYLVPDKMLRKANIFDICYADSNRSCCFTKAYTHYVEGTGSVFTETSYDIVQKYLKLANYFEVGSDEFLQTLKKLKLRFFTSKEILQLMSFPSEYSFPKTVTRKQCYRLLGNSVNVKVISELLQILFDE

Description

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).

Catalytic Activity

a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Keywords

3D-structure Alternative splicing Complete proteome Methyltransferase Nucleus Polymorphism Reference proteome RNA-binding S-adenosyl-L-methionine Transferase tRNA processing

Feature

chain  tRNA (cytosine(38)-C(5))-methyltransferase
splice variant  In isoform F.
sequence variant  In dbSNP:rs11254413.

Uniprot

Q5W7N5 H9JQQ1 A0A2W1BBQ8 A0A2A4JPD0 A0A2H1VE33 L7MTK8 + More
K0A166 A0A194PWT6 A0A0N1I6Q1 A0A212FP48 A0A0L7L4U9 S4PS89 A0A1L7N292 A0A1Y1KSV3 A0A0T6B8W7 A0A232EF07 A0A026X2X1 A0A3L8DU54 U4UJY9 N6T6W2 E2AWU0 A0A088AR60 D6WXT9 A0A221HL08 A0A1W4XGJ5 B4Q3Q2 A0A158NJF4 A0A3B0K8U9 A0A182I7Z6 A0A2A3EAV5 A0A0N0BE75 E9IKK8 A0A182L7L2 B3MVH6 Q9VKB3 H0UVC3 B3N3X2 Q7QBB3 A0A182V4I0 A0A0K8WMN7 B4P1Y6 A0A182UJ61 F6URL6 A0A154PPB3 A0A3B4X646 A0A0D9RJU8 A0A034WQ86 A0A1W4UYS3 A0A182XFK0 B4GQK4 A0A2Y9KQQ7 Q29NK7 A0A0Q9WAY5 A0A0N8DQU0 A0A336LUK9 A0A0P5AYV8 A0A369SEZ3 A0A1I8ME20 E9FZL3 A0A0C9RIU5 A0A0P6EK43 A0A182JSI0 W8BEE1 A0A182PNN0 A0A1J1IAR4 A0A0P6DM48 A0A2I2Y2J7 A0A0A9XYC4 A0A2R5L5D2 Q177E1 A0A182FAT0 A0A0A1WFE1 A0A096MXD0 A0A2K5Y8H2 F4W9K0 A0A2K5NLX7 A0A2R9ATZ5 H2R2B5 K7AMJ6 A0A2K5HSG3 A0A182N5K8 A0A1S4FCM5 A0A293LLK5 G1RPT3 Q6ICS7 O14717 A0A182Q262 A0A2J8VKR1 A0A182G4T4 B4IE64 A0A0K8VQS9 A0A2M4AVT4 A0A2K5W043 G7PEG2 A0A2K6D2Q3 A0A1B0DR06 B4KI02 A0A2P8Y5Q5 A0A1I8PK95 A0A2M4AVC3

EC Number

2.1.1.37
2.1.1.204

Pubmed

19121390 28756777 23103599 26354079 22118469 26227816 + More
23622113 27956627 28004739 28648823 24508170 30249741 23537049 20798317 18362917 19820115 28449092 17994087 22936249 21347285 21282665 20966253 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 21993624 12364791 14747013 17210077 17550304 25243066 25348373 15632085 30042472 25315136 21292972 24495485 22398555 25401762 17510324 25830018 21719571 22722832 16136131 11181995 9425235 9599025 9592134 15164054 15489334 11551826 16424344 11139614 26483478 22002653 29403074

EMBL

AB194009 BAD67190.1 BABH01012279 BABH01012280 BABH01012281 BABH01012282 + More
BABH01012283 KZ150297 PZC71555.1 NWSH01000980 PCG73272.1 ODYU01001870 SOQ38672.1 JX428898 AFS64716.1 KQ459590 KPI97224.1 KQ461161 KPJ08018.1 AGBW02003646 OWR55521.1 JTDY01002901 KOB70518.1 GAIX01000145 JAA92415.1 LC100111 BAW19576.1 GEZM01079180 JAV62496.1 LJIG01009139 KRT83678.1 NNAY01005163 OXU16931.1 KK107046 EZA61744.1 QOIP01000004 RLU23924.1 KB632356 ERL93422.1 APGK01041556 KB740994 ENN75969.1 GL443425 EFN62060.1 KX553975 KQ971362 ASA69507.1 EFA09160.1 GU907554 ASM42031.1 CM000361 CM002910 EDX04777.1 KMY89876.1 ADTU01017674 OUUW01000006 SPP81451.1 APCN01002591 KZ288313 PBC28339.1 KQ435837 KOX71481.1 GL763991 EFZ18927.1 CH902624 EDV33241.1 AE014134 AAF53163.2 ABI31309.1 AAKN02052630 CH954177 EDV58824.2 AAAB01008880 EAA08679.5 GDHF01000104 JAI52210.1 CM000157 EDW88157.2 GAMS01005394 JAB17742.1 KQ435010 KZC13735.1 AQIB01160602 AQIB01160603 GAKP01003029 JAC55923.1 CH479187 EDW39876.1 CH379059 EAL34212.2 CH940649 KRF81852.1 GDIP01009927 LRGB01001581 JAM93788.1 KZS11395.1 UFQS01000005 UFQT01000005 SSW96951.1 SSX17338.1 GDIP01192491 JAJ30911.1 NOWV01000020 RDD45044.1 GL732528 EFX87248.1 GBYB01008175 JAG77942.1 GDIQ01063371 GDIQ01061619 JAN33118.1 GAMC01014999 JAB91556.1 CVRI01000044 CRK96652.1 GDIQ01076704 JAN18033.1 CABD030068230 CABD030068231 CABD030068232 GBHO01021325 GBHO01021324 JAG22279.1 JAG22280.1 GGLE01000572 MBY04698.1 CH477377 EAT42284.1 GBXI01017097 JAC97194.1 GL888032 EGI69118.1 AJFE02110283 AACZ04054000 GABD01007879 GABE01003765 NBAG03000390 JAA25221.1 JAA40974.1 PNI30490.1 GABC01008324 GABF01004606 JAA03014.1 JAA17539.1 GFWV01002970 MAA27700.1 ADFV01176360 EF444974 AK291417 CR450316 CH471072 ACA05983.1 ACA05987.1 BAF84106.1 CAG29312.1 EAW86217.1 AF012128 AJ223333 AF045888 AC067747 AL133415 BC047733 AF329940 AF329941 AF329942 AF329943 AF329944 AXCN02001161 NDHI03003418 PNJ58118.1 JXUM01042569 KQ561330 KXJ78955.1 CH480831 EDW45891.1 GDHF01011083 JAI41231.1 GGFK01011417 MBW44738.1 AQIA01070184 AQIA01070185 CM001284 EHH64588.1 AJVK01008840 CH933807 EDW11284.2 PYGN01000896 PSN39589.1 GGFK01011416 MBW44737.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000053240 UP000007151 UP000037510 + More
UP000215335 UP000053097 UP000279307 UP000030742 UP000019118 UP000000311 UP000005203 UP000007266 UP000192223 UP000000304 UP000005205 UP000268350 UP000075840 UP000242457 UP000053105 UP000075882 UP000007801 UP000000803 UP000005447 UP000008711 UP000007062 UP000075903 UP000002282 UP000075902 UP000008225 UP000076502 UP000261360 UP000029965 UP000192221 UP000076407 UP000008744 UP000248482 UP000001819 UP000008792 UP000076858 UP000253843 UP000095301 UP000000305 UP000075881 UP000075885 UP000183832 UP000001519 UP000008820 UP000069272 UP000028761 UP000233140 UP000007755 UP000233060 UP000240080 UP000002277 UP000233080 UP000075884 UP000001073 UP000005640 UP000075886 UP000069940 UP000249989 UP000001292 UP000233100 UP000009130 UP000233120 UP000092462 UP000009192 UP000245037 UP000095300

PRIDE

Q5W7N5 H9JQQ1 Q9VKB3 O14717

Pfam

PF00145 DNA_methylase + More
PF00567 TUDOR

Interpro

IPR031303   C5_meth_CS        + More
IPR001525   C5_MeTfrase
IPR029063   SAM-dependent_MTases
IPR035437   SNase_OB-fold_sf
IPR002999   Tudor
IPR018117   C5_DNA_meth_AS

SUPFAM

SSF53335 SSF53335

Gene 3D

2.40.50.90

ProteinModelPortal

Q5W7N5 H9JQQ1 A0A2W1BBQ8 A0A2A4JPD0 A0A2H1VE33 L7MTK8 + More
K0A166 A0A194PWT6 A0A0N1I6Q1 A0A212FP48 A0A0L7L4U9 S4PS89 A0A1L7N292 A0A1Y1KSV3 A0A0T6B8W7 A0A232EF07 A0A026X2X1 A0A3L8DU54 U4UJY9 N6T6W2 E2AWU0 A0A088AR60 D6WXT9 A0A221HL08 A0A1W4XGJ5 B4Q3Q2 A0A158NJF4 A0A3B0K8U9 A0A182I7Z6 A0A2A3EAV5 A0A0N0BE75 E9IKK8 A0A182L7L2 B3MVH6 Q9VKB3 H0UVC3 B3N3X2 Q7QBB3 A0A182V4I0 A0A0K8WMN7 B4P1Y6 A0A182UJ61 F6URL6 A0A154PPB3 A0A3B4X646 A0A0D9RJU8 A0A034WQ86 A0A1W4UYS3 A0A182XFK0 B4GQK4 A0A2Y9KQQ7 Q29NK7 A0A0Q9WAY5 A0A0N8DQU0 A0A336LUK9 A0A0P5AYV8 A0A369SEZ3 A0A1I8ME20 E9FZL3 A0A0C9RIU5 A0A0P6EK43 A0A182JSI0 W8BEE1 A0A182PNN0 A0A1J1IAR4 A0A0P6DM48 A0A2I2Y2J7 A0A0A9XYC4 A0A2R5L5D2 Q177E1 A0A182FAT0 A0A0A1WFE1 A0A096MXD0 A0A2K5Y8H2 F4W9K0 A0A2K5NLX7 A0A2R9ATZ5 H2R2B5 K7AMJ6 A0A2K5HSG3 A0A182N5K8 A0A1S4FCM5 A0A293LLK5 G1RPT3 Q6ICS7 O14717 A0A182Q262 A0A2J8VKR1 A0A182G4T4 B4IE64 A0A0K8VQS9 A0A2M4AVT4 A0A2K5W043 G7PEG2 A0A2K6D2Q3 A0A1B0DR06 B4KI02 A0A2P8Y5Q5 A0A1I8PK95 A0A2M4AVC3

PDB

4H0N E-value=6.49276e-132, Score=1205

KEGG

692480 K15336 tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204] | (RefSeq) Dnmt2, BmDnmt2; DNA cytosine

GO

GO:0008168 GO:0046872 GO:0008340 GO:0000723 GO:0006979 GO:0008175 GO:0002230 GO:0009408 GO:0043045 GO:0010494 GO:0016363 GO:0003886 GO:0045089 GO:0016458 GO:0005634 GO:0030488 GO:0006306 GO:0005737 GO:0001975 GO:0006400 GO:0016428 GO:0003723 GO:0005654 GO:0016021 GO:0005622 GO:0005840 GO:0006412 GO:0006259 GO:0004813 GO:0006419 GO:0015923 GO:0006260

Subcellular location

Nucleus

Length:

336

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03356

Exp number, first 60 AAs:

0.00203

Total prob of N-in:

0.01983

outside

1 - 336

Pi

187.941407

Theta

197.944655

Tajima's D

-0.394513

CLR

0.994368

CSRT

0.268736563171841

Interpretation

Possibly Positive selection

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics