Silkworm Genome Informatics Database

Gene

KWMTBOMO06418

Pre Gene Modal

BGIBMGA011952

Annotation

PREDICTED:_1-acylglycerophosphocholine_O-acyltransferase_1_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):6825351-6829140 View in EpiBrowser

Full name

Lysophosphatidylcholine acyltransferase 1

Alternative Name

1-acylglycerophosphocholine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Acyltransferase-like 2

Location in the cell

Cytoplasmic Reliability : 1.012 Extracellular Reliability : 1.358

CDS

ATGTGTGTAGAAGACCTAAAGCTTCATATAAAATACAGCAATGCAAACCACACAACCATACTACTCTCATTCCCTTTGTTAAATGTAAGAAATATTTCTAGAAGCCTCACGAGGCGGCTTAATGTCCTAATATTCCCTGAAGGCACATGCACGAATCGCTCCTGTCTCATCACGTTCAAGCCTGGAGGCTTCTACCCAGGAGTTCCAGTGCAGCCCGTCACCATCAGATACCCGAATGCCAGGGACACGGTTACCTGGACGTGGGAAGGACCCGGGGCTTTAAAGCTGCTTTGGCTGACTCTGACACAAGTACACAGCTCGTGTGAGATTGAGTTCTTGCCTGTATACTATCCGAGTGAAGAGGAGAAGCGAGATCCGAAACTGTATGCGAGGAATGTTCGAGATGTTATGGCTAAAGCCCTAGGAGTTCCAGTATTAGATTATACTTACGACGACTGCCGGCTGATTGCTAGAGCCAAGAATCTGGGTATACCAGGAGCTCCGTGTGCCAGGGAGGTCAGCGAGCTAAGAGCTGCTCTTGGCCTAGAGAGGTCCCAACTAGAGCTGCACCTAGCTGCCCAGGGACTGCAGGATAGGGCTCGTTGGCTCACGGCTGAGGAGTTCTGCCAGAGGCTCGGGGTGCCTAACGATCAAAAGACGCAGAGGCTATTTGAAATATTTGTCCAGAGGTCCAGTGGCCTGGTGTACTTTCCCGACTATCTACTGTGCGCCGTCTTCCTCTCCCTCCAGCAGGCGCCGCTATCTAAAGTGCTCAATTACGCTTGGAAGTTGTACGACACTGGTCGGACCGGGAGACTCAACTCTGCCGGCTTCGAAGAGGTGACCGGCAAATGTCTTGGACTGTGTCAGCAAGATGCCAGCAACACGTTCCACCAGGCCGACCTGGACGAGAAGGGATATTTGACTTACGATGAATTCATATCGTTCGCTCAGAAACGCTCAGAATTCTCTTTCGTTTTCACCACCGACGGAGCTCACAAGCCGAAGGCGCAGTGA

Protein

MCVEDLKLHIKYSNANHTTILLSFPLLNVRNISRSLTRRLNVLIFPEGTCTNRSCLITFKPGGFYPGVPVQPVTIRYPNARDTVTWTWEGPGALKLLWLTLTQVHSSCEIEFLPVYYPSEEEKRDPKLYARNVRDVMAKALGVPVLDYTYDDCRLIARAKNLGIPGAPCAREVSELRAALGLERSQLELHLAAQGLQDRARWLTAEEFCQRLGVPNDQKTQRLFEIFVQRSSGLVYFPDYLLCAVFLSLQQAPLSKVLNYAWKLYDTGRTGRLNSAGFEEVTGKCLGLCQQDASNTFHQADLDEKGYLTYDEFISFAQKRSEFSFVFTTDGAHKPKAQ

Description

Possesses both acyltransferase and acetyltransferase activities (PubMed:16704971). Activity is calcium-independent (PubMed:18285344). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:16704971, PubMed:18156367). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971, PubMed:18285344). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16704971). Involved in the regulation of lipid droplet number and size (By similarity).

Catalytic Activity

a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

Biophysicochemical Properties

2.3 uM for 1-palmitoyl-LPC
3 uM for palmitoyl-CoA

Similarity

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Keywords

Acyltransferase Alternative splicing Calcium Complete proteome Endoplasmic reticulum Golgi apparatus Lipid biosynthesis Lipid droplet Lipid metabolism Membrane Metal-binding Phospholipid biosynthesis Phospholipid metabolism Reference proteome Repeat Signal-anchor Transferase Transmembrane Transmembrane helix

Feature

chain Lysophosphatidylcholine acyltransferase 1
splice variant In isoform 3.

Uniprot

A0A2A4K8M8 A0A2A4K8A0 A0A2H1V821 A0A212ESI1 A0A194PWN2 D6WF80 + More
A0A139WLL9 A0A2J7PQW8 A0A1W4XWH6 A0A1W4XVH2 A0A1W4XWD4 A0A1Y1N7B4 A0A1L8DYR7 E0VLS7 A0A336M5E7 A0A1Q3FYU7 A0A1Q3FYX5 A0A182HCZ9 A0A336M8L2 A0A2R7X4U4 A0A182GYE6 A0A1B0DJ85 Q17L75 A0A1S4EYT1 A0A336MZM7 U4U5D7 A0A023F8I1 V4BQE9 A0A1B6FY65 A0A384AWS0 A0A1B6F148 A0A1B6LQQ2 A0A2Y9SQN5 A0A384AWD3 A0A091EYR4 A0A091UHU3 A0A384AWC4 A0A093PAI3 A0A2Y9SN37 A0A1B6D369 A0A094LNN3 K7J6L8 A0A2M4APX7 A0A2Y9NVS4 A0A087ZZK9 R4G7P3 A0A310SP75 A0A341ACU1 A0A0L7R134 A0A2Y9NPF9 A0A2Y9P164 A0A093IJQ8 A0A2I0ULJ3 A0A091LIX0 F1S029 A0A2Y9P4E9 A0A2Y9P159 A0A093PBT6 E2B639 A0A091SKL8 A0A091FHM3 A0A1B6DE58 A0A154PJS6 A0A093JDZ3 H0ZDT5 A0A091QLY9 A0A2M4AKU9 A0A232FA96 A0A2M3Z8Q0 T1J518 G1N5M4 A0A091JED2 A0A0N0U6B7 R0KYR3 F1MTK4 A0A091PQU1 A0A091HUV4 F1NME3 E2A7X7 A0A340YGD0 A0A0Q3Q349 A0A091KAZ9 F6S3K0 A0A3L8DBF3 A0A218VB71 A0A091SMU0 A0A195CAM2 A0A099Z060 A0A091V5D2 W5JT87 U3JHJ1 A0A2I0MWV1 Q3TFD2-3 A0A087R3W4 A0A158NEU9 A0A1S3H618 A0A1S3H634

EC Number

2.3.1.23

Pubmed

22118469 26354079 18362917 19820115 28004739 20566863 + More
26483478 17510324 23537049 25474469 23254933 20075255 30723633 20798317 20360741 28648823 20838655 19393038 15592404 20431018 30249741 20920257 23761445 23371554 16704971 16864775 16141072 15489334 18285344 18156367 21183079 21347285

EMBL

NWSH01000065 PCG80022.1 PCG80023.1 ODYU01001153 SOQ36961.1 AGBW02012788 + More
OWR44440.1 KQ459590 KPI97169.1 KQ971319 EFA00469.2 KYB28832.1 NEVH01022635 PNF18733.1 GEZM01010839 JAV93783.1 GFDF01002500 JAV11584.1 DS235281 EEB14333.1 UFQT01000555 SSX25240.1 GFDL01002300 JAV32745.1 GFDL01002299 JAV32746.1 JXUM01034557 JXUM01034558 JXUM01034559 KQ561028 KXJ79975.1 SSX25239.1 KK857094 PTY26814.1 JXUM01097346 JXUM01097347 JXUM01097348 JXUM01097349 JXUM01097350 JXUM01097351 JXUM01097352 JXUM01097353 JXUM01097354 JXUM01097355 KQ564336 KXJ72411.1 AJVK01064622 CH477218 EAT47420.1 UFQT01004423 SSX35686.1 KB632148 ERL89104.1 GBBI01001067 JAC17645.1 KB202284 ESO91104.1 GECZ01014698 JAS55071.1 GECZ01025881 JAS43888.1 GEBQ01014020 JAT25957.1 KK719225 KFO62096.1 KK434029 KFQ89732.1 KL412413 KFW73938.1 GEDC01017149 GEDC01008980 JAS20149.1 JAS28318.1 KL360901 KFZ65339.1 AAZX01001307 AAZX01004295 GGFK01009506 MBW42827.1 ACPB03006856 GAHY01002372 JAA75138.1 KQ761738 OAD57132.1 KQ414669 KOC64511.1 KL215849 KFV66956.1 KZ505694 PKU46927.1 KL323181 KFP55335.1 AEMK02000102 DQIR01112214 HDA67690.1 KL225406 KFW71645.1 GL445914 EFN88828.1 KK475593 KFQ58898.1 KL447126 KFO70075.1 GEDC01013376 JAS23922.1 KQ434938 KZC12141.1 KK607674 KFW10087.1 ABQF01022878 ABQF01022879 KK799762 KFQ27899.1 GGFK01008031 MBW41352.1 NNAY01000544 OXU27771.1 GGFM01004153 MBW24904.1 JH431850 KK501805 KFP18060.1 KQ435732 KOX77452.1 KB748326 EOA93147.1 KK676942 KFQ09676.1 KL217809 KFO98939.1 AADN05000026 GL437442 EFN70456.1 LMAW01001792 KQK82620.1 KK737898 KFP37704.1 AAMC01019412 AAMC01019413 AAMC01019414 QOIP01000010 RLU17827.1 MUZQ01000018 OWK63000.1 KK929257 KFQ44377.1 KQ978023 KYM97919.1 KL886754 KGL74170.1 KL410602 KFQ97607.1 ADMH02000151 ETN67592.1 AGTO01001914 AKCR02000001 PKK34155.1 AB244717 AK046079 AK046507 AK081865 AK155286 AK169190 AK170723 AK171582 BC005662 BC066809 KL226084 KFM08168.1 ADTU01013177 ADTU01013178

Proteomes

UP000218220 UP000007151 UP000053268 UP000007266 UP000235965 UP000192223 + More
UP000009046 UP000069940 UP000249989 UP000092462 UP000008820 UP000030742 UP000030746 UP000261681 UP000052976 UP000248484 UP000002358 UP000248483 UP000005203 UP000015103 UP000252040 UP000053825 UP000053875 UP000008227 UP000054081 UP000008237 UP000053760 UP000076502 UP000007754 UP000215335 UP000001645 UP000053119 UP000053105 UP000009136 UP000054308 UP000000539 UP000000311 UP000265300 UP000051836 UP000008143 UP000279307 UP000197619 UP000078542 UP000053641 UP000053283 UP000000673 UP000016665 UP000053872 UP000000589 UP000053286 UP000005205 UP000085678

PRIDE

F1S029 Q3TFD2

Pfam

PF01553   Acyltransferase        + More
PF13833   EF-hand_8
PF13499   EF-hand_7
PF13202   EF-hand_5

Interpro

IPR002123   Plipid/glycerol_acylTrfase        + More
IPR002048   EF_hand_dom
IPR011992   EF-hand-dom_pair
IPR018247   EF_Hand_1_Ca_BS

SUPFAM

SSF47473 SSF47473

CDD

cd00051 EFh

ProteinModelPortal

A0A2A4K8M8 A0A2A4K8A0 A0A2H1V821 A0A212ESI1 A0A194PWN2 D6WF80 + More
A0A139WLL9 A0A2J7PQW8 A0A1W4XWH6 A0A1W4XVH2 A0A1W4XWD4 A0A1Y1N7B4 A0A1L8DYR7 E0VLS7 A0A336M5E7 A0A1Q3FYU7 A0A1Q3FYX5 A0A182HCZ9 A0A336M8L2 A0A2R7X4U4 A0A182GYE6 A0A1B0DJ85 Q17L75 A0A1S4EYT1 A0A336MZM7 U4U5D7 A0A023F8I1 V4BQE9 A0A1B6FY65 A0A384AWS0 A0A1B6F148 A0A1B6LQQ2 A0A2Y9SQN5 A0A384AWD3 A0A091EYR4 A0A091UHU3 A0A384AWC4 A0A093PAI3 A0A2Y9SN37 A0A1B6D369 A0A094LNN3 K7J6L8 A0A2M4APX7 A0A2Y9NVS4 A0A087ZZK9 R4G7P3 A0A310SP75 A0A341ACU1 A0A0L7R134 A0A2Y9NPF9 A0A2Y9P164 A0A093IJQ8 A0A2I0ULJ3 A0A091LIX0 F1S029 A0A2Y9P4E9 A0A2Y9P159 A0A093PBT6 E2B639 A0A091SKL8 A0A091FHM3 A0A1B6DE58 A0A154PJS6 A0A093JDZ3 H0ZDT5 A0A091QLY9 A0A2M4AKU9 A0A232FA96 A0A2M3Z8Q0 T1J518 G1N5M4 A0A091JED2 A0A0N0U6B7 R0KYR3 F1MTK4 A0A091PQU1 A0A091HUV4 F1NME3 E2A7X7 A0A340YGD0 A0A0Q3Q349 A0A091KAZ9 F6S3K0 A0A3L8DBF3 A0A218VB71 A0A091SMU0 A0A195CAM2 A0A099Z060 A0A091V5D2 W5JT87 U3JHJ1 A0A2I0MWV1 Q3TFD2-3 A0A087R3W4 A0A158NEU9 A0A1S3H618 A0A1S3H634

PDB

2JU0 E-value=0.00340188, Score=95

KEGG

101742486 K13510 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67] |

GO

GO:0016021 GO:0005509 GO:0016746 GO:0036151 GO:0045732 GO:0005783 GO:0047191 GO:0047184 GO:2001246 GO:0005794 GO:0008654 GO:0005811 GO:0047159 GO:0043129 GO:0060041 GO:0047192 GO:0005789 GO:0000139 GO:0030170 GO:0003824 GO:0051536 GO:0016740 GO:0043412 GO:0015074 GO:0015923 GO:0005634 GO:0006260

Subcellular location

Endoplasmic reticulum membrane   May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.   With evidence from 3 publications.
Golgi apparatus membrane   May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.   With evidence from 3 publications.
Lipid droplet   May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.   With evidence from 3 publications.

Length:

338

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.572

Exp number, first 60 AAs:

0.25149

Total prob of N-in:

0.02441

outside

1 - 338

Pi

243.067871

Theta

185.026142

Tajima's D

0.01489

CLR

421.813623

CSRT

0.374531273436328

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics