Gene

KWMTBOMO06387

Pre Gene Modal

BGIBMGA011929

Annotation

PREDICTED:_bombyxin_A-1_[Bombyx_mori]

Location

Bomo_Chr11(-):6108017-6108460      View in EpiBrowser

Full name

Bombyxin A-1       + More
Bombyxin A-6      
Bombyxin A-4      
Bombyxin A      
Bombyxin A-3      
Bombyxin A-7      
Bombyxin A-9      
Bombyxin A-5      
Bombyxin A-2      
Bombyxin A-8      
Bombyxin B-3      
Bombyxin B-2      
Bombyxin B-10      
Bombyxin B      
Bombyxin B-4      
Bombyxin B-12      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin C-1      
Bombyxin D-1      
Bombyxin B-8      
Bombyxin C-2      
Bombyxin B-6      
Bombyxin B-9      
Bombyxin E-1      
Bombyxin B-5      
Bombyxin B-2 homolog      
Bombyxin B-1 homolog      
Bombyxin B-11      
Insulin-related peptide 2      
Bombyxin G-1      
Bombyxin F-1      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Insulin-related peptide 4      
Insulin-related peptide 1      
Bombyxin A-3 homolog      
Bombyxin A-2 homolog      
Bombyxin A-1 homolog      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.512

CDS

ATGAAGATACTCCTTGCTATTGCATTAATGTTGTCAACAGTAATGTGGGTGTCAACACAACAGCCACAAAGAGTGCACACGTACTGCGGGCGTCACTTGGCTCGCACTCTGGCCGACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCGGTGCTCAGTTCGCGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGAAGGACGCGGCAAACGAGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTACTGTTAG

Protein

MKILLAIALMLSTVMWVSTQQPQRVHTYCGRHLARTLADLCWEAGVDKRSGAQFASYGSAWLMPYSEGRGKRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Direct protein sequencing   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-1 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

Q17192   P26729   P26727   H9JQX3   P26726   P26730   + More
P26732   P26728   P15411   P26731   H9JY76   Q17193   H9JQX2   P26737   P26734   Q17194   H9JY77   P26738   P29519   H9JY78   P26733   P26741   P15410   H9JR12   H9JR11   P26736   P26742   P26735   P26740   P26743   P21808   Q53X51   P26739   H9JRY4   P33722   P33721   Q17196   C0HKS4   O61271   M4QC54   A0A385H8W6   H9JQX4   P91896   A0A385H8W3   M4QNU1   A0A2A4JKA0   A0A2H1WZM1   O09209   Q4JJX8   A0A194RGH1   M4QEN0   B9A0V1   A0A2H1WD29   A0A2H1WLR7   F6KMX2   A0A2A4JKR2   A0A2H1WTS8   O09210   A0A2H1WD32   A0A212EPD8   A0A385H8W9   A0A0L7KQ08   A0A2W1BXR4   H9JRY3   A0A194PZ95   A0A194RFE4   A0A2H1WPS9   S4NYE8   A0A0L7KP19   A0A194PZA6   A0A385H8X0   C0HKS5   A0A2H1WPT3   A0A194Q5I3   A0A2H1WZT3   A0A194QKH9   A0A194RG26   A0A194RKP6   C0HKS3   M4QG01   A0A385H8W5   A0A2H1X245   A0A2A4J1N6   P33720   A0A194Q0Y1   P33719   P33718   A0A194RGU3   A0A385H8W4   A0A212F2W7   A0A087T302   A0A336MJK3   A0A194Q039   A0A194PJ20   A0A0L7L7G8   A0A3S2NJC1   A0A194RFD7   H9ITT7  

Pubmed

8683595    16593744    7473749    19121390    2674935    2708384    + More
9253178    1515030    1601275    29466015    9732555    30171635    9401466    8673077    26354079    17559850    22118469    26227816    28756777    23622113   

EMBL

D00340    D00771    D00769    BABH01028595    M26069    D00772    + More
D00773    D00776    D00770    J04727    M26068    D00774    D00775    BABH01042454    D00777    BAA00673.1    BABH01028597    D00778    D00787    D00779    D00789    BABH01042456    D00782    D00783    D00790    D00791    J04728    BABH01028594    D00797    AB003905    D00784    D00792    D00781    D00785    D78138    D00786    BAA00682.1    D00780    BABH01016939    D13924    D13923    D00788    AB010380    AB010381    KC340940    AGH25572.1    MH028092    AXY04261.1    AB001049    AB001050    MH028095    AXY04264.1    KC340941    AGH25573.1    NWSH01001233    PCG72024.1    ODYU01012310    SOQ58560.1    D63147    D63146    DQ080209    AAY84557.1    KQ460211    KPJ16544.1    KC340942    AGH25574.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    ODYU01007848    SOQ50980.1    ODYU01009526    SOQ54023.1    HQ451072    AEE43936.1    PCG72023.1    ODYU01011005    SOQ56475.1    D63148    BAA20092.1    ODYU01007998    SOQ50979.1    SOQ51243.1    AGBW02013503    OWR43321.1    MH028097    AXY04266.1    JTDY01007633    KOB65059.1    KZ149928    PZC77476.1    KQ459583    KPI98657.1    KPJ16548.1    ODYU01010158    SOQ55081.1    GAIX01011802    JAA80758.1    JTDY01000351    KOB65058.1    KOB77585.1    KPI98656.1    MH028093    AXY04262.1    SOQ55080.1    KPI98655.1    SOQ58561.1    KQ461198    KPJ06073.1    KPJ16547.1    KPJ16546.1    KC340943    AGH25575.1    MH028098    AXY04267.1    ODYU01012871    SOQ59389.1    NWSH01003834    PCG65779.1    D13925    KPI98654.1    KPJ16545.1    MH028096    AXY04265.1    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    KK113157    KFM59491.1    UFQS01001151    UFQT01001151    SSX09257.1    SSX29159.1    KPI98658.1    KQ459606    KPI91080.1    JTDY01002420    KOB71447.1    RSAL01000529    RVE41449.1    KPJ16543.1    BABH01006963   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000037510    UP000053268    + More
UP000054359    UP000283053   

PRIDE

P26729    P26727    H9JQX3    P26726    P26730    P26732    + More
P26728    P15411    P26731    H9JY76    Q17193    H9JQX2    P26737    P26734    Q17194    H9JY77    P26738    P29519    H9JY78    P26733    P26741    P15410    H9JR12    H9JR11    P26736    P26742    P26735    P26740    P26743    P21808    P26739    H9JRY4    Q17196    O61271    H9JQX4    P91896    B9A0V1    H9JRY3    P33719    H9ITT7   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR036438   Insulin-like_sf        + More
IPR022353   Insulin_CS       
IPR030680   Bombyxin_A       
IPR022352   Insulin_family       
IPR017097   Bombyxin       
IPR040228   Insulin-relat-peptide_inver       
IPR016179   Insulin-like       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

Q17192   P26729   P26727   H9JQX3   P26726   P26730   + More
P26732   P26728   P15411   P26731   H9JY76   Q17193   H9JQX2   P26737   P26734   Q17194   H9JY77   P26738   P29519   H9JY78   P26733   P26741   P15410   H9JR12   H9JR11   P26736   P26742   P26735   P26740   P26743   P21808   Q53X51   P26739   H9JRY4   P33722   P33721   Q17196   C0HKS4   O61271   M4QC54   A0A385H8W6   H9JQX4   P91896   A0A385H8W3   M4QNU1   A0A2A4JKA0   A0A2H1WZM1   O09209   Q4JJX8   A0A194RGH1   M4QEN0   B9A0V1   A0A2H1WD29   A0A2H1WLR7   F6KMX2   A0A2A4JKR2   A0A2H1WTS8   O09210   A0A2H1WD32   A0A212EPD8   A0A385H8W9   A0A0L7KQ08   A0A2W1BXR4   H9JRY3   A0A194PZ95   A0A194RFE4   A0A2H1WPS9   S4NYE8   A0A0L7KP19   A0A194PZA6   A0A385H8X0   C0HKS5   A0A2H1WPT3   A0A194Q5I3   A0A2H1WZT3   A0A194QKH9   A0A194RG26   A0A194RKP6   C0HKS3   M4QG01   A0A385H8W5   A0A2H1X245   A0A2A4J1N6   P33720   A0A194Q0Y1   P33719   P33718   A0A194RGU3   A0A385H8W4   A0A212F2W7   A0A087T302   A0A336MJK3   A0A194Q039   A0A194PJ20   A0A0L7L7G8   A0A3S2NJC1   A0A194RFD7   H9ITT7  

PDB

1BON     E-value=3.56834e-09,     Score=140

KEGG

101736783    no KO assigned | (RefSeq) bombyxin A-1

GO

GO:0005179   GO:0005615   GO:0008083   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.997603

 

 

Length:

92

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.26437

Exp number, first 60 AAs:

0.26424

Total prob of N-in:

0.09946

outside

1  -  92

 

 

Pi

24.758686

Theta

54.073648

Tajima's D

-0.333941

CLR

361.060078

CSRT

0.27613619319034

Interpretation

Uncertain