Gene

KWMTBOMO06479

Pre Gene Modal

BGIBMGA011859

Annotation

PREDICTED:_kelch-like_protein_10_[Amyelois_transitella]

Location

Bomo_Chr11(-):8637988-8644000      View in EpiBrowser

Full name

Kelch-like protein 10      

Location in the cell

PlasmaMembrane   Reliability : 2.815

CDS

ATGGAATTTAATACGAAACATAAAAAATTAACAAAAGCCAAAAATTCTGTACGTACGCCTTCAATTGCGAGATCACGTTTAAACAAAAAGAAAATTATCACGAGACAAAGAAAATGTGCGTGTCTTCCTGAAAATTATTCTGTGGTAGAATTCCCAGCAATTTGGAATGAACTACGACAAAACGGTCAGCTCTGTGATGGAACGATAATGTGTAGGGATTTGAAAGCAATAGGTGTTCATCGCGCCATACTATCAGCAGTTAGCCCATATTTTAAAGCTATATTTATAAACTCTTTAAACAAAGGTGAACCTGAGGAAACTAAAATATTTGTAGATGTTCCTAGTTTCTATATGAATCTAATACTGGATTACGCTTATACTGGAACTTGTAAGGTTACAGCAGAGAATGTTGAGTATCTTCTGCCATACGCAGACAAATTCGATGTTGTGGGAGTTATCCAACTTTGTTGCCAGTACTTACTGCAAGAATTAAAACCTCATAATTGCCTAGGAATATTTAAATTTGCTCGATATTATTTTTGCGGTGAATTAGAAAAGAAGGGGAAAATGTTTATAAGACAGCACTTTAATAAGATACTAAAGGAATGTAATGAATTTAAATCGCTTACTTTCGAAGAATTGGAAGACATTTTACGAGATGACGAACTGAACGTTAAAAATGAAGAAATTGTTTTTCAAGCTTTAAAGACTTGGGTCGAACATGACTTAGAAAACAGGAGAAAGTACATTCCGTCATTGCTTTCATGCGTTAGATTTGGTCACATAAGTTTTAAATATTTCAAATCAAAAATATTACAATGGCAGCCAGTGGTTGATGATGTGAAATGCCAAGAAGCGTTATACCCAGCAGTGGTGTTTTTAACATTACTAGATTCAAGACCTGGTATGGAAGCAGATTTAAACGATCCACTGGCGCGACCTAGAATTCCTTTTGAAATACTTTTTGCTGTTGGAGGATGGAGTGCTGGTAGTCCTACGAGCTTTGTTGAAACATACGATACAAGAGCTGACCGCTGGTTTCTTTCAATTCACATGGACCTTACTCCACGTGCTTATCACGGCCTCTGCACACTGAACAATCTGATTTATATGATCGGAGGTTTTGATGGTAGTGACCATTTTAATACGGTACGTTGTTACGACCCTGTCACTAATACGTGGCACGAACGCGCCTGTATGTATCAAGCCAGATGCTACGTCAGCGTTGTCGTGCACGACGGTATGATATACGCACTTGGAGGATATAATGGACGTACTCGTATGGCTTCAGTAGAACGGTACTATCCTGACAGAAATCAATGGGAGATGACCACTCCAATGAATAAACAGCGCTCAGACGCTAGCGCGGCATCACTAGGTGGCAAGATTTATATAGTGGGCGGTTTTAATGGACAAGAAGTATTGAGTTCTGCAGAAGTCTTTGACCCAGAGACGCGTCAATGGAGTTTCATCAGGTCGATGCTCAGTCCTCGCTCGGGAGTTAGTCTCATCGCCTACAGGGAATGCTTATTCGCGCTAGGTGGCTTCAATGGATACAGTCGTCTTAATACTGGTGAGAAATTTAATCCACAACGCGGCGGCGAATGGCAGGAAGTAACGGAAATGTTTAGTGCAAGAAGTAATTTCGCCACGGTTCTGTTGGACGATATGATTTTTGTCATCGGAGGATTTAATGGGTCCACAACAATTCCTCTCGTGGAATGCTACGATGGAGATACTCTAGAGTGGTACGACGCCGCTCCAATGAACTTGAATCGTTCAGCGCTCAGTGCTTGTGTTCTTGCCGGTTTACCGAACGCGCGTTCCTTCTCTTATTTGGCGAAAGCTGTGCCTGCCGCTGGTGCTGATCAAGCTCCTCAATCCTAA

Protein

MEFNTKHKKLTKAKNSVRTPSIARSRLNKKKIITRQRKCACLPENYSVVEFPAIWNELRQNGQLCDGTIMCRDLKAIGVHRAILSAVSPYFKAIFINSLNKGEPEETKIFVDVPSFYMNLILDYAYTGTCKVTAENVEYLLPYADKFDVVGVIQLCCQYLLQELKPHNCLGIFKFARYYFCGELEKKGKMFIRQHFNKILKECNEFKSLTFEELEDILRDDELNVKNEEIVFQALKTWVEHDLENRRKYIPSLLSCVRFGHISFKYFKSKILQWQPVVDDVKCQEALYPAVVFLTLLDSRPGMEADLNDPLARPRIPFEILFAVGGWSAGSPTSFVETYDTRADRWFLSIHMDLTPRAYHGLCTLNNLIYMIGGFDGSDHFNTVRCYDPVTNTWHERACMYQARCYVSVVVHDGMIYALGGYNGRTRMASVERYYPDRNQWEMTTPMNKQRSDASAASLGGKIYIVGGFNGQEVLSSAEVFDPETRQWSFIRSMLSPRSGVSLIAYRECLFALGGFNGYSRLNTGEKFNPQRGGEWQEVTEMFSARSNFATVLLDDMIFVIGGFNGSTTIPLVECYDGDTLEWYDAAPMNLNRSALSACVLAGLPNARSFSYLAKAVPAAGADQAPQS

Description

May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility.

Subunit

Self-associates. Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex (By similarity).
Self-associates (By similarity). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex.
Self-associates (Probable). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex (By similarity).

Miscellaneous

Does not seem to associate with actin.

Keywords

Complete proteome   Cytoplasm   Differentiation   Kelch repeat   Phosphoprotein   Reference proteome   Repeat   Spermatogenesis   Ubl conjugation pathway   Disease mutation  

Feature

chain  Kelch-like protein 10
sequence variant  In SPGF11; results in impaired self-association; dbSNP:rs116420871.

Uniprot

H9JQQ3   A0A2W1BU36   A0A2H1WL14   A0A2A4JPE0   A0A3S2P6P5   A0A194PWT1   + More
A0A212FP59   A0A0L7KNF5   A0A195CUZ8   A0A151X7K8   A0A195DLS5   A0A088A511   A0A195BKG8   A0A158NAS0   A0A195FR76   A0A154PC83   A0A0L7QTB4   A0A026WMW5   A0A2P8ZKG0   A0A3L8D7J3   A0A1W4X0Q7   E0V9G0   A0A1W4WPP8   A0A0C9RC58   E9IXQ8   A0A139WKL2   A0A139WKC4   A0A1Y1KKP3   T1IMJ6   N6TZP3   A0A0M9A696   A0A226EDW8   A0A2J7R646   A0A2C9KFA9   A0A2C9KF84   A0A3S1AGY3   A0A210QDN8   V4B2M3   A0A210QKN9   V4BZ38   K1QZM1   A0A210QRR8   E0VNX1   A0A0N1PI19   K1R9Z0   A0A1W4X0E7   T1HSE5   A0A151PC46   A0A2A3EI13   A0A088A9H5   H2ZWD1   A0A224X953   A0A195D368   K7FXG8   E2AY31   A0A1B6IL54   A0A0L8HH00   A0A2C9JDU9   A0A151WTN2   A0A195DM84   A0A383ZRK8   A0A0L7RH03   A0A195FJR8   A0A195BTD2   A0A158P2D9   A0A2K5YXL9   A0A1S3S5E1   D2HIS0   H2NU21   F1Q2G6   A0A3Q7RC13   A0A0A9YPI4   A0A2R9AIC9   H2QD07   A0A1Y1NHD7   L8IEH6   F1MBZ1   G3SZ77   G1PJA9   A0A1S3GWH7   I3M727   B2RTD7   A0A2Y9EBS7   Q6JEL3   Q9D5V2   A0A1S3AIB7   H0WGF8   A0A1U7QWK6   G3R3Q6   A0A140VJM8   Q6JEL2   A0A2K5Q0A6   A0A2K6S0A5   A0A384CXH6   A0A287BE53   F6XWF4   A0A3Q7NGP2   A0A2Y9JWC6   A0A3P4MXN4  

Pubmed

19121390    28756777    26354079    22118469    26227816    21347285    + More
24508170    29403074    30249741    20566863    21282665    18362917    19820115    28004739    23537049    15562597    28812685    23254933    22992520    22293439    9215903    17381049    20798317    20010809    16341006    25401762    22722832    16136131    22751099    19393038    21993624    12040188    15489334    21183079    15136734    22673903    16141072    16162871    22398555    11181995    14702039    17047026    24813606    19892987   

EMBL

BABH01012284    KZ149967    PZC76156.1    ODYU01009339    SOQ53697.1    NWSH01000980    + More
PCG73282.1    RSAL01000010    RVE53719.1    KQ459590    KPI97219.1    AGBW02003646    OWR55515.1    JTDY01008346    KOB64611.1    KQ977276    KYN04498.1    KQ982446    KYQ56314.1    KQ980734    KYN13828.1    KQ976455    KYM85143.1    ADTU01010045    KQ981305    KYN42968.1    KQ434870    KZC09505.1    KQ414755    KOC61721.1    KK107153    EZA56991.1    PYGN01000029    PSN56988.1    QOIP01000012    RLU16269.1    DS234992    EEB10016.1    GBYB01014169    JAG83936.1    GL766762    EFZ14665.1    KQ971329    KYB28355.1    KYB28354.1    GEZM01080967    JAV61963.1    JH431067    APGK01045172    APGK01045173    KB741031    KI208367    KI208683    ENN74765.1    ERL95846.1    ERL95906.1    KQ435727    KOX78097.1    LNIX01000004    OXA55334.1    NEVH01006981    PNF36303.1    RQTK01000005    RUS91794.1    NEDP02004067    OWF46852.1    KB200701    ESP00682.1    NEDP02003184    OWF49315.1    KB201813    ESO94394.1    JH818378    EKC42522.1    NEDP02002269    OWF51388.1    DS235354    EEB15077.1    KQ461161    KPJ08012.1    EKC42523.1    ACPB03004813    AKHW03000499    KYO46686.1    KZ288254    PBC30839.1    AFYH01149238    AFYH01149239    GFTR01007560    JAW08866.1    KQ976885    KYN07355.1    AGCU01138943    GL443762    EFN61627.1    GECU01020049    JAS87657.1    KQ418269    KOF88050.1    KQ982753    KYQ51196.1    KYN13946.1    KQ414594    KOC70140.1    KQ981523    KYN40249.1    KQ976408    KYM91196.1    ADTU01007164    ADTU01007165    ACTA01012009    GL192892    EFB20106.1    ABGA01331353    ABGA01331354    ABGA01331355    NDHI03003706    PNJ07227.1    AAEX03006455    GBHO01010073    GBRD01001242    JAG33531.1    JAG64579.1    AJFE02044423    AJFE02044424    AJFE02044425    AJFE02044426    AJFE02044427    AJFE02044428    AACZ04038960    NBAG03000371    PNI33986.1    GEZM01002346    JAV97312.1    JH881506    ELR53939.1    AAPE02024581    AGTP01023477    BC139267    BC139268    CH466662    AAI39268.1    EDL02558.1    AY495338    BC085842    AY495337    AK006288    AK014906    AK077202    AAQR03042772    AAQR03042773    CABD030037877    HM005417    CH471152    AEE61015.1    EAW60774.1    AY495339    AK057224    AEMK02000080    CYRY02015514    VCW85495.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000037510    + More
UP000078542    UP000075809    UP000078492    UP000005203    UP000078540    UP000005205    UP000078541    UP000076502    UP000053825    UP000053097    UP000245037    UP000279307    UP000192223    UP000009046    UP000007266    UP000019118    UP000030742    UP000053105    UP000198287    UP000235965    UP000076420    UP000271974    UP000242188    UP000030746    UP000005408    UP000053240    UP000015103    UP000050525    UP000242457    UP000008672    UP000007267    UP000000311    UP000053454    UP000261681    UP000233140    UP000087266    UP000008912    UP000001595    UP000002254    UP000286640    UP000240080    UP000002277    UP000009136    UP000007646    UP000001074    UP000081671    UP000005215    UP000248480    UP000002494    UP000000589    UP000079721    UP000005225    UP000189706    UP000001519    UP000005640    UP000233040    UP000233220    UP000261680    UP000291021    UP000008227    UP000002281    UP000286641    UP000248482   

PRIDE

H9JQQ3    Q6JEL3    Q9D5V2    A0A140VJM8    Q6JEL2   

Pfam

PF07707   BACK        + More
PF01344   Kelch_1
PF00651   BTB
PF00106   adh_short

Interpro

IPR011705   BACK        + More
IPR017096   BTB-kelch_protein       
IPR011333   SKP1/BTB/POZ_sf       
IPR006652   Kelch_1       
IPR000210   BTB/POZ_dom       
IPR015915   Kelch-typ_b-propeller       
IPR036291   NAD(P)-bd_dom_sf       
IPR002347   SDR_fam       

SUPFAM

SSF54695   SSF54695        + More
SSF117281   SSF117281       
SSF51735   SSF51735       

Gene 3D

2.120.10.80    

ProteinModelPortal

H9JQQ3   A0A2W1BU36   A0A2H1WL14   A0A2A4JPE0   A0A3S2P6P5   A0A194PWT1   + More
A0A212FP59   A0A0L7KNF5   A0A195CUZ8   A0A151X7K8   A0A195DLS5   A0A088A511   A0A195BKG8   A0A158NAS0   A0A195FR76   A0A154PC83   A0A0L7QTB4   A0A026WMW5   A0A2P8ZKG0   A0A3L8D7J3   A0A1W4X0Q7   E0V9G0   A0A1W4WPP8   A0A0C9RC58   E9IXQ8   A0A139WKL2   A0A139WKC4   A0A1Y1KKP3   T1IMJ6   N6TZP3   A0A0M9A696   A0A226EDW8   A0A2J7R646   A0A2C9KFA9   A0A2C9KF84   A0A3S1AGY3   A0A210QDN8   V4B2M3   A0A210QKN9   V4BZ38   K1QZM1   A0A210QRR8   E0VNX1   A0A0N1PI19   K1R9Z0   A0A1W4X0E7   T1HSE5   A0A151PC46   A0A2A3EI13   A0A088A9H5   H2ZWD1   A0A224X953   A0A195D368   K7FXG8   E2AY31   A0A1B6IL54   A0A0L8HH00   A0A2C9JDU9   A0A151WTN2   A0A195DM84   A0A383ZRK8   A0A0L7RH03   A0A195FJR8   A0A195BTD2   A0A158P2D9   A0A2K5YXL9   A0A1S3S5E1   D2HIS0   H2NU21   F1Q2G6   A0A3Q7RC13   A0A0A9YPI4   A0A2R9AIC9   H2QD07   A0A1Y1NHD7   L8IEH6   F1MBZ1   G3SZ77   G1PJA9   A0A1S3GWH7   I3M727   B2RTD7   A0A2Y9EBS7   Q6JEL3   Q9D5V2   A0A1S3AIB7   H0WGF8   A0A1U7QWK6   G3R3Q6   A0A140VJM8   Q6JEL2   A0A2K5Q0A6   A0A2K6S0A5   A0A384CXH6   A0A287BE53   F6XWF4   A0A3Q7NGP2   A0A2Y9JWC6   A0A3P4MXN4  

PDB

6GY5     E-value=1.80452e-49,     Score=497

KEGG

101742076    K10448 kelch-like protein 10 | (RefSeq) kelch-like protein 10

GO

GO:0016021   GO:0000902   GO:0009566   GO:0005737   GO:0048873   GO:0048808   GO:0007286   GO:0008584   GO:0016567   GO:0005515   GO:0007076   GO:0005524   GO:0006265   GO:0006259   GO:0004813   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

Subcellular location

Cytoplasm  

Length:

628

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.41963

Exp number, first 60 AAs:

0.00074

Total prob of N-in:

0.01492

outside

1  -  628

 

 

Pi

233.443947

Theta

186.532085

Tajima's D

0.534471

CLR

0.531301

CSRT

0.528223588820559

Interpretation

Uncertain