Gene

KWMTBOMO06373  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011920

Annotation

ribosomal_protein_L7Ae_[Bombyx_mori]

Location

Bomo_Chr11(+):5923761-5924513      View in EpiBrowser

Full name

NHP2-like protein 1      

Alternative Name

High mobility group-like nuclear protein 2 homolog 1
U4/U6.U5 small nuclear ribonucleoprotein SNU13
U4/U6.U5 tri-snRNP 15.5 kDa protein

Location in the cell

Nuclear   Reliability : 0.894

CDS

ATGGCTGAAACCGAAGCTGCAGTGAACCCCAAGGCATACCCATTGGCGGATGCCGCCTTAACCGCTAAAATCCTGAACTTGGTGCAACAAGCTACCAATTACAAGCAACTTCGTAAAGGCGCGAACGAGGCCACAAAGACCCTTAATCGTGGTCTATCTGAGCTCATCATAATGGCAGCAGATGCCGAACCTCTCGAAATTGTTCTTCACATTCCAATTCTGTGCGAAGATAAGAATGTGCCATATGTGTTTGTTAGGTCTAAGCAAGCACTCGGTCGTGCTTGCGGTGTTTCCAGACCCATCATATCTTGCTCGATAACCATCAATGAGGGCTCACAACTAAAGCCTCAGATCCAAACTATTCAGCAAGAAATCGAAAGACTATTAGTTTAA

Protein

MAETEAAVNPKAYPLADAALTAKILNLVQQATNYKQLRKGANEATKTLNRGLSELIIMAADAEPLEIVLHIPILCEDKNVPYVFVRSKQALGRACGVSRPIISCSITINEGSQLKPQIQTIQQEIERLLV

Description

Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Subunit

Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex.

Similarity

Belongs to the eukaryotic ribosomal protein eL8 family.

Keywords

mRNA processing   mRNA splicing   Nucleus   Ribonucleoprotein   RNA-binding   Spliceosome  

Feature

chain  NHP2-like protein 1

Uniprot

Q2F5L8   A0A1E1WPQ8   A0A2W1C0R2   A0A2H1X3M7   A0A0L7L6Q2   G0ZEA6   + More
I4DJX4   H9JQW4   E7DYZ1   D1LYQ0   S4NX67   A0A0N0PET8   A0A194PUZ3   A0A212EIZ0   A0A0P4W061   R4FLB4   A0A0A9Z6C3   G3WBC6   H9H704   F7GEU7   A0A0Q3M839   A0A1Q3G0B3   B0WGK5   Q1HQW0   A0A023EFJ9   Q7ZWY8   A0A091FVM6   A0A091QK75   K7GDW5   M7C157   A0A224YY08   A0A131YQE2   L7M423   A0A131XG53   A0A2I0USE8   Q4S4J7   T1E1U6   I3KV38   A0A226MPR1   A0A3L8SDV1   A0A218V045   A0A3M0JT51   A0A226NW21   A0A1V4JA16   F1NII6   U3KBJ9   A0A2P4TF59   A0A1U7RQY6   B5FZ04   G1NHT8   A0A091JUQ8   A0A091H863   A0A099ZNP3   A0A093FNS6   A0A093QFE2   A0A091U9T8   A0A091HID5   A0A091W1Q3   A0A093QSX1   A0A091W6F4   A0A093IQ90   A0A091IS81   A0A0A0A2I0   A0A091N8C8   A0A091PWN3   R7VVE1   A0A093QQZ9   A0A091S7P7   A0A093EG99   A0A091KTV2   A0A091EXK0   A0A093H272   A0A087QLV1   A0A094N7V5   A0A091R342   H0ZHU0   Q7ZV23   A0A3B4GXG1   A0A3Q1EE91   E6ZGP5   A0A0F8BVA5   A0A3Q2W481   A0A3Q4IAK8   A0A3Q1B4F7   A0A3P8PXF7   A0A3P9BPN6   A0A3P8RN37   A0A3B3BIX9   A0A3P8RLK6   A0A3Q3DFX1   A0A0F7Z1B6   A0A1W7RFB3   J3SCS9   T1E5N4   C3Y952   A0A1L8GGN7   Q5XH16   G3P4V7   C3KJ00   A0A3B4WIZ0  

Pubmed

28756777    26227816    22651552    19121390    23622113    26354079    + More
22118469    27129103    25401762    21709235    17495919    18464734    17204158    17510324    24945155    27762356    17381049    23624526    28797301    26830274    25576852    28049606    15496914    24330624    25186727    30282656    24621616    15592404    17018643    20838655    23371554    20360741    23594743    25835551    29451363    26358130    23025625    23758969    25727380    18563158   

EMBL

DQ311405    ABD36349.1    GDQN01002082    JAT88972.1    KZ149897    PZC78700.1    + More
ODYU01013251    SOQ59950.1    JTDY01002659    KOB70996.1    JF264984    AEL28815.1    AK401592    BAM18214.1    BABH01028611    HQ424694    ADT80638.1    GU084324    ACY95357.1    GAIX01012282    JAA80278.1    KQ459692    KPJ20431.1    KQ459590    KPI97142.1    AGBW02014545    OWR41463.1    GDKW01001460    JAI55135.1    ACPB03006719    GAHY01002164    JAA75346.1    GBHO01002802    GBRD01013410    JAG40802.1    JAG52416.1    AEFK01203881    LMAW01002623    KQK78919.1    GFDL01001811    JAV33234.1    DS231927    EDS27034.1    DQ440334    CH477269    ABF18367.1    EAT45362.1    GAPW01005998    GAPW01005997    JAC07601.1    BC046579    CM004472    AAH46579.1    OCT85331.1    KL447393    KFO73041.1    KK799808    KFQ27940.1    AGCU01068171    KB481965    EMP41870.1    GFPF01011372    MAA22518.1    GEDV01007857    JAP80700.1    GACK01006437    JAA58597.1    GEFH01003426    JAP65155.1    KZ505643    PKU48974.1    CAAE01014738    CAG04435.1    GALA01001354    JAA93498.1    AERX01002284    MCFN01000581    OXB57029.1    QUSF01000028    RLW00223.1    MUZQ01000080    OWK59286.1    QRBI01000131    RMC03381.1    AWGT02000326    OXB71966.1    LSYS01008398    OPJ68991.1    AADN05000523    AGTO01000068    PPHD01000991    POI34976.1    DQ214255    ACH44265.1    KK529804    KFP27663.1    KL527345    KFO91634.1    KL896982    KGL84029.1    KK631538    KFV55964.1    KL672898    KFW87291.1    KK421299    KFQ86620.1    KL217504    KFO96068.1    KL411538    KFR08940.1    KL422980    KFW89470.1    KK734814    KFR11029.1    KL216282    KFV68841.1    KK500774    KFP10285.1    KL870368    KGL88162.1    KL379146    KFP86068.1    KK679388    KFQ11658.1    KB376364    EMC89968.1    KL224555    KFW61114.1    KK943949    KFQ52862.1    KK368136    KFV42179.1    KK756378    KFP43467.1    KK719069    KFO61327.1    KL205872    KFV75751.1    KL225739    KFM02205.1    KL267764    KFZ62666.1    KK712480    KFQ34230.1    ABQF01015862    ABQF01080857    CU104767    BC046034    AAH46034.1    FQ310507    CBN81229.1    KQ042188    KKF18284.1    GBEW01000637    JAI09728.1    GDAY02001595    JAV49832.1    JU175246    GBEX01002235    AFJ50770.1    JAI12325.1    GAAZ01001616    GBKC01002377    GBKD01001442    JAA96327.1    JAG43693.1    JAG46176.1    GG666492    EEN63108.1    CM004473    OCT82985.1    BC084259    BT082915    ACQ58622.1   

Proteomes

UP000037510    UP000005204    UP000053240    UP000053268    UP000007151    UP000015103    + More
UP000007648    UP000002280    UP000002279    UP000051836    UP000002320    UP000008820    UP000186698    UP000053760    UP000007267    UP000031443    UP000007303    UP000005207    UP000198323    UP000276834    UP000197619    UP000269221    UP000198419    UP000190648    UP000000539    UP000016665    UP000189705    UP000001645    UP000053641    UP000053258    UP000054308    UP000053283    UP000053605    UP000053875    UP000053119    UP000053858    UP000054081    UP000052976    UP000053584    UP000053286    UP000007754    UP000000437    UP000261460    UP000257200    UP000264840    UP000261580    UP000257160    UP000265100    UP000265160    UP000265080    UP000261560    UP000264820    UP000001554    UP000007635    UP000261360   

PRIDE

Q2F5L8    H9JQW4    I3KV38    Q5XH16   

Pfam

PF01248   Ribosomal_L7Ae        + More
PF00642   zf-CCCH
PF00098   zf-CCHC

Interpro

IPR018492   Ribosomal_L7Ae/L8/Nhp2        + More
IPR004038   Ribosomal_L7Ae/L30e/S12e/Gad45       
IPR029064   L30e-like       
IPR004037   Ribosomal_L7Ae_CS       
IPR002415   H/ACA_rnp_Nhp2_euk       
IPR036875   Znf_CCHC_sf       
IPR001878   Znf_CCHC       
IPR000571   Znf_CCCH       
IPR036855   Znf_CCCH_sf       

SUPFAM

SSF55315   SSF55315        + More
SSF57756   SSF57756       
SSF90229   SSF90229       

Gene 3D

3.30.1330.30    

ProteinModelPortal

Q2F5L8   A0A1E1WPQ8   A0A2W1C0R2   A0A2H1X3M7   A0A0L7L6Q2   G0ZEA6   + More
I4DJX4   H9JQW4   E7DYZ1   D1LYQ0   S4NX67   A0A0N0PET8   A0A194PUZ3   A0A212EIZ0   A0A0P4W061   R4FLB4   A0A0A9Z6C3   G3WBC6   H9H704   F7GEU7   A0A0Q3M839   A0A1Q3G0B3   B0WGK5   Q1HQW0   A0A023EFJ9   Q7ZWY8   A0A091FVM6   A0A091QK75   K7GDW5   M7C157   A0A224YY08   A0A131YQE2   L7M423   A0A131XG53   A0A2I0USE8   Q4S4J7   T1E1U6   I3KV38   A0A226MPR1   A0A3L8SDV1   A0A218V045   A0A3M0JT51   A0A226NW21   A0A1V4JA16   F1NII6   U3KBJ9   A0A2P4TF59   A0A1U7RQY6   B5FZ04   G1NHT8   A0A091JUQ8   A0A091H863   A0A099ZNP3   A0A093FNS6   A0A093QFE2   A0A091U9T8   A0A091HID5   A0A091W1Q3   A0A093QSX1   A0A091W6F4   A0A093IQ90   A0A091IS81   A0A0A0A2I0   A0A091N8C8   A0A091PWN3   R7VVE1   A0A093QQZ9   A0A091S7P7   A0A093EG99   A0A091KTV2   A0A091EXK0   A0A093H272   A0A087QLV1   A0A094N7V5   A0A091R342   H0ZHU0   Q7ZV23   A0A3B4GXG1   A0A3Q1EE91   E6ZGP5   A0A0F8BVA5   A0A3Q2W481   A0A3Q4IAK8   A0A3Q1B4F7   A0A3P8PXF7   A0A3P9BPN6   A0A3P8RN37   A0A3B3BIX9   A0A3P8RLK6   A0A3Q3DFX1   A0A0F7Z1B6   A0A1W7RFB3   J3SCS9   T1E5N4   C3Y952   A0A1L8GGN7   Q5XH16   G3P4V7   C3KJ00   A0A3B4WIZ0  

PDB

2JNB     E-value=4.65017e-51,     Score=501

KEGG

692972    K12845 U4/U6 small nuclear ribonucleoprotein SNU13 | (RefSeq) RpL7Ae; ribosomal protein L7Ae

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)
03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0005840   GO:0003723   GO:0042254   GO:0005730   GO:1990904   GO:0008270   GO:0046872   GO:0071005   GO:0030621   GO:0000398   GO:0005690   GO:0030622   GO:0007338   GO:0051117   GO:0031428   GO:0046540   GO:0034512   GO:0001651   GO:0000492   GO:0034511   GO:0032040   GO:0000470   GO:0061053   GO:0005634   GO:0030529   GO:0016310   GO:0016627   GO:0030145   GO:0015923   GO:0006260  

Subcellular location

Nucleus  
Nucleolus  

Length:

130

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05661

Exp number, first 60 AAs:

0.05063

Total prob of N-in:

0.18352

outside

1  -  130

 

 

Pi

199.653984

Theta

192.520416

Tajima's D

0.099541

CLR

134.435368

CSRT

0.398030098495075

Interpretation

Uncertain