Gene

KWMTBOMO06314  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011887

Annotation

PREDICTED:_dihydroorotate_dehydrogenase_(quinone)?_mitochondrial_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr11(+):4631633-4637212      View in EpiBrowser

Full name

Dihydroorotate dehydrogenase (quinone), mitochondrial      

Location in the cell

Cytoplasmic   Reliability : 1.426 Mitochondrial   Reliability : 1.925

CDS

ATGTCGCAGAAGAAAGACCCTTTGAAAAAAATTAGATCCCTTTGTTATGTGACAATCGGAGGAGCTATCGCCTACCAGTATATTTATTACAAGAAGGACTTTAACAGTTATTACGAGAACGTCCTCCAACCTCTCAGTCAGTATCTGAGTCCTGAAGTCGCTCATCGAATCGGAGTGGCAGCGATCAAACACGGACTATTTCCACCTGATCAAAATGAAGACCCAAAGATTTTAAAAACAAGATTGCTTGACTACGACCTAAGCAATCCACTTGGCATAGCCGCCGGGTTCGACAAGCACGGAGACGCGGTCGTGGGCCTGATGAAACTGGGCTTCTCGATCATCGAAGTGGGCTCGGTCACGCCGCAGCCGCAGCCCGGGAATCCCAAGCCGAGGGTCTTCCGACTCCCGGAGGACGGAGCCGTCATCAACAGATATGGCTTCAACAGCATAGGGCACGACGAAGTATACAAAAAGCTGGAAGGAATCGAGAAGGCCGTAATGAATCGGGCACTCCTCGGCGTGAATCTGGGAAAGAATAAGCTCTCCGATGATGCAGGGAAGGATTATGTGTCCGGCATTGAAAAGTTCTCGGATGTGGCTGATTATTTTGTTGTGAACGTTAGCAGCCCTAACACCCCCGGCCTGAGATCATTACAAAACAAGAACGAACTAGAAAACTTATTGACCGAAATAAACAGAGCTAGAAAACGGCGGAACTCGAACAAGCCGCTGCTCCTCAAACTGGCTCCGGACCTGAACGAGGACGAGCTAAAAGACGTGGTCAATGTCATTGGCAAACAGCACAGCAAGGTTGACGGCCTGATCATATCGAACACGACCGTCGAGAGGCAGAGCCTCAAGAATAAGGAGTTTGTGAACGAACCGGGCGGCCTGAGCGGGAAGCCGCTGACCAACAGATCTACGGAGATGATCAGGGACGTGTACAGATTAACTAAAGGTAAAGTTCCGATAATAGGAGTAGGGGGAGTGTTCACGGGGCGTGACGCGTATGAGAAGATCCTGGCGGGCGCCGGCGCCGTGCAAGTGTACACCGCGCTCATCTACCACGGACCTCCGGTCGTGAGGAGGATAAAGGACGAACTGGCCGAGCTACTAGAGAGGGACGGATATACTTCCGTCAATGACGCCGTCGGTAAAGGAGTTAAATAG

Protein

MSQKKDPLKKIRSLCYVTIGGAIAYQYIYYKKDFNSYYENVLQPLSQYLSPEVAHRIGVAAIKHGLFPPDQNEDPKILKTRLLDYDLSNPLGIAAGFDKHGDAVVGLMKLGFSIIEVGSVTPQPQPGNPKPRVFRLPEDGAVINRYGFNSIGHDEVYKKLEGIEKAVMNRALLGVNLGKNKLSDDAGKDYVSGIEKFSDVADYFVVNVSSPNTPGLRSLQNKNELENLLTEINRARKRRNSNKPLLLKLAPDLNEDELKDVVNVIGKQHSKVDGLIISNTTVERQSLKNKEFVNEPGGLSGKPLTNRSTEMIRDVYRLTKGKVPIIGVGGVFTGRDAYEKILAGAGAVQVYTALIYHGPPVVRRIKDELAELLERDGYTSVNDAVGKGVK

Catalytic Activity

(S)-dihydroorotate + a quinone = a quinol + orotate

Cofactor

FMN

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Feature

chain  Dihydroorotate dehydrogenase (quinone), mitochondrial

Uniprot

A0A2A4JRW4   A0A2W1BM13   H9JQT1   A0A212FE82   A0A0N0P9Y3   A0A194RR17   + More
A0A2H1VTV9   A0A0L7KQR1   A0A232FK56   A0A151I8L9   K7IV72   A0A0L7QKU1   E9IG07   A0A0J7KDC7   A0A195FHK3   A0A158NY02   B0W4C3   F4X5R2   A0A195BQN8   A0A1Q3F595   A0A026VZ14   A0A154PUY4   D6X3Z9   A0A182VB65   A0A0C9QVV7   W5JPS2   A0A182U258   A0A182XB88   A0A182LH38   Q7PYN9   E2AD36   A0A1Y9H2S5   A0A182JX82   A0A182I031   A0A182GVP7   A0A2J7PNT2   A0A084VTW7   A0A182ILH6   A0A182PRI2   Q177S6   A0A1Y9HEN3   A0A182YAT0   A0A182T4P1   A0A182VZ37   A0A0K8TKL0   A0A182LS84   U5EXS8   A0A2A3ET49   A0A1B6G2N7   A0A0T6AUM4   A0A067R2K3   A0A1I8PEP4   L7LZA5   A0A088AF14   T1PH49   A0A1W4WUH8   A0A1I8MQ26   A0A1A9ZA90   A0A1J1J568   A0A1B6DRI4   E2BRB5   W8C685   A0A2A3EUN4   G3MQA6   E9GTU3   A0A1B6L4R0   A0A0A1XQP5   A0A3S0ZGA9   A0A0K8T8P9   A0A034V1M0   A0A146M731   A0A0A9WG38   A0A0K8URE4   A0A0P5YWH4   A0A0P6GRI0   A0A293MVJ8   A7SLG1   E0VQ82   A0A0P6AMA6   A0A1Y1NH83   A0A2P8XK77   A0A0V0GC74   A0A336M2C9   A0A224YL24   A0A0L0CPQ6   A0A0P5YQI2   A0A2R5L8K3   A0A0P6FX32   A0A2T7NGX8   A0A069DTM0   A0A1B0CTK1   A0A0P5HQ02   C3YFF0   A0A131YUV3   A0A0N8B0J4   A0A0P5HMR5   A0A0P5HKW6   A0A0N8EM82   A0A210PJJ5   A0A1A9VGV6  

EC Number

1.3.5.2

Pubmed

28756777    19121390    22118469    26354079    26227816    28648823    + More
20075255    21282665    21347285    21719571    24508170    30249741    18362917    19820115    20920257    23761445    20966253    12364791    14747013    17210077    20798317    26483478    24438588    17510324    25244985    26369729    24845553    25576852    25315136    24495485    22216098    21292972    25830018    25348373    26823975    25401762    17615350    20566863    28004739    29403074    28797301    26108605    26334808    18563158    26830274    28812685   

EMBL

NWSH01000798    PCG74150.1    KZ150160    PZC72723.1    BABH01028744    AGBW02008970    + More
OWR52030.1    KQ459037    KPJ04273.1    KQ459833    KPJ19839.1    ODYU01004426    SOQ44281.1    JTDY01006866    KOB65633.1    NNAY01000129    OXU30707.1    KQ978339    KYM95014.1    AAZX01005118    KQ414940    KOC59237.1    GL762905    EFZ20496.1    LBMM01009139    KMQ88362.1    KQ981606    KYN39484.1    ADTU01000548    DS231836    EDS33208.1    GL888740    EGI58213.1    KQ976423    KYM88886.1    GFDL01012319    JAV22726.1    KK107555    QOIP01000002    EZA49012.1    RLU26168.1    KQ435180    KZC15010.1    KQ971379    EEZ97344.2    GBYB01007884    JAG77651.1    ADMH02000517    ETN66131.1    AAAB01008987    EAA01242.5    GL438658    EFN68672.1    APCN01002042    JXUM01019119    KQ560533    KXJ81955.1    NEVH01023316    PNF17971.1    ATLV01016520    KE525092    KFB41411.1    CH477371    EAT42442.1    GDAI01002940    JAI14663.1    AXCM01001079    GANO01002394    JAB57477.1    KZ288185    PBC34925.1    GECZ01013072    JAS56697.1    LJIG01022760    KRT78863.1    KK852747    KDR17253.1    GACK01007929    JAA57105.1    KA648142    AFP62771.1    CVRI01000072    CRL07555.1    GEDC01009002    JAS28296.1    GL449942    EFN81778.1    GAMC01001267    JAC05289.1    PBC34926.1    JO844057    AEO35674.1    GL732564    EFX77146.1    GEBQ01021264    JAT18713.1    GBXI01001419    JAD12873.1    RQTK01000620    RUS76978.1    GBRD01004326    JAG61495.1    GAKP01021801    JAC37151.1    GDHC01004042    JAQ14587.1    GBHO01037238    JAG06366.1    GDHF01023067    JAI29247.1    GDIP01142101    GDIP01106142    GDIP01052358    LRGB01000868    JAL61613.1    JAM51357.1    KZS15672.1    GDIQ01029833    JAN64904.1    GFWV01019411    MAA44139.1    DS469698    EDO35448.1    DS235402    EEB15538.1    GDIP01027258    JAM76457.1    GEZM01003120    JAV96908.1    PYGN01001878    PSN32364.1    GECL01000756    JAP05368.1    UFQT01000446    SSX24404.1    GFPF01007201    MAA18347.1    JRES01000088    KNC34241.1    GDIP01055120    JAM48595.1    GGLE01001697    MBY05823.1    GDIQ01225911    GDIQ01052525    JAN42212.1    PZQS01000012    PVD20405.1    GBGD01001778    JAC87111.1    AJWK01027747    GDIQ01224708    JAK27017.1    GG666509    EEN60913.1    GEDV01005544    JAP83013.1    GDIQ01224707    JAK27018.1    GDIQ01225912    JAK25813.1    GDIQ01225910    JAK25815.1    GDIQ01013012    JAN81725.1    NEDP02076522    OWF36657.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000215335    UP000078542    UP000002358    UP000053825    UP000036403    UP000078541    UP000005205    UP000002320    UP000007755    UP000078540    UP000053097    UP000279307    UP000076502    UP000007266    UP000075903    UP000000673    UP000075902    UP000076407    UP000075882    UP000007062    UP000000311    UP000075884    UP000075881    UP000075840    UP000069940    UP000249989    UP000235965    UP000030765    UP000075880    UP000075885    UP000008820    UP000075900    UP000076408    UP000075901    UP000075920    UP000075883    UP000242457    UP000027135    UP000095300    UP000005203    UP000192223    UP000095301    UP000092445    UP000183832    UP000008237    UP000000305    UP000271974    UP000076858    UP000001593    UP000009046    UP000245037    UP000037069    UP000245119    UP000092461    UP000001554    UP000242188    UP000078200   

PRIDE

H9JQT1   

Pfam

PF01180   DHO_dh        + More
PF00071   Ras
PF02949   7tm_6
PF05622   HOOK
PF00107   ADH_zinc_N
PF08240   ADH_N

Interpro

IPR005719   Dihydroorotate_DH_2        + More
IPR013785   Aldolase_TIM       
IPR005720   Dihydroorotate_DH       
IPR001295   Dihydroorotate_DH_CS       
IPR012135   Dihydroorotate_DH_1_2       
IPR005225   Small_GTP-bd_dom       
IPR027417   P-loop_NTPase       
IPR001806   Small_GTPase       
IPR004117   7tm6_olfct_rcpt       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR008636   Hook-like_fam       
IPR036872   CH_dom_sf       
IPR013154   ADH_N       
IPR011032   GroES-like_sf       
IPR013149   ADH_C       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF56219   SSF56219       
SSF51735   SSF51735       
SSF50129   SSF50129       

Gene 3D

3.20.20.70     3.60.10.10     1.10.418.10    

CDD

cd04738  DHOD_2_like

ProteinModelPortal

A0A2A4JRW4   A0A2W1BM13   H9JQT1   A0A212FE82   A0A0N0P9Y3   A0A194RR17   + More
A0A2H1VTV9   A0A0L7KQR1   A0A232FK56   A0A151I8L9   K7IV72   A0A0L7QKU1   E9IG07   A0A0J7KDC7   A0A195FHK3   A0A158NY02   B0W4C3   F4X5R2   A0A195BQN8   A0A1Q3F595   A0A026VZ14   A0A154PUY4   D6X3Z9   A0A182VB65   A0A0C9QVV7   W5JPS2   A0A182U258   A0A182XB88   A0A182LH38   Q7PYN9   E2AD36   A0A1Y9H2S5   A0A182JX82   A0A182I031   A0A182GVP7   A0A2J7PNT2   A0A084VTW7   A0A182ILH6   A0A182PRI2   Q177S6   A0A1Y9HEN3   A0A182YAT0   A0A182T4P1   A0A182VZ37   A0A0K8TKL0   A0A182LS84   U5EXS8   A0A2A3ET49   A0A1B6G2N7   A0A0T6AUM4   A0A067R2K3   A0A1I8PEP4   L7LZA5   A0A088AF14   T1PH49   A0A1W4WUH8   A0A1I8MQ26   A0A1A9ZA90   A0A1J1J568   A0A1B6DRI4   E2BRB5   W8C685   A0A2A3EUN4   G3MQA6   E9GTU3   A0A1B6L4R0   A0A0A1XQP5   A0A3S0ZGA9   A0A0K8T8P9   A0A034V1M0   A0A146M731   A0A0A9WG38   A0A0K8URE4   A0A0P5YWH4   A0A0P6GRI0   A0A293MVJ8   A7SLG1   E0VQ82   A0A0P6AMA6   A0A1Y1NH83   A0A2P8XK77   A0A0V0GC74   A0A336M2C9   A0A224YL24   A0A0L0CPQ6   A0A0P5YQI2   A0A2R5L8K3   A0A0P6FX32   A0A2T7NGX8   A0A069DTM0   A0A1B0CTK1   A0A0P5HQ02   C3YFF0   A0A131YUV3   A0A0N8B0J4   A0A0P5HMR5   A0A0P5HKW6   A0A0N8EM82   A0A210PJJ5   A0A1A9VGV6  

PDB

6FMD     E-value=1.00955e-85,     Score=807

KEGG

101737574    K00254 dihydroorotate dehydrogenase [EC:1.3.5.2] | (RefSeq) dihydroorotate dehydrogenase (quinone),

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0044205   GO:0005743   GO:0006207   GO:0004152   GO:0005525   GO:0003924   GO:0009220   GO:0005739   GO:0016021   GO:0005549   GO:0004984   GO:0016020   GO:0005737   GO:0006222   GO:0003824   GO:0016627   GO:0030145   GO:0015923   GO:0005634   GO:0006260   GO:0055114  

Subcellular location

Mitochondrion inner membrane  

Length:

390

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.2842199999999

Exp number, first 60 AAs:

17.1666

Total prob of N-in:

0.95388

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  30

outside

31  -  390

 

 

Pi

188.257988

Theta

165.881556

Tajima's D

0.328469

CLR

0.0228

CSRT

0.464176791160442

Interpretation

Uncertain