Gene

KWMTBOMO06438  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011879

Annotation

PREDICTED:_organic_cation_transporter_protein-like_[Bombyx_mori]

Location

Bomo_Chr11(-):7100622-7107750      View in EpiBrowser

Full name

Beta-alanine transporter      

Location in the cell

PlasmaMembrane   Reliability : 4.862

CDS

ATGAAGATGGATTTCGACGCCATCTTAGAGGACGTTGGACCCTTTGGTACTTATCAGAAATTAGTGATCTATCTAGTACTACTGCCTGCCGTGATTCCTTGCGGCTTCCACGCTTACGCACAGCTCTTCATGGCCGCCGATGTCAAGCATTGGTGTAGAGTGCCCGAGCTCGAACACGTAGCTGATCAGGACCTGGTCAAGAATTTAAGTATACCACTGGAGCTGAAGAATGGCGTATTACAGTATTCATCATGCACGATGTACAATTTAAACTATAGCGAAATCGTGAAGAGCTACCAGAACTTGGTTGATGCTGCGGCCAATAAGGCACCCGCAGACATCATCCCTTGTACTCAAGGATGGATTTACGATAAAAGCATTTATAAGAGCACTATCGTTACTGAGTGGAATCTGGTCTGCAATAAAGATTTCTACTCGACTCTTGGACTGGTGCTACTGGCTGCTGGTGGTATAATCGGCAATTACATATTCGGCTACCTCCAGGATTCCCTTGGGAGGAAACCATCGTTTTTCATCTACCTCCTTATTGAGTGCATCTTTGGGATAGCTACGGCTTTTGCACAAAACTACATAATATGGATTATTTATAGAATTGGAGTCGGGTTTACGGTTCCTGCCATCATGACTACTCCTTACGTTCTTGCAATTGAGTTGGTTGGACCCCGCTATCGCACACTCTGCACTATTATTTCGAATATTGCGTACTCCATGGGTCTAATCCTGCTTGCTGGTGTCGTTTATTTGGTCCGCGATTGGCGGCCCTTGGCTTTAGCAACGACCCTGCCGTTCCTTTGTTTCTTCTTGTATTTATGGCCGATGCCGGAAAGCCCAAGATGGCTACTTGCTAGGGGACAGTTCGACAAAGCGGAGGCTATATTAAAAACGATGGCCAGGATCAACGGTAAATCTCTGCCAGCCAATTATATGGTACACCTGCACCGAAAATACGAAACCGACAAACAGCACCATGAAGTGAAAAAATTCAAGGCGCGGAAGTACGGCATCATGGACCTATTTCGAACACCGAATTTGAGGAAGAAAACTATCATCATCACGTTTATCTGGTTCACTAATACCAGCGTATACGTTGGGCTGTCGTATTACGCGCCCGTACTTGGAGGTGATGAGTTCTTGAACTTTTTCCTGGCCGGTGTAGTGGAGCTGCCGACGTATCTGTTTCTGTGGCCTTCGATGGAGAGACTCGGGAGACGATGGACTCTGTGCATGAGTATGGTGGTCGGCGGAGTGGCTTGTTTGACCACGTTTTTAGTGCAACATGAAGCGAACGTCACTCTCGCACTTTACTGCGTGGGAAAGATGGGCATTTCATCATCATTCGTGGTATTACCATTGATGGCTTCGGAGTTGTATCCCACAGTGGTCAGAGGTCTCGGTATGAGTCTCAGCTCAGTACTGGGCATGCTCGGACCTATATTCATACCGCTTGTGAATTACTTGGGCTCGGATATCATGGTTCTCCCATTAATTATAATGGGAGCGTTACTCGTAGCGGGAGGCATTGCCAGTTTACTCCTTCCCGAAACACTGAACCAGAATCTGCCGCAGACTTTGGAAGATGGAGAGAAAATGGGCTTGGATACGGACTTCTGCTGTCATCCACCAGTCAAAGAAACTGTAACACACGAGCTGGAACGAAAAAACATACCAACTTGTGGAGCTTGCAATGTTTTATGTTCTTGTGAAATGATTAATATTACTCTAGAAACTGGTGAAAAAGAACCGGAAAAAAACGATTTTGTTATTTTAACCCCAAAACATACTGAATAA

Protein

MKMDFDAILEDVGPFGTYQKLVIYLVLLPAVIPCGFHAYAQLFMAADVKHWCRVPELEHVADQDLVKNLSIPLELKNGVLQYSSCTMYNLNYSEIVKSYQNLVDAAANKAPADIIPCTQGWIYDKSIYKSTIVTEWNLVCNKDFYSTLGLVLLAAGGIIGNYIFGYLQDSLGRKPSFFIYLLIECIFGIATAFAQNYIIWIIYRIGVGFTVPAIMTTPYVLAIELVGPRYRTLCTIISNIAYSMGLILLAGVVYLVRDWRPLALATTLPFLCFFLYLWPMPESPRWLLARGQFDKAEAILKTMARINGKSLPANYMVHLHRKYETDKQHHEVKKFKARKYGIMDLFRTPNLRKKTIIITFIWFTNTSVYVGLSYYAPVLGGDEFLNFFLAGVVELPTYLFLWPSMERLGRRWTLCMSMVVGGVACLTTFLVQHEANVTLALYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSLSSVLGMLGPIFIPLVNYLGSDIMVLPLIIMGALLVAGGIASLLLPETLNQNLPQTLEDGEKMGLDTDFCCHPPVKETVTHELERKNIPTCGACNVLCSCEMINITLETGEKEPEKNDFVILTPKHTE

Description

Beta-alanine transporter required for the uptake of beta-alanine by the glia (PubMed:28806173). Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission (PubMed:28806173). Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine (PubMed:28806173).

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M3 family.
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Keywords

Amino-acid transport   Cell membrane   Complete proteome   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Beta-alanine transporter

Uniprot

H9JQS3   A0A2W1BWN9   A0A2A4JLH8   A0A2H1W3D2   A0A0L7LPS2   A0A3S2PEA1   + More
A0A0N0PBB1   A0A194PWP8   A0A212FK50   A0A1B6LIV0   A0A1B6C2J3   D6WE15   A0A1J1IIS3   A0A336K0U7   A0A0N7ZMT3   A0A0P5VWW3   A0A0P5AUM8   A0A0P5NI05   A0A0P5IDS9   A0A1W4VCA6   A0A0M4EUC5   A0A0P5B4K1   A0A0P5H9S2   A0A0P5U1J4   A0A0N8CVS6   A0A0P4YWI1   A0A164PL56   B4J8X8   A0A0P6ERI2   B4P4X7   B4HPX5   B4QDI2   Q961J5   B4KRH4   B3NRU2   A0A0P6I164   B4LQ65   A0A0P6I6N1   A0A034W1F8   A0A0N7ZLX6   B4GH32   A0A0P6BYB7   U4U9U7   A0A0K8VE01   E9GHV7   A0A3B0JPN7   B4MJR3   Q28XU8   B3MDB2   A0A1D2MWJ3   A0A1S4FT25   Q16QI7   A0A0N8P055   A0A0P4ZYW6   W8CCD8   A0A0L0CAC9   A0A0A1XIT8   A0A1I8P766   A0A1A9X3R8   A0A0P6E7U8   A0A0N8BN24   Q7Q734   A0A2C9GQQ3   A0A182K796   A0A182WQN2   A0A182NM26   A0A1B0GG75   A0A1B0A9G0   A0A1I8N4M8   A0A0K8UM19   A0A1B0BE72   W5JQ75   A0A1B0CUN0   A0A182QYC2   J9K5J8   A0A2H8TIJ1   A0A1A9XN89   A0A1A9USR1   A0A0P5WD28   E0VMK7   A0A182V7D7   A0A182LJG7   A0A0P5TVD5   A0A1I8P785   A0A0N8DG30   E9G0N5   A0A0P6ETD0   A0A182RN18   A0A0N8EHR9   A0A0P5VAX3   T1GL65   A0A182Y0Z9   A0A1I8N4M3   A0A182MH37   A0A0P6F4L3   E2A047  

Pubmed

19121390    28756777    26227816    26354079    22118469    18362917    + More
19820115    17994087    17550304    22936249    10731132    12537572    12537569    28806173    25348373    23537049    21292972    15632085    27289101    17510324    24495485    26108605    25830018    12364791    14747013    17210077    25315136    20920257    23761445    20566863    20966253    25244985    20798317   

EMBL

BABH01012391    BABH01012392    KZ149896    PZC78751.1    NWSH01001090    PCG72669.1    + More
ODYU01006045    SOQ47547.1    JTDY01000437    KOB77176.1    RSAL01000076    RVE48852.1    KQ460971    KPJ10128.1    KQ459590    KPI97184.1    AGBW02008141    OWR54123.1    GEBQ01016409    JAT23568.1    GEDC01029566    JAS07732.1    KQ971324    EFA01181.1    CVRI01000054    CRL00143.1    UFQS01000048    UFQT01000048    SSW98574.1    SSX18960.1    GDIP01230073    JAI93328.1    GDIP01094040    JAM09675.1    GDIP01193931    JAJ29471.1    GDIQ01164313    JAK87412.1    GDIQ01214842    GDIQ01062045    JAK36883.1    CP012524    ALC41275.1    GDIP01204613    JAJ18789.1    GDIQ01236129    JAK15596.1    GDIP01119091    JAL84623.1    GDIP01094039    JAM09676.1    GDIP01222036    JAJ01366.1    LRGB01002580    KZS06937.1    CH916367    EDW01327.1    GDIQ01059954    JAN34783.1    CM000158    EDW90698.1    CH480816    EDW47638.1    CM000362    CM002911    EDX06847.1    KMY93358.1    AE013599    AY051555    AAK92979.1    CH933808    EDW10400.1    CH954179    EDV56244.1    GDIQ01011005    JAN83732.1    CH940648    EDW61350.1    GDIQ01034727    JAN60010.1    GAKP01011339    JAC47613.1    GDIP01232529    JAI90872.1    CH479183    EDW35802.1    GDIP01007685    JAM96030.1    KB632256    ERL90709.1    GDHF01015569    JAI36745.1    GL732545    EFX80981.1    OUUW01000001    SPP75599.1    CH963846    EDW72352.1    CM000071    EAL26218.1    CH902619    EDV36360.1    LJIJ01000447    ODM97396.1    CH477747    EAT36653.1    KPU76180.1    GDIP01206622    JAJ16780.1    GAMC01003871    JAC02685.1    JRES01000780    KNC28389.1    GBXI01003371    JAD10921.1    GDIQ01068037    JAN26700.1    GDIQ01161667    JAK90058.1    AAAB01008960    EAA11213.4    APCN01004290    CCAG010007475    GDHF01024899    JAI27415.1    JXJN01012806    ADMH02000483    ETN66286.1    AJWK01029420    AXCN02002327    ABLF02014730    GFXV01002054    MBW13859.1    GDIP01087898    JAM15817.1    DS235315    EEB14614.1    GDIP01121145    JAL82569.1    GDIP01037207    JAM66508.1    GL732528    EFX87372.1    GDIP01069132    GDIQ01071591    LRGB01001581    JAM34583.1    JAN23146.1    KZS11223.1    GDIQ01025516    JAN69221.1    GDIP01102481    JAM01234.1    CAQQ02001330    AXCM01003247    GDIQ01052862    JAN41875.1    GL435551    EFN73180.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000283053    UP000053240    UP000053268    + More
UP000007151    UP000007266    UP000183832    UP000192221    UP000092553    UP000076858    UP000001070    UP000002282    UP000001292    UP000000304    UP000000803    UP000009192    UP000008711    UP000008792    UP000008744    UP000030742    UP000000305    UP000268350    UP000007798    UP000001819    UP000007801    UP000094527    UP000008820    UP000037069    UP000095300    UP000091820    UP000007062    UP000075840    UP000075881    UP000075920    UP000075884    UP000092444    UP000092445    UP000095301    UP000092460    UP000000673    UP000092461    UP000075886    UP000007819    UP000092443    UP000078200    UP000009046    UP000075903    UP000075882    UP000075900    UP000015102    UP000076408    UP000075883    UP000000311   

PRIDE

H9JQS3    Q961J5   

Pfam

PF00083   Sugar_tr        + More
PF01432   Peptidase_M3
PF03097   BRO1
PF13949   ALIX_LYPXL_bnd

Interpro

IPR001567   Pept_M3A_M3B        + More
IPR024077   Neurolysin/TOP_dom2       
IPR005828   MFS_sugar_transport-like       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR005829   Sugar_transporter_CS       
IPR038499   BRO1_sf       
IPR004328   BRO1_dom       
IPR025304   ALIX_V_dom       

SUPFAM

SSF103473   SSF103473       

Gene 3D

1.10.1370.10     1.25.40.280    

CDD

cd06174  MFS

ProteinModelPortal

H9JQS3   A0A2W1BWN9   A0A2A4JLH8   A0A2H1W3D2   A0A0L7LPS2   A0A3S2PEA1   + More
A0A0N0PBB1   A0A194PWP8   A0A212FK50   A0A1B6LIV0   A0A1B6C2J3   D6WE15   A0A1J1IIS3   A0A336K0U7   A0A0N7ZMT3   A0A0P5VWW3   A0A0P5AUM8   A0A0P5NI05   A0A0P5IDS9   A0A1W4VCA6   A0A0M4EUC5   A0A0P5B4K1   A0A0P5H9S2   A0A0P5U1J4   A0A0N8CVS6   A0A0P4YWI1   A0A164PL56   B4J8X8   A0A0P6ERI2   B4P4X7   B4HPX5   B4QDI2   Q961J5   B4KRH4   B3NRU2   A0A0P6I164   B4LQ65   A0A0P6I6N1   A0A034W1F8   A0A0N7ZLX6   B4GH32   A0A0P6BYB7   U4U9U7   A0A0K8VE01   E9GHV7   A0A3B0JPN7   B4MJR3   Q28XU8   B3MDB2   A0A1D2MWJ3   A0A1S4FT25   Q16QI7   A0A0N8P055   A0A0P4ZYW6   W8CCD8   A0A0L0CAC9   A0A0A1XIT8   A0A1I8P766   A0A1A9X3R8   A0A0P6E7U8   A0A0N8BN24   Q7Q734   A0A2C9GQQ3   A0A182K796   A0A182WQN2   A0A182NM26   A0A1B0GG75   A0A1B0A9G0   A0A1I8N4M8   A0A0K8UM19   A0A1B0BE72   W5JQ75   A0A1B0CUN0   A0A182QYC2   J9K5J8   A0A2H8TIJ1   A0A1A9XN89   A0A1A9USR1   A0A0P5WD28   E0VMK7   A0A182V7D7   A0A182LJG7   A0A0P5TVD5   A0A1I8P785   A0A0N8DG30   E9G0N5   A0A0P6ETD0   A0A182RN18   A0A0N8EHR9   A0A0P5VAX3   T1GL65   A0A182Y0Z9   A0A1I8N4M3   A0A182MH37   A0A0P6F4L3   E2A047  

PDB

6N3I     E-value=1.64907e-08,     Score=143

KEGG

101743901    K08202 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/

GO

GO:0016021   GO:0004222   GO:0046872   GO:0022857   GO:0001694   GO:0005887   GO:0001761   GO:0001762   GO:0006508   GO:0005524   GO:0003676   GO:0004813   GO:0006419   GO:0015923   GO:0005634   GO:0006260   GO:0055085  

Subcellular location

Cell membrane  

Length:

602

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

256.58966

Exp number, first 60 AAs:

21.94292

Total prob of N-in:

0.93429

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  143

TMhelix

144  -  166

inside

167  -  178

TMhelix

179  -  201

outside

202  -  204

TMhelix

205  -  227

inside

228  -  233

TMhelix

234  -  256

outside

257  -  260

TMhelix

261  -  278

inside

279  -  355

TMhelix

356  -  378

outside

379  -  382

TMhelix

383  -  405

inside

406  -  411

TMhelix

412  -  431

outside

432  -  435

TMhelix

436  -  458

inside

459  -  464

TMhelix

465  -  487

outside

488  -  496

TMhelix

497  -  519

inside

520  -  602

 

 

Pi

206.845573

Theta

180.642812

Tajima's D

0.688725

CLR

0.154482

CSRT

0.572721363931803

Interpretation

Uncertain