Gene

KWMTBOMO06388

Pre Gene Modal

BGIBMGA014205

Annotation

bombyxin_A-7_precursor_[Bombyx_mori]

Location

Bomo_Chr11(-):6113750-6114200      View in EpiBrowser

Full name

Bombyxin A-5       + More
Bombyxin A-9      
Bombyxin A-7      
Bombyxin A      
Bombyxin A-6      
Bombyxin A-1      
Bombyxin A-4      
Bombyxin A-3      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin B-3      
Bombyxin B-2      
Bombyxin B-12      
Bombyxin B-10      
Bombyxin C-1      
Bombyxin B      
Bombyxin B-4      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin B-8      
Bombyxin D-1      
Bombyxin B-6      
Bombyxin C-2      
Bombyxin B-9      
Bombyxin B-5      
Bombyxin E-1      
Bombyxin G-1      
Bombyxin B-11      
Bombyxin B-2 homolog      
Bombyxin B-1 homolog      
Insulin-related peptide 2      
Bombyxin F-1      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Insulin-related peptide 4      
Bombyxin A-3 homolog      
Bombyxin A-2 homolog      
Bombyxin A-1 homolog      
Insulin-related peptide 1      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.6

CDS

ATGAAATTACTCCTTGCTATTGCATTAATGTTGACAACAGTAATGTGGGCGTCAACACAACAGCCTCAAACAGTGCACACGTACTGCGGGCATCACTTGGCCCGCACTCTGGCCGACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCGATGCTCAGTTCGCGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGAAGGGCGCGACCAACGAGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTATTGTTAG

Protein

MKLLLAIALMLTTVMWASTQQPQTVHTYCGHHLARTLADLCWEAGVDKRSDAQFASYGSAWLMPYSEGRDQRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   Direct protein sequencing   3D-structure   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-5 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

P26728   P26732   P26730   H9JQX3   P26729   Q17192   + More
P26727   P26726   P26731   P15411   Q17193   H9JY76   H9JQX2   P26737   P26734   P29519   Q17194   P15410   H9JY77   P26738   P26733   P26741   H9JY78   H9JR12   P26742   P26736   P26740   H9JR11   P26735   P26743   Q53X51   P26739   P21808   H9JRY4   O61271   Q17196   P33722   P33721   C0HKS4   H9JQX4   P91896   M4QC54   A0A385H8W6   B9A0V1   M4QNU1   O09209   A0A385H8W3   H9JRY3   A0A2A4JKA0   A0A2H1WZM1   A0A212EPD8   Q4JJX8   M4QEN0   A0A2A4JKR2   F6KMX2   A0A194RFE4   A0A2W1BXR4   A0A194RGH1   O09210   A0A2H1WD29   A0A2H1WLR7   A0A194Q5I3   A0A2H1WPS9   A0A2H1WD32   A0A2H1WTS8   S4NYE8   A0A194QKH9   A0A194PZ95   C0HKS5   A0A385H8W9   A0A194RG26   A0A0L7KQ08   M4QG01   A0A2H1X245   A0A2A4J1N6   A0A194PZA6   A0A385H8X0   A0A0L7KP19   A0A2H1WZT3   A0A385H8W5   A0A0L7L7G8   P33720   A0A087T302   A0A2H1WPT3   A0A194PJ20   A0A3S2NJC1   A0A194RKP6   A0A385H8W4   P33719   P33718   H9ITT7   F8WTP8   C0HKS3   A0A194Q0Y1   A0EZS0   A0A1S4F886   A0A023EHB8   F6KMX3   Q17CI7  

Pubmed

8683595    16593744    19121390    7473749    2674935    2708384    + More
9253178    1515030    9732555    1601275    29466015    9401466    30171635    8673077    22118469    17559850    26354079    28756777    23622113    26227816    16934367    24945155    17510324   

EMBL

D00770    D00776    D00772    D00773    BABH01028595    D00771    + More
D00340    D00769    M26069    D00774    D00775    J04727    M26068    D00777    BAA00673.1    BABH01042454    BABH01028597    D00778    D00789    D00787    D00790    D00791    J04728    D00779    D00782    D00783    BABH01042456    D00784    D00797    AB003905    D00781    BABH01028594    D00792    D00785    D00786    BAA00682.1    D00780    D78138    BABH01016939    AB010380    AB010381    D00788    D13924    D13923    AB001049    AB001050    KC340940    AGH25572.1    MH028092    AXY04261.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    KC340941    AGH25573.1    D63147    D63146    MH028095    AXY04264.1    NWSH01001233    PCG72024.1    ODYU01012310    SOQ58560.1    AGBW02013503    OWR43321.1    DQ080209    AAY84557.1    KC340942    AGH25574.1    PCG72023.1    HQ451072    AEE43936.1    KQ460211    KPJ16548.1    KZ149928    PZC77476.1    KPJ16544.1    D63148    BAA20092.1    ODYU01007848    SOQ50980.1    ODYU01009526    SOQ54023.1    KQ459583    KPI98655.1    ODYU01010158    SOQ55081.1    ODYU01007998    SOQ50979.1    SOQ51243.1    ODYU01011005    SOQ56475.1    GAIX01011802    JAA80758.1    KQ461198    KPJ06073.1    KPI98657.1    MH028097    AXY04266.1    KPJ16547.1    JTDY01007633    KOB65059.1    KC340943    AGH25575.1    ODYU01012871    SOQ59389.1    NWSH01003834    PCG65779.1    KPI98656.1    MH028093    AXY04262.1    JTDY01000351    KOB65058.1    KOB77585.1    SOQ58561.1    MH028098    AXY04267.1    JTDY01002420    KOB71447.1    D13925    KK113157    KFM59491.1    SOQ55080.1    KQ459606    KPI91080.1    RSAL01000529    RVE41449.1    KPJ16546.1    MH028096    AXY04265.1    BABH01006963    AB661462    BAK57501.1    KPI98654.1    DQ845755    ABI64121.1    GAPW01005354    JAC08244.1    HQ451073    AEE43937.1    CH477308    EAT44034.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000054359    UP000283053    UP000008820   

PRIDE

P26728    P26732    P26730    H9JQX3    P26729    P26727    + More
P26726    P26731    P15411    Q17193    H9JY76    H9JQX2    P26737    P26734    P29519    Q17194    P15410    H9JY77    P26738    P26733    P26741    H9JY78    H9JR12    P26742    P26736    P26740    H9JR11    P26735    P26743    P26739    P21808    H9JRY4    O61271    Q17196    H9JQX4    P91896    B9A0V1    H9JRY3    P33719    H9ITT7    F8WTP8   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR040228   Insulin-relat-peptide_inver        + More
IPR022352   Insulin_family       
IPR017097   Bombyxin       
IPR016179   Insulin-like       
IPR036438   Insulin-like_sf       
IPR022353   Insulin_CS       
IPR030680   Bombyxin_A       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

P26728   P26732   P26730   H9JQX3   P26729   Q17192   + More
P26727   P26726   P26731   P15411   Q17193   H9JY76   H9JQX2   P26737   P26734   P29519   Q17194   P15410   H9JY77   P26738   P26733   P26741   H9JY78   H9JR12   P26742   P26736   P26740   H9JR11   P26735   P26743   Q53X51   P26739   P21808   H9JRY4   O61271   Q17196   P33722   P33721   C0HKS4   H9JQX4   P91896   M4QC54   A0A385H8W6   B9A0V1   M4QNU1   O09209   A0A385H8W3   H9JRY3   A0A2A4JKA0   A0A2H1WZM1   A0A212EPD8   Q4JJX8   M4QEN0   A0A2A4JKR2   F6KMX2   A0A194RFE4   A0A2W1BXR4   A0A194RGH1   O09210   A0A2H1WD29   A0A2H1WLR7   A0A194Q5I3   A0A2H1WPS9   A0A2H1WD32   A0A2H1WTS8   S4NYE8   A0A194QKH9   A0A194PZ95   C0HKS5   A0A385H8W9   A0A194RG26   A0A0L7KQ08   M4QG01   A0A2H1X245   A0A2A4J1N6   A0A194PZA6   A0A385H8X0   A0A0L7KP19   A0A2H1WZT3   A0A385H8W5   A0A0L7L7G8   P33720   A0A087T302   A0A2H1WPT3   A0A194PJ20   A0A3S2NJC1   A0A194RKP6   A0A385H8W4   P33719   P33718   H9ITT7   F8WTP8   C0HKS3   A0A194Q0Y1   A0EZS0   A0A1S4F886   A0A023EHB8   F6KMX3   Q17CI7  

PDB

1BON     E-value=3.02078e-08,     Score=132

KEGG

100169658    no KO assigned | (RefSeq) Bbx-a5, bbxA5; bombyxin A-5

GO

GO:0005179   GO:0005615   GO:0008083   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.999157

 

 

Length:

92

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.19037

Exp number, first 60 AAs:

0.19037

Total prob of N-in:

0.06682

outside

1  -  92

 

 

Pi

254.175198

Theta

179.821818

Tajima's D

1.300933

CLR

0.284911

CSRT

0.738263086845658

Interpretation

Uncertain