Gene

KWMTBOMO06443

Pre Gene Modal

BGIBMGA011876

Annotation

PREDICTED:_elongation_of_very_long_chain_fatty_acids_protein_7-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):7152260-7154420      View in EpiBrowser

Full name

Elongation of very long chain fatty acids protein       + More
Elongation of very long chain fatty acids protein 7      

Alternative Name

Very-long-chain 3-oxoacyl-CoA synthase
3-keto acyl-CoA synthase ELOVL7
ELOVL fatty acid elongase 7
Very long chain 3-ketoacyl-CoA synthase 7
Very long chain 3-oxoacyl-CoA synthase 7

Location in the cell

PlasmaMembrane   Reliability : 2.838

CDS

ATGGAAAGAATAGATGTGCCATCGTTCTGGGAGTTCAAAGGAGCCGGTGATTATACGGATCAAAAACTATTGATGTCATCCCCATTTCCTGTTACCACGATTATAATCCTATACTTGTGGTTCGTTTTGAAATTCGGTCCGGAATTCATGAGGCAACGAAAACCCTACAATGTTGAAAAGCTTCTTGTTGTATACAACAATTTACAAGTTGCCGTCTCGTTTTACATCTTTTATTTGGAAAAATCGTAA

Protein

MERIDVPSFWEFKGAGDYTDQKLLMSSPFPVTTIIILYLWFVLKFGPEFMRQRKPYNVEKLLVVYNNLQVAVSFYIFYLEKS

Description

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Catalytic Activity

a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA

Similarity

Belongs to the ELO family.
Belongs to the ELO family. ELOVL7 subfamily.

Uniprot

H9JQS0   A0A0L7LJB9   A0A2H1VQJ9   A0A2H1WH44   A0A1E1WBM7   A0A0K8VDZ8   + More
A0A0K8VS01   A0A0A1XAS6   A0A1A9XJ22   A0A1B0BXZ2   A0A034W2T7   W8AWR6   A0A1B0BXZ1   A0A1A9XJ24   A0A034WG82   A0A0K8VXE8   A0A1A9V757   A0A1A9Z493   A0A1A9V750   A0A1A9Z486   A0A182VTN0   A0A1B0FQK1   A0A1B0FQL7   A0A194PYL9   A0A0M4F374   A0A2R7WMF5   A0A1A9W5Z6   A0A182RA82   A0A182M983   A0A1B6CDH2   T1PEI5   Q17HH4   A0A182T880   A0A182X629   A0A182VEV3   A0A182TLQ9   A0A182LJX9   Q7PPN4   A0A182PW57   A0A3B0JEF4   A0A182F0V7   A0A182IB52   A0A182K6I1   A0A182Y8I0   A0A084VMS9   A0A182QAU9   A0A212EWH4   A0A023EP01   Q29BK4   W5J4Z1   A0A182ISK0   B4GP37   B4NJS5   A0A182NB63   A0A1Q3G529   A0A0A1XAY8   A0A1B0D2D9   A0A0L0C049   W8BNS1   A0A3P8ZCE6   A0A0L7RD74   A0A1I8NVN9   A0A1W4WV09   A0A1A9W5Z8   A0A1W4WV14   A0A2A3EJY7   E9ICJ1   A0A3B0JJ32   A0A0L0CGV6   A0A2D0R3G6   B4M165   E3TCK8   J9JX82   A0A1I8M3I9   A0A146M9A3   B4K958   B4GP38   Q29BK5   A0A067R7E0   A0A3P8XC63   A0A1A8H4U3   A0A087ZPK7   B3M000   A0A2J7QVP9   A0A1E1W7T1  

EC Number

2.3.1.199

Pubmed

19121390    26227816    25830018    25348373    24495485    26354079    + More
25315136    17510324    20966253    12364791    14747013    17210077    25244985    24438588    22118469    24945155    26483478    15632085    17994087    23185243    20920257    23761445    26108605    25069045    21282665    20634964    26823975    18057021    24845553   

EMBL

BABH01012389    JTDY01000960    KOB75281.1    ODYU01003837    SOQ43090.1    ODYU01008314    + More
SOQ51794.1    GDQN01006662    JAT84392.1    GDHF01015574    JAI36740.1    GDHF01010979    JAI41335.1    GBXI01008419    GBXI01006261    JAD05873.1    JAD08031.1    JXJN01022417    GAKP01010864    JAC48088.1    GAMC01021294    GAMC01021292    JAB85261.1    JXJN01022416    GAKP01004356    JAC54596.1    GDHF01008780    JAI43534.1    CCAG010007298    CCAG010007299    KQ459586    KPI98123.1    CP012526    ALC45632.1    KK854897    PTY19585.1    AXCM01003970    GEDC01025805    JAS11493.1    KA647151    AFP61780.1    CH477248    EAT46133.1    AAAB01008944    EAA10106.4    OUUW01000005    SPP80764.1    APCN01000639    ATLV01014624    KE524975    KFB39273.1    AXCN02000640    AGBW02011990    OWR45833.1    JXUM01010789    JXUM01010790    JXUM01010791    JXUM01069333    JXUM01069334    JXUM01069335    GAPW01002918    KQ562547    KQ560317    JAC10680.1    KXJ75646.1    KXJ83082.1    CM000070    EAL26992.1    ADMH02002132    ETN58473.1    CH479186    EDW38920.1    CH964272    EDW85037.1    GFDL01000135    JAV34910.1    GBXI01006392    JAD07900.1    AJVK01022764    JRES01001095    KNC25616.1    GAMC01003780    JAC02776.1    KQ414614    KOC68917.1    KZ288222    PBC32085.1    GL762294    EFZ21714.1    SPP80763.1    JRES01000413    KNC31471.1    CH940650    EDW67476.1    GU588088    ADO28044.1    ABLF02039128    GDHC01009670    GDHC01002997    JAQ08959.1    JAQ15632.1    CH933806    EDW14471.1    KRG01025.1    EDW38921.1    EAL26993.1    KK852652    KDR19404.1    HAEC01010038    SBQ78254.1    CH902617    EDV44190.1    KPU80676.1    NEVH01009772    PNF32665.1    GDQN01007992    GDQN01000519    JAT83062.1    JAT90535.1   

Proteomes

UP000005204    UP000037510    UP000092443    UP000092460    UP000078200    UP000092445    + More
UP000075920    UP000092444    UP000053268    UP000092553    UP000091820    UP000075900    UP000075883    UP000095301    UP000008820    UP000075901    UP000076407    UP000075903    UP000075902    UP000075882    UP000007062    UP000075885    UP000268350    UP000069272    UP000075840    UP000075881    UP000076408    UP000030765    UP000075886    UP000007151    UP000069940    UP000249989    UP000001819    UP000000673    UP000075880    UP000008744    UP000007798    UP000075884    UP000092462    UP000037069    UP000265140    UP000053825    UP000095300    UP000192223    UP000242457    UP000221080    UP000008792    UP000007819    UP000009192    UP000027135    UP000005203    UP000007801    UP000235965   

PRIDE

H9JQS0   

Pfam

PF01151   ELO

Interpro

IPR002076   ELO_fam        + More
IPR030457   ELO_CS       
IPR033670   ELOVL7       

ProteinModelPortal

H9JQS0   A0A0L7LJB9   A0A2H1VQJ9   A0A2H1WH44   A0A1E1WBM7   A0A0K8VDZ8   + More
A0A0K8VS01   A0A0A1XAS6   A0A1A9XJ22   A0A1B0BXZ2   A0A034W2T7   W8AWR6   A0A1B0BXZ1   A0A1A9XJ24   A0A034WG82   A0A0K8VXE8   A0A1A9V757   A0A1A9Z493   A0A1A9V750   A0A1A9Z486   A0A182VTN0   A0A1B0FQK1   A0A1B0FQL7   A0A194PYL9   A0A0M4F374   A0A2R7WMF5   A0A1A9W5Z6   A0A182RA82   A0A182M983   A0A1B6CDH2   T1PEI5   Q17HH4   A0A182T880   A0A182X629   A0A182VEV3   A0A182TLQ9   A0A182LJX9   Q7PPN4   A0A182PW57   A0A3B0JEF4   A0A182F0V7   A0A182IB52   A0A182K6I1   A0A182Y8I0   A0A084VMS9   A0A182QAU9   A0A212EWH4   A0A023EP01   Q29BK4   W5J4Z1   A0A182ISK0   B4GP37   B4NJS5   A0A182NB63   A0A1Q3G529   A0A0A1XAY8   A0A1B0D2D9   A0A0L0C049   W8BNS1   A0A3P8ZCE6   A0A0L7RD74   A0A1I8NVN9   A0A1W4WV09   A0A1A9W5Z8   A0A1W4WV14   A0A2A3EJY7   E9ICJ1   A0A3B0JJ32   A0A0L0CGV6   A0A2D0R3G6   B4M165   E3TCK8   J9JX82   A0A1I8M3I9   A0A146M9A3   B4K958   B4GP38   Q29BK5   A0A067R7E0   A0A3P8XC63   A0A1A8H4U3   A0A087ZPK7   B3M000   A0A2J7QVP9   A0A1E1W7T1  

KEGG

101743752    no KO assigned | (RefSeq) elongation of very long chain fatty acids protein 7-like

GO

GO:0102337   GO:0102756   GO:0102336   GO:0006633   GO:0016021   GO:0102338   GO:0009922   GO:0034626   GO:0019367   GO:0030148   GO:0042761   GO:0034625   GO:0030176   GO:0030497   GO:0007110   GO:0051225   GO:0007111   GO:0000915   GO:0007112   GO:0000212   GO:0042811   GO:0005789   GO:0035338   GO:0006636   GO:0006694   GO:0042632   GO:0035209   GO:0005783   GO:0022857   GO:0006508   GO:0005524   GO:0003676   GO:0004813   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11157   PTHR11157:SF118  

Subcellular location

Endoplasmic reticulum membrane  

Length:

82

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

37.35958

Exp number, first 60 AAs:

20.73387

Total prob of N-in:

0.05161

POSSIBLE N-term signal

sequence

outside

1  -  22

TMhelix

23  -  42

inside

43  -  61

TMhelix

62  -  79

outside

80  -  82

 

 

Pi

280.783957

Theta

221.896329

Tajima's D

0.961771

CLR

0

CSRT

0.647467626618669

Interpretation

Uncertain