Gene

KWMTBOMO06266

Annotation

PREDICTED:_nuclear_pore_complex_protein_Nup98-Nup96_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(+):3559536-3566798      View in EpiBrowser

Full name

Nuclear pore complex protein Nup98-Nup96      

Location in the cell

Nuclear   Reliability : 3.196

CDS

ATGATAAACTACATGCGGCCGGACGGCACGTGTCCTGTTCCGCACCTGACGATCGGACGCAAGAACTACGGGAACGTGTACTACGACTCGGAGATCGACGTGGCCGGCCTCGACCTGGACGCCCTGGTGCACTTCCTGAACAAGGAGGTGATAGTCTATCCGGAGGACAGCGACAAGCCGCCGGTCGGAGTCGGCCTGAACAGGCGGGCCATCGTGACCCTCGACCGGGTGTGGCCCCGGGACAAGACCGAGAAACGACTCATCACCGAGCCCGACAGATTACTAAAACTGGATTACGAAGGGAAGCTGCGCAGGGTTTGCGAGAAACATGACACCAAGTTTATCGAGTATCGACCTCAAACGGGCAGCTGGGTGTTCAGGGTGGAGCATTTCAGTAAGTACGGTCTCACTGATTCCGACGAGGAGGACGACCCCACTCCGGACGTCCTGAAGCGGCAACTCCTCACCGAGTCTCTACAGAAAGCCAGCGCACCAGGTCCCAAGTCGCCTGTGAATGTGTCGGAGGCGGGGGCTGCGGTCCCGGGGCTCTTGGGGCCCGGACATCCCGGGCTGGGGGGCTCCGGCCCGCCAGGCCTGCTCAGCGAGGACAGCCTCTACAATCTCCACCACACTTCCTTACTGACTCTAAACGGCACCAGCAAAGGTGAGACAATATGA

Protein

MINYMRPDGTCPVPHLTIGRKNYGNVYYDSEIDVAGLDLDALVHFLNKEVIVYPEDSDKPPVGVGLNRRAIVTLDRVWPRDKTEKRLITEPDRLLKLDYEGKLRRVCEKHDTKFIEYRPQTGSWVFRVEHFSKYGLTDSDEEDDPTPDVLKRQLLTESLQKASAPGPKSPVNVSEAGAAVPGLLGPGHPGLGGSGPPGLLSEDSLYNLHHTSLLTLNGTSKGETI

Description

Part of the nuclear pore complex (NPC) (PubMed:25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PubMed:20547758, PubMed:28554770). Plays a role in nuclear mRNA export (PubMed:28554770). Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription (PubMed:25197089, PubMed:25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PubMed:21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PubMed:25201876).
Nuclear pore complex protein Nup98: Part of the nuclear pore complex (NPC) (PubMed:25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PubMed:20144760, PubMed:20144761, PubMed:28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PubMed:28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PubMed:20144761, PubMed:25310983, PubMed:28366641).
Nuclear pore complex protein Nup96: Part of the nuclear pore complex (NPC).

Subunit

Part of the nuclear pore complex (NPC) (PubMed:25310983). Interacts with Rae1 (PubMed:21874015, PubMed:28554770). Nuclear pore complex protein Nup98: Interacts with pzg and Chro (PubMed:25310983). Interacts with MBD-R2; the interaction allows Nup98 recruitment to chromatin (PubMed:25310983). Interacts with Trx (PubMed:25310983). Interacts with Wds (PubMed:25310983). Interacts with Mtor and Cp190 (PubMed:28366641). Upon ecdysone stimulation, interacts with EcR, CTCF, su(Hw) and Trl (PubMed:28366641).

Similarity

Belongs to the nucleoporin GLFG family.

Keywords

Alternative splicing   Autocatalytic cleavage   Chromosome   Complete proteome   Hydrolase   Membrane   mRNA transport   Nuclear pore complex   Nucleus   Protease   Protein transport   Reference proteome   Repeat   Serine protease   Transcription   Transcription regulation   Translocation   Transport  

Feature

chain  Nuclear pore complex protein Nup98
splice variant  In isoform C.

Uniprot

A0A2W1BM74   A0A2A4K4I0   A0A212FEA7   A0A194Q4W3   A0A212F926   H9IX35   + More
Q86G33   B4R252   B4PNY2   Q9VCH5-2   Q9VCH5   B3LY45   Q17CY0   Q171M2   A0A1Q3F4P6   A0A1Q3F4H1   A0A1Q3F4Q0  

EC Number

3.4.21.-

Pubmed

28756777    22118469    26354079    19121390    12802326    17994087    + More
17550304    10731132    12537572    20144760    20144761    20547758    21874015    21949861    25310983    25201876    25197089    25852164    28554770    28366641    17510324   

EMBL

KZ150084    PZC73810.1    NWSH01000160    PCG78936.1    AGBW02008966    OWR52038.1    + More
KQ459463    KPJ00394.1    AGBW02009652    OWR50231.1    BABH01021286    AY250799    AAP13294.1    CM000364    EDX14109.1    CM000160    EDW98192.1    AE014297    BT056313    BT011076    AAR82742.1    ACL68760.1    CH902617    EDV43949.1    CH477302    EAT44225.1    CH477450    EAT40699.1    GFDL01012515    JAV22530.1    GFDL01012591    JAV22454.1    GFDL01012538    JAV22507.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000005204    UP000000304    UP000002282    + More
UP000000803    UP000007801    UP000008820   

PRIDE

H9IX35    Q9VCH5   

Pfam

PF04096   Nucleoporin2        + More
PF12110   Nup96
PF13634   Nucleoporin_FG

Interpro

IPR037665   Nucleoporin_S59-like        + More
IPR037637   NUP98-NUP96       
IPR007230   Peptidase_S59       
IPR036903   Peptidase_S59_sf       
IPR021967   Nup96       
IPR025574   Nucleoporin_FG_rpt       

SUPFAM

SSF82215   SSF82215       

Gene 3D

3.30.1610.10    

ProteinModelPortal

A0A2W1BM74   A0A2A4K4I0   A0A212FEA7   A0A194Q4W3   A0A212F926   H9IX35   + More
Q86G33   B4R252   B4PNY2   Q9VCH5-2   Q9VCH5   B3LY45   Q17CY0   Q171M2   A0A1Q3F4P6   A0A1Q3F4H1   A0A1Q3F4Q0  

PDB

2Q5X     E-value=2.1611e-39,     Score=405

KEGG

101746229    K14297 nuclear pore complex protein Nup98-Nup96 | (RefSeq) nuclear pore complex protein Nup98-Nup96

GO

GO:0017056   GO:0005643   GO:0071733   GO:0043922   GO:0000785   GO:0005737   GO:0035080   GO:1990841   GO:0006405   GO:0006606   GO:0005704   GO:0030838   GO:0035167   GO:0071390   GO:0060261   GO:0005703   GO:0036098   GO:0031490   GO:0002230   GO:0008236   GO:0010628   GO:0031965   GO:0044613   GO:0005634   GO:0005654   GO:0051028   GO:0035075   GO:0005700   GO:0045944   GO:0034605   GO:0030718   GO:0006810   GO:0006378   GO:0016787   GO:0008235   GO:0019538   GO:0030145   GO:0015923   GO:0006260   GO:0006913  

PANTHER

PTHR23198:SF6   PTHR23198  

Subcellular location

Chromosome   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleus   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleoplasm   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nucleus membrane   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
Nuclear pore complex   Associates with transcriptionally active chromatin.   With evidence from 4 publications.
  

Length:

225

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00111

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10909

outside

1  -  225

 

 

Pi

188.733706

Theta

147.324851

Tajima's D

1.311991

CLR

0.157804

CSRT

0.747212639368032

Interpretation

Uncertain