Gene

KWMTBOMO06390

Pre Gene Modal

BGIBMGA014205

Annotation

bombyxin_A-10_[Bombyx_mori]

Location

Bomo_Chr11(-):6123750-6124280      View in EpiBrowser

Full name

Bombyxin A       + More
Bombyxin A-9      
Bombyxin A-7      
Bombyxin A-6      
Bombyxin A-5      
Bombyxin A-4      
Bombyxin A-1      
Bombyxin A-3      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin B-10      
Bombyxin B-2      
Bombyxin B      
Bombyxin B-3      
Bombyxin B-4      
Bombyxin C-1      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin B-12      
Bombyxin C-2      
Bombyxin D-1      
Bombyxin B-8      
Bombyxin B-6      
Bombyxin B-9      
Bombyxin B-11      
Bombyxin G-1      
Bombyxin B-5      
Bombyxin E-1      
Bombyxin B-2 homolog      
Bombyxin B-1 homolog      
Insulin-related peptide 2      
Bombyxin F-1      
Bombyxin-related peptide A      
Insulin-related peptide 4      
Bombyxin-related peptide B      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.241

CDS

ATGAAATTACTACTTGCTATTGCATTAATGTTGACAACAGTAATGTGGGCGTCAACACAACAGCCTCAAGCAGTGCACACGTACTGCGGGCGTCACTTGGCCCGCACTCTGGCCGACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCAATGCTCAGTACGCGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGAAGGACGCGGCCAACGAGGCATCGTGGATGAGTGCTGTCTCAGACCCTGA

Protein

MKLLLAIALMLTTVMWASTQQPQAVHTYCGRHLARTLADLCWEAGVDKRSNAQYASYGSAWLMPYSEGRGQRGIVDECCLRP

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Amidation   Neuropeptide  

Feature

chain  Bombyxin A
peptide  Bombyxin A-9 B chain
propeptide  C peptide like

Uniprot

Q17193   P26732   P26730   H9JQX3   P26729   P26728   + More
P26727   Q17192   P26726   P26731   P15411   H9JY76   H9JQX2   Q17194   P26734   H9JY77   P26737   P26738   P15410   H9JY78   P26733   P26741   H9JR12   P29519   P26735   P26736   P26742   H9JR11   P26740   P26743   Q17196   O61271   Q53X51   P26739   P21808   H9JRY4   P33722   P33721   C0HKS4   M4QC54   H9JQX4   P91896   A0A385H8W6   Q4JJX8   A0A0L7KQ08   A0A2H1WZM1   A0A385H8W3   H9JRY3   M4QNU1   B9A0V1   A0A2H1WD29   F6KMX2   A0A2H1WLR7   A0A2H1WTS8   A0A2H1WD32   A0A2A4JKA0   O09209   A0A385H8W9   A0A212EPD8   C0HKS5   A0A2H1WPS9   A0A194QKH9   O09210   A0A0L7KP19   A0A2A4JKR2   A0A194RGH1   M4QEN0   A0A2H1WZT3   A0A385H8X0   A0A2W1BXR4   A0EZS0   S4NYE8   A0A194RFE4   A0A2H1WPT3   A0A1S4F886   Q17CI7   M4QG01   A0A1S4F823   Q17CI6   A0A023EHB8   A0A194Q5I3   A0A2A4J1N6  

Pubmed

8683595    16593744    19121390    7473749    2674935    2708384    + More
9732555    9253178    1515030    1601275    29466015    9401466    30171635    26227816    17559850    8673077    22118469    26354079    28756777    16934367    23622113    17510324    24945155   

EMBL

D00777    BAA00673.1    D00776    D00772    D00773    BABH01028595    + More
D00771    D00770    D00769    D00340    M26069    D00774    D00775    J04727    M26068    BABH01042454    BABH01028597    D00787    D00778    D00779    D00790    D00791    J04728    BABH01042456    D00782    D00783    D00789    D00792    D00797    AB003905    D00784    BABH01028594    D00781    D00785    D00788    AB010380    AB010381    D00786    BAA00682.1    D00780    D78138    BABH01016939    D13924    D13923    KC340940    AGH25572.1    AB001049    AB001050    MH028092    AXY04261.1    DQ080209    AAY84557.1    JTDY01007633    KOB65059.1    ODYU01012310    SOQ58560.1    MH028095    AXY04264.1    KC340941    AGH25573.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    ODYU01007848    SOQ50980.1    HQ451072    AEE43936.1    ODYU01009526    SOQ54023.1    ODYU01011005    SOQ56475.1    ODYU01007998    SOQ50979.1    SOQ51243.1    NWSH01001233    PCG72024.1    D63147    D63146    MH028097    AXY04266.1    AGBW02013503    OWR43321.1    ODYU01010158    SOQ55081.1    KQ461198    KPJ06073.1    D63148    BAA20092.1    JTDY01000351    KOB65058.1    KOB77585.1    PCG72023.1    KQ460211    KPJ16544.1    KC340942    AGH25574.1    SOQ58561.1    MH028093    AXY04262.1    KZ149928    PZC77476.1    DQ845755    ABI64121.1    GAIX01011802    JAA80758.1    KPJ16548.1    SOQ55080.1    CH477308    EAT44034.1    KC340943    AGH25575.1    DQ845756    ABI64122.1    EAT44035.1    GAPW01005354    JAC08244.1    KQ459583    KPI98655.1    NWSH01003834    PCG65779.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000053240    UP000008820    + More
UP000053268   

PRIDE

Q17193    P26732    P26730    H9JQX3    P26729    P26728    + More
P26727    P26726    P26731    P15411    H9JY76    H9JQX2    Q17194    P26734    H9JY77    P26737    P26738    P15410    H9JY78    P26733    P26741    H9JR12    P29519    P26735    P26736    P26742    H9JR11    P26740    P26743    Q17196    O61271    P26739    P21808    H9JRY4    H9JQX4    P91896    H9JRY3    B9A0V1   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR016179   Insulin-like        + More
IPR017097   Bombyxin       
IPR030680   Bombyxin_A       
IPR036438   Insulin-like_sf       
IPR022352   Insulin_family       
IPR040228   Insulin-relat-peptide_inver       
IPR022353   Insulin_CS       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

Q17193   P26732   P26730   H9JQX3   P26729   P26728   + More
P26727   Q17192   P26726   P26731   P15411   H9JY76   H9JQX2   Q17194   P26734   H9JY77   P26737   P26738   P15410   H9JY78   P26733   P26741   H9JR12   P29519   P26735   P26736   P26742   H9JR11   P26740   P26743   Q17196   O61271   Q53X51   P26739   P21808   H9JRY4   P33722   P33721   C0HKS4   M4QC54   H9JQX4   P91896   A0A385H8W6   Q4JJX8   A0A0L7KQ08   A0A2H1WZM1   A0A385H8W3   H9JRY3   M4QNU1   B9A0V1   A0A2H1WD29   F6KMX2   A0A2H1WLR7   A0A2H1WTS8   A0A2H1WD32   A0A2A4JKA0   O09209   A0A385H8W9   A0A212EPD8   C0HKS5   A0A2H1WPS9   A0A194QKH9   O09210   A0A0L7KP19   A0A2A4JKR2   A0A194RGH1   M4QEN0   A0A2H1WZT3   A0A385H8X0   A0A2W1BXR4   A0EZS0   S4NYE8   A0A194RFE4   A0A2H1WPT3   A0A1S4F886   Q17CI7   M4QG01   A0A1S4F823   Q17CI6   A0A023EHB8   A0A194Q5I3   A0A2A4J1N6  

PDB

1BON     E-value=1.96333e-09,     Score=142

KEGG

100169707    no KO assigned | (RefSeq) Bbx-a10, bbxA10; bombyxin A-10

GO

GO:0005179   GO:0008083   GO:0005615   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.998787

 

 

Length:

82

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.25898

Exp number, first 60 AAs:

0.25898

Total prob of N-in:

0.07643

outside

1  -  82

 

 

Pi

339.219154

Theta

233.225516

Tajima's D

1.431317

CLR

0

CSRT

0.772111394430279

Interpretation

Uncertain