Gene

KWMTBOMO06386

Pre Gene Modal

BGIBMGA011930

Annotation

bombyxin_F-1_precursor_[Bombyx_mori]

Location

Bomo_Chr11(+):6100361-6100780      View in EpiBrowser

Full name

Bombyxin F-1       + More
Bombyxin A-3      
Bombyxin A-7      
Bombyxin A-4      
Bombyxin A-9      
Bombyxin A-6      
Bombyxin A      
Bombyxin A-1      
Bombyxin E-1      
Bombyxin A-5      
Bombyxin A-8      
Bombyxin G-1      
Bombyxin A-2      
Bombyxin C-1      
Bombyxin D-1      
Bombyxin B-2 homolog      
Bombyxin B-2      
Bombyxin B-4      
Bombyxin B      
Bombyxin B-1      
Bombyxin B-1 homolog      
Bombyxin B-7      
Bombyxin B-12      
Bombyxin-related peptide A      
Bombyxin C-2      
Bombyxin B-3      
Bombyxin B-10      
Bombyxin B-6      
Bombyxin B-8      
Bombyxin-related peptide B      
Insulin-related peptide 2      
Bombyxin B-9      
Bombyxin B-5      
Insulin-related peptide 1      
Insulin-related peptide 4      
Probable insulin-like peptide 3      
Bombyxin B-11      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP
Insulin-related peptide 3

Location in the cell

Extracellular   Reliability : 3.489

CDS

ATGAAGTTGGTTGTTATCGTCCTGTTGGTGATTTCCGTCAGCATTTTGGTGTCAGCGCAAGAGTTAGGAGGCTCTCGTAGATATTGTGGACGACACCTAGCTCAGACTATGGCAGTGCTCTGCTGGGGCATAGATGAAATGTCAGCCGAGAAACGTAATAGTGATATGGTTTATGAAGACTCCGGCATGCCCGAACTTCTCCCGGCTGATGCTCGTAAAAAGCGAGGCATCATCGACGAATGTTGTCTCCAAGCCTGCACCCGGGACGTCCTTCTGTCTTACTGCTAG

Protein

MKLVVIVLLVISVSILVSAQELGGSRRYCGRHLAQTMAVLCWGIDEMSAEKRNSDMVYEDSGMPELLPADARKKRGIIDECCLQACTRDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Reference proteome   Secreted   Signal   Pyrrolidone carboxylic acid   Direct protein sequencing   3D-structure   Amidation   Neuropeptide  

Feature

peptide  Bombyxin F-1 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

H9JQX4   P91896   P26726   P26730   H9JY76   P26727   + More
P26732   H9JRY4   P26729   H9JQX3   Q17192   P21808   P26728   H9JQX2   P26731   O61271   P15411   P15410   P26736   Q4JJX8   P33722   P26734   P26738   H9JY77   P26733   H9JY78   P33721   P26741   P29519   O09209   H9JR12   M4QC54   P26735   P26737   H9JR11   Q17194   P26740   H9JRY3   P26742   O09210   C0HKS4   A0A2H1WTS8   A0A2H1WD29   A0A2A4JKA0   B9A0V1   M4QNU1   A0A2A4JKR2   A0A2H1WLR7   P26743   A0A0L7KP19   M4QEN0   A0A2W1BXR4   A0A385H8W3   A0A385H8X0   A0A2H1WPS9   Q53X51   P26739   C0HKS3   B3NGM0   A0A194PZA6   A0A194Q7C8   C0HKS5   A0A2H1WZM1   A0A385H8W6   B4HLB1   A0A2A4JGH3   A0A087U844   E7BBS2   Q9VT52   A0A212F2W7   A0A194PZ95   B4QNP6   Q4V6B2   A0A2H1V286   A0A194Q039   A0A1E1G7T0   A0A2H1WPT3   A0A2W1BUP0   A0A026WJK1   F6KMX2   A0A385H8W9   Q17196   F6KMX3   A0A194RGH1   A0A0C9QS78   A0A0C9RE29   A0A2H1WZT3   A0A2H1WD32   A0A3Q8S5S4   A0A194RG26   A0A3L8E218   A0A194RFD7   A0A194RKP6   A0A182W2H7   A0A194Q5I3   A0A2H1X245   A0A2A3EE95   A0A3S2NJC1  

Pubmed

19121390    9401466    2674935    8683595    16593744    7473749    + More
9253178    1515030    9732555    2708384    1601275    8673077    29466015    26227816    28756777    30171635    17994087    26354079    10731132    12537572    11250149    22118469    22936249    24508170    17559850    30467353    30249741   

EMBL

BABH01028594    AB001049    AB001050    M26069    D00772    D00773    + More
BABH01042454    D00769    D00776    BABH01016939    D00771    BABH01028595    D00340    D78138    D00770    BABH01028597    D00774    D00775    AB010380    AB010381    J04727    M26068    D00790    D00791    J04728    D00797    AB003905    DQ080209    AAY84557.1    D13924    D00779    BABH01042456    D13923    D00782    D00783    D00789    D63147    D63146    KC340940    AGH25572.1    D00792    D00778    D00787    D00781    D00784    D63148    BAA20092.1    ODYU01011005    SOQ56475.1    ODYU01007848    SOQ50980.1    NWSH01001233    PCG72024.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    KC340941    AGH25573.1    PCG72023.1    ODYU01009526    SOQ54023.1    D00785    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    KC340942    AGH25574.1    KZ149928    PZC77476.1    MH028095    AXY04264.1    MH028093    AXY04262.1    ODYU01010158    SOQ55081.1    D00786    BAA00682.1    D00780    CH954178    EDV51256.1    KQ459583    KPI98656.1    KQ459324    KPJ01447.1    ODYU01012310    SOQ58560.1    MH028092    AXY04261.1    CH480815    EDW40930.1    NWSH01001540    PCG70919.1    KK118648    KFM73533.1    KX532021    FR751150    HE654170    HE654171    HE654172    HE654173    HE654174    HE654175    HE654176    HE654177    HE654178    HE654179    ANY27831.1    CBY85560.1    CCF74162.1    CCF74166.1    CCF74170.1    CCF74174.1    CCF74178.1    CCF74182.1    CCF74186.1    CCF74190.1    CCF74194.1    CCF74198.1    AE014296    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    KPI98657.1    FR751157    HE654180    CM000363    CM002912    CBY85567.1    CCF74202.1    EDX09913.1    KMY98773.1    BT022394    AAY54810.1    ODYU01000348    SOQ34957.1    KPI98658.1    LC146509    BAV78813.1    SOQ55080.1    KZ149897    PZC78689.1    KK107168    EZA56175.1    HQ451072    AEE43936.1    MH028097    AXY04266.1    D00788    HQ451073    AEE43937.1    KQ460211    KPJ16544.1    GBYB01006609    JAG76376.1    GBYB01006610    GBYB01006611    JAG76377.1    JAG76378.1    SOQ58561.1    ODYU01007998    SOQ50979.1    SOQ51243.1    MH311632    AZK31342.1    KPJ16547.1    QOIP01000001    RLU26771.1    KPJ16543.1    KPJ16546.1    KPI98655.1    ODYU01012871    SOQ59389.1    KZ288288    PBC29331.1    RSAL01000529    RVE41449.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000008711    UP000053268    UP000001292    + More
UP000054359    UP000000803    UP000007151    UP000000304    UP000053097    UP000053240    UP000279307    UP000075920    UP000242457    UP000283053   

PRIDE

H9JQX4    P91896    P26726    P26730    H9JY76    P26727    + More
P26732    H9JRY4    P26729    H9JQX3    P21808    P26728    H9JQX2    P26731    O61271    P15411    P15410    P26736    P26734    P26738    H9JY77    P26733    H9JY78    P26741    P29519    H9JR12    P26735    P26737    H9JR11    Q17194    P26740    H9JRY3    P26742    B9A0V1    P26743    P26739    Q9VT52    Q4V6B2    Q17196   

Pfam

PF00049   Insulin

Interpro

IPR022353   Insulin_CS        + More
IPR036438   Insulin-like_sf       
IPR022352   Insulin_family       
IPR017097   Bombyxin       
IPR040228   Insulin-relat-peptide_inver       
IPR016179   Insulin-like       
IPR030680   Bombyxin_A       
IPR027285   Bombyxin_B       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994       

ProteinModelPortal

H9JQX4   P91896   P26726   P26730   H9JY76   P26727   + More
P26732   H9JRY4   P26729   H9JQX3   Q17192   P21808   P26728   H9JQX2   P26731   O61271   P15411   P15410   P26736   Q4JJX8   P33722   P26734   P26738   H9JY77   P26733   H9JY78   P33721   P26741   P29519   O09209   H9JR12   M4QC54   P26735   P26737   H9JR11   Q17194   P26740   H9JRY3   P26742   O09210   C0HKS4   A0A2H1WTS8   A0A2H1WD29   A0A2A4JKA0   B9A0V1   M4QNU1   A0A2A4JKR2   A0A2H1WLR7   P26743   A0A0L7KP19   M4QEN0   A0A2W1BXR4   A0A385H8W3   A0A385H8X0   A0A2H1WPS9   Q53X51   P26739   C0HKS3   B3NGM0   A0A194PZA6   A0A194Q7C8   C0HKS5   A0A2H1WZM1   A0A385H8W6   B4HLB1   A0A2A4JGH3   A0A087U844   E7BBS2   Q9VT52   A0A212F2W7   A0A194PZ95   B4QNP6   Q4V6B2   A0A2H1V286   A0A194Q039   A0A1E1G7T0   A0A2H1WPT3   A0A2W1BUP0   A0A026WJK1   F6KMX2   A0A385H8W9   Q17196   F6KMX3   A0A194RGH1   A0A0C9QS78   A0A0C9RE29   A0A2H1WZT3   A0A2H1WD32   A0A3Q8S5S4   A0A194RG26   A0A3L8E218   A0A194RFD7   A0A194RKP6   A0A182W2H7   A0A194Q5I3   A0A2H1X245   A0A2A3EE95   A0A3S2NJC1  

KEGG

100146110    K04526 insulin | (RefSeq) Bbx-f1, BBXF1; bombyxin F1

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005179   GO:0008083   GO:0005615   GO:0018445   GO:0005576   GO:0007218   GO:0016021   GO:0008286   GO:0009743   GO:0045475   GO:0032008   GO:0030431   GO:0060180   GO:0061964   GO:0005158   GO:0007166   GO:0046854   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.997129

 

 

Length:

95

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

15.54128

Exp number, first 60 AAs:

15.54128

Total prob of N-in:

0.38665

POSSIBLE N-term signal

sequence

outside

1  -  95

 

 

Pi

137.529962

Theta

118.205266

Tajima's D

0.513197

CLR

0

CSRT

0.518274086295685

Interpretation

Uncertain