Silkworm Genome Informatics Database

Gene

KWMTBOMO06267 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001818

Annotation

PREDICTED:_nuclear_pore_complex_protein_Nup98-Nup96_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(+):3567466-3575831 View in EpiBrowser

Full name

Nuclear pore complex protein Nup98-Nup96

Location in the cell

Nuclear Reliability : 2.182

CDS

ATGGACACCGCTGAAGACAACGCGGAGTCACAAAGCCTGTTTCTAGAAAACAGAGCGTTCGGCGTGAAGAGTCCCACCTCGGAGCTGGCGCGCCTGGAGAATAGACGCAGCCACAGCGTGCAGCTGATGAAGGCCTCGCTGTACCCTGATGAAGAAATGGACGATGACGTGTCAGTGTCGACGGGAGAACAGCTGGTGCCGAACTCGGCTCCGATATTTAACGATCAACGGTTACCGTCGCCCTCGCTGGGGACCGTCGTGGGGGCCCCGCCCCCGCCGCCGGAGCGCGCGCCCGAACCACCAATGCGACCGCTCACTGTCCAACCCCATACGATAGTATTGAAATACCACAGAAAGGTTCCACCATTCAAAGACACCATTGCGGGTCGGCTGGACAGCGCCTGCCTGGCCGACATGTCGGTGAGCCACGCGCGCCACAGCCGCGTCGGCTTCGGGCCCGCCTCCACCGTCGCCCTCCTCACCACGTACGACGCCTTCAGCGACCTGCCCAGATCGTCTGAGCTCTCGTCGTTAGACCGGTACTTGAGCGGCAGGGCCAGCGGGGACTGGTCGGAGCGTCTGGTGGCGCGTCTGGCGCTAGCCGCCGACCGGCCGCAACACCCGCTGCAGGAGATCTTGGAGCCGCACATCTCTACGTTGCTGGAGTGGTCCACGCTATCGGAGTGCGCAGAGGACGAGTGCCCGCGCCTCTCCCTCCGCCCCGAGCCGGAGGCGCGCCTGGCCGTGCTCAGGGACAATCTGAGACACTCCTCCAAACACGACTACGTAGTGAAGTTCGGCGTGTCTGCCGCGTACTGCCGCGAGGTGTGGAGGCTGTGCGACGCGCTGTGGGGAGCCGATCTGGAGAACGGTGGCATCCCTGGCACGGACGAGCAGTCGATAGTGAACAGACACAAGAAGCTGCTGCGTTGGTTCGAGGACGCCGTGGCGGGGGTCACGGACGCGGAGCTGGCCGAGCCCCGGGGGACAGAGCTGGAGGATGAGTCCGACACGCACAGCGCTCGAATCTGGACTTTGCTGCTGGGCGGCAGGACGCTTGAGGCCTGCAAGCTGGCCAGGGACAGCGGGGACCTCAACATGGCCATGCTCCTCGCTCAGGCCGGCGGCGATGCGGCGTACCGGGGGCTGGTGGCGCGGCAGCTGGCGCAGTGGAGCGCGTGCGGCGCCGACACGCACGTGGCGGGCGCGCGCCTGCACGCGCTGCGGGCGCTGGGCGGCGCCGCCCCCCCCGCGCTGGCGGGCGCCGGCTGGCTGCGCGCGCTGCACGCCACGGCAAGGTACGCCGCGCACTACGCTGCACTGGAGCATAGTTAA

Protein

MDTAEDNAESQSLFLENRAFGVKSPTSELARLENRRSHSVQLMKASLYPDEEMDDDVSVSTGEQLVPNSAPIFNDQRLPSPSLGTVVGAPPPPPERAPEPPMRPLTVQPHTIVLKYHRKVPPFKDTIAGRLDSACLADMSVSHARHSRVGFGPASTVALLTTYDAFSDLPRSSELSSLDRYLSGRASGDWSERLVARLALAADRPQHPLQEILEPHISTLLEWSTLSECAEDECPRLSLRPEPEARLAVLRDNLRHSSKHDYVVKFGVSAAYCREVWRLCDALWGADLENGGIPGTDEQSIVNRHKKLLRWFEDAVAGVTDAELAEPRGTELEDESDTHSARIWTLLLGGRTLEACKLARDSGDLNMAMLLAQAGGDAAYRGLVARQLAQWSACGADTHVAGARLHALRALGGAAPPALAGAGWLRALHATARYAAHYAALEHS

Description

Part of the nuclear pore complex (NPC) (PubMed:25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PubMed:20547758, PubMed:28554770). Plays a role in nuclear mRNA export (PubMed:28554770). Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription (PubMed:25197089, PubMed:25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PubMed:21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PubMed:25201876).
Nuclear pore complex protein Nup98: Part of the nuclear pore complex (NPC) (PubMed:25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PubMed:20144760, PubMed:20144761, PubMed:28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PubMed:28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PubMed:20144761, PubMed:25310983, PubMed:28366641).
Nuclear pore complex protein Nup96: Part of the nuclear pore complex (NPC).

Subunit

Part of the nuclear pore complex (NPC) (PubMed:25310983). Interacts with Rae1 (PubMed:21874015, PubMed:28554770). Nuclear pore complex protein Nup98: Interacts with pzg and Chro (PubMed:25310983). Interacts with MBD-R2; the interaction allows Nup98 recruitment to chromatin (PubMed:25310983). Interacts with Trx (PubMed:25310983). Interacts with Wds (PubMed:25310983). Interacts with Mtor and Cp190 (PubMed:28366641). Upon ecdysone stimulation, interacts with EcR, CTCF, su(Hw) and Trl (PubMed:28366641).

Similarity

Belongs to the nucleoporin GLFG family.

Keywords

Alternative splicing Autocatalytic cleavage Chromosome Complete proteome Hydrolase Membrane mRNA transport Nuclear pore complex Nucleus Protease Protein transport Reference proteome Repeat Serine protease Transcription Transcription regulation Translocation Transport

Feature

chain Nuclear pore complex protein Nup98
splice variant In isoform C.

Uniprot

H9IX35 A0A2W1BFC5 A0A2A4K4I0 A0A194Q4W3 A0A212F926 A0A067RJY6 + More
A0A2J7PIF9 A0A2J7PID5 A0A1B0D922 A0A0J7KRZ3 A0A1L8DXK6 A0A1L8DWH8 A0A1B6IT63 A0A0L7QVG1 A0A1B6GJC9 A0A336LFV7 A0A1B6LH84 A0A1B0CEY7 E1ZUV9 A0A026WQF6 A0A158NHQ4 A0A195AUR2 A0A336KXZ5 A0A151IV19 E9J1Z2 F4WU23 A0A151WGG7 E0W2X1 A0A0M4F7F3 Q86G42 Q86G35 Q86G34 Q86G36 A0A195C3G3 Q867J6 A0A195ETN9 Q86G44 Q86G41 Q86G40 A0A087ZWJ6 Q86G37 Q867X7 Q86G38 Q86G39 Q867Y8 Q867H5 Q867M2 Q868A8 A0A0N0BJJ6 Q867W7 Q86G43 Q867M7 B4R252 Q86G32 Q86G33 Q9VCH5 A0A2A3EKU0 H2S1E7 A0A1B6CZW3 B4PNY2 B4HFZ0 A0A1W4ULL3 B3P8D7 A0A182QPM2

EC Number

3.4.21.-

Pubmed

19121390 28756777 26354079 22118469 24845553 20798317 + More
24508170 30249741 21347285 21282665 21719571 20566863 12802326 17994087 10731132 12537572 20144760 20144761 20547758 21874015 21949861 25310983 25201876 25197089 25852164 28554770 28366641 21551351 17550304

EMBL

BABH01021286 KZ150084 PZC73809.1 NWSH01000160 PCG78936.1 KQ459463 + More
KPJ00394.1 AGBW02009652 OWR50231.1 KK852463 KDR23338.1 NEVH01025127 PNF16103.1 PNF16102.1 AJVK01028052 AJVK01028053 AJVK01028054 AJVK01028055 AJVK01028056 LBMM01003781 KMQ93147.1 GFDF01002940 JAV11144.1 GFDF01003302 JAV10782.1 GECU01017585 GECU01011931 JAS90121.1 JAS95775.1 KQ414727 KOC62610.1 GECZ01007221 JAS62548.1 UFQS01003267 UFQT01003267 SSX15435.1 SSX34804.1 GEBQ01016922 JAT23055.1 AJWK01009472 GL434297 EFN75051.1 KK107131 QOIP01000012 EZA58163.1 RLU16096.1 ADTU01015961 ADTU01015962 ADTU01015963 ADTU01015964 KQ976737 KYM75978.1 UFQS01001329 UFQT01001329 SSX10382.1 SSX30070.1 KQ980924 KYN11404.1 GL767689 EFZ13155.1 GL888346 EGI62302.1 KQ983167 KYQ46936.1 DS235880 EEB19977.1 CP012526 ALC47795.1 AY250784 AAP13279.1 AY250797 AAP13292.1 AY250798 AAP13293.1 AY250796 AAP13291.1 KQ978350 KYM94718.1 AY250789 AY250790 AAP13284.1 AAP13285.1 KQ981975 KYN31615.1 AY250768 AAP13263.1 AY250785 AAP13280.1 AY250786 AAP13281.1 AY250793 AAP13288.1 AY250788 AY250795 AAP13283.1 AAP13290.1 AY250792 AAP13287.1 AY250791 AAP13286.1 AY250787 AY250794 AAP13282.1 AAP13289.1 AY250772 AY250773 AAP13267.1 AAP13268.1 AY250769 AY250779 AAP13264.1 AAP13274.1 AY250770 AY250783 AAP13266.1 AAP13278.1 KQ435713 KOX79242.1 AY250775 AY250776 AY250777 AY250780 AY250781 AY250782 AAP13270.1 AAP13271.1 AAP13272.1 AAP13275.1 AAP13276.1 AAP13277.1 AY250771 AAP13265.1 AY250774 AY250778 AAP13269.1 AAP13273.1 CM000364 EDX14109.1 AY250800 AAP13295.1 AY250799 AAP13294.1 AE014297 BT056313 BT011076 AAR82742.1 ACL68760.1 KZ288215 PBC32433.1 GEDC01018318 JAS18980.1 CM000160 EDW98192.1 CH480815 EDW43383.1 CH954182 EDV53961.1 AXCN02000051

Proteomes

UP000005204 UP000218220 UP000053268 UP000007151 UP000027135 UP000235965 + More
UP000092462 UP000036403 UP000053825 UP000092461 UP000000311 UP000053097 UP000279307 UP000005205 UP000078540 UP000078492 UP000007755 UP000075809 UP000009046 UP000092553 UP000078542 UP000078541 UP000005203 UP000053105 UP000000304 UP000000803 UP000242457 UP000005226 UP000002282 UP000001292 UP000192221 UP000008711 UP000075886

PRIDE

H9IX35 Q867H5 Q867M2 Q868A8 Q867W7 Q86G43 + More
Q867M7 Q9VCH5

Pfam

PF12110   Nup96        + More
PF04096   Nucleoporin2
PF13634   Nucleoporin_FG

Interpro

IPR036903   Peptidase_S59_sf        + More
IPR021967   Nup96
IPR007230   Peptidase_S59
IPR037637   NUP98-NUP96
IPR037665   Nucleoporin_S59-like
IPR025574   Nucleoporin_FG_rpt

SUPFAM

SSF82215 SSF82215

Gene 3D

3.30.1610.10

ProteinModelPortal

H9IX35 A0A2W1BFC5 A0A2A4K4I0 A0A194Q4W3 A0A212F926 A0A067RJY6 + More
A0A2J7PIF9 A0A2J7PID5 A0A1B0D922 A0A0J7KRZ3 A0A1L8DXK6 A0A1L8DWH8 A0A1B6IT63 A0A0L7QVG1 A0A1B6GJC9 A0A336LFV7 A0A1B6LH84 A0A1B0CEY7 E1ZUV9 A0A026WQF6 A0A158NHQ4 A0A195AUR2 A0A336KXZ5 A0A151IV19 E9J1Z2 F4WU23 A0A151WGG7 E0W2X1 A0A0M4F7F3 Q86G42 Q86G35 Q86G34 Q86G36 A0A195C3G3 Q867J6 A0A195ETN9 Q86G44 Q86G41 Q86G40 A0A087ZWJ6 Q86G37 Q867X7 Q86G38 Q86G39 Q867Y8 Q867H5 Q867M2 Q868A8 A0A0N0BJJ6 Q867W7 Q86G43 Q867M7 B4R252 Q86G32 Q86G33 Q9VCH5 A0A2A3EKU0 H2S1E7 A0A1B6CZW3 B4PNY2 B4HFZ0 A0A1W4ULL3 B3P8D7 A0A182QPM2

PDB

5A9Q E-value=1.995e-07, Score=133

KEGG

101746229 K14297 nuclear pore complex protein Nup98-Nup96 | (RefSeq) nuclear pore complex protein Nup98-Nup96

GO

GO:0005643 GO:0017056 GO:0031080 GO:0016973 GO:0030718 GO:0035167 GO:0010628 GO:0006606 GO:0044613 GO:0005704 GO:1990841 GO:0006405 GO:0005634 GO:0035080 GO:0051028 GO:0005737 GO:0005654 GO:0008236 GO:0000785 GO:0031965 GO:0071733 GO:0043922 GO:0002230 GO:0031490 GO:0036098 GO:0005703 GO:0060261 GO:0005700 GO:0045944 GO:0071390 GO:0035075 GO:0034605 GO:0030838 GO:0048484

PANTHER

PTHR23198:SF6 PTHR23198

Subcellular location

Chromosome   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleus   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleoplasm   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleus membrane   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nuclear pore complex   Associates with transcriptionally active chromatin.   With evidence from 4 publications.

Length:

444

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.41052

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00980

outside

1 - 444

Pi

173.945856

Theta

167.490362

Tajima's D

0.38376

CLR

0.303574

CSRT

0.485575721213939

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics