Gene

KWMTBOMO06236  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001637

Annotation

PREDICTED:_histone_chaperone_asf1_[Papilio_polytes]

Location

Bomo_Chr11(-):3097512-3099274      View in EpiBrowser

Full name

Histone chaperone asf1      

Alternative Name

Anti-silencing function protein 1
Replication-coupling assembly factor subunit ASF1
dASF1

Location in the cell

Cytoplasmic   Reliability : 1.451 Nuclear   Reliability : 1.608

CDS

ATGGCCAAAGTTCATATAACCAATGTAGTTGTATTAGACAATCCAAGCCCATTTCTCAATCCGTTTCAATTCGAGTTAACCTTTGAATGCATCGAAGAACTCAAAGAAGATTTGGAATGGAAGATGATTTACGTTGGTTCTGCGGAAACGGAAGAGCACGATCAAGTTTTAGACACAATTTACGTTGGACCCATCCCAGAGGGAAGACACATGTTCGTATTTCAAGCGCCACCACCGGACGTCACAAAAATACCGGAGAATGACGCTCTCGGAGTTACTGTCGTATTATTAACGTGTTCGTATCGGGGACAGGAGTTCGTGAGAGTAGGCTATTTCATAAATAATGACTACAGTGAAAGCGAACCTGAATTACGAGAGAATACACCAGCTAAGCCTCAGTTTGATAAAGTAGTGCGTAATATATTAGCTTCAGCGCCCCGTGTGACGCGGTTTAAGATAAACTGGGCAGAGCCTGATGCTGGTACGGCCATCGACGCTGGTGACAGCAATCTAGAAATTTCTCATGCGCCCAGCAACGACTCTTACAGTGCTAGTTTTAATGCTGAGAGTCAGATAAGTGGAATAGAGTTTCAAGGTAGTTTAAGCGGCTATGGAGACAATTCTAACTCAATAGCGCCAATGGAATGCTGA

Protein

MAKVHITNVVVLDNPSPFLNPFQFELTFECIEELKEDLEWKMIYVGSAETEEHDQVLDTIYVGPIPEGRHMFVFQAPPPDVTKIPENDALGVTVVLLTCSYRGQEFVRVGYFINNDYSESEPELRENTPAKPQFDKVVRNILASAPRVTRFKINWAEPDAGTAIDAGDSNLEISHAPSNDSYSASFNAESQISGIEFQGSLSGYGDNSNSIAPMEC

Description

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Plays a role in the formation of silent heterochromatin.

Subunit

Component of the replication coupling assembly factor (RCAF), composed of asf1, histone H3 and histone H4. Interacts with the Caf1-105 subunit of the CAF-1 complex. Interacts with brm, mor and tlk.

Similarity

Belongs to the ASF1 family.

Keywords

Chaperone   Chromatin regulator   Chromosome   Complete proteome   Direct protein sequencing   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Histone chaperone asf1

Uniprot

H9IWK5   A0A194Q648   A0A2W1B7L3   A0A2A4K9Y2   A0A0N1PJC6   A0A2H1WRK4   + More
A0A212FA81   A0A3S2PAM1   A0A0L7LK42   S4P9F2   A0A1B0CEL6   A0A1L8DWG4   A0A1W4WXK4   N6UI86   J3JWP6   A0A336KWN6   A0A336KZK2   A0A0A1WUH1   A0A0M4F241   A0A0A9WIE4   D1GYX3   B4LD12   D3TQB4   B3M6Y9   W8C834   A0A1I8PPG3   A0A1B6C0R9   A0A1J1HSC8   A0A0L0C671   A0A1A9W758   B4N3L5   A0A069DQA5   A0A1A9Y0X4   A0A1B0B6X0   Q1HQS2   B4PGE1   A0A034WHK8   A0A0V0GC72   B4H9B1   A0A0P4W004   R4G4I2   A0A1W4URR4   A0A0P6IWX1   C0MIY4   Q9V464   A0A023FAK0   B4IY29   A0A170ZWW1   A0A1B6HAE2   T1PM72   B3NIG5   A0A3B0J494   A0A2J7PSX3   B4KZB4   A0A1Y1NHH0   A0A1B6L0D9   T1H5Q8   V5G7K8   Q29DE9   B0XH11   B4IIN6   A0A0T6B4W3   A0A026WUA1   A0A1Q3EX52   A0ANK9   A0A182MFZ2   A0A0J7L5L4   A0A067QSR9   D2A443   A0A1B6FXB1   Q7PNM2   A0A1B0DFP7   A0A182KPR9   D1GZ40   A0A195C1L9   A0A195DGN1   A0A195BPK6   A0A158P2S9   A0A151XHZ6   E9IWT8   A0A2S2P702   E2AKG5   A0A195EZ00   A0A182UDA1   F4W5U4   B0WK08   A0A2H8TCT0   A0A084W2K8   J9KA92   U5EZW0   A0A182I202   E2C002   A0A182P6D0   A0A182X6Y2   A0A0L7QXC7   A0A182K526   A0A2A3E6G2   V9IKJ4   A0A088A566  

Pubmed

19121390    26354079    28756777    22118469    26227816    23622113    + More
23537049    22516182    25830018    25401762    26823975    17994087    20353571    18057021    24495485    26108605    26334808    17204158    17510324    17550304    25348373    27129103    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19126864    26109357    26109356    10591219    16951084    12537569    11533245    12381660    14561777    16151251    16396992    18327897    25474469    25315136    28004739    15632085    24508170    30249741    22936249    24845553    18362917    19820115    12364791    14747013    17210077    20966253    21347285    21282665    20798317    21719571    24438588   

EMBL

BABH01021246    KQ459463    KPJ00480.1    KZ150245    PZC71879.1    NWSH01000027    + More
PCG80593.1    KQ459920    KPJ19324.1    ODYU01010472    SOQ55606.1    AGBW02009512    OWR50641.1    RSAL01000142    RVE46041.1    JTDY01000804    KOB75817.1    GAIX01003779    JAA88781.1    AJWK01008993    GFDF01003303    JAV10781.1    APGK01019132    KB740092    KB632429    ENN81450.1    ERL95444.1    BT127664    AEE62626.1    UFQS01001237    UFQT01001237    SSX09879.1    SSX29602.1    UFQS01001214    UFQT01001214    SSX09816.1    SSX29539.1    GBXI01012031    JAD02261.1    CP012525    ALC45132.1    GBHO01037308    GBHO01037307    GBHO01037306    GBHO01037305    GBRD01011190    GDHC01020144    GDHC01019464    JAG06296.1    JAG06297.1    JAG06298.1    JAG06299.1    JAG54634.1    JAP98484.1    JAP99164.1    FN546712    FN546714    CBE67011.1    CBE67013.1    CH940647    EDW69893.1    CCAG010000259    EZ423616    ADD19892.1    FN546705    FN546706    FN546707    FN546708    FN546709    FN546710    FN546711    FN546713    CH902618    CBE67004.1    CBE67005.1    CBE67006.1    CBE67007.1    CBE67008.1    CBE67009.1    CBE67010.1    CBE67012.1    EDV40854.1    GAMC01003249    JAC03307.1    GEDC01030187    GEDC01002454    JAS07111.1    JAS34844.1    CVRI01000019    CRK90434.1    JRES01000836    KNC27873.1    CH964095    EDW79220.1    GBGD01003092    JAC85797.1    JXJN01009253    JXJN01009254    DQ440372    CH477932    ABF18405.1    EAT34972.1    CM000159    EDW95300.1    GAKP01005140    JAC53812.1    GECL01000501    JAP05623.1    CH479227    EDW35335.1    GDKW01000444    JAI56151.1    GAHY01000751    JAA76759.1    GDIQ01003258    JAN91479.1    AE014296    FM245306    FM245307    FM245308    FM245309    FM245310    FM245311    FM245312    FM245313    FM245314    FM245315    FM245316    FM245317    ADV37567.1    CAR93232.1    CAR93233.1    CAR93234.1    CAR93235.1    CAR93236.1    CAR93237.1    CAR93238.1    CAR93239.1    CAR93240.1    CAR93241.1    CAR93242.1    CAR93243.1    AF189278    AM294236    AM294237    AM294238    AM294239    AM294240    AM294241    AM294242    AM294243    AM294244    AM294245    AM294246    BT004869    GBBI01000663    JAC18049.1    CH916366    EDV97572.1    GEMB01001761    JAS01407.1    GECU01036099    JAS71607.1    KA644741    KA649824    AFP64453.1    CH954178    EDV52390.1    OUUW01000002    SPP76614.1    NEVH01021922    PNF19430.1    CH933809    EDW18940.1    GEZM01002148    JAV97353.1    GEBQ01022804    JAT17173.1    GALX01002346    JAB66120.1    CH379070    EAL30465.1    DS233085    EDS27979.1    CH480844    EDW49807.1    LJIG01009773    KRT82409.1    KK107102    QOIP01000005    EZA59605.1    RLU23011.1    GFDL01015189    JAV19856.1    AM294247    CM000363    CM002912    CAL26151.1    EDX11101.1    KMZ00580.1    AXCM01006029    LBMM01000641    KMQ97911.1    KK853326    KDR08478.1    KQ971348    EFA05613.1    GECZ01014955    JAS54814.1    AAAB01008960    EAA11934.5    AJVK01058905    FN546779    CBE67078.1    KQ978379    KYM94510.1    KQ980903    KYN11619.1    KQ976432    KYM87429.1    ADTU01007456    KQ982116    KYQ59908.1    GL766607    EFZ14965.1    GGMR01012622    MBY25241.1    GL440262    EFN66107.1    KQ981905    KYN33356.1    GL887695    EGI70420.1    DS231966    EDS29552.1    GFXV01000116    MBW11921.1    ATLV01019628    KE525275    KFB44452.1    ABLF02016063    GANO01000038    JAB59833.1    APCN01000102    GL451712    EFN78698.1    KQ414705    KOC63267.1    KZ288364    PBC26862.1    JR049037    AEY60839.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000007151    UP000283053    + More
UP000037510    UP000092461    UP000192223    UP000019118    UP000030742    UP000092553    UP000008792    UP000092444    UP000007801    UP000095300    UP000183832    UP000037069    UP000091820    UP000007798    UP000092443    UP000092460    UP000008820    UP000002282    UP000008744    UP000192221    UP000000803    UP000001070    UP000095301    UP000008711    UP000268350    UP000235965    UP000009192    UP000015102    UP000001819    UP000002320    UP000001292    UP000053097    UP000279307    UP000000304    UP000075883    UP000036403    UP000027135    UP000007266    UP000007062    UP000092462    UP000075882    UP000078542    UP000078492    UP000078540    UP000005205    UP000075809    UP000000311    UP000078541    UP000075902    UP000007755    UP000030765    UP000007819    UP000075840    UP000008237    UP000075885    UP000076407    UP000053825    UP000075881    UP000242457    UP000005203   

PRIDE

H9IWK5    Q9V464   

Pfam

PF04729   ASF1_hist_chap        + More
PF03266   NTPase_1

Interpro

IPR006818   ASF1-like        + More
IPR036747   ASF1-like_sf       
IPR017282   Hist_deposition_Asf1       
IPR027417   P-loop_NTPase       
IPR004948   Nuc-triphosphatase_THEP1       

SUPFAM

SSF101546   SSF101546        + More
SSF52540   SSF52540       

Gene 3D

2.60.40.1490    

ProteinModelPortal

H9IWK5   A0A194Q648   A0A2W1B7L3   A0A2A4K9Y2   A0A0N1PJC6   A0A2H1WRK4   + More
A0A212FA81   A0A3S2PAM1   A0A0L7LK42   S4P9F2   A0A1B0CEL6   A0A1L8DWG4   A0A1W4WXK4   N6UI86   J3JWP6   A0A336KWN6   A0A336KZK2   A0A0A1WUH1   A0A0M4F241   A0A0A9WIE4   D1GYX3   B4LD12   D3TQB4   B3M6Y9   W8C834   A0A1I8PPG3   A0A1B6C0R9   A0A1J1HSC8   A0A0L0C671   A0A1A9W758   B4N3L5   A0A069DQA5   A0A1A9Y0X4   A0A1B0B6X0   Q1HQS2   B4PGE1   A0A034WHK8   A0A0V0GC72   B4H9B1   A0A0P4W004   R4G4I2   A0A1W4URR4   A0A0P6IWX1   C0MIY4   Q9V464   A0A023FAK0   B4IY29   A0A170ZWW1   A0A1B6HAE2   T1PM72   B3NIG5   A0A3B0J494   A0A2J7PSX3   B4KZB4   A0A1Y1NHH0   A0A1B6L0D9   T1H5Q8   V5G7K8   Q29DE9   B0XH11   B4IIN6   A0A0T6B4W3   A0A026WUA1   A0A1Q3EX52   A0ANK9   A0A182MFZ2   A0A0J7L5L4   A0A067QSR9   D2A443   A0A1B6FXB1   Q7PNM2   A0A1B0DFP7   A0A182KPR9   D1GZ40   A0A195C1L9   A0A195DGN1   A0A195BPK6   A0A158P2S9   A0A151XHZ6   E9IWT8   A0A2S2P702   E2AKG5   A0A195EZ00   A0A182UDA1   F4W5U4   B0WK08   A0A2H8TCT0   A0A084W2K8   J9KA92   U5EZW0   A0A182I202   E2C002   A0A182P6D0   A0A182X6Y2   A0A0L7QXC7   A0A182K526   A0A2A3E6G2   V9IKJ4   A0A088A566  

PDB

3AAD     E-value=8.90553e-63,     Score=606

KEGG

101742242    K10753 histone chaperone ASF1 | (RefSeq) histone chaperone asf1

GO

GO:0005634   GO:0006333   GO:0000122   GO:0006334   GO:0001103   GO:0005700   GO:0035059   GO:0048024   GO:0017053   GO:0042393   GO:0006337   GO:0016573   GO:0006325   GO:0098519   GO:0006412   GO:0016020   GO:0022857   GO:0004559   GO:0006013   GO:0015923   GO:0006260  

PANTHER

PTHR12040  

Subcellular location

Nucleus   Localizes to multiple sites on polytene chromosomes including transcriptionally active developmental puffs, the chromocenter and the histone gene cluster (PubMed:12381660). Localizes to active foci of DNA replication throughout S-phase and is lost from stalled replication forks (PubMed:16396992). Not detected on condensed chromatin during mitosis (PubMed:16396992).   With evidence from 3 publications.
Chromosome   Localizes to multiple sites on polytene chromosomes including transcriptionally active developmental puffs, the chromocenter and the histone gene cluster (PubMed:12381660). Localizes to active foci of DNA replication throughout S-phase and is lost from stalled replication forks (PubMed:16396992). Not detected on condensed chromatin during mitosis (PubMed:16396992).   With evidence from 3 publications.

Length:

216

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00248

Exp number, first 60 AAs:

0.00072

Total prob of N-in:

0.17023

outside

1  -  216

 

 

Pi

199.286126

Theta

184.353509

Tajima's D

0.200879

CLR

0.195321

CSRT

0.427828608569572

Interpretation

Uncertain