Pre Gene Modal
BGIBMGA011615
Annotation
DNA_topoisomerase_2_[Bombyx_mori]
Full name
DNA topoisomerase 2
Alternative Name
DNA topoisomerase II
Location in the cell
Nuclear Reliability : 4.241
Sequence
CDS
ATGGCTGATATAAAGTCAATGTTTAATAAAATGAGCAGCCCAAAGCAGAATGGCACTGGGGAGCCTGCACCCGCTAAAGGTCAGAAGGGTGCCATTGAAAAGATATACCAGAAGAAATCACAGCTAGAGCACATCCTCCTACGTCCTGACACCTATATTGGTTCAGTGGAAAGAGCCACCGAGACTATGTGGGTTTATGACAAGGTGAAGGAGTGTATGATGCAAAAAGAGTTGACTTTTGTGCCAGGTTTGTACAAAATTTATGACGAAATCTTGGTTAATGCGGCTGACAATAAGCAGAGAGACCCCAAAATGGATGTCATTAAAATTGACATAAATCAAGAAACAAACACAATATCCGTCTACAATAATGGTTGTGGTATCCCTGTAGTTATGCATAAAGATGAGAAGATGTATGTGCCGACTATGATCTTTGGGCATTTGTTGACTTCGTCCAATTATAATGATGAAGAGGAAAAAGTCACAGGTGGTAGGAATGGTTATGGTGCAAAACTCTGTAATATTTTCTCAACTAAATTCACAGTGGAAACTGCTTCAAAGCAGTACAAGAAACACTTTAAACAGACATGGGGTTCCAATATGACTAAGGCTTCTGAACCTAAGATTAAAGATTCTGGGAAAGACGATGACTTTACTAAAATAGTGTTTAGTCCAGATTTGGCTAAATTTAAAATGGAAAAATTAGAAGACGACATTGTGTTACTAATGTCAAGACGAGCATATGACGTAGCAGCCTCATCGCAAGGTGTAAAGGTTTATTTAAATGGTGAAAGACTAAAAATTAATAAATTTAAGGACTATGTAGATTTATACATTAAAGGAAAAGACGATGAAAATGGCCAACCATTGAAAGTTGTTTATGAGAAAGTGAGTGACCGCTGGGAGGTCGCTCTTACAATATCTGACATGGGATTCCAACAAGTTTCTTTTGTTAACTCTATTGCAACCACAAAAGGTGGTAAACATGTTGATACAGTAGCTGACAGTGTGGTCAAGAATGTTTTAGAAGTACTTAAAAAGAAGAATAAAGGTGGTGTTAATATTAAACCATACCAAGTTAAAACTCACATGTGGTTATTTGTCAACTGCCTGATTGTAAACCCTACCTTTGATTCACAAACTAAAGAGAACATGACACTCCAAGCTAAAAGCTTTGGGTCAAAATGTAATTTGTCTGAAAAGTTCATCACAGCAGTTACCAAATGTGGTTTGGTGGAATCTGTTCTGACTTGGGCGAAATTTAAGGCTCAAGATCAATTAGTTAAGGCATCTGGAAAGAAACAGAGTAAATTGAAGGGCATACCGAAATTGGAAGATGCTAATGATGCAGGCACAAAGAATGCACATCTCTGTACATTGATTTTGACTGAGGGAGACTCGGCTAAAACATTGGCTGTATCAGGACTCAGTGTTGTAGGTAGAGATCATTACGGAGTGTTTCCATTAAAGGGTAAACCTTTAAATGTGCGAGATGCGTCCCACAAGCAAGTTCTAGAAAATGTTGAAATCAATAATTTGATTAAAATTCTTGGATTACAGTACAAGAAAAAATATAACTCAGTTGATGATTTGAAAACATTACGTTATGGTAAAGTAATGATCATGGCTGATCAGGATCAAGATGGATCGCATATTAAAGGTCTGATTATCAATTTTATACATCATAATTGGCCTGAGCTATTGAAATTGCCATTTTTAGAAGAATTCATTACACCTATTGTCAAAGCTACAAAAAAAGACAAAGAAATATCTTTCTACTCTTTACCAGAGTTTGAAGAATGGAAAAAAGAAACAGAAAACCATCACACATATAATATAAAATACTACAAAGGTTTGGGTACCTCCACATCAAAGGAGGCTAAAGAATATTTCCAAAATATGGATAGGCACCGAATTCGATTCAAGTATAGTGGTCCAACTGATGATCACCATATTGAACTTGCATTTTCAAAGAAAGGTGCAGATCAACGTAAGGAATGGTTGACTAATCACATGGATGAAGTTAAGAGGAGAAAGGAAATAGGACTGTCAGAGAGATACCTGTACACAAAAGAGACGAAAACAGTGACTTATTCTGATTTCGTTAATTTGGAACTTGTACTATTCTCAAATGGTGACAATGTGAGATCAATTCCATCAATGATAGATGGCTTGAAGCCGGGTCAACGTAAAGTTATCTTCACTTGTATAAAACGTAATGACAAGCGTGAAGTGAAAGTGGCACAACTGGCTGGTTCCGTTGCAGAGCATTCGGCTTACCATCACGGTGAACAGTCCCTGGCAATGACCATAGTGAACCTGGCTCAGAACTACGTCGGTTCGAACAACATCAATCTGCTGGAGCCGCGCGGACAGTTCGGCACGCGGCTCAGCGGCGGCAAGGACTCGGCCAGCCCCCGATACATCTTCACTCTCATGTCCCCGCTCACAAGACTCATATTCCATCCGCACGACGACCCGCTGCTTGTCCATGAATTTGAGGACAACCAGAAGATAGAACCAGTTTACTATCTGCCCATTATCCCAATGGTGTTGGTGAACGGAGCTGAAGGTATTGGTACAGGCTGGTCCACTAAAATACCTAATTACAACCCCAGGGATATTGCTGAAAACTTACGGAGGTTGCTGGACGGCGAAGAGCCTAAAGTGATGCATCCGTGGTATAAGAACTTCAAGGGCAATGTGGAGGGCTTCGGCGATAAATACGTCATATCCGGTGAGGCGGCCATATTGCCTGGCGACAAAATCGAGATCACGGAGCTTCCGGTCGGGACGTGGACCCAGAATTACAAGGAAAATGTCCTCGAACCTATGCTTGGAACAGATAAAGTGAAACCATTAATATCTGAATACAGGGAATACAATACTGACACGACAGTTCGGTTTGTCGTGTCACTTTTACCTGGAAAGCTATCTGAAATAGAGGCTGAGGGCATACACAAGGTGTTCAAACTGCAAACTACCATATCTATGACATGTATGAACGCCTTCGACTATAACTGCTGCCTTAAAAAATACGACAAAGTAGAGGAAATCCTACGTGAGTTTTACGACCTGCGCGTTAAATACTACGTCCGTCGCAAGGATTACCTCGAGGGACAGTTGCAGGCCGAAGCAGACAAGCTGTCCAATCAGGCTCGGTTTATCCTAGAAAAGTGTGACAAAGGATTAGTCATCGAGAACAAGAAAAGAAAGGCTATGGTTGAAGAACTCATCAAGAGAGGCTACGCTCCCGACCCAATCGCGGACTGGAAGAAGCGAGCCAGCAAGATCCAAGGTCTCACCGCGTTAGAGGACGACGACGCTCAGGAATCTGAAGATGAGGAACCGGAACCTGATCCTAAAGGGAAACCCGTTGACCCTGATAAAGCATTCCAGCAATTGAAAGAAGTAAAGAAATTTAACTATCTGCTGGGAATGTCGATGTGGATGCTCACTAAAGAGAAGAAAGATGAACTCCTCAAGCAGAGAGACCAGAAATTGACTGAGCTGACCACATTGAAAAATAAAACGGCACCAATGCTGTGGCGGGAAGATCTAGACGCGTTTTTGATCAAATTAGACGAAGTTGAAGATAAGGAGCGACAGGAGGAACTCAATGTCAACAAGAAGACTTCTAAAGCGATGGCTGGTAAGAAGAATCGCAAGTCAATGTTTGATATTATCCCGTCCGAGAATGGTAGAAGAGTTGAGCCGAAGATATCTGATGACCTGATCAAGAGGATACAGGCCGCAGAGAAAGCTAAAACCAGGAAAGAGATTAAGAAGGAATATGATCCAGATGACCCTACAGGCATAAGCCCATCAAGCGGAGAGAAAAAACCTAAAGCTCGAGTAAAGAAAGAGAAGCCAGAGAAAGCTGAGAAACCTGATAAAGTTGACAAAGCTGAAAAAACAGATGGGCTTAAACAAACTAAACTTACTTTTAAAAAGGAACCTAAAAAGAAGAAGATGACGTTCAGCGGCAGCAGTTCAGGAGAAATGTCAGCATCTGATGCTGAGGTGGAAGTTCTAGTACCTCGGGAACGTACCAATGCGAGGAGAGCTGCCACTAAGGTACAGAAATACAAAGACGGTTCAGATGACTCTGGTTCTGATTCAGAACCAGAACTGTTGGATAACAAGATAGATTCGGACCATGAAGCGCCACAAACTCTCTCCATCAGTGATGAGGATGATGATTTCAACATCAAGAAGAATCCCGCAAAGAAACCAGCCGAGATGGATTCTGATTGCTTATTCGACTCTCTGATAGAAGATGCTAAAAAAGATGAACCACAAAAGACATTGACAAAATCTAAATCAGAGAGCAATCCTCATCCGACGAACTTAATATCGAGCGACAGCGACGCTGCGATACAAGCGTCACCGCCGAAGAAAAAAGCAGCTCCCAAACGTAAACTGATGAATGTCGATAAAGATGAGAAGAAGACCAAGAAGAGGCCGGCGCGGGTCATGCTCGACCAGGACTCCGACGACGAGGACAGCATATTTGACAGTAAAAAGGGTAAAAAGAAACTTGCTGCGAATCCCAAAAAGAAGGCTAAGAAGAAGGTGGAAAGTGATTCTGAATCTGACTTCAATATAAGCGACAGCTCATTGAGCGATTAG
Protein
MADIKSMFNKMSSPKQNGTGEPAPAKGQKGAIEKIYQKKSQLEHILLRPDTYIGSVERATETMWVYDKVKECMMQKELTFVPGLYKIYDEILVNAADNKQRDPKMDVIKIDINQETNTISVYNNGCGIPVVMHKDEKMYVPTMIFGHLLTSSNYNDEEEKVTGGRNGYGAKLCNIFSTKFTVETASKQYKKHFKQTWGSNMTKASEPKIKDSGKDDDFTKIVFSPDLAKFKMEKLEDDIVLLMSRRAYDVAASSQGVKVYLNGERLKINKFKDYVDLYIKGKDDENGQPLKVVYEKVSDRWEVALTISDMGFQQVSFVNSIATTKGGKHVDTVADSVVKNVLEVLKKKNKGGVNIKPYQVKTHMWLFVNCLIVNPTFDSQTKENMTLQAKSFGSKCNLSEKFITAVTKCGLVESVLTWAKFKAQDQLVKASGKKQSKLKGIPKLEDANDAGTKNAHLCTLILTEGDSAKTLAVSGLSVVGRDHYGVFPLKGKPLNVRDASHKQVLENVEINNLIKILGLQYKKKYNSVDDLKTLRYGKVMIMADQDQDGSHIKGLIINFIHHNWPELLKLPFLEEFITPIVKATKKDKEISFYSLPEFEEWKKETENHHTYNIKYYKGLGTSTSKEAKEYFQNMDRHRIRFKYSGPTDDHHIELAFSKKGADQRKEWLTNHMDEVKRRKEIGLSERYLYTKETKTVTYSDFVNLELVLFSNGDNVRSIPSMIDGLKPGQRKVIFTCIKRNDKREVKVAQLAGSVAEHSAYHHGEQSLAMTIVNLAQNYVGSNNINLLEPRGQFGTRLSGGKDSASPRYIFTLMSPLTRLIFHPHDDPLLVHEFEDNQKIEPVYYLPIIPMVLVNGAEGIGTGWSTKIPNYNPRDIAENLRRLLDGEEPKVMHPWYKNFKGNVEGFGDKYVISGEAAILPGDKIEITELPVGTWTQNYKENVLEPMLGTDKVKPLISEYREYNTDTTVRFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFILEKCDKGLVIENKKRKAMVEELIKRGYAPDPIADWKKRASKIQGLTALEDDDAQESEDEEPEPDPKGKPVDPDKAFQQLKEVKKFNYLLGMSMWMLTKEKKDELLKQRDQKLTELTTLKNKTAPMLWREDLDAFLIKLDEVEDKERQEELNVNKKTSKAMAGKKNRKSMFDIIPSENGRRVEPKISDDLIKRIQAAEKAKTRKEIKKEYDPDDPTGISPSSGEKKPKARVKKEKPEKAEKPDKVDKAEKTDGLKQTKLTFKKEPKKKKMTFSGSSSGEMSASDAEVEVLVPRERTNARRAATKVQKYKDGSDDSGSDSEPELLDNKIDSDHEAPQTLSISDEDDDFNIKKNPAKKPAEMDSDCLFDSLIEDAKKDEPQKTLTKSKSESNPHPTNLISSDSDAAIQASPPKKKAAPKRKLMNVDKDEKKTKKRPARVMLDQDSDDEDSIFDSKKGKKKLAANPKKKAKKKVESDSESDFNISDSSLSD
Summary
Description
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:8978614). Topoisomerase II makes double-strand breaks (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:9545289). Essential during mitosis and meiosis for proper segregation of daughter chromosomes (PubMed:10751154, PubMed:14600258, PubMed:18752348, PubMed:25340780). During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I (PubMed:25340780). During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles (PubMed:18752348). May have a role in chromatin condensation and chromosome structure (PubMed:14600258, PubMed:18752348, PubMed:25340780). May be involved in X-chromosome dosage compensation, perhaps by modifying the topological state of compensated genes (PubMed:23989663). Regulates activity of the gypsy chromatin insulator complex by binding to mod(mdg4) and preventing its degradation (PubMed:21304601).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:8978614). Topoisomerase II makes double-strand breaks (PubMed:6308011, PubMed:2547764, PubMed:1328202, PubMed:8383533, PubMed:10786800, PubMed:9545289). Essential during mitosis and meiosis for proper segregation of daughter chromosomes (PubMed:10751154, PubMed:14600258, PubMed:18752348, PubMed:25340780). During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I (PubMed:25340780). During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles (PubMed:18752348). May have a role in chromatin condensation and chromosome structure (PubMed:14600258, PubMed:18752348, PubMed:25340780). May be involved in X-chromosome dosage compensation, perhaps by modifying the topological state of compensated genes (PubMed:23989663). Regulates activity of the gypsy chromatin insulator complex by binding to mod(mdg4) and preventing its degradation (PubMed:21304601).
Catalytic Activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Biophysicochemical Properties
200 uM for negatively supercoiled double-stranded plasmid DNA (at 30 degrees Celsius)
140 uM for negatively supercoiled double-stranded viral DNA (at 30 degrees Celsius)
270 uM for positively supercoiled double-stranded linear DNA
280 uM for ATP (at 30 degrees Celsius)
630 uM for dATP (at 30 degrees Celsius)
140 uM for negatively supercoiled double-stranded viral DNA (at 30 degrees Celsius)
270 uM for positively supercoiled double-stranded linear DNA
280 uM for ATP (at 30 degrees Celsius)
630 uM for dATP (at 30 degrees Celsius)
Subunit
Homodimer.
Homodimer (By similarity). Interacts with mod(mdg4) (PubMed:21304601). Interacts with barr (PubMed:8978614, PubMed:11172718). Interacts with ph-p (PubMed:11172718). Interacts with mle; the interaction mediates association with the MSL dosage compensation complex (PubMed:23989663).
Homodimer (By similarity). Interacts with mod(mdg4) (PubMed:21304601). Interacts with barr (PubMed:8978614, PubMed:11172718). Interacts with ph-p (PubMed:11172718). Interacts with mle; the interaction mediates association with the MSL dosage compensation complex (PubMed:23989663).
Miscellaneous
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
Similarity
Belongs to the type II topoisomerase family.
Keywords
ATP-binding
Complete proteome
DNA-binding
Isomerase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Topoisomerase
Chromosome
Cytoplasm
Phosphoprotein
Feature
chain DNA topoisomerase 2
Uniprot
H9JQ10
O16140
A0A3S2P0C6
A0A194PUX2
A0A2H1VFE3
A0A0N1I8J4
+ More
A0A212FJM3 A0A2A4KA73 A0A2W1BYX4 D6WF48 A0A1S4G770 A0A023EXD7 Q0IEA2 A0A336MND2 B0WRP3 A0A1Q3EZQ4 A0A1Q3EZR8 A0A182MCQ8 W5JM53 A0A182K2H0 A0A182MZ68 A0A182RIR3 A0A182QAL6 A0A182F1D1 W4VRX5 A0A182VUE5 A0A182I7B6 A0A182UQR4 A0A182XNQ8 A0A2M4ABL1 A0A182U6T6 A0A084W7E2 A0A2M4ABJ4 A0A182IK02 A0A1S4GZL9 A0A0L0CDH2 A0A1W4WLN8 Q7PWM2 A0A336LDC4 A0A1I8M4W3 T1P9C9 A0A182PWC0 A0A195C4U4 A0A220T3U3 A0A1B6FFK1 A0A182Y0C2 A0A3B0KBF1 A0A3B0KK10 A0A1J1I6T6 K7INH7 A0A0M4E904 A0A232FEP6 F4WEK4 B4I5V4 A0A195AVH6 A0A0J9R4V1 A0A151WHT0 N6T8X6 A0A1A9WKD3 A0A158NF34 A0A1L8DWX6 A0A195E948 E2AE09 B4M8I9 A0A1A9UPN0 Q29K53 B4GWX0 A0A0R3P1N4 A0A195FNB3 A0A1A9Y564 A0A1B0C1G3 B4KIH0 A0A2H8TT26 A0A026WD57 A0A1I8P1U0 A0A2J7QSS2 B4JCU9 E9J360 E2BA67 P15348 B3MN65 A0A154PL90 A0A1B0GA76 A0A0C9RGK5 A0A2S2PQA0 A0A2S2NZR7 A0A1A9ZP13 A0A0J7KV50 A0A1W4V2W4 B4N154 B3NM53 A0A023F4H3 A0A0V0G4L5 A0A0M8ZX95 A0A069DY35 A0A2S2Q8Z8 B4PAY8 A0A224X533 J9K4Y7 A0A146M5H1
A0A212FJM3 A0A2A4KA73 A0A2W1BYX4 D6WF48 A0A1S4G770 A0A023EXD7 Q0IEA2 A0A336MND2 B0WRP3 A0A1Q3EZQ4 A0A1Q3EZR8 A0A182MCQ8 W5JM53 A0A182K2H0 A0A182MZ68 A0A182RIR3 A0A182QAL6 A0A182F1D1 W4VRX5 A0A182VUE5 A0A182I7B6 A0A182UQR4 A0A182XNQ8 A0A2M4ABL1 A0A182U6T6 A0A084W7E2 A0A2M4ABJ4 A0A182IK02 A0A1S4GZL9 A0A0L0CDH2 A0A1W4WLN8 Q7PWM2 A0A336LDC4 A0A1I8M4W3 T1P9C9 A0A182PWC0 A0A195C4U4 A0A220T3U3 A0A1B6FFK1 A0A182Y0C2 A0A3B0KBF1 A0A3B0KK10 A0A1J1I6T6 K7INH7 A0A0M4E904 A0A232FEP6 F4WEK4 B4I5V4 A0A195AVH6 A0A0J9R4V1 A0A151WHT0 N6T8X6 A0A1A9WKD3 A0A158NF34 A0A1L8DWX6 A0A195E948 E2AE09 B4M8I9 A0A1A9UPN0 Q29K53 B4GWX0 A0A0R3P1N4 A0A195FNB3 A0A1A9Y564 A0A1B0C1G3 B4KIH0 A0A2H8TT26 A0A026WD57 A0A1I8P1U0 A0A2J7QSS2 B4JCU9 E9J360 E2BA67 P15348 B3MN65 A0A154PL90 A0A1B0GA76 A0A0C9RGK5 A0A2S2PQA0 A0A2S2NZR7 A0A1A9ZP13 A0A0J7KV50 A0A1W4V2W4 B4N154 B3NM53 A0A023F4H3 A0A0V0G4L5 A0A0M8ZX95 A0A069DY35 A0A2S2Q8Z8 B4PAY8 A0A224X533 J9K4Y7 A0A146M5H1
EC Number
5.6.2.3
Pubmed
19121390
26354079
22118469
28756777
18362917
19820115
+ More
24945155 26483478 17510324 20920257 23761445 24438588 12364791 26108605 25315136 28367986 25244985 20075255 28648823 21719571 17994087 22936249 23537049 21347285 20798317 18057021 15632085 24508170 21282665 2538621 10731132 12537572 6308011 2547764 1328202 8383533 8978614 9545289 10885744 10751154 10786800 11172718 14600258 18327897 18752348 21304601 23989663 25340780 25474469 26334808 17550304 26823975
24945155 26483478 17510324 20920257 23761445 24438588 12364791 26108605 25315136 28367986 25244985 20075255 28648823 21719571 17994087 22936249 23537049 21347285 20798317 18057021 15632085 24508170 21282665 2538621 10731132 12537572 6308011 2547764 1328202 8383533 8978614 9545289 10885744 10751154 10786800 11172718 14600258 18327897 18752348 21304601 23989663 25340780 25474469 26334808 17550304 26823975
EMBL
BABH01012345
BABH01012346
AF013277
RSAL01000010
RVE53729.1
KQ459590
+ More
KPI97206.1 ODYU01002280 SOQ39549.1 KQ460391 KPJ15409.1 AGBW02008251 OWR53943.1 NWSH01000006 PCG80979.1 KZ149896 PZC78774.1 KQ971327 EFA01344.2 JXUM01070453 JXUM01070454 JXUM01070455 JXUM01070456 GAPW01000012 KQ562607 JAC13586.1 KXJ75497.1 CH477899 EAT35234.1 UFQT01001257 SSX29717.1 DS232058 EDS33447.1 GFDL01014262 JAV20783.1 GFDL01014317 JAV20728.1 AXCM01003842 ADMH02000654 ETN65432.1 AXCN02002068 GANO01000357 JAB59514.1 APCN01003377 GGFK01004819 MBW38140.1 ATLV01021228 KE525315 KFB46136.1 GGFK01004840 MBW38161.1 AAAB01008984 JRES01000523 KNC30443.1 EAA14841.5 UFQS01003307 UFQT01003307 SSX15469.1 SSX34837.1 KA645386 AFP60015.1 KQ978287 KYM95625.1 KY211688 ASK50299.1 GECZ01020865 GECZ01019696 JAS48904.1 JAS50073.1 OUUW01000010 SPP85480.1 SPP85481.1 CVRI01000043 CRK96023.1 CP012523 ALC39502.1 NNAY01000334 OXU29132.1 GL888103 EGI67367.1 CH480822 EDW55760.1 KQ976736 KYM76030.1 CM002910 KMY91016.1 KQ983106 KYQ47393.1 APGK01039221 KB740969 KB632165 ENN76679.1 ERL89297.1 ADTU01013726 ADTU01013727 GFDF01003200 JAV10884.1 KQ979479 KYN21352.1 GL438827 EFN68242.1 CH940654 EDW57515.1 KRF77804.1 CH379061 EAL33325.3 CH479195 EDW27297.1 KRT04902.1 KQ981490 KYN41379.1 JXJN01024045 CH933807 EDW13467.1 KRG03775.1 GFXV01005589 MBW17394.1 KK107295 EZA52979.1 NEVH01011228 PNF31624.1 CH916368 EDW03188.1 GL768057 EFZ12747.1 GL446678 EFN87409.1 AE014134 X61209 BT010240 BT150455 AAQ23558.1 CH902620 EDV32043.1 KQ434959 KZC12629.1 CCAG010019840 GBYB01007500 JAG77267.1 GGMR01018928 MBY31547.1 GGMR01010066 MBY22685.1 LBMM01002923 KMQ94173.1 CH963920 EDW78045.1 CH954179 EDV54653.1 GBBI01002640 JAC16072.1 GECL01003135 JAP02989.1 KQ435840 KOX71459.1 GBGD01000089 JAC88800.1 GGMS01005003 MBY74206.1 CM000158 EDW90417.1 GFTR01008819 JAW07607.1 ABLF02038748 ABLF02038754 ABLF02038760 ABLF02038761 GDHC01003611 JAQ15018.1
KPI97206.1 ODYU01002280 SOQ39549.1 KQ460391 KPJ15409.1 AGBW02008251 OWR53943.1 NWSH01000006 PCG80979.1 KZ149896 PZC78774.1 KQ971327 EFA01344.2 JXUM01070453 JXUM01070454 JXUM01070455 JXUM01070456 GAPW01000012 KQ562607 JAC13586.1 KXJ75497.1 CH477899 EAT35234.1 UFQT01001257 SSX29717.1 DS232058 EDS33447.1 GFDL01014262 JAV20783.1 GFDL01014317 JAV20728.1 AXCM01003842 ADMH02000654 ETN65432.1 AXCN02002068 GANO01000357 JAB59514.1 APCN01003377 GGFK01004819 MBW38140.1 ATLV01021228 KE525315 KFB46136.1 GGFK01004840 MBW38161.1 AAAB01008984 JRES01000523 KNC30443.1 EAA14841.5 UFQS01003307 UFQT01003307 SSX15469.1 SSX34837.1 KA645386 AFP60015.1 KQ978287 KYM95625.1 KY211688 ASK50299.1 GECZ01020865 GECZ01019696 JAS48904.1 JAS50073.1 OUUW01000010 SPP85480.1 SPP85481.1 CVRI01000043 CRK96023.1 CP012523 ALC39502.1 NNAY01000334 OXU29132.1 GL888103 EGI67367.1 CH480822 EDW55760.1 KQ976736 KYM76030.1 CM002910 KMY91016.1 KQ983106 KYQ47393.1 APGK01039221 KB740969 KB632165 ENN76679.1 ERL89297.1 ADTU01013726 ADTU01013727 GFDF01003200 JAV10884.1 KQ979479 KYN21352.1 GL438827 EFN68242.1 CH940654 EDW57515.1 KRF77804.1 CH379061 EAL33325.3 CH479195 EDW27297.1 KRT04902.1 KQ981490 KYN41379.1 JXJN01024045 CH933807 EDW13467.1 KRG03775.1 GFXV01005589 MBW17394.1 KK107295 EZA52979.1 NEVH01011228 PNF31624.1 CH916368 EDW03188.1 GL768057 EFZ12747.1 GL446678 EFN87409.1 AE014134 X61209 BT010240 BT150455 AAQ23558.1 CH902620 EDV32043.1 KQ434959 KZC12629.1 CCAG010019840 GBYB01007500 JAG77267.1 GGMR01018928 MBY31547.1 GGMR01010066 MBY22685.1 LBMM01002923 KMQ94173.1 CH963920 EDW78045.1 CH954179 EDV54653.1 GBBI01002640 JAC16072.1 GECL01003135 JAP02989.1 KQ435840 KOX71459.1 GBGD01000089 JAC88800.1 GGMS01005003 MBY74206.1 CM000158 EDW90417.1 GFTR01008819 JAW07607.1 ABLF02038748 ABLF02038754 ABLF02038760 ABLF02038761 GDHC01003611 JAQ15018.1
Proteomes
UP000005204
UP000283053
UP000053268
UP000053240
UP000007151
UP000218220
+ More
UP000007266 UP000069940 UP000249989 UP000008820 UP000002320 UP000075883 UP000000673 UP000075881 UP000075884 UP000075900 UP000075886 UP000069272 UP000075920 UP000075840 UP000075903 UP000076407 UP000075902 UP000030765 UP000075880 UP000037069 UP000192223 UP000007062 UP000095301 UP000075885 UP000078542 UP000076408 UP000268350 UP000183832 UP000002358 UP000092553 UP000215335 UP000007755 UP000001292 UP000078540 UP000075809 UP000019118 UP000030742 UP000091820 UP000005205 UP000078492 UP000000311 UP000008792 UP000078200 UP000001819 UP000008744 UP000078541 UP000092443 UP000092460 UP000009192 UP000053097 UP000095300 UP000235965 UP000001070 UP000008237 UP000000803 UP000007801 UP000076502 UP000092444 UP000092445 UP000036403 UP000192221 UP000007798 UP000008711 UP000053105 UP000002282 UP000007819
UP000007266 UP000069940 UP000249989 UP000008820 UP000002320 UP000075883 UP000000673 UP000075881 UP000075884 UP000075900 UP000075886 UP000069272 UP000075920 UP000075840 UP000075903 UP000076407 UP000075902 UP000030765 UP000075880 UP000037069 UP000192223 UP000007062 UP000095301 UP000075885 UP000078542 UP000076408 UP000268350 UP000183832 UP000002358 UP000092553 UP000215335 UP000007755 UP000001292 UP000078540 UP000075809 UP000019118 UP000030742 UP000091820 UP000005205 UP000078492 UP000000311 UP000008792 UP000078200 UP000001819 UP000008744 UP000078541 UP000092443 UP000092460 UP000009192 UP000053097 UP000095300 UP000235965 UP000001070 UP000008237 UP000000803 UP000007801 UP000076502 UP000092444 UP000092445 UP000036403 UP000192221 UP000007798 UP000008711 UP000053105 UP000002282 UP000007819
Pfam
Interpro
IPR013759
Topo_IIA_B_C
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IPR013758 Topo_IIA_A/C_ab
IPR018522 TopoIIA_CS
IPR034157 TOPRIM_TopoII
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR006171 TOPRIM_domain
IPR013506 Topo_IIA_bsu_dom2
IPR002205 Topo_IIA_A/C
IPR001241 Topo_IIA
IPR031660 TOPRIM_C
IPR036890 HATPase_C_sf
IPR013760 Topo_IIA-like_dom_sf
IPR003594 HATPase_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR013757 Topo_IIA_A_a_sf
IPR012542 DTHCT
IPR013758 Topo_IIA_A/C_ab
IPR018522 TopoIIA_CS
IPR034157 TOPRIM_TopoII
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR006171 TOPRIM_domain
IPR013506 Topo_IIA_bsu_dom2
IPR002205 Topo_IIA_A/C
IPR001241 Topo_IIA
IPR031660 TOPRIM_C
IPR036890 HATPase_C_sf
IPR013760 Topo_IIA-like_dom_sf
IPR003594 HATPase_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR013757 Topo_IIA_A_a_sf
IPR012542 DTHCT
ProteinModelPortal
H9JQ10
O16140
A0A3S2P0C6
A0A194PUX2
A0A2H1VFE3
A0A0N1I8J4
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A0A212FJM3 A0A2A4KA73 A0A2W1BYX4 D6WF48 A0A1S4G770 A0A023EXD7 Q0IEA2 A0A336MND2 B0WRP3 A0A1Q3EZQ4 A0A1Q3EZR8 A0A182MCQ8 W5JM53 A0A182K2H0 A0A182MZ68 A0A182RIR3 A0A182QAL6 A0A182F1D1 W4VRX5 A0A182VUE5 A0A182I7B6 A0A182UQR4 A0A182XNQ8 A0A2M4ABL1 A0A182U6T6 A0A084W7E2 A0A2M4ABJ4 A0A182IK02 A0A1S4GZL9 A0A0L0CDH2 A0A1W4WLN8 Q7PWM2 A0A336LDC4 A0A1I8M4W3 T1P9C9 A0A182PWC0 A0A195C4U4 A0A220T3U3 A0A1B6FFK1 A0A182Y0C2 A0A3B0KBF1 A0A3B0KK10 A0A1J1I6T6 K7INH7 A0A0M4E904 A0A232FEP6 F4WEK4 B4I5V4 A0A195AVH6 A0A0J9R4V1 A0A151WHT0 N6T8X6 A0A1A9WKD3 A0A158NF34 A0A1L8DWX6 A0A195E948 E2AE09 B4M8I9 A0A1A9UPN0 Q29K53 B4GWX0 A0A0R3P1N4 A0A195FNB3 A0A1A9Y564 A0A1B0C1G3 B4KIH0 A0A2H8TT26 A0A026WD57 A0A1I8P1U0 A0A2J7QSS2 B4JCU9 E9J360 E2BA67 P15348 B3MN65 A0A154PL90 A0A1B0GA76 A0A0C9RGK5 A0A2S2PQA0 A0A2S2NZR7 A0A1A9ZP13 A0A0J7KV50 A0A1W4V2W4 B4N154 B3NM53 A0A023F4H3 A0A0V0G4L5 A0A0M8ZX95 A0A069DY35 A0A2S2Q8Z8 B4PAY8 A0A224X533 J9K4Y7 A0A146M5H1
A0A212FJM3 A0A2A4KA73 A0A2W1BYX4 D6WF48 A0A1S4G770 A0A023EXD7 Q0IEA2 A0A336MND2 B0WRP3 A0A1Q3EZQ4 A0A1Q3EZR8 A0A182MCQ8 W5JM53 A0A182K2H0 A0A182MZ68 A0A182RIR3 A0A182QAL6 A0A182F1D1 W4VRX5 A0A182VUE5 A0A182I7B6 A0A182UQR4 A0A182XNQ8 A0A2M4ABL1 A0A182U6T6 A0A084W7E2 A0A2M4ABJ4 A0A182IK02 A0A1S4GZL9 A0A0L0CDH2 A0A1W4WLN8 Q7PWM2 A0A336LDC4 A0A1I8M4W3 T1P9C9 A0A182PWC0 A0A195C4U4 A0A220T3U3 A0A1B6FFK1 A0A182Y0C2 A0A3B0KBF1 A0A3B0KK10 A0A1J1I6T6 K7INH7 A0A0M4E904 A0A232FEP6 F4WEK4 B4I5V4 A0A195AVH6 A0A0J9R4V1 A0A151WHT0 N6T8X6 A0A1A9WKD3 A0A158NF34 A0A1L8DWX6 A0A195E948 E2AE09 B4M8I9 A0A1A9UPN0 Q29K53 B4GWX0 A0A0R3P1N4 A0A195FNB3 A0A1A9Y564 A0A1B0C1G3 B4KIH0 A0A2H8TT26 A0A026WD57 A0A1I8P1U0 A0A2J7QSS2 B4JCU9 E9J360 E2BA67 P15348 B3MN65 A0A154PL90 A0A1B0GA76 A0A0C9RGK5 A0A2S2PQA0 A0A2S2NZR7 A0A1A9ZP13 A0A0J7KV50 A0A1W4V2W4 B4N154 B3NM53 A0A023F4H3 A0A0V0G4L5 A0A0M8ZX95 A0A069DY35 A0A2S2Q8Z8 B4PAY8 A0A224X533 J9K4Y7 A0A146M5H1
PDB
4GFH
E-value=0,
Score=2636
Ontologies
GO
GO:0005524
GO:0003677
GO:0006265
GO:0003918
GO:0005634
GO:0046872
GO:0003916
GO:0044774
GO:0000819
GO:0000712
GO:0003682
GO:0000400
GO:0003696
GO:0000182
GO:0051310
GO:0003729
GO:0000793
GO:0008623
GO:0007076
GO:0006342
GO:0007060
GO:0000278
GO:0000070
GO:0030261
GO:0051321
GO:0005737
GO:0005694
GO:0006259
GO:0004813
GO:0006419
GO:0015923
GO:0006260
Topology
Subcellular location
Nucleus
Chromosome Nuclear at interphase, becoming diffusely dispersed in the cytoplasm at later cell cycle stages (PubMed:10885744, PubMed:10751154). However in early developing embryos, some may remain associated with condensed chromosomes at metaphase (PubMed:10885744). With evidence from 5 publications.
Cytoplasm Nuclear at interphase, becoming diffusely dispersed in the cytoplasm at later cell cycle stages (PubMed:10885744, PubMed:10751154). However in early developing embryos, some may remain associated with condensed chromosomes at metaphase (PubMed:10885744). With evidence from 5 publications.
Chromosome Nuclear at interphase, becoming diffusely dispersed in the cytoplasm at later cell cycle stages (PubMed:10885744, PubMed:10751154). However in early developing embryos, some may remain associated with condensed chromosomes at metaphase (PubMed:10885744). With evidence from 5 publications.
Cytoplasm Nuclear at interphase, becoming diffusely dispersed in the cytoplasm at later cell cycle stages (PubMed:10885744, PubMed:10751154). However in early developing embryos, some may remain associated with condensed chromosomes at metaphase (PubMed:10885744). With evidence from 5 publications.
Length:
1543
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00239
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00012
outside
1 - 1543
Population Genetic Test Statistics
Pi
225.088571
Theta
183.894504
Tajima's D
0.922851
CLR
0.669824
CSRT
0.632668366581671
Interpretation
Uncertain
