Gene

KWMTBOMO06421

Pre Gene Modal

BGIBMGA011951

Annotation

1-acylglycerophosphocholine_O-acyltransferase_1_[Papilio_machaon]

Location

Bomo_Chr11(-):6856416-6869470      View in EpiBrowser

Full name

Lysophosphatidylcholine acyltransferase      

Alternative Name

1-acylglycerophosphocholine O-acyltransferase
Acyltransferase-like 2

Location in the cell

PlasmaMembrane   Reliability : 4.731

CDS

ATGAATGGTAAACTGCATAGTGAAACCGGCGCTTTCTCATCTGACGACATGCGTGCCGAAATATTAAACCCTTTTGTCCATAAATTGGAATTGGACAACACATACGATAAGATAAAGACGGCAATTTTCACAGTCATTTTATTACCGTTTCGAGTGATAGTCATATGCTATCTGATCGTGACAGCATGGTTCCTAGCATGCATCGGCCTCTATGGACTCAGCGAGGAGGATTTGAGACGGAAGCCCATGACTGGATGGAGAAGCAAGCTTCGTTTCTCGATCCTCTCCCTCATGCGACTGGTGGTGGTAGCCGCCGGCTTCCACCGCGTCAGGATCTTGGGTCGCCAGCACCAGGCGGGCAGCTCCCGGGAGGCCCCGGTCGTGGTCATGGCCCCGCATTCCAGTTTCTTCGACGCGATCGCCATTGTCTGCCTCGGGGCTCCCAGCGTGGTAGCGAAGGCGGACACAGCTCGTATACCGTTCATTGGACGTAGGTCACAAGCCACGATAACGTTTGTTTGGTTAATGTCAATGTTAATGGAAACATAA

Protein

MNGKLHSETGAFSSDDMRAEILNPFVHKLELDNTYDKIKTAIFTVILLPFRVIVICYLIVTAWFLACIGLYGLSEEDLRRKPMTGWRSKLRFSILSLMRLVVVAAGFHRVRILGRQHQAGSSREAPVVVMAPHSSFFDAIAIVCLGAPSVVAKADTARIPFIGRRSQATITFVWLMSMLMET

Description

Acetyltransferase which mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).

Catalytic Activity

a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

Similarity

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Keywords

Acyltransferase   Calcium   Complete proteome   Endoplasmic reticulum   Golgi apparatus   Lipid biosynthesis   Lipid droplet   Lipid metabolism   Membrane   Phospholipid biosynthesis   Phospholipid metabolism   Reference proteome   Repeat   RNA editing   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Lysophosphatidylcholine acyltransferase

Uniprot

A0A0N1INL9   A0A2A4K8A0   A0A194PWN2   H9JQZ4   A0A2W1C3J5   A0A3S2NSH5   + More
A0A2A4K8M8   A0A154PJS6   A0A139WLL9   K7J6L8   A0A1B0CMD7   A0A3L8DBF3   A0A195CAM2   A0A151WT93   A0A158NEU9   A0A026WVZ5   A0A151J0G0   V9IFZ8   A0A0L7LNR1   A0A195FPY9   F4WJD4   A0A195BX85   A0A2J7PQW8   A0A1Y1N789   D6WF80   A0A087ZZK9   A0A1W4XWH6   A0A1Y1N7U0   A0A0C9RSK2   A0A1B6CA35   A0A1Y1N7B4   E2A7X7   A0A1B6CA70   A0A182IMK7   A0A1B6DYU8   T1J518   E2B639   W5JK41   A0A0L7R134   A0A336M4P5   A0A084VDE2   A0A336M8L2   A0A1B6DE58   A0A2M3Z5R6   A0A1W4XVH2   A0A1Q3FYX5   A0A1Q3FYU7   A0A2C9GSC7   A0A182M8L9   Q17L75   A0A1W4VUZ7   A0A2M4AKU9   A0A1S4EYT1   A0A2M4BL71   A0A182RZ54   A0A2M4BLS5   A0A2M4BKZ1   A0A182GYE6   A0A182W4D7   A0A2M4BHD4   Q0KHU5   B4ND19   A0A182FM85   B4GV79   E9IEM1   B5DKE5   W8C9M2   A0A0A1X7Q8   B4PWX4   B4IDH4   A0A3B0J789   A0A182MZR2   B3NT60   A0A182Y7M3   Q7QFP0   A0A0K8UYC6   A0A2A3EIH4   A0A034VCH0   A0A182QJ75   T1PLY4   A0A1I8MTS0   A0A1I8PIU4   B4L1J4   A0A0P6F3K0   A0A2S2R6H9   A0A2S2QQR2   B4JIX5   A0A2H8TK65   E9FU51   J9KB66   B3MW59   A0A0P5KTG0   B4M363   A0A164SUQ2   A0A182IU42   A0A182MRP3  

Pubmed

26354079    19121390    28756777    18362917    19820115    20075255    + More
30249741    21347285    24508170    26227816    21719571    28004739    20798317    20920257    23761445    24438588    17510324    26483478    10731132    12537572    12537569    17018572    25491198    17994087    21282665    15632085    24495485    25830018    17550304    25244985    12364791    14747013    17210077    25348373    25315136    21292972   

EMBL

KQ460971    KPJ10144.1    NWSH01000065    PCG80023.1    KQ459590    KPI97169.1    + More
BABH01028534    KZ149896    PZC78733.1    RSAL01000104    RVE47394.1    PCG80022.1    KQ434938    KZC12141.1    KQ971319    KYB28832.1    AAZX01001307    AAZX01004295    AJWK01018610    AJWK01018611    QOIP01000010    RLU17827.1    KQ978023    KYM97919.1    KQ982769    KYQ50855.1    ADTU01013177    ADTU01013178    KK107079    EZA60162.1    KQ980636    KYN14940.1    JR040698    AEY59249.1    JTDY01000460    KOB77070.1    KQ981335    KYN42660.1    GL888182    EGI65712.1    KQ976401    KYM92573.1    NEVH01022635    PNF18733.1    GEZM01010842    GEZM01010840    JAV93782.1    EFA00469.2    GEZM01010841    JAV93779.1    GBYB01010451    JAG80218.1    GEDC01027188    JAS10110.1    GEZM01010839    JAV93783.1    GL437442    EFN70456.1    GEDC01027113    JAS10185.1    GEDC01006436    JAS30862.1    JH431850    GL445914    EFN88828.1    ADMH02001273    ETN63265.1    KQ414669    KOC64511.1    UFQT01000555    SSX25242.1    ATLV01011272    ATLV01011273    ATLV01011274    ATLV01011275    ATLV01011276    ATLV01011277    ATLV01011278    KE524660    KFB35986.1    SSX25239.1    GEDC01013376    JAS23922.1    GGFM01003047    MBW23798.1    GFDL01002299    JAV32746.1    GFDL01002300    JAV32745.1    APCN01001102    APCN01001103    AXCM01001776    AXCM01001777    CH477218    EAT47420.1    GGFK01008031    MBW41352.1    GGFJ01004678    MBW53819.1    GGFJ01004597    MBW53738.1    GGFJ01004596    MBW53737.1    JXUM01097346    JXUM01097347    JXUM01097348    JXUM01097349    JXUM01097350    JXUM01097351    JXUM01097352    JXUM01097353    JXUM01097354    JXUM01097355    KQ564336    KXJ72411.1    GGFJ01003328    MBW52469.1    AE014298    BT003594    AY060832    AAL28380.1    AAO39597.1    ABI30972.1    CH964239    EDW82728.1    CH479192    EDW26616.1    GL762647    EFZ20982.1    CH379063    EDY72378.2    GAMC01006523    GAMC01006522    GAMC01006521    JAC00035.1    GBXI01012125    GBXI01007361    GBXI01000916    JAD02167.1    JAD06931.1    JAD13376.1    CM000162    EDX02858.2    CH480830    EDW45632.1    OUUW01000003    SPP77937.1    CH954180    EDV46240.2    AAAB01008846    EAA06656.4    GDHF01020766    JAI31548.1    KZ288230    PBC31585.1    GAKP01019145    GAKP01019144    JAC39807.1    AXCN02001242    KA649797    KA649798    AFP64426.1    CH933810    EDW07630.1    GDIQ01054323    JAN40414.1    GGMS01016365    MBY85568.1    GGMS01010667    MBY79870.1    CH916370    EDV99539.1    GFXV01001873    MBW13678.1    GL732524    EFX89532.1    ABLF02031451    ABLF02031457    CH902625    EDV35204.1    GDIQ01184966    JAK66759.1    CH940651    EDW65238.2    LRGB01001937    KZS09961.1   

Proteomes

UP000053240    UP000218220    UP000053268    UP000005204    UP000283053    UP000076502    + More
UP000007266    UP000002358    UP000092461    UP000279307    UP000078542    UP000075809    UP000005205    UP000053097    UP000078492    UP000037510    UP000078541    UP000007755    UP000078540    UP000235965    UP000005203    UP000192223    UP000000311    UP000075880    UP000008237    UP000000673    UP000053825    UP000030765    UP000075840    UP000075883    UP000008820    UP000192221    UP000075900    UP000069940    UP000249989    UP000075920    UP000000803    UP000007798    UP000069272    UP000008744    UP000001819    UP000002282    UP000001292    UP000268350    UP000075884    UP000008711    UP000076408    UP000007062    UP000242457    UP000075886    UP000095301    UP000095300    UP000009192    UP000001070    UP000000305    UP000007819    UP000007801    UP000008792    UP000076858   

PRIDE

H9JQZ4    Q0KHU5   

Pfam

PF01553   Acyltransferase        + More
PF00078   RVT_1
PF14529   Exo_endo_phos_2
PF13833   EF-hand_8
PF13499   EF-hand_7

Interpro

IPR002123   Plipid/glycerol_acylTrfase        + More
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR000477   RT_dom       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR018247   EF_Hand_1_Ca_BS       
IPR000048   IQ_motif_EF-hand-BS       

SUPFAM

SSF47473   SSF47473        + More
SSF56219   SSF56219       

Gene 3D

3.60.10.10    

CDD

cd00051  EFh

ProteinModelPortal

A0A0N1INL9   A0A2A4K8A0   A0A194PWN2   H9JQZ4   A0A2W1C3J5   A0A3S2NSH5   + More
A0A2A4K8M8   A0A154PJS6   A0A139WLL9   K7J6L8   A0A1B0CMD7   A0A3L8DBF3   A0A195CAM2   A0A151WT93   A0A158NEU9   A0A026WVZ5   A0A151J0G0   V9IFZ8   A0A0L7LNR1   A0A195FPY9   F4WJD4   A0A195BX85   A0A2J7PQW8   A0A1Y1N789   D6WF80   A0A087ZZK9   A0A1W4XWH6   A0A1Y1N7U0   A0A0C9RSK2   A0A1B6CA35   A0A1Y1N7B4   E2A7X7   A0A1B6CA70   A0A182IMK7   A0A1B6DYU8   T1J518   E2B639   W5JK41   A0A0L7R134   A0A336M4P5   A0A084VDE2   A0A336M8L2   A0A1B6DE58   A0A2M3Z5R6   A0A1W4XVH2   A0A1Q3FYX5   A0A1Q3FYU7   A0A2C9GSC7   A0A182M8L9   Q17L75   A0A1W4VUZ7   A0A2M4AKU9   A0A1S4EYT1   A0A2M4BL71   A0A182RZ54   A0A2M4BLS5   A0A2M4BKZ1   A0A182GYE6   A0A182W4D7   A0A2M4BHD4   Q0KHU5   B4ND19   A0A182FM85   B4GV79   E9IEM1   B5DKE5   W8C9M2   A0A0A1X7Q8   B4PWX4   B4IDH4   A0A3B0J789   A0A182MZR2   B3NT60   A0A182Y7M3   Q7QFP0   A0A0K8UYC6   A0A2A3EIH4   A0A034VCH0   A0A182QJ75   T1PLY4   A0A1I8MTS0   A0A1I8PIU4   B4L1J4   A0A0P6F3K0   A0A2S2R6H9   A0A2S2QQR2   B4JIX5   A0A2H8TK65   E9FU51   J9KB66   B3MW59   A0A0P5KTG0   B4M363   A0A164SUQ2   A0A182IU42   A0A182MRP3  

KEGG

101742486    K13510 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67] |

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016746   GO:0005509   GO:0071617   GO:0000139   GO:0005789   GO:0005783   GO:0030258   GO:0005811   GO:0008654   GO:0005794   GO:0047184  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  
Lipid droplet  

Length:

182

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

57.84021

Exp number, first 60 AAs:

14.09248

Total prob of N-in:

0.24558

POSSIBLE N-term signal

sequence

outside

1  -  49

TMhelix

50  -  72

inside

73  -  91

TMhelix

92  -  114

outside

115  -  128

TMhelix

129  -  151

inside

152  -  182

 

 

Pi

298.184372

Theta

196.509206

Tajima's D

1.796867

CLR

0.106543

CSRT

0.850857457127144

Interpretation

Uncertain