Gene

KWMTBOMO06378

Pre Gene Modal

BGIBMGA011974

Annotation

PREDICTED:_uncharacterized_protein_C18orf8_[Bombyx_mori]

Location

Bomo_Chr11(-):5948661-5960290      View in EpiBrowser

Full name

Tyrosine--tRNA ligase       + More
Regulator of MON1-CCZ1 complex      

Alternative Name

Tyrosyl-tRNA synthetase
Colon cancer-associated protein Mic1
WD repeat-containing protein 98

Location in the cell

Mitochondrial   Reliability : 0.985

CDS

ATGGCCAGATTTAATTTGAAAGATAGTGATGAATATTACTTGACTCTCACCGAACAGCCCAAACGTTTTGACCCGGACTGCCCTGTGACAAATGTATTTTTTGACGACACTAATGGACAGGTATTCACAGTACGTTCGGGTGGAATCGGAGGCGTAACCGTAAACAGTATGGATGATAGAAAGTGTACATCTTTCCAAATGGAAGACAAAGGACCCATAATATCAATTAAATTATCACCCGACCAGAAAATATTGGCGATACAACGTAATCATGAGAGTCAGAGTGCTGCAGTAGAATTCGTGAACTTCAAGGACATGTCACCTACTAATGTAGAGTACTCTCACAGCTGTAAATGGAAGAACGCAAAAATATTAGGCTTTGTTTGGCCTAAAGCAAACGAAATTGCGTTCATAACTGATCACGGTATTGAGCTGTTTCAAGTTTTACCTGAGAAAAAACAATTGAAAAGTTTGAAGAATACCACATTTAGTGGTGCGTGGTTTTCGTGGTGTCCACAAAGCAATATAGTATTGTTAGCTGGAAACAACGGAATCCTCTTGCAGCCATTTTACCTCAACAATTCTACTATAACAAAACTACAGAAGTTAGAGTTAGATTCAATGAGACCAGTGGTAGAAAGGGACGTCTTCCTGCTCTGCTTGTGCGACACGACATGGTGCGCTGTGTTCAGGCACGGCGTATCCGCTTCTGTTGCTGCCCCCGGGCCTACCGAGGTCTGGTTGATGCCCATTACGGGCCCCAGCGGCTTCCACTACACCCACATCCTCAAGACTGGACTGGTCGGGAGATTCGCTGTCAATGTGGTCGATGACTTGGTCGTAGTGCACCACCAGTCGACACAAACCTCACAAGTGTTCGACATAATGGAAGAGTCGAAGGTAGAGAACAGTATCGCCGTTCACATCCCGCTGGTGGCAGGAGCCAGCATGCGACCGGCCCTCGTGGAGGGGCAGCCGTGTTCCATGTATTCGGGCACGTGGGTGGTGTTCCAACCCGACTACATCATAGACGCCAGGCTCGGCTGTCTGTGGCAGGTCCAGCTGCTGCCAGCGGGGCTAGCGCACTCGGTGCCAAAAGACGAGATATCGAAGATAGTGGCCGCGCTGCTCCGTCGGACGGACGGCAGGGACACCATCTACAGGATCCTCCACCAGCTGATCAGCGACGCGGGAGTCTACCTGGTGGAGCTGTCTAAGGTCTTTGACGAAATCAATTCTGTTTACAGGAAGTGGGCGGACCTGGAGGCGGCGCGGCACACAGCGGGGCAGGTGGCGCCGCGCCCCCGCGCCCCCGCCCCCGCCCGCGTGCTCGTGTCGCAGGCCGACGTGTGCGAGCAGCTGCTGCCCGCGCACTCGGACGACCGCCATCTGGTGCAGGTGGTGACGGCGTACCTGGCGTCGCTGAGCCGGCAGGAGCTGGTGGTGCAGGCGGGCACGAGCGCGGCGGGAGTACGCGCGCTGGTGGCGCGGCGCGCGGGCGGGCGGCTGCGGGCGCTGGTGCGGCGCGCGGCGCTGGCCGACTCGCGCCCGCTCGCGTGCCAGCTGCTGTCCCTGCACCGCCTGCACGCCGCCGCCGCGCAGCTCGCGCTCGACATGCTGTGGAGGCTCAAGGGACACGAGGAAGTGGTAGAAGTACTACTGAGTTGGGAGGAGCCTATCAGCGCTGTGGGGGCAGCTAAGCAGGCAGGCGGTAACGTTTGGAACAATCTACCAGCTAGGAAGCTCTTGGCAGGAGCCAAGAATGACCCTTCTGCCTTCGTGGCGGTTTACCACGCCTTGCTCAACAGAAACGACAGGCTGAGGGGATCGCCGCATTTCTTGAAAGCTGAACAATGCGACATCTACGTTGAACACTATAAGAAATTGACTTCGGAACAATGA

Protein

MARFNLKDSDEYYLTLTEQPKRFDPDCPVTNVFFDDTNGQVFTVRSGGIGGVTVNSMDDRKCTSFQMEDKGPIISIKLSPDQKILAIQRNHESQSAAVEFVNFKDMSPTNVEYSHSCKWKNAKILGFVWPKANEIAFITDHGIELFQVLPEKKQLKSLKNTTFSGAWFSWCPQSNIVLLAGNNGILLQPFYLNNSTITKLQKLELDSMRPVVERDVFLLCLCDTTWCAVFRHGVSASVAAPGPTEVWLMPITGPSGFHYTHILKTGLVGRFAVNVVDDLVVVHHQSTQTSQVFDIMEESKVENSIAVHIPLVAGASMRPALVEGQPCSMYSGTWVVFQPDYIIDARLGCLWQVQLLPAGLAHSVPKDEISKIVAALLRRTDGRDTIYRILHQLISDAGVYLVELSKVFDEINSVYRKWADLEAARHTAGQVAPRPRAPAPARVLVSQADVCEQLLPAHSDDRHLVQVVTAYLASLSRQELVVQAGTSAAGVRALVARRAGGRLRALVRRAALADSRPLACQLLSLHRLHAAAAQLALDMLWRLKGHEEVVEVLLSWEEPISAVGAAKQAGGNVWNNLPARKLLAGAKNDPSAFVAVYHALLNRNDRLRGSPHFLKAEQCDIYVEHYKKLTSEQ

Description

Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162).

Catalytic Activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)

Subunit

Found in a complex with RMC1, CCZ1 MON1A and MON1B.

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.
Belongs to the RMC1 family.

Keywords

Autophagy   Complete proteome   Endosome   Lysosome   Membrane   Reference proteome  

Feature

chain  Regulator of MON1-CCZ1 complex

Uniprot

A0A2A4JNA9   A0A2A4JLW7   A0A2W1BYG5   A0A212EJ28   A0A2H1VXR0   A0A0N1PKG0   + More
K7IPJ5   A0A232F423   E9INW8   A0A1L8DAT8   A0A182H294   A0A0L7R0M1   F4WH29   Q16YN5   A0A1B0CUY8   A0A154PP96   A0A067RIM8   E2BEF6   A0A195CTJ2   A0A0C9QXM8   A0A336N2B0   A0A336MM14   A0A151JWB8   A0A0L8FQH6   A0A158NT90   A0A2C9KK17   A0A195E3C8   A0A0C9RK10   E2A5A8   A0A226EYR3   A0A3L8D2M2   A0A088AP33   A0A2Y9P611   A0A1Y1MXS9   T1IWP7   A0A3B3XQN6   N6U4N5   A0A2Y9SHQ8   A0A146YIV9   A0A0L8FQN6   A0A139WKS6   V4B0J6   A0A340WLZ9   A0A087YHN7   A0A3B3V8S5   W5M0I6   A0A2U4AZ40   A0A3P8RVK3   V5IDY0   U4UBY7   A0A1W4ZTM9   A0A3B5PVT3   A0A250YKU4   A0A1S3ID23   A0A2K5Z8N1   A0A1W4WFA4   A0A3S2MGU0   A0A287A4H7   V9KK72   E1BHW7   A0A3Q1GPP9   G3QQX7   H2QEC4   F7IQV6   A0A1L8H8A2   A0A2K5RB78   F7E5Z1   Q96DM3   A0A3B4UUY0   A0A2K6DFW0   A0A2K6LAJ3   A0A0D9RYL8   A0A096N685   A0A2K6PJS9   A0A2K5MRB0   H9YZM4   H2NW17   A0A2R9AR20   A0A3Q7Q8Y6   M3VUX5   B0VZT4   G7PWI4   A0A2D4IE86   A0A195BUR0   A0A1U7Q7T4   H0XBD2   E9FQM0   A0A2K5EGB6   A0A0P5MIT7   A0A2Y9E668   A0A3B4F3H1   A0A3P9CXL8   A4IHS1   H0V7B0   A0A2U3WW73  

EC Number

6.1.1.1

Pubmed

28756777    22118469    26354079    20075255    28648823    21282665    + More
26483478    21719571    17510324    24845553    20798317    21347285    15562597    30249741    28004739    23537049    18362917    19820115    23254933    25765539    23542700    28087693    30723633    24402279    19393038    22398555    16136131    27762356    17431167    14702039    16177791    15489334    17897319    23186163    29038162    25362486    25319552    22722832    17975172    22002653    21292972    25186727    21993624   

EMBL

NWSH01001020    PCG73074.1    PCG73075.1    KZ149897    PZC78695.1    AGBW02014545    + More
OWR41468.1    ODYU01005074    SOQ45598.1    KQ459692    KPJ20425.1    NNAY01001008    OXU25511.1    GL764397    EFZ17717.1    GFDF01010542    JAV03542.1    JXUM01104940    KQ564928    KXJ71556.1    KQ414670    KOC64336.1    GL888148    EGI66508.1    CH477513    EAT39738.1    AJWK01029841    KQ435007    KZC13682.1    KK852609    KDR20306.1    GL447768    EFN86001.1    KQ977329    KYN03449.1    GBYB01008539    JAG78306.1    UFQT01003365    SSX34917.1    UFQT01001291    SSX29873.1    KQ981686    KYN37947.1    KQ427521    KOF66976.1    ADTU01025732    KQ979701    KYN19581.1    GBYB01008540    JAG78307.1    GL436894    EFN71389.1    LNIX01000001    OXA62745.1    QOIP01000014    RLU14755.1    GEZM01017806    GEZM01017804    GEZM01017803    GEZM01017802    JAV90453.1    JH431627    APGK01043065    KB741011    ENN75566.1    GCES01032212    GCES01003365    JAR54111.1    KOF66977.1    KQ971322    KYB28599.1    KB199952    ESP03633.1    AYCK01020879    AYCK01020880    AHAT01004140    GANP01011152    JAB73316.1    KB631957    ERL87460.1    GFFW01000642    JAV44146.1    CM012456    RVE59085.1    AEMK02000045    DQIR01292723    DQIR01297601    HDC48201.1    JW866360    AFO98877.1    CABD030108617    AACZ04065262    NBAG03000249    PNI61442.1    CM004469    OCT92310.1    JSUE03019310    JSUE03019311    AK057192    BC002950    BC008305    AF143536    AC010853    AC026634    AQIB01129108    AHZZ02012420    JU472336    AFH29140.1    ABGA01346099    ABGA01346100    ABGA01346101    NDHI03003366    PNJ81079.1    AJFE02106629    AJFE02106630    AJFE02106631    AJFE02106632    AANG04003548    DS231815    EDS35176.1    AQIA01032729    CM001293    EHH58807.1    IACK01094361    IACK01094363    LAA82528.1    KQ976409    KYM90931.1    AAQR03029291    AAQR03029292    AAQR03029293    AAQR03029294    AAQR03029295    AAQR03029296    AAQR03029297    GL732523    EFX90343.1    GDIQ01178704    JAK73021.1    BC135661    AAI35662.1    AAKN02020644   

Proteomes

UP000218220    UP000007151    UP000053240    UP000002358    UP000215335    UP000069940    + More
UP000249989    UP000053825    UP000007755    UP000008820    UP000092461    UP000076502    UP000027135    UP000008237    UP000078542    UP000078541    UP000053454    UP000005205    UP000076420    UP000078492    UP000000311    UP000198287    UP000279307    UP000005203    UP000248483    UP000261480    UP000019118    UP000248484    UP000265000    UP000007266    UP000030746    UP000265300    UP000028760    UP000261500    UP000018468    UP000245320    UP000265080    UP000030742    UP000192224    UP000002852    UP000085678    UP000233140    UP000192223    UP000008227    UP000009136    UP000257200    UP000001519    UP000002277    UP000008225    UP000186698    UP000233040    UP000006718    UP000005640    UP000261420    UP000233120    UP000233180    UP000029965    UP000028761    UP000233200    UP000233060    UP000001595    UP000240080    UP000286641    UP000011712    UP000002320    UP000009130    UP000233100    UP000078540    UP000189706    UP000005225    UP000000305    UP000233020    UP000248480    UP000261460    UP000265160    UP000005447    UP000245340   

PRIDE

V5IDY0    Q96DM3   

Pfam

PF07035   Mic1        + More
PF00579   tRNA-synt_1b

Interpro

IPR009755   RMC1_C        + More
IPR040371   RMC1       
IPR036322   WD40_repeat_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR002305   aa-tRNA-synth_Ic       
IPR002307   Tyr-tRNA-ligase       
IPR001412   aa-tRNA-synth_I_CS       
IPR014729   Rossmann-like_a/b/a_fold       
IPR036986   S4_RNA-bd_sf       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10     3.10.290.10     3.40.50.620    

ProteinModelPortal

A0A2A4JNA9   A0A2A4JLW7   A0A2W1BYG5   A0A212EJ28   A0A2H1VXR0   A0A0N1PKG0   + More
K7IPJ5   A0A232F423   E9INW8   A0A1L8DAT8   A0A182H294   A0A0L7R0M1   F4WH29   Q16YN5   A0A1B0CUY8   A0A154PP96   A0A067RIM8   E2BEF6   A0A195CTJ2   A0A0C9QXM8   A0A336N2B0   A0A336MM14   A0A151JWB8   A0A0L8FQH6   A0A158NT90   A0A2C9KK17   A0A195E3C8   A0A0C9RK10   E2A5A8   A0A226EYR3   A0A3L8D2M2   A0A088AP33   A0A2Y9P611   A0A1Y1MXS9   T1IWP7   A0A3B3XQN6   N6U4N5   A0A2Y9SHQ8   A0A146YIV9   A0A0L8FQN6   A0A139WKS6   V4B0J6   A0A340WLZ9   A0A087YHN7   A0A3B3V8S5   W5M0I6   A0A2U4AZ40   A0A3P8RVK3   V5IDY0   U4UBY7   A0A1W4ZTM9   A0A3B5PVT3   A0A250YKU4   A0A1S3ID23   A0A2K5Z8N1   A0A1W4WFA4   A0A3S2MGU0   A0A287A4H7   V9KK72   E1BHW7   A0A3Q1GPP9   G3QQX7   H2QEC4   F7IQV6   A0A1L8H8A2   A0A2K5RB78   F7E5Z1   Q96DM3   A0A3B4UUY0   A0A2K6DFW0   A0A2K6LAJ3   A0A0D9RYL8   A0A096N685   A0A2K6PJS9   A0A2K5MRB0   H9YZM4   H2NW17   A0A2R9AR20   A0A3Q7Q8Y6   M3VUX5   B0VZT4   G7PWI4   A0A2D4IE86   A0A195BUR0   A0A1U7Q7T4   H0XBD2   E9FQM0   A0A2K5EGB6   A0A0P5MIT7   A0A2Y9E668   A0A3B4F3H1   A0A3P9CXL8   A4IHS1   H0V7B0   A0A2U3WW73  

KEGG

101745126    no KO assigned | (RefSeq) uncharacterized protein C18orf8

GO

GO:0035658   GO:0010506   GO:0005524   GO:0004831   GO:0003723   GO:0006437   GO:0031902   GO:0006914   GO:0005765   GO:0016021   GO:0005515   GO:0008270   GO:0051903   GO:0016491   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR12897  

Subcellular location

Lysosome membrane  
Late endosome membrane  

Length:

633

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07425

Exp number, first 60 AAs:

0.00105

Total prob of N-in:

0.00378

outside

1  -  633

 

 

Pi

185.070343

Theta

154.954151

Tajima's D

0.94714

CLR

0.701324

CSRT

0.645017749112544

Interpretation

Uncertain