Gene

KWMTBOMO06233  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001639

Annotation

PREDICTED:_probable_Xaa-Pro_aminopeptidase_P_[Papilio_xuthus]

Location

Bomo_Chr11(-):3048037-3063434      View in EpiBrowser

Full name

Xaa-Pro aminopeptidase ApepP      

Alternative Name

Aminopeptidase P

Location in the cell

PlasmaMembrane   Reliability : 2.268

CDS

ATGGCCCGTGCCTTCGTTCTAATTATATGGTGTTTATGTTTCAGTATATCTCGATGTCATATTCCTAATAATTATTACGATTCGGCCGAGAGTGTTGCACCGGTGGCAGTGCTTCCCGGAAATGTAACAAAGTTGACTCGTTCCGAGAGTCAAGAGCGTCTCAGGGCAGTGCGACTTGTCTTGGCTTCTAGAGCAGTCGACGCATACATCGTGCCCACAGCTGATGCCCATAACTCGCAATACATAGCGCCTTCTGATGCTCGCCGAGAATGGGTGTCGGGTCTGCGTGGCTCGTCTGGTACTTCGGTGGTGACCGCCACCAGAGCTTTAGTCTGGACAGACGCTAGATACTTCACGCAGTTCGAAGTGGAAGTAGACGGGAGTCTTTGGGAGCTGATGAGGCAAGGCACCGATCCCTCGATCCAAAATTGGTTAGTTGCGAATATGCCACCGAACTCTGTAGTTGCTGTCGACCCAACTACGTACACCAGAAACTCATGGAACACTCTCCAGGCGGCACTAACTCGAGCCAACATCAAATTAGAAGCAATATCTGAAAATTTAATAGACTTGGCCAGAGTTAGTATTGGTGATGGTCCTCCGAGCCGACCTAACAATCCATTGATTCCTCTGACCGTGAACTTTACTGGTCGACCTTCGAGTGACAAAATCTCGCAACTGCTTCAACAAATGAATTCAAGAGGCGCCTCCGCTTTGGTCCTGACAGCCCTCGATGATATAGCCTACACACTAAATCTCCGTGGTACTGATATACCGTTTAATCCGGTGTTCTTTGCCTATTTGGTCATCAGAACGGATCTGGTAGCACCGAACAATATTATTCTGTTCTGGGGCAACGGAGTTCTGTCGTCAGACATATCACAGCACTTGGCTTCAGAGAACACCCGATTACAGGCAAGACCGTATGCAGAAATCTTCACGTATCTCGGTACGTTGGCGTCCGAAGTATCCGGTAGGAGTATCTGGTTGTCCGATGACGCGAGCCACGCTGTCTATTCTGCGGTTGAAAGTGCCTCAAACGTTAACATTCAGTCTTCTGTATCTCCTGTAGCCTTGATGAAGGTTATCAAGAATGAAGTCGAATTGCAGGGCTTCCGTAACGCACATGTCAAAGATGGCGTAGCTGTGGTAAGGGCGCTCTACTGGCTTCACCGGCAGTTGGACACTGGAGCCGAGGTCACCGAGGTCGGCTTGGTAAACAAACTCGCTGAATACAGGAGTGAAGAAACCGACTCCATGGGTCCTTCGTTTTCGACTATCGCCGGCGCCGGAGAGAATGGTGCGATAATACACTACAGTCCTCTGAGCGAGGGTCCTCAGAGAGTGATCACCAAGGATGACATGGTTCTGGTTGATTCAGGAGGGCAATACAAAGATGGCACCACCGATATCACCAGGACCCGGCACATGAACTCTTCCCCAACTCCTGAACAGCGTCGAGCGTTCACAAGGGTCATGAAGGGACAGATCGCTCTGGGAACTGCCGTCTTGCCAGCAGGCATATTGGGTCACACAATTGAGGTGCTGGCCCGCAAGGCGCTTTGGGACATCGGCCTCAACTATGGTCACGGGACGGGTCACGGCGTGGGACACTACCTCAACGTGCACGAGGCACCGGCCTGGATCCTCAGTGCAGTCTCGGTTGATGACCCTGGCATCAGACCAAACATGATATACAGTAATGAACCCGGGTACTACGAAGTAGGGGAGTACGGGATTCGCCACGAAGATCTGGTCCAGACTATCGAGATGAACAGCAGCGCTGATCATGTACTGGTACGTGAGCATTCGATGTACTGTAAACAAAATTGA

Protein

MARAFVLIIWCLCFSISRCHIPNNYYDSAESVAPVAVLPGNVTKLTRSESQERLRAVRLVLASRAVDAYIVPTADAHNSQYIAPSDARREWVSGLRGSSGTSVVTATRALVWTDARYFTQFEVEVDGSLWELMRQGTDPSIQNWLVANMPPNSVVAVDPTTYTRNSWNTLQAALTRANIKLEAISENLIDLARVSIGDGPPSRPNNPLIPLTVNFTGRPSSDKISQLLQQMNSRGASALVLTALDDIAYTLNLRGTDIPFNPVFFAYLVIRTDLVAPNNIILFWGNGVLSSDISQHLASENTRLQARPYAEIFTYLGTLASEVSGRSIWLSDDASHAVYSAVESASNVNIQSSVSPVALMKVIKNEVELQGFRNAHVKDGVAVVRALYWLHRQLDTGAEVTEVGLVNKLAEYRSEETDSMGPSFSTIAGAGENGAIIHYSPLSEGPQRVITKDDMVLVDSGGQYKDGTTDITRTRHMNSSPTPEQRRAFTRVMKGQIALGTAVLPAGILGHTIEVLARKALWDIGLNYGHGTGHGVGHYLNVHEAPAWILSAVSVDDPGIRPNMIYSNEPGYYEVGEYGIRHEDLVQTIEMNSSADHVLVREHSMYCKQN

Description

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.

Catalytic Activity

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactor

Mn(2+)

Biophysicochemical Properties

Optimum pH is 7.6.

Similarity

Belongs to the peptidase M24B family.

Keywords

Aminopeptidase   Complete proteome   Cytoplasm   Hydrolase   Manganese   Metal-binding   Protease   Reference proteome  

Feature

chain  Xaa-Pro aminopeptidase ApepP

Uniprot

A0A2A4JIL6   F2YHL8   A0A194Q663   A0A2H1WE50   A0A2W1B3H4   A0A194Q542   + More
A0A2A4K1N0   H9IWK6   A0A2W1B9K5   A0A0N0PEM0   A0A1Y1MRV6   D6WLY7   A0A2M4AFN2   A0A2M4BHK4   A0A2M4AFQ4   A0A0P4XLX8   A0A0P4XT88   A0A162P4Y4   A0A182N8Z8   A0A0M4EED9   A0A0P5N2B9   A0A182Y514   A0A2M4BHM1   A0A0P5AQ29   A0A0P5UYA9   A0A0P5TIS6   A0A0P5YIN6   A0A0P4YFM3   A0A0P6AUE6   A0A0P4ZJN6   A0A1S4FNB2   Q16UX2   A0A182FME0   A0A0P6A1X3   A0A1S4FNP6   A0A0P5ZQD5   Q16UX1   W5JQL7   A0A2M3Z589   A0A182Q0F4   A0A0N8BPT7   A0A0P5S2U6   A0A0P5N4C8   A0A0P6GIR2   A0A0P5V5V5   A0A0P5MR17   A0A034UZ61   A0A0P5JZH2   A0A1W4VXW7   A0A0P5LGJ8   A0A0P6CY66   A0A1Q3G343   A0A0P5MKE7   A0A0P6CIW7   A0A0P5VVJ4   T1DPD1   A0A0P5HT27   E9G2Q5   U5EW56   A0A182M9W8   A0A182RP79   A0A1I8N275   A0A336ML55   A0A336MWP6   A0A336MJJ6   A0A182W4V1   A0A182K5H5   A0A336N4Y0   T1PD98   A0A0J9R3N8   A0A182XPM7   Q9VJG0   O96794   A0A0K8VUN3   A0A0A1XP05   A0A182VC76   Q5TW92   A0A023EVH9   A0A1B6C516   A0A182KL97   A0A182IDV1   B4Q7I7   B3NLF8   A0A182PNQ4   A0A1A9WYM0   A0A1L8E2Y5   A0A0T6ATZ3   A0A1L8E2K1   A0A1L8EFL3   A0A1L8EFT0   A0A0P5Z7Q9   A0A1L8EFY8   A0A1L8EFQ1   B3MML0   A0A1J1INB7   A0A1L8EFL9   A0A226ELD4   A0A2J7PRP2  

EC Number

3.4.11.9

Pubmed

26354079    28756777    19121390    28004739    18362917    19820115    + More
25244985    17510324    20920257    23761445    25348373    21292972    25315136    22936249    11872174    10731132    12537572    12537569    25830018    12364791    14747013    17210077    24945155    20966253    17994087   

EMBL

NWSH01001426    PCG71273.1    JF262040    ADZ74177.1    KQ459463    KPJ00495.1    + More
ODYU01008066    SOQ51348.1    KZ150382    PZC71089.1    KPJ00479.1    NWSH01000280    PCG77804.1    BABH01021246    KZ150245    PZC71878.1    KQ459920    KPJ19323.1    GEZM01029634    JAV86027.1    KQ971343    EFA04188.1    GGFK01006280    MBW39601.1    GGFJ01003395    MBW52536.1    GGFK01006293    MBW39614.1    GDIP01239376    JAI84025.1    GDIP01238077    JAI85324.1    LRGB01000512    KZS18524.1    CP012525    ALC44134.1    GDIQ01148334    JAL03392.1    GGFJ01003396    MBW52537.1    GDIP01196076    GDIP01081431    JAJ27326.1    GDIP01107138    JAL96576.1    GDIP01125689    JAL78025.1    GDIP01058753    JAM44962.1    GDIP01229272    JAI94129.1    GDIP01038153    JAM65562.1    GDIP01215680    JAJ07722.1    CH477612    EAT38334.1    GDIP01040200    JAM63515.1    GDIP01041094    JAM62621.1    EAT38333.1    ADMH02000792    ETN65044.1    GGFM01002936    MBW23687.1    AXCN02001401    GDIQ01156763    JAK94962.1    GDIQ01145525    GDIQ01093087    GDIQ01030273    JAL58639.1    GDIQ01158765    JAK92960.1    GDIQ01108886    GDIQ01052418    JAN42319.1    GDIP01104536    JAL99178.1    GDIQ01152570    JAK99155.1    GAKP01022691    JAC36261.1    GDIQ01191342    GDIQ01036630    JAK60383.1    GDIQ01195106    JAK56619.1    GDIQ01088145    GDIQ01086396    JAN06592.1    GFDL01000869    JAV34176.1    GDIQ01155365    JAK96360.1    GDIQ01090633    JAN04104.1    GDIP01094597    JAM09118.1    GAMD01003444    JAA98146.1    GDIQ01229144    JAK22581.1    GL732530    EFX86469.1    GANO01001581    JAB58290.1    AXCM01002320    UFQT01001441    SSX30595.1    UFQT01002456    SSX33509.1    SSX30594.1    SSX33508.1    KA646762    AFP61391.1    CM002910    KMY90641.1    AY082012    AE014134    AY061297    AAL28845.1    AAL99293.1    AJ131920    CAA10526.2    GDHF01009720    JAI42594.1    GBXI01001615    JAD12677.1    AAAB01008811    EAL41692.4    GAPW01000577    JAC13021.1    GEDC01028978    JAS08320.1    APCN01004825    CM000361    EDX05285.1    CH954179    EDV54874.1    GFDF01001142    JAV12942.1    LJIG01022812    KRT78593.1    GFDF01001143    JAV12941.1    GFDG01001277    JAV17522.1    GFDG01001283    JAV17516.1    GDIP01047684    JAM56031.1    GFDG01001280    JAV17519.1    GFDG01001281    JAV17518.1    CH902620    EDV30956.1    CVRI01000054    CRL00590.1    GFDG01001282    JAV17517.1    LNIX01000003    OXA57386.1    NEVH01021955    PNF19004.1   

Proteomes

UP000218220    UP000053268    UP000005204    UP000053240    UP000007266    UP000076858    + More
UP000075884    UP000092553    UP000076408    UP000008820    UP000069272    UP000000673    UP000075886    UP000192221    UP000000305    UP000075883    UP000075900    UP000095301    UP000075920    UP000075881    UP000076407    UP000000803    UP000075903    UP000007062    UP000075882    UP000075840    UP000000304    UP000008711    UP000075885    UP000091820    UP000007801    UP000183832    UP000198287    UP000235965   

PRIDE

H9IWK6    Q9VJG0    O96794   

Pfam

PF01321   Creatinase_N        + More
PF16188   Peptidase_M24_C
PF00557   Peptidase_M24

Interpro

IPR000587   Creatinase_N        + More
IPR000994   Pept_M24       
IPR029149   Creatin/AminoP/Spt16_NTD       
IPR032416   Peptidase_M24_C       
IPR036005   Creatinase/aminopeptidase-like       
IPR033740   Pept_M24B       
IPR001131   Peptidase_M24B_aminopep-P_CS       

SUPFAM

SSF55920   SSF55920        + More
SSF53092   SSF53092       

Gene 3D

3.40.350.10    

CDD

cd01085  APP

ProteinModelPortal

A0A2A4JIL6   F2YHL8   A0A194Q663   A0A2H1WE50   A0A2W1B3H4   A0A194Q542   + More
A0A2A4K1N0   H9IWK6   A0A2W1B9K5   A0A0N0PEM0   A0A1Y1MRV6   D6WLY7   A0A2M4AFN2   A0A2M4BHK4   A0A2M4AFQ4   A0A0P4XLX8   A0A0P4XT88   A0A162P4Y4   A0A182N8Z8   A0A0M4EED9   A0A0P5N2B9   A0A182Y514   A0A2M4BHM1   A0A0P5AQ29   A0A0P5UYA9   A0A0P5TIS6   A0A0P5YIN6   A0A0P4YFM3   A0A0P6AUE6   A0A0P4ZJN6   A0A1S4FNB2   Q16UX2   A0A182FME0   A0A0P6A1X3   A0A1S4FNP6   A0A0P5ZQD5   Q16UX1   W5JQL7   A0A2M3Z589   A0A182Q0F4   A0A0N8BPT7   A0A0P5S2U6   A0A0P5N4C8   A0A0P6GIR2   A0A0P5V5V5   A0A0P5MR17   A0A034UZ61   A0A0P5JZH2   A0A1W4VXW7   A0A0P5LGJ8   A0A0P6CY66   A0A1Q3G343   A0A0P5MKE7   A0A0P6CIW7   A0A0P5VVJ4   T1DPD1   A0A0P5HT27   E9G2Q5   U5EW56   A0A182M9W8   A0A182RP79   A0A1I8N275   A0A336ML55   A0A336MWP6   A0A336MJJ6   A0A182W4V1   A0A182K5H5   A0A336N4Y0   T1PD98   A0A0J9R3N8   A0A182XPM7   Q9VJG0   O96794   A0A0K8VUN3   A0A0A1XP05   A0A182VC76   Q5TW92   A0A023EVH9   A0A1B6C516   A0A182KL97   A0A182IDV1   B4Q7I7   B3NLF8   A0A182PNQ4   A0A1A9WYM0   A0A1L8E2Y5   A0A0T6ATZ3   A0A1L8E2K1   A0A1L8EFL3   A0A1L8EFT0   A0A0P5Z7Q9   A0A1L8EFY8   A0A1L8EFQ1   B3MML0   A0A1J1INB7   A0A1L8EFL9   A0A226ELD4   A0A2J7PRP2  

PDB

3CTZ     E-value=3.17488e-107,     Score=995

KEGG

101742084    K01262 Xaa-Pro aminopeptidase [EC:3.4.11.9] | (RefSeq) xaa-Pro aminopeptidase 1

GO

GO:0046872   GO:0016787   GO:0004177   GO:0070006   GO:0016021   GO:0005737   GO:0005829   GO:0006508   GO:0005524   GO:0006412   GO:0016020   GO:0022857   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

Subcellular location

Cytoplasm  

SignalP

Position:   1 - 19,         Likelihood:  0.981929

 

 

Length:

610

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.167

Exp number, first 60 AAs:

0.09112

Total prob of N-in:

0.00653

outside

1  -  610

 

 

Pi

228.24743

Theta

168.874019

Tajima's D

1.197278

CLR

0.775049

CSRT

0.709114544272786

Interpretation

Uncertain