Gene

KWMTBOMO06394

Pre Gene Modal

BGIBMGA014494

Annotation

bombyxin_A-2_precursor_[Bombyx_mori]

Location

Bomo_Chr11(-):6154950-6155450      View in EpiBrowser

Full name

Bombyxin A-2       + More
Bombyxin A-8      
Bombyxin A-1      
Bombyxin A-6      
Bombyxin A-4      
Bombyxin A-9      
Bombyxin A-3      
Bombyxin A-7      
Bombyxin A-5      
Bombyxin A      
Bombyxin B-10      
Bombyxin B-3      
Bombyxin B-2      
Bombyxin C-1      
Bombyxin B      
Bombyxin B-4      
Bombyxin B-12      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin D-1      
Bombyxin C-2      
Bombyxin B-8      
Bombyxin B-6      
Bombyxin B-5      
Bombyxin E-1      
Bombyxin B-9      
Bombyxin B-11      
Bombyxin B-1 homolog      
Bombyxin B-2 homolog      
Bombyxin G-1      
Insulin-related peptide 2      
Bombyxin F-1      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Insulin-related peptide 4      
Bombyxin A-3 homolog      
Insulin-related peptide 1      
Bombyxin A-1 homolog      
Bombyxin A-2 homolog      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.542

CDS

ATGAAGATACTCCTTGCTATTGCATTAATGTTGTCAACAGTAATGTGGGTGTCAACACAACAGCCACAAGAAGTGCACACGTATTGCGGGCGCCACTTAGCTCGCACTATGGCCGACCTATGCTGGGAAGAGGGCGTGGATAAGCGCAGCGATGCTCAGTTCGCGAGCTACGGCTCCGCGTGGCTGATGCCCTACTCGGCAGGACGCGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTACTGTTAG

Protein

MKILLAIALMLSTVMWVSTQQPQEVHTYCGRHLARTMADLCWEEGVDKRSDAQFASYGSAWLMPYSAGRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

3D-structure   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   Direct protein sequencing   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-2 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

P15411   P26731   Q17192   P26729   P26727   P26732   + More
P26726   P26730   P26728   H9JQX3   H9JQX2   Q17193   H9JY76   Q17194   P26737   P26734   P15410   H9JY77   P26738   P29519   H9JR11   H9JR12   P26733   P26741   H9JY78   P26736   P26735   P26742   P26740   Q53X51   P26739   P21808   H9JRY4   P26743   Q17196   P33721   P33722   O61271   C0HKS4   H9JQX4   P91896   A0A385H8W6   M4QC54   O09209   H9JRY3   B9A0V1   M4QNU1   A0A385H8W3   A0A2A4JKA0   M4QEN0   Q4JJX8   A0A2A4JKR2   F6KMX2   A0A2H1WZM1   A0A2W1BXR4   O09210   A0A194QKH9   A0A2H1WD29   A0A2H1WLR7   A0A2H1WD32   A0A2H1WTS8   A0A2H1WPT3   A0A2H1WPS9   A0A385H8X0   S4NYE8   A0A212EPD8   A0A194RGH1   A0A385H8W9   C0HKS5   A0A2H1WZT3   A0A194RFE4   M4QG01   A0A2H1X245   A0A194PJ20   A0A2A4J1N6   A0A0L7KP19   A0A0L7KQ08   A0A385H8W5   A0A194Q5I3   P33720   C0HKS3   H9ITT7   A0A194PZ95   F8WTP8   P33718   A0A0L7L7G8   A0A194RG26   A0A194PZA6   A0A3S2NJC1   A0A194RKP6   A0A087T302   F6KMX3   V4A388   P33719   A0A212EI08   A0EZS0   Q17CI6   A0A212F2W7  

Pubmed

2708384    2674935    7473749    8683595    16593744    19121390    + More
9253178    1515030    1601275    9732555    29466015    9401466    30171635    8673077    17559850    28756777    26354079    23622113    22118469    26227816    23254933    16934367    17510324   

EMBL

J04727    M26068    D00774    D00775    D00340    D00771    + More
D00769    D00776    M26069    D00772    D00773    D00770    BABH01028595    BABH01028597    D00777    BAA00673.1    BABH01042454    D00787    D00778    D00790    D00791    J04728    D00779    D00789    BABH01028594    D00782    D00783    BABH01042456    D00797    AB003905    D00792    D00784    D00781    D00786    BAA00682.1    D00780    D78138    BABH01016939    D00785    D00788    D13923    D13924    AB010380    AB010381    AB001049    AB001050    MH028092    AXY04261.1    KC340940    AGH25572.1    D63147    D63146    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    KC340941    AGH25573.1    MH028095    AXY04264.1    NWSH01001233    PCG72024.1    KC340942    AGH25574.1    DQ080209    AAY84557.1    PCG72023.1    HQ451072    AEE43936.1    ODYU01012310    SOQ58560.1    KZ149928    PZC77476.1    D63148    BAA20092.1    KQ461198    KPJ06073.1    ODYU01007848    SOQ50980.1    ODYU01009526    SOQ54023.1    ODYU01007998    SOQ50979.1    SOQ51243.1    ODYU01011005    SOQ56475.1    ODYU01010158    SOQ55080.1    SOQ55081.1    MH028093    AXY04262.1    GAIX01011802    JAA80758.1    AGBW02013503    OWR43321.1    KQ460211    KPJ16544.1    MH028097    AXY04266.1    SOQ58561.1    KPJ16548.1    KC340943    AGH25575.1    ODYU01012871    SOQ59389.1    KQ459606    KPI91080.1    NWSH01003834    PCG65779.1    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    KOB65059.1    MH028098    AXY04267.1    KQ459583    KPI98655.1    D13925    BABH01006963    KPI98657.1    AB661462    BAK57501.1    JTDY01002420    KOB71447.1    KPJ16547.1    KPI98656.1    RSAL01000529    RVE41449.1    KPJ16546.1    KK113157    KFM59491.1    HQ451073    AEE43937.1    KB202619    ESO89360.1    AGBW02014744    OWR41114.1    DQ845755    ABI64121.1    DQ845756    CH477308    ABI64122.1    EAT44035.1    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000283053    UP000054359    UP000030746    UP000008820   

PRIDE

P15411    P26731    P26729    P26727    P26732    P26726    + More
P26730    P26728    H9JQX3    H9JQX2    Q17193    H9JY76    Q17194    P26737    P26734    P15410    H9JY77    P26738    P29519    H9JR11    H9JR12    P26733    P26741    H9JY78    P26736    P26735    P26742    P26740    P26739    P21808    H9JRY4    P26743    Q17196    O61271    H9JQX4    P91896    H9JRY3    B9A0V1    H9ITT7    F8WTP8    P33719   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR030680   Bombyxin_A        + More
IPR036438   Insulin-like_sf       
IPR022353   Insulin_CS       
IPR016179   Insulin-like       
IPR040228   Insulin-relat-peptide_inver       
IPR017097   Bombyxin       
IPR022352   Insulin_family       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

P15411   P26731   Q17192   P26729   P26727   P26732   + More
P26726   P26730   P26728   H9JQX3   H9JQX2   Q17193   H9JY76   Q17194   P26737   P26734   P15410   H9JY77   P26738   P29519   H9JR11   H9JR12   P26733   P26741   H9JY78   P26736   P26735   P26742   P26740   Q53X51   P26739   P21808   H9JRY4   P26743   Q17196   P33721   P33722   O61271   C0HKS4   H9JQX4   P91896   A0A385H8W6   M4QC54   O09209   H9JRY3   B9A0V1   M4QNU1   A0A385H8W3   A0A2A4JKA0   M4QEN0   Q4JJX8   A0A2A4JKR2   F6KMX2   A0A2H1WZM1   A0A2W1BXR4   O09210   A0A194QKH9   A0A2H1WD29   A0A2H1WLR7   A0A2H1WD32   A0A2H1WTS8   A0A2H1WPT3   A0A2H1WPS9   A0A385H8X0   S4NYE8   A0A212EPD8   A0A194RGH1   A0A385H8W9   C0HKS5   A0A2H1WZT3   A0A194RFE4   M4QG01   A0A2H1X245   A0A194PJ20   A0A2A4J1N6   A0A0L7KP19   A0A0L7KQ08   A0A385H8W5   A0A194Q5I3   P33720   C0HKS3   H9ITT7   A0A194PZ95   F8WTP8   P33718   A0A0L7L7G8   A0A194RG26   A0A194PZA6   A0A3S2NJC1   A0A194RKP6   A0A087T302   F6KMX3   V4A388   P33719   A0A212EI08   A0EZS0   Q17CI6   A0A212F2W7  

PDB

1BON     E-value=2.15552e-08,     Score=133

KEGG

693012    no KO assigned | (RefSeq) Bbx-a2, 4K-PTTH, BBXA2; bombyxin A2

GO

GO:0005179   GO:0008083   GO:0005615   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0015074   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.998394

 

 

Length:

89

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.141

Exp number, first 60 AAs:

0.13924

Total prob of N-in:

0.09946

outside

1  -  89

 

 

Pi

141.297576

Theta

138.391347

Tajima's D

0.065986

CLR

0

CSRT

0.386280685965702

Interpretation

Uncertain