Gene

KWMTBOMO06327

Pre Gene Modal

BGIBMGA011995

Annotation

PREDICTED:_4-hydroxybenzoate_polyprenyltransferase?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr11(-):4834117-4840872      View in EpiBrowser

Full name

4-hydroxybenzoate polyprenyltransferase, mitochondrial      

Alternative Name

Para-hydroxybenzoate--polyprenyltransferase
Coenzyme Q biosynthesis protein 2

Location in the cell

PlasmaMembrane   Reliability : 2.505

CDS

ATGTTGAAAACGTCGAAAATTTACCAATTAAAAAAACTTTTATACATTACAAATGTTAATTTGAAAATAAGTAAAAAGGTGCATCTGCTAATGAAGTACAATGCTCATGGGTGCACCGCATGCAGAAACGCATGCTCAAGAAGGTACAATGTGAGAGTTCATTCAACACAGAGCGACCACCACAGACAAAAAGTTGTGATAGAAACTAGTCAACCAAAGATAGTCATAGACAAACTGAGTGAGGTGCTGCCAGATTCACAAAGAAAACAAATATGGAAAGACAAAGTATTGCCGTATGTGAGGTTAGCTAGATGGGATCGACCTATAGGAGTGTATCTCCTCTACTGGCCTTGTACATGGTCCATTGCCTTGGCTTCGATTCCTGGTGTACCCATACAAACTACGCTGCAGACGGCCGCGCTATTCCTCGTAGGAGCCGGCTTAATGAGAGGGGCTGGATGCACAATCAATGACATGTGGGATCGAGATATAGACAAACAGGTAGCAAGAACAAAAGACAGACCCTTAGTGTCTGGTGCTGTCTCACAGACCGGTGCTATGATATTTTTGGCCGCTCAGCTCTCATTAGCTTTGGGTGTACTGCTGCAGTTGAACTGTTACAGCGTAGCACTCGGAGCCAGCAGCATGCTGCTAGTGGTGACGTATCCGTTGGCGAAGCGTTTCACGGCTTACCCTCAAGTGTTCCTGGGGGCCACGTTCAACTGGGGCGCGCTGCTGGGCTACAGTGCGGTGCAAGGCTCCCTGGACGCGGCCGTGTGCCTCCCGCTGTACGTCGCCGCCCTCGGCTGGACCGTCCACTACGACACCATATACGCTCACCAAGATAAAAAGGACGATGCCCGTATAGGGATCAAGTCGACTGCGCTGACGTTCGGGCGGCACACGCGGGCGGCGCTGGGTGCGGTGCTGGCTGCGAGCGGGGTCAGCTTCGCCGCCGCCGGGGCCGCCGCGGGGCTGGGCCCGCTGTACCACGCCGCCGTGCTGGCATACGTTGCCGCCGCCGCGCGACAGATTTACACGCTCAAAACGGATGACGCGAAGGATTGCGCTGATAAGTTTAAATCTAATTCGTCCTTTGGTTTCCTGATACTGTTAGGAATATTGGGCGGGGGATGCGCTCCATACGTCGATAGTCTCAAAAAAGACAATAATAATTACGATGTTAACGCGGCAAAGAGTTGCTTCTTTTGA

Protein

MLKTSKIYQLKKLLYITNVNLKISKKVHLLMKYNAHGCTACRNACSRRYNVRVHSTQSDHHRQKVVIETSQPKIVIDKLSEVLPDSQRKQIWKDKVLPYVRLARWDRPIGVYLLYWPCTWSIALASIPGVPIQTTLQTAALFLVGAGLMRGAGCTINDMWDRDIDKQVARTKDRPLVSGAVSQTGAMIFLAAQLSLALGVLLQLNCYSVALGASSMLLVVTYPLAKRFTAYPQVFLGATFNWGALLGYSAVQGSLDAAVCLPLYVAALGWTVHYDTIYAHQDKKDDARIGIKSTALTFGRHTRAALGAVLAASGVSFAAAGAAAGLGPLYHAAVLAYVAAAARQIYTLKTDDAKDCADKFKSNSSFGFLILLGILGGGCAPYVDSLKKDNNNYDVNAAKSCFF

Description

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.

Catalytic Activity

4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the UbiA prenyltransferase family.

Keywords

Complete proteome   Isoprene biosynthesis   Membrane   Mitochondrion   Mitochondrion inner membrane   Reference proteome   Transferase   Transit peptide   Transmembrane   Transmembrane helix   Ubiquinone biosynthesis  

Feature

chain  4-hydroxybenzoate polyprenyltransferase, mitochondrial

Uniprot

H9JR35   A0A2H1V2P1   A0A2A4JX67   A0A194Q4E8   A0A2W1BJ99   A0A212EVD4   + More
A0A232F0H8   K7ITV5   A0A1L8DZS7   A0A1Y1MA46   A0A1L8DZB3   A0A1I8M688   A0A3B3IJZ0   A0A3P9JKE5   A0A3B3DIK6   A0A0L8HWQ0   A0A1B6F4G8   A0A023ES56   A0A182J8M5   A0A2M4AQ23   A0A139WEL7   A0A2J7PYB6   C1EFZ3   T1EAD4   Q16QL3   A0A182XIH2   A0A182HYQ7   Q7Q9Z4   W8BRG8   A0A182TGA4   A0A182LDA0   U4UF55   N6SYF3   J3JU38  

EC Number

2.5.1.39

Pubmed

19121390    26354079    28756777    22118469    28648823    20075255    + More
28004739    25315136    17554307    29451363    24945155    18362917    19820115    19359590    17510324    12364791    14747013    17210077    24495485    20966253    23537049    22516182   

EMBL

BABH01028712    ODYU01000394    SOQ35103.1    NWSH01000480    PCG76093.1    KQ459463    + More
KPJ00413.1    KZ150084    PZC73785.1    AGBW02012212    OWR45439.1    NNAY01001370    OXU24205.1    GFDF01002282    JAV11802.1    GEZM01039802    GEZM01039801    JAV81175.1    GFDF01002283    JAV11801.1    KQ417118    KOF93627.1    GECZ01024692    JAS45077.1    GAPW01001533    JAC12065.1    GGFK01009549    MBW42870.1    KQ971354    KYB26307.1    NEVH01020850    PNF21314.1    CP001331    ACO66686.1    GAMD01001108    JAB00483.1    CH477745    EAT36680.1    APCN01005399    AAAB01008898    EAA09225.5    GAMC01004843    JAC01713.1    KB632263    ERL90953.1    APGK01052268    KB741211    ENN72819.1    BT126750    AEE61712.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000215335    UP000002358    + More
UP000095301    UP000001038    UP000265200    UP000261560    UP000053454    UP000075880    UP000007266    UP000235965    UP000002009    UP000008820    UP000076407    UP000075840    UP000007062    UP000075902    UP000075882    UP000030742    UP000019118   

PRIDE

H9JR35    Q16QL3   

Pfam

PF01040   UbiA        + More
PF02815   MIR
PF16192   PMT_4TMC

Interpro

IPR030470   UbiA_prenylTrfase_CS        + More
IPR000537   UbiA_prenyltransferase       
IPR039653   Prenyltransferase       
IPR006370   HB_polyprenyltransferase-like       
IPR013087   Znf_C2H2_type       
IPR016093   MIR_motif       
IPR032421   PMT_4TMC       
IPR036300   MIR_dom_sf       
IPR027005   GlyclTrfase_39-like       

SUPFAM

SSF82109   SSF82109       

ProteinModelPortal

H9JR35   A0A2H1V2P1   A0A2A4JX67   A0A194Q4E8   A0A2W1BJ99   A0A212EVD4   + More
A0A232F0H8   K7ITV5   A0A1L8DZS7   A0A1Y1MA46   A0A1L8DZB3   A0A1I8M688   A0A3B3IJZ0   A0A3P9JKE5   A0A3B3DIK6   A0A0L8HWQ0   A0A1B6F4G8   A0A023ES56   A0A182J8M5   A0A2M4AQ23   A0A139WEL7   A0A2J7PYB6   C1EFZ3   T1EAD4   Q16QL3   A0A182XIH2   A0A182HYQ7   Q7Q9Z4   W8BRG8   A0A182TGA4   A0A182LDA0   U4UF55   N6SYF3   J3JU38  

PDB

4OD5     E-value=2.30055e-12,     Score=175

KEGG

101740579    K06125 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] | (RefSeq) 4-hydroxybenzoate polyprenyl

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008299   GO:0031305   GO:0006744   GO:0002083   GO:0003676   GO:0047293   GO:0016021   GO:0004659   GO:0004169   GO:0071712   GO:0005789   GO:0035269   GO:0008412   GO:0005743   GO:0005666   GO:0006360   GO:0005736   GO:0006383   GO:0016765   GO:0005739   GO:0046872   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11048   PTHR10050  

Subcellular location

Mitochondrion inner membrane  

Length:

403

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

157.75504

Exp number, first 60 AAs:

0.00314

Total prob of N-in:

0.98334

inside

1  -  108

TMhelix

109  -  131

outside

132  -  134

TMhelix

135  -  154

inside

155  -  174

TMhelix

175  -  197

outside

198  -  200

TMhelix

201  -  223

inside

224  -  243

TMhelix

244  -  266

outside

267  -  318

TMhelix

319  -  341

inside

342  -  361

TMhelix

362  -  384

outside

385  -  403

 

 

Pi

199.570427

Theta

164.560661

Tajima's D

0.041735

CLR

0.204345

CSRT

0.378831058447078

Interpretation

Uncertain