Gene

KWMTBOMO06393

Pre Gene Modal

BGIBMGA014495

Annotation

bombyxin_A-3_precursor_[Bombyx_mori]

Location

Bomo_Chr11(-):6148194-6148640      View in EpiBrowser

Full name

Bombyxin A-3       + More
Bombyxin A-4      
Bombyxin A-6      
Bombyxin A-7      
Bombyxin A-1      
Bombyxin A-9      
Bombyxin A      
Bombyxin A-5      
Bombyxin A-2      
Bombyxin A-8      
Bombyxin B-2      
Bombyxin B-3      
Bombyxin C-1      
Bombyxin B-10      
Bombyxin B      
Bombyxin D-1      
Bombyxin B-4      
Bombyxin B-12      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin B-6      
Bombyxin C-2      
Bombyxin B-8      
Insulin-related peptide 2      
Bombyxin B-1 homolog      
Bombyxin E-1      
Bombyxin B-9      
Bombyxin B-2 homolog      
Bombyxin B-5      
Bombyxin B-11      
Bombyxin F-1      
Bombyxin G-1      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Insulin-related peptide 4      
Insulin-related peptide 1      
Bombyxin A-3 homolog      
Bombyxin A-1 homolog      
Bombyxin A-2 homolog      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.722

CDS

ATGAAGATTCTCCTTGCTATTGCATTAATGTTGTCAACAGTAATGTGGGTGTCAACACAACAGCCACAAGGAGTGCACACGTACTGCGGGCGCCACTTGGCTCGCACTCTGGCCAACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCGATGCTCAGTACGTGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGAAGGACGCGGCAAACGAGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTACTGTTAG

Protein

MKILLAIALMLSTVMWVSTQQPQGVHTYCGRHLARTLANLCWEAGVDKRSDAQYVSYGSAWLMPYSEGRGKRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Direct protein sequencing   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-3 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

P26726   P26727   P26729   P26730   Q17192   P26732   + More
H9JQX3   P26728   P15411   P26731   Q17193   H9JY76   H9JQX2   P26734   P26737   P15410   Q17194   H9JY77   P26736   P26738   P29519   H9JY78   P26733   P26741   H9JR12   H9JR11   P26740   P26735   P26742   C0HKS4   P33721   P21808   P26743   P33722   H9JRY4   Q53X51   P26739   H9JQX4   M4QC54   Q17196   P91896   O61271   A0A385H8W6   A0A385H8W3   M4QNU1   M4QEN0   F6KMX2   A0A2A4JKR2   A0A2H1WD32   A0A212EPD8   A0A2H1WZM1   A0A2A4JKA0   A0A2H1WLR7   A0A2H1WD29   A0A2H1WTS8   B9A0V1   Q4JJX8   A0A2H1WPS9   A0A2W1BXR4   A0A385H8W9   H9JRY3   A0A194RGH1   A0A194RFE4   O09209   A0A2H1WZT3   A0A194QKH9   S4NYE8   O09210   A0A194Q5I3   C0HKS5   A0A0L7KP19   A0A194PZA6   A0A385H8X0   M4QG01   A0A194PZ95   A0A2A4J1N6   A0A2H1WPT3   A0A2H1X245   A0A194RG26   A0A0L7KQ08   A0A385H8W5   A0A2W1BUP0   A0A385H8W4   C0HKS3   P33720   A0A194PJ20   A0A3S2NJC1   A0A194RKP6   P33718   P33719   A0A0L7L7G8   A0A194Q039   H9ITT7   A0A194Q0Y1   F8WTP8   A0A212F2W7   A0A212EI08   A0A087T302   A0A336MJK3  

Pubmed

2674935    8683595    16593744    7473749    19121390    2708384    + More
29466015    1601275    9253178    1515030    9401466    9732555    30171635    17559850    22118469    28756777    26354079    8673077    23622113    26227816   

EMBL

M26069    D00769    D00771    D00772    D00773    D00340    + More
D00776    BABH01028595    D00770    J04727    M26068    D00774    D00775    D00777    BAA00673.1    BABH01042454    BABH01028597    D00778    D00790    D00791    J04728    D00787    D00797    AB003905    D00779    D00789    BABH01042456    D00782    D00783    BABH01028594    D00781    D00792    D00784    D13923    D78138    D00785    D13924    BABH01016939    D00786    BAA00682.1    D00780    KC340940    AGH25572.1    D00788    AB001049    AB001050    AB010380    AB010381    MH028092    AXY04261.1    MH028095    AXY04264.1    KC340941    AGH25573.1    KC340942    AGH25574.1    HQ451072    AEE43936.1    NWSH01001233    PCG72023.1    ODYU01007848    ODYU01007998    SOQ50979.1    SOQ51243.1    AGBW02013503    OWR43321.1    ODYU01012310    SOQ58560.1    PCG72024.1    ODYU01009526    SOQ54023.1    SOQ50980.1    ODYU01011005    SOQ56475.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    DQ080209    AAY84557.1    ODYU01010158    SOQ55081.1    KZ149928    PZC77476.1    MH028097    AXY04266.1    KQ460211    KPJ16544.1    KPJ16548.1    D63147    D63146    SOQ58561.1    KQ461198    KPJ06073.1    GAIX01011802    JAA80758.1    D63148    BAA20092.1    KQ459583    KPI98655.1    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    KPI98656.1    MH028093    AXY04262.1    KC340943    AGH25575.1    KPI98657.1    NWSH01003834    PCG65779.1    SOQ55080.1    ODYU01012871    SOQ59389.1    KPJ16547.1    KOB65059.1    MH028098    AXY04267.1    KZ149897    PZC78689.1    MH028096    AXY04265.1    D13925    KQ459606    KPI91080.1    RSAL01000529    RVE41449.1    KPJ16546.1    JTDY01002420    KOB71447.1    KPI98658.1    BABH01006963    KPI98654.1    AB661462    BAK57501.1    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    AGBW02014744    OWR41114.1    KK113157    KFM59491.1    UFQS01001151    UFQT01001151    SSX09257.1    SSX29159.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000283053    UP000054359   

PRIDE

P26726    P26727    P26729    P26730    P26732    H9JQX3    + More
P26728    P15411    P26731    Q17193    H9JY76    H9JQX2    P26734    P26737    P15410    Q17194    H9JY77    P26736    P26738    P29519    H9JY78    P26733    P26741    H9JR12    H9JR11    P26740    P26735    P26742    P21808    P26743    H9JRY4    P26739    H9JQX4    Q17196    P91896    O61271    B9A0V1    H9JRY3    P33719    H9ITT7    F8WTP8   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR022353   Insulin_CS        + More
IPR036438   Insulin-like_sf       
IPR030680   Bombyxin_A       
IPR017097   Bombyxin       
IPR022352   Insulin_family       
IPR040228   Insulin-relat-peptide_inver       
IPR016179   Insulin-like       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

P26726   P26727   P26729   P26730   Q17192   P26732   + More
H9JQX3   P26728   P15411   P26731   Q17193   H9JY76   H9JQX2   P26734   P26737   P15410   Q17194   H9JY77   P26736   P26738   P29519   H9JY78   P26733   P26741   H9JR12   H9JR11   P26740   P26735   P26742   C0HKS4   P33721   P21808   P26743   P33722   H9JRY4   Q53X51   P26739   H9JQX4   M4QC54   Q17196   P91896   O61271   A0A385H8W6   A0A385H8W3   M4QNU1   M4QEN0   F6KMX2   A0A2A4JKR2   A0A2H1WD32   A0A212EPD8   A0A2H1WZM1   A0A2A4JKA0   A0A2H1WLR7   A0A2H1WD29   A0A2H1WTS8   B9A0V1   Q4JJX8   A0A2H1WPS9   A0A2W1BXR4   A0A385H8W9   H9JRY3   A0A194RGH1   A0A194RFE4   O09209   A0A2H1WZT3   A0A194QKH9   S4NYE8   O09210   A0A194Q5I3   C0HKS5   A0A0L7KP19   A0A194PZA6   A0A385H8X0   M4QG01   A0A194PZ95   A0A2A4J1N6   A0A2H1WPT3   A0A2H1X245   A0A194RG26   A0A0L7KQ08   A0A385H8W5   A0A2W1BUP0   A0A385H8W4   C0HKS3   P33720   A0A194PJ20   A0A3S2NJC1   A0A194RKP6   P33718   P33719   A0A0L7L7G8   A0A194Q039   H9ITT7   A0A194Q0Y1   F8WTP8   A0A212F2W7   A0A212EI08   A0A087T302   A0A336MJK3  

PDB

1BON     E-value=6.34597e-09,     Score=138

KEGG

100169712    K04526 insulin | (RefSeq) Bbx-a3, BBXA3; bombyxin A-3

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005179   GO:0008083   GO:0005615   GO:0007218   GO:0005576   GO:0016021   GO:0018445   GO:0015074   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.998170

 

 

Length:

92

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.23768

Exp number, first 60 AAs:

0.23768

Total prob of N-in:

0.10028

outside

1  -  92

 

 

Pi

223.906841

Theta

166.40163

Tajima's D

1.049934

CLR

0

CSRT

0.674616269186541

Interpretation

Uncertain