Gene

KWMTBOMO06384

Pre Gene Modal

BGIBMGA014494

Annotation

bombyxin_A-8_precursor_[Bombyx_mori]

Location

Bomo_Chr11(+):6090951-6091338      View in EpiBrowser

Full name

Bombyxin A-8       + More
Bombyxin A-2      
Bombyxin A-9      
Bombyxin A-1      
Bombyxin A-6      
Bombyxin A-4      
Bombyxin A-7      
Bombyxin A-5      
Bombyxin A-3      
Bombyxin A      
Bombyxin B-10      
Bombyxin B-3      
Bombyxin D-1      
Bombyxin B-2      
Bombyxin B      
Bombyxin B-4      
Bombyxin C-1      
Bombyxin B-12      
Bombyxin B-1      
Bombyxin B-7      
Bombyxin B-8      
Bombyxin B-6      
Bombyxin C-2      
Bombyxin B-5      
Bombyxin E-1      
Bombyxin B-9      
Bombyxin B-11      
Bombyxin G-1      
Bombyxin B-2 homolog      
Insulin-related peptide 2      
Bombyxin B-1 homolog      
Bombyxin F-1      
Bombyxin-related peptide A      
Insulin-related peptide 4      
Bombyxin-related peptide B      
Insulin-related peptide 1      
Bombyxin A-3 homolog      
Bombyxin A-1 homolog      
Bombyxin A-2 homolog      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
4K-prothoracicotropic hormone IV
Bombyxin IV
ABRP

Location in the cell

Extracellular   Reliability : 4.428

CDS

ATGAAGTTACTCCTTACTATTGCGTTAATGTTGTCAACAGTAATGTGGGTGTCAACACAACAGCCACAAGAAGTGCACACGTACTGCGGGCGCCACTTGGCTCGCACTATGGCCGACCTGTGCTGGGAAGCGGGCGTGGACAAGCGCAGCGATGCTCAGTTCGCGAGCTACGGCTCCGCGTGGCTGATGCCGTACTCGGCAGGACGCGGCATCGTGGATGAGTGCTGTCTCAGACCCTGCAGCGTGGACGTGCTTCTGTCGTACTGTTAG

Protein

MKLLLTIALMLSTVMWVSTQQPQEVHTYCGRHLARTMADLCWEAGVDKRSDAQFASYGSAWLMPYSAGRGIVDECCLRPCSVDVLLSYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Direct protein sequencing   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-8 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

P26731   P15411   P26732   Q17192   P26729   P26727   + More
P26730   P26728   P26726   H9JQX3   H9JQX2   Q17193   H9JY76   Q17194   P26737   P26736   P26734   H9JY77   P26738   P15410   H9JR11   H9JR12   P29519   P26733   P26741   H9JY78   P26742   P26740   P26735   Q53X51   P26739   P21808   H9JRY4   P26743   Q17196   O61271   P33722   C0HKS4   H9JQX4   P33721   P91896   M4QC54   A0A385H8W6   B9A0V1   H9JRY3   A0A2A4JKA0   O09209   M4QEN0   A0A2A4JKR2   M4QNU1   A0A385H8W3   F6KMX2   Q4JJX8   A0A2H1WZM1   A0A2W1BXR4   S4NYE8   A0A2H1WD29   A0A2H1WLR7   A0A2H1WPS9   A0A2H1WD32   A0A385H8X0   A0A2H1WTS8   A0A2H1WPT3   C0HKS5   A0A194QKH9   O09210   A0A385H8W9   A0A194RGH1   A0A212EPD8   A0A2H1WZT3   A0A194RFE4   A0A0L7KP19   A0A2H1X245   A0A194RG26   C0HKS3   H9ITT7   A0A194Q5I3   F8WTP8   A0A194PJ20   A0A194PZA6   A0A194PZ95   A0A385H8W5   P33720   A0A0L7KQ08   M4QG01   A0A087T302   A0A0L7L7G8   P33718   A0A2A4J1N6   A0A194RKP6   A0A3S2NJC1   P33719   A0EZS0   A0A1S4F823   Q17CI6   A0A1S4F886   Q17CI7   A0A212EZ83  

Pubmed

8683595    2708384    2674935    7473749    16593744    19121390    + More
9253178    1515030    9732555    1601275    29466015    9401466    30171635    8673077    17559850    28756777    23622113    26354079    22118469    26227816    16934367    17510324   

EMBL

D00774    D00775    J04727    M26068    D00776    D00340    + More
D00771    D00769    D00772    D00773    D00770    M26069    BABH01028595    BABH01028597    D00777    BAA00673.1    BABH01042454    D00787    D00778    D00797    AB003905    D00779    D00790    D00791    J04728    BABH01028594    D00789    D00782    D00783    BABH01042456    D00784    D00781    D00792    D00786    BAA00682.1    D00780    D78138    BABH01016939    D00785    D00788    AB010380    AB010381    D13924    D13923    AB001049    AB001050    KC340940    AGH25572.1    MH028092    AXY04261.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    NWSH01001233    PCG72024.1    D63147    D63146    KC340942    AGH25574.1    PCG72023.1    KC340941    AGH25573.1    MH028095    AXY04264.1    HQ451072    AEE43936.1    DQ080209    AAY84557.1    ODYU01012310    SOQ58560.1    KZ149928    PZC77476.1    GAIX01011802    JAA80758.1    ODYU01007848    SOQ50980.1    ODYU01009526    SOQ54023.1    ODYU01010158    SOQ55081.1    ODYU01007998    SOQ50979.1    SOQ51243.1    MH028093    AXY04262.1    ODYU01011005    SOQ56475.1    SOQ55080.1    KQ461198    KPJ06073.1    D63148    BAA20092.1    MH028097    AXY04266.1    KQ460211    KPJ16544.1    AGBW02013503    OWR43321.1    SOQ58561.1    KPJ16548.1    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    ODYU01012871    SOQ59389.1    KPJ16547.1    BABH01006963    KQ459583    KPI98655.1    AB661462    BAK57501.1    KQ459606    KPI91080.1    KPI98656.1    KPI98657.1    MH028098    AXY04267.1    D13925    KOB65059.1    KC340943    AGH25575.1    KK113157    KFM59491.1    JTDY01002420    KOB71447.1    NWSH01003834    PCG65779.1    KPJ16546.1    RSAL01000529    RVE41449.1    DQ845755    ABI64121.1    DQ845756    CH477308    ABI64122.1    EAT44035.1    EAT44034.1    AGBW02011334    OWR46809.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000037510    UP000053268    + More
UP000054359    UP000283053    UP000008820   

PRIDE

P26731    P15411    P26732    P26729    P26727    P26730    + More
P26728    P26726    H9JQX3    H9JQX2    Q17193    H9JY76    Q17194    P26737    P26736    P26734    H9JY77    P26738    P15410    H9JR11    H9JR12    P29519    P26733    P26741    H9JY78    P26742    P26740    P26735    P26739    P21808    H9JRY4    P26743    Q17196    O61271    H9JQX4    P91896    B9A0V1    H9JRY3    H9ITT7    F8WTP8    P33719   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR036438   Insulin-like_sf        + More
IPR022353   Insulin_CS       
IPR030680   Bombyxin_A       
IPR017097   Bombyxin       
IPR022352   Insulin_family       
IPR040228   Insulin-relat-peptide_inver       
IPR016179   Insulin-like       
IPR027285   Bombyxin_B       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

P26731   P15411   P26732   Q17192   P26729   P26727   + More
P26730   P26728   P26726   H9JQX3   H9JQX2   Q17193   H9JY76   Q17194   P26737   P26736   P26734   H9JY77   P26738   P15410   H9JR11   H9JR12   P29519   P26733   P26741   H9JY78   P26742   P26740   P26735   Q53X51   P26739   P21808   H9JRY4   P26743   Q17196   O61271   P33722   C0HKS4   H9JQX4   P33721   P91896   M4QC54   A0A385H8W6   B9A0V1   H9JRY3   A0A2A4JKA0   O09209   M4QEN0   A0A2A4JKR2   M4QNU1   A0A385H8W3   F6KMX2   Q4JJX8   A0A2H1WZM1   A0A2W1BXR4   S4NYE8   A0A2H1WD29   A0A2H1WLR7   A0A2H1WPS9   A0A2H1WD32   A0A385H8X0   A0A2H1WTS8   A0A2H1WPT3   C0HKS5   A0A194QKH9   O09210   A0A385H8W9   A0A194RGH1   A0A212EPD8   A0A2H1WZT3   A0A194RFE4   A0A0L7KP19   A0A2H1X245   A0A194RG26   C0HKS3   H9ITT7   A0A194Q5I3   F8WTP8   A0A194PJ20   A0A194PZA6   A0A194PZ95   A0A385H8W5   P33720   A0A0L7KQ08   M4QG01   A0A087T302   A0A0L7L7G8   P33718   A0A2A4J1N6   A0A194RKP6   A0A3S2NJC1   P33719   A0EZS0   A0A1S4F823   Q17CI6   A0A1S4F886   Q17CI7   A0A212EZ83  

PDB

1BON     E-value=6.81538e-09,     Score=138

KEGG

100169709    no KO assigned | (RefSeq) Bbx-a8, bbxA8; bombyxin A-8

GO

GO:0005179   GO:0005615   GO:0008083   GO:0007218   GO:0005576   GO:0018445   GO:0016021   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.998740

 

 

Length:

89

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05897

Exp number, first 60 AAs:

0.05689

Total prob of N-in:

0.07896

outside

1  -  89

 

 

Pi

247.17307

Theta

217.47254

Tajima's D

0.428389

CLR

0.849266

CSRT

0.488425578721064

Interpretation

Uncertain