Gene

KWMTBOMO06385

Pre Gene Modal

BGIBMGA011929

Annotation

bombyxin_A-7_precursor_[Bombyx_mori]

Location

Bomo_Chr11(+):6095641-6096107      View in EpiBrowser

Full name

Bombyxin A       + More
Bombyxin A-6      
Bombyxin A-7      
Bombyxin A-4      
Bombyxin A-1      
Bombyxin A-9      
Bombyxin A-3      
Bombyxin A-5      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin B-3      
Bombyxin B-2      
Bombyxin B      
Bombyxin B-4      
Bombyxin B-12      
Bombyxin B-7      
Bombyxin B-1      
Bombyxin B-10      
Bombyxin C-1      
Bombyxin D-1      
Bombyxin B-6      
Bombyxin B-8      
Bombyxin C-2      
Bombyxin B-9      
Bombyxin B-5      
Bombyxin E-1      
Bombyxin B-2 homolog      
Bombyxin B-11      
Bombyxin B-1 homolog      
Bombyxin G-1      
Insulin-related peptide 2      
Bombyxin F-1      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Insulin-related peptide 4      
Bombyxin A-2 homolog      
Insulin-related peptide 1      
Bombyxin A-3 homolog      
Bombyxin A-1 homolog      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.325

CDS

ATGAAGTTACTCCTTGCTATTGCATTAATGTTGACAATAGTAATGTGGGTGTCAACACAACAGCCACAAGCAGTGCACACGTACTGTGGGCGTCACTTGGCTCGCACTCTGGCCGACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCGGTGCTCAGTTCGCGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGAAGGACGCGGCAAACGAGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTACTGTTAG

Protein

MKLLLAIALMLTIVMWVSTQQPQAVHTYCGRHLARTLADLCWEAGVDKRSGAQFASYGSAWLMPYSEGRGKRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

3D-structure   Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   Amidation   Neuropeptide  

Feature

chain  Bombyxin A
peptide  Bombyxin A-6 B chain
propeptide  C peptide like

Uniprot

H9JQX3   P26729   P26730   P26727   Q17192   P26732   + More
P26726   P26728   P26731   P15411   H9JY76   Q17193   H9JQX2   P26737   P26734   H9JY77   P26738   P29519   P26741   H9JY78   P26733   Q17194   H9JR12   P15410   H9JR11   P26736   P26740   P26742   P26735   P26743   Q53X51   P26739   P21808   H9JRY4   P33722   Q17196   P33721   O61271   C0HKS4   M4QC54   A0A385H8W6   H9JQX4   P91896   A0A385H8W3   A0A2H1WZM1   O09209   M4QNU1   M4QEN0   A0A2A4JKA0   B9A0V1   Q4JJX8   A0A2A4JKR2   F6KMX2   A0A194RGH1   A0A2W1BXR4   O09210   H9JRY3   A0A212EPD8   A0A2H1WD29   A0A2H1WLR7   A0A2H1WTS8   A0A2H1WD32   A0A194RFE4   A0A385H8W9   C0HKS5   A0A2H1WPS9   A0A194PZ95   A0A0L7KQ08   S4NYE8   A0A2H1WZT3   A0A194PZA6   A0A0L7KP19   A0A194Q5I3   A0A385H8X0   A0A2H1WPT3   A0A194QKH9   P33719   A0A194RG26   C0HKS3   A0A194RKP6   A0A385H8W5   A0A2H1X245   A0A194Q0Y1   P33720   A0EZS0   A0A194Q039   A0A1S4F886   Q17CI7   M4QG01   A0A385H8W4   A0A194RGU3   P33718   Q17CI6   A0A2A4J1N6   A0A1S4F823   A0A212F2W7   A0A087T302   A0A023EHB8  

Pubmed

19121390    8683595    16593744    7473749    2674935    2708384    + More
9253178    1515030    1601275    9732555    29466015    30171635    9401466    8673077    17559850    26354079    28756777    22118469    26227816    23622113    16934367    17510324    24945155   

EMBL

BABH01028595    D00771    D00772    D00773    D00769    D00340    + More
D00776    M26069    D00770    D00774    D00775    J04727    M26068    BABH01042454    D00777    BAA00673.1    BABH01028597    D00778    D00779    D00789    D00782    D00783    BABH01042456    D00787    D00790    D00791    J04728    BABH01028594    D00797    AB003905    D00781    D00784    D00792    D00785    D00786    BAA00682.1    D00780    D78138    BABH01016939    D13924    D00788    D13923    AB010380    AB010381    KC340940    AGH25572.1    MH028092    AXY04261.1    AB001049    AB001050    MH028095    AXY04264.1    ODYU01012310    SOQ58560.1    D63147    D63146    KC340941    AGH25573.1    KC340942    AGH25574.1    NWSH01001233    PCG72024.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    DQ080209    AAY84557.1    PCG72023.1    HQ451072    AEE43936.1    KQ460211    KPJ16544.1    KZ149928    PZC77476.1    D63148    BAA20092.1    AGBW02013503    OWR43321.1    ODYU01007848    SOQ50980.1    ODYU01009526    SOQ54023.1    ODYU01011005    SOQ56475.1    ODYU01007998    SOQ50979.1    SOQ51243.1    KPJ16548.1    MH028097    AXY04266.1    ODYU01010158    SOQ55081.1    KQ459583    KPI98657.1    JTDY01007633    KOB65059.1    GAIX01011802    JAA80758.1    SOQ58561.1    KPI98656.1    JTDY01000351    KOB65058.1    KOB77585.1    KPI98655.1    MH028093    AXY04262.1    SOQ55080.1    KQ461198    KPJ06073.1    KPJ16547.1    KPJ16546.1    MH028098    AXY04267.1    ODYU01012871    SOQ59389.1    KPI98654.1    D13925    DQ845755    ABI64121.1    KPI98658.1    CH477308    EAT44034.1    KC340943    AGH25575.1    MH028096    AXY04265.1    KPJ16545.1    DQ845756    ABI64122.1    EAT44035.1    NWSH01003834    PCG65779.1    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    KK113157    KFM59491.1    GAPW01005354    JAC08244.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000008820    UP000054359   

PRIDE

H9JQX3    P26729    P26730    P26727    P26732    P26726    + More
P26728    P26731    P15411    H9JY76    Q17193    H9JQX2    P26737    P26734    H9JY77    P26738    P29519    P26741    H9JY78    P26733    Q17194    H9JR12    P15410    H9JR11    P26736    P26740    P26742    P26735    P26743    P26739    P21808    H9JRY4    Q17196    O61271    H9JQX4    P91896    B9A0V1    H9JRY3    P33719   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR040228   Insulin-relat-peptide_inver        + More
IPR017097   Bombyxin       
IPR022352   Insulin_family       
IPR016179   Insulin-like       
IPR036438   Insulin-like_sf       
IPR022353   Insulin_CS       
IPR030680   Bombyxin_A       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

H9JQX3   P26729   P26730   P26727   Q17192   P26732   + More
P26726   P26728   P26731   P15411   H9JY76   Q17193   H9JQX2   P26737   P26734   H9JY77   P26738   P29519   P26741   H9JY78   P26733   Q17194   H9JR12   P15410   H9JR11   P26736   P26740   P26742   P26735   P26743   Q53X51   P26739   P21808   H9JRY4   P33722   Q17196   P33721   O61271   C0HKS4   M4QC54   A0A385H8W6   H9JQX4   P91896   A0A385H8W3   A0A2H1WZM1   O09209   M4QNU1   M4QEN0   A0A2A4JKA0   B9A0V1   Q4JJX8   A0A2A4JKR2   F6KMX2   A0A194RGH1   A0A2W1BXR4   O09210   H9JRY3   A0A212EPD8   A0A2H1WD29   A0A2H1WLR7   A0A2H1WTS8   A0A2H1WD32   A0A194RFE4   A0A385H8W9   C0HKS5   A0A2H1WPS9   A0A194PZ95   A0A0L7KQ08   S4NYE8   A0A2H1WZT3   A0A194PZA6   A0A0L7KP19   A0A194Q5I3   A0A385H8X0   A0A2H1WPT3   A0A194QKH9   P33719   A0A194RG26   C0HKS3   A0A194RKP6   A0A385H8W5   A0A2H1X245   A0A194Q0Y1   P33720   A0EZS0   A0A194Q039   A0A1S4F886   Q17CI7   M4QG01   A0A385H8W4   A0A194RGU3   P33718   Q17CI6   A0A2A4J1N6   A0A1S4F823   A0A212F2W7   A0A087T302   A0A023EHB8  

PDB

1BON     E-value=9.79043e-10,     Score=145

KEGG

100169708    K04526 insulin | (RefSeq) Bbx-a7, bbxA7; bombyxin A-7

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0008083   GO:0005615   GO:0005179   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.997328

 

 

Length:

92

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.55823

Exp number, first 60 AAs:

1.5579

Total prob of N-in:

0.11427

outside

1  -  92

 

 

Pi

260.446991

Theta

194.844732

Tajima's D

1.059677

CLR

0

CSRT

0.675766211689416

Interpretation

Uncertain