Gene

KWMTBOMO06235  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001638

Annotation

PREDICTED:_xaa-Pro_aminopeptidase_1_[Bombyx_mori]

Location

Bomo_Chr11(-):3075826-3093434      View in EpiBrowser

Full name

Xaa-Pro aminopeptidase ApepP      

Alternative Name

Aminopeptidase P

Location in the cell

Cytoplasmic   Reliability : 1.625 Mitochondrial   Reliability : 1.61

CDS

ATGCTAGCCGTCGCACTGATCGTCATTTTAACAGTCAAATGTAGCCTGACAGAAGGCGCTTTGGCCAGTAACAGTTCTATCGACCGAAAAGATCGCAACCGCGAGATGTCGCTACAGCGCTTGCAAGCGCTCCGAGCGCTAATGTCGAGTCAGCGTCCCGTGTTGGCAGCTTATATTATACCGACCGCCGATGCTCATAATTCGGAGTACATAGATGCAGCGGACGCCAGACGCGAGTGGATATCCGCCTTCACCGGGTCGGCTGGCACTGCAGTTGTGACGTCATCGCAGGCTCTCGTCTGGACCGACGGTAGATACTACACGCAGTTCGAGAGGGAGGTCGACTTGTCAGCGTGGACTTTAATGAAACAGACACTACCGGACACTCCCACTTTGGAGAAATGGCTGGCCTCGAACCTCAAAGACGGTGACGTAGTCGGCGTGGATCCCCAAACGATGACCAGAGACGAATGGACTCCGATACAGACTGCCCTAAAGAAAATTAGCGCTCAACTAGTGCCGATTTCGAACAACCTCGTGGATGATGTCAGGATTGAACTTGGGGACCCGGCGCCTAAGAGATCGCACAATGAACTCGCGCCATTACACGTCCGCTACACTGGCAGAACAGCGGGAGAGAAGATCGCGGAATTAAGACGGAAGATGGCGGAGAAGAAAGCTTCGGCCCTCGTTCTAACGGCCTTAGACGATATTGCTTACACGTTAAATCTACGCGGCTCCGACATCGAATATAATCCGGTCTTCTTTTCGTACCTGATCGTGATGGAGACCAATGTTGTTCTATACTGGGGCGACGGTCAACTGCCCCCCTCCGTGACGGATCACCTGAGGGAGGAGGGCGTGGACAGTGTCGAGGGCAAACCTTACGGGGACATTTTGGAGGGCTTAAAGGAAATGGCGCGAGAACTGTCGGAGAGCGGCGACGGGAGACACGTGATCTGGTTGTCCAATGACGCTAATGAGGCGATCCACAGAGCCGCCTCCGGGTCTGATGTCCTAAAGCGTCCGATTGATTTAATATCGGAGGTGTCGCCCGTGAAACTGGCTAAATTGGTCAAAAACGAAATCGAACTGCAAGGCTTCCGTAACTGCCACATCAAGGACGGTATAGCCGTGGTCAGGTTCTTCAGGTGGCTCCACGATCAAATTGACAGCGGCGAGCAGATCACAGAGGTGCAGGCTTCGGATAAACTTCTGGAGTTTAGGAGGGACGAAAAGGACTTCATGGGTCCTTCGTTTGGAACGATAGCGGGCAGCGGCGCGAACGGCGCAATCATACACTACAGCCCCGATAGAGAGGGACAGCAGACCGTGATAGAGAGAGACCACATGTTCCTTCTCGACTCCGGCGGGCAATACAGGGATGGCACGACCGACATAACTCGCACGCGGCACATGAGCGGCAACCCTACCGCGGAACAGAAGGATGCGTTCACTCGAGTGCTAAAAGGTCAGATTATGATCGGCAGCGCTTTATTCCCGAAAGGCGTTAAGGGCAACGTTCTGGACAGCTTCGCGCGTCACGCCCTGTGGGAGGTGGGCCTGGACTACGGTCACGGGACGGGTCACGGCGTGGGTCACTACCTCAACGTGCACGAGGGTCCGTCCGGAGTCTCTTGGCGTCCGTACCCCGACGATCCTGGACTGAACGTTGGACAGATATTGAGCAACGAACCAGGCTTCTACAAAGTCGGCGAATACGGAATTCGCCACGAAGATCTAATAGAGATTGTGGCTGTCGATAAGGGAAGCGATCATCCTAAGGCGAAGAATCTGAGAGGCGATTACGATGGTCGAGGCGTTTTGGGCTTCAGCACGTTGACTTTAGTGCCCAATCAAAGGGAATGTATCGATGCAGAGATTATGACCGATTTCGAGATTTCATACGTGAACGCGTACCATCGAAGAGTGCTTGACACATTGAGTCCGATACTGAAGGAGCGCGGTTTGCTTAAGGATTTGGAGTGGCTCGAAGGTCAATGCATCCCGATAACCAGGAAGTGA

Protein

MLAVALIVILTVKCSLTEGALASNSSIDRKDRNREMSLQRLQALRALMSSQRPVLAAYIIPTADAHNSEYIDAADARREWISAFTGSAGTAVVTSSQALVWTDGRYYTQFEREVDLSAWTLMKQTLPDTPTLEKWLASNLKDGDVVGVDPQTMTRDEWTPIQTALKKISAQLVPISNNLVDDVRIELGDPAPKRSHNELAPLHVRYTGRTAGEKIAELRRKMAEKKASALVLTALDDIAYTLNLRGSDIEYNPVFFSYLIVMETNVVLYWGDGQLPPSVTDHLREEGVDSVEGKPYGDILEGLKEMARELSESGDGRHVIWLSNDANEAIHRAASGSDVLKRPIDLISEVSPVKLAKLVKNEIELQGFRNCHIKDGIAVVRFFRWLHDQIDSGEQITEVQASDKLLEFRRDEKDFMGPSFGTIAGSGANGAIIHYSPDREGQQTVIERDHMFLLDSGGQYRDGTTDITRTRHMSGNPTAEQKDAFTRVLKGQIMIGSALFPKGVKGNVLDSFARHALWEVGLDYGHGTGHGVGHYLNVHEGPSGVSWRPYPDDPGLNVGQILSNEPGFYKVGEYGIRHEDLIEIVAVDKGSDHPKAKNLRGDYDGRGVLGFSTLTLVPNQRECIDAEIMTDFEISYVNAYHRRVLDTLSPILKERGLLKDLEWLEGQCIPITRK

Description

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.

Catalytic Activity

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactor

Mn(2+)

Biophysicochemical Properties

Optimum pH is 7.6.

Similarity

Belongs to the peptidase M24B family.

Keywords

Aminopeptidase   Complete proteome   Cytoplasm   Hydrolase   Manganese   Metal-binding   Protease   Reference proteome  

Feature

chain  Xaa-Pro aminopeptidase ApepP

Uniprot

H9IWK6   A0A2A4K1N0   A0A194Q542   A0A0N0PEM0   A0A194Q663   F2YHL8   + More
A0A2H1WE50   A0A2A4JIL6   A0A0T6ATZ3   A0A182JDI6   A0A182N8Z8   A0A0A1XP05   A0A182W4V1   D6WLY7   A0A182Y514   A0A182Q0F4   A0A1W4VXW7   A0A182M9W8   A0A1L8EFL3   A0A1L8EFY8   A0A1L8EFT0   A0A182XPM7   A0A1L8EFQ1   A0A182PNQ4   A0A182RP79   A0A1L8EFL9   A0A034UZ61   Q5TW92   A0A182VC76   A0A182K5H5   A0A182KL97   A0A0K8VUN3   A0A2M3Z589   A0A1Q3G343   A0A182IDV1   A0A0K8TT40   A0A182FME0   A0A1S4FNP6   Q16UX2   A0A1S4FNB2   Q16UX1   A0A1I8NYB9   T1DPD1   A0A2M4BHK4   A0A1I8NYD3   B5DWN6   A0A1J1INB7   A0A2M4BHM1   A0A1Y1MRV6   B3MML0   A0A023EVH9   W5JQL7   A0A3B0KAY1   B4GE57   A0A2M4AFN2   W8C8S2   A0A2M4AFQ4   O96794   Q9VJG0   B4NBP8   E0V912   A0A0J9R3N8   A0A0P5N2B9   A0A0P5YIN6   A0A0P5UYA9   B4P8U5   A0A0P5AQ29   B3NLF8   A0A0P6AUE6   A0A0P6CIW7   A0A0P5ZQD5   A0A0P6A1X3   B4Q7I7   A0A0P4ZJN6   A0A1L8E2Y5   A0A1L8E2K1   A0A0P5V5V5   A0A0P5S2U6   A0A0P5MR17   A0A0P5JZH2   A0A0P6GIR2   A0A0P4XLX8   A0A0P5MKE7   A0A0P6CY66   A0A0P5VVJ4   T1PD98   A0A0P4XT88   A0A1A9YT01   A0A1A9WYM0   A0A0P5HT27   B4L176   A0A1A9VFT0   R4FNJ0   A0A067RCX1   A0A1I8N275   A0A0P4VTP9   A0A2J7PRP2  

EC Number

3.4.11.9

Pubmed

19121390    26354079    25830018    18362917    19820115    25244985    + More
25348373    12364791    14747013    17210077    20966253    26369729    17510324    15632085    17994087    28004739    24945155    20920257    23761445    24495485    11872174    10731132    12537572    12537569    20566863    22936249    17550304    24845553    25315136    27129103   

EMBL

BABH01021246    NWSH01000280    PCG77804.1    KQ459463    KPJ00479.1    KQ459920    + More
KPJ19323.1    KPJ00495.1    JF262040    ADZ74177.1    ODYU01008066    SOQ51348.1    NWSH01001426    PCG71273.1    LJIG01022812    KRT78593.1    GBXI01001615    JAD12677.1    KQ971343    EFA04188.1    AXCN02001401    AXCM01002320    GFDG01001277    JAV17522.1    GFDG01001280    JAV17519.1    GFDG01001283    JAV17516.1    GFDG01001281    JAV17518.1    GFDG01001282    JAV17517.1    GAKP01022691    JAC36261.1    AAAB01008811    EAL41692.4    GDHF01009720    JAI42594.1    GGFM01002936    MBW23687.1    GFDL01000869    JAV34176.1    APCN01004825    GDAI01000081    JAI17522.1    CH477612    EAT38334.1    EAT38333.1    GAMD01003444    JAA98146.1    GGFJ01003395    MBW52536.1    CM000070    EDY68177.2    CVRI01000054    CRL00590.1    GGFJ01003396    MBW52537.1    GEZM01029634    JAV86027.1    CH902620    EDV30956.1    GAPW01000577    JAC13021.1    ADMH02000792    ETN65044.1    OUUW01000007    SPP83259.1    CH479182    EDW33892.1    GGFK01006280    MBW39601.1    GAMC01002794    JAC03762.1    GGFK01006293    MBW39614.1    AJ131920    CAA10526.2    AY082012    AE014134    AY061297    AAL28845.1    AAL99293.1    CH964232    EDW81212.2    DS234988    EEB09868.1    CM002910    KMY90641.1    GDIQ01148334    JAL03392.1    GDIP01058753    JAM44962.1    GDIP01107138    JAL96576.1    CM000158    EDW90203.1    GDIP01196076    GDIP01081431    JAJ27326.1    CH954179    EDV54874.1    GDIP01038153    JAM65562.1    GDIQ01090633    JAN04104.1    GDIP01041094    JAM62621.1    GDIP01040200    JAM63515.1    CM000361    EDX05285.1    GDIP01215680    JAJ07722.1    GFDF01001142    JAV12942.1    GFDF01001143    JAV12941.1    GDIP01104536    JAL99178.1    GDIQ01145525    GDIQ01093087    GDIQ01030273    JAL58639.1    GDIQ01152570    JAK99155.1    GDIQ01191342    GDIQ01036630    JAK60383.1    GDIQ01108886    GDIQ01052418    JAN42319.1    GDIP01239376    JAI84025.1    GDIQ01155365    JAK96360.1    GDIQ01088145    GDIQ01086396    JAN06592.1    GDIP01094597    JAM09118.1    KA646762    AFP61391.1    GDIP01238077    JAI85324.1    GDIQ01229144    JAK22581.1    CH933809    EDW19258.2    ACPB03006450    GAHY01001269    JAA76241.1    KK852543    KDR21696.1    GDKW01001241    JAI55354.1    NEVH01021955    PNF19004.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000075880    UP000075884    + More
UP000075920    UP000007266    UP000076408    UP000075886    UP000192221    UP000075883    UP000076407    UP000075885    UP000075900    UP000007062    UP000075903    UP000075881    UP000075882    UP000075840    UP000069272    UP000008820    UP000095300    UP000001819    UP000183832    UP000007801    UP000000673    UP000268350    UP000008744    UP000000803    UP000007798    UP000009046    UP000002282    UP000008711    UP000000304    UP000092443    UP000091820    UP000009192    UP000078200    UP000015103    UP000027135    UP000095301    UP000235965   

PRIDE

H9IWK6    O96794    Q9VJG0   

Pfam

PF00557   Peptidase_M24        + More
PF01321   Creatinase_N
PF16188   Peptidase_M24_C

Interpro

IPR000587   Creatinase_N        + More
IPR000994   Pept_M24       
IPR036005   Creatinase/aminopeptidase-like       
IPR029149   Creatin/AminoP/Spt16_NTD       
IPR033740   Pept_M24B       
IPR032416   Peptidase_M24_C       
IPR001131   Peptidase_M24B_aminopep-P_CS       

SUPFAM

SSF55920   SSF55920        + More
SSF53092   SSF53092       

Gene 3D

3.40.350.10    

CDD

cd01085  APP

ProteinModelPortal

H9IWK6   A0A2A4K1N0   A0A194Q542   A0A0N0PEM0   A0A194Q663   F2YHL8   + More
A0A2H1WE50   A0A2A4JIL6   A0A0T6ATZ3   A0A182JDI6   A0A182N8Z8   A0A0A1XP05   A0A182W4V1   D6WLY7   A0A182Y514   A0A182Q0F4   A0A1W4VXW7   A0A182M9W8   A0A1L8EFL3   A0A1L8EFY8   A0A1L8EFT0   A0A182XPM7   A0A1L8EFQ1   A0A182PNQ4   A0A182RP79   A0A1L8EFL9   A0A034UZ61   Q5TW92   A0A182VC76   A0A182K5H5   A0A182KL97   A0A0K8VUN3   A0A2M3Z589   A0A1Q3G343   A0A182IDV1   A0A0K8TT40   A0A182FME0   A0A1S4FNP6   Q16UX2   A0A1S4FNB2   Q16UX1   A0A1I8NYB9   T1DPD1   A0A2M4BHK4   A0A1I8NYD3   B5DWN6   A0A1J1INB7   A0A2M4BHM1   A0A1Y1MRV6   B3MML0   A0A023EVH9   W5JQL7   A0A3B0KAY1   B4GE57   A0A2M4AFN2   W8C8S2   A0A2M4AFQ4   O96794   Q9VJG0   B4NBP8   E0V912   A0A0J9R3N8   A0A0P5N2B9   A0A0P5YIN6   A0A0P5UYA9   B4P8U5   A0A0P5AQ29   B3NLF8   A0A0P6AUE6   A0A0P6CIW7   A0A0P5ZQD5   A0A0P6A1X3   B4Q7I7   A0A0P4ZJN6   A0A1L8E2Y5   A0A1L8E2K1   A0A0P5V5V5   A0A0P5S2U6   A0A0P5MR17   A0A0P5JZH2   A0A0P6GIR2   A0A0P4XLX8   A0A0P5MKE7   A0A0P6CY66   A0A0P5VVJ4   T1PD98   A0A0P4XT88   A0A1A9YT01   A0A1A9WYM0   A0A0P5HT27   B4L176   A0A1A9VFT0   R4FNJ0   A0A067RCX1   A0A1I8N275   A0A0P4VTP9   A0A2J7PRP2  

PDB

3CTZ     E-value=1.16215e-133,     Score=1223

KEGG

101744492    K01262 Xaa-Pro aminopeptidase [EC:3.4.11.9] | (RefSeq) xaa-Pro aminopeptidase 1

GO

GO:0046872   GO:0070006   GO:0016021   GO:0004177   GO:0016787   GO:0005737   GO:0005829   GO:0006508   GO:0005524   GO:0006412   GO:0016020   GO:0022857   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

Subcellular location

Cytoplasm  

SignalP

Position:   1 - 19,         Likelihood:  0.752820

 

 

Length:

674

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.9563

Exp number, first 60 AAs:

0.47144

Total prob of N-in:

0.01115

outside

1  -  674

 

 

Pi

257.893549

Theta

218.959086

Tajima's D

1.750412

CLR

0.120774

CSRT

0.84110794460277

Interpretation

Uncertain