Gene

KWMTBOMO06221  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001648

Annotation

PREDICTED:_ferrochelatase?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr11(-):2724409-2741582      View in EpiBrowser

Full name

Ferrochelatase       + More
Ferrochelatase, mitochondrial      

Alternative Name

Heme synthase
Protoheme ferro-lyase

Location in the cell

Mitochondrial   Reliability : 2.264

CDS

ATGATGTCTAAAATTCATCGCTTCAATTCCATGATACTACCTCGTTTACCTCCTGCATTCAGCACGGCTTCAGGAACCGCTGTCAAACCTAAGACTGCTATAGTCATGCTGAATATGGGTGGGCCGGAGACCACGGACCAGGTTGGTGACTATCTTCACAGGATAATGACAGACAGAGACATGATCCAGCTTCCGGTGCAGAGTAAACTGGGACCGTGGATAGCCAGTAGAAGGACCGAGGAAGTCAAGAAGAAGTATTCGGAGATTGGTGGAGGATCACCTATATTGAAATGGACAAATAGTCAAGGTAGCTTATTAACGCAGGCCTTAGATCAGATGCTCCCGGAGTCAGCCCCTCATAAGCACTACGTGGCGTTCAGATACGTTCCTCCGTTCACGGAAGACGCCTTCAGGGAGGTGGAAAGCGACGGAGCGGACAGAGTTATCATATTCTCGCAGTATCCTCAGTACAGTTGTGCGACGACTGGTTCTAGTCTGAACGCGATCGCGGATTTCTATAGGAACAGGACGACACCGGCAAACGTAAAGTTTAGTTTGATAGAACGCTGGGCGTCCCACAAGCTGTTGGCGAAGGTCTTCTCCGAGAGGATCAAGGAGAAACTGGACAAATTCGATGAGAAGATCAGGGATGACGTATTGATACTGTTCACGGCGCATAGTCTGCCTTTGAAGGCCGTATCGAGAGGCGACACGTATCCTCACGAGGTGGCCTCCACCGTATCGAGGACCATGGAGGAGCTCGGCGGCCGGAATCCGCACCGGCTGGTCTGGCAGTCGAAGGTGGGCCCCCTGCCCTGGCTCCAGCCCTATACCGACGACGCGATCAAGTTGTACGCGAAGCAAGGAGTCAAGCACCTGATCCTGGTGCCAGTGGCCTTCGTCAACGAACACATCGAGACCCTGCACGAGCTGGACATCGAGTACTGCGACGAGGTAGCCAAGGAGGCCGGGATCCTCCAAATCGAGAGGGCGGAGGCGCCGAACGTGCACCCCACGTTCATCGCGGCGCTGGCGGACGTCGTCGCGGGCCACATCAGCAACGGACCGAGGATCTCGAAGCAGTTCCTGACCAGATGTCCACATTGCGTGAGTCAGAGATGTCTCGCGTCGAAAGAGTTCTTCAAGAGATTGTGTGGCGCCGATCAGAACGTGGATAAAATAGGATCTTAA

Protein

MMSKIHRFNSMILPRLPPAFSTASGTAVKPKTAIVMLNMGGPETTDQVGDYLHRIMTDRDMIQLPVQSKLGPWIASRRTEEVKKKYSEIGGGSPILKWTNSQGSLLTQALDQMLPESAPHKHYVAFRYVPPFTEDAFREVESDGADRVIIFSQYPQYSCATTGSSLNAIADFYRNRTTPANVKFSLIERWASHKLLAKVFSERIKEKLDKFDEKIRDDVLILFTAHSLPLKAVSRGDTYPHEVASTVSRTMEELGGRNPHRLVWQSKVGPLPWLQPYTDDAIKLYAKQGVKHLILVPVAFVNEHIETLHELDIEYCDEVAKEAGILQIERAEAPNVHPTFIAALADVVAGHISNGPRISKQFLTRCPHCVSQRCLASKEFFKRLCGADQNVDKIGS

Description

Catalyzes the ferrous insertion into protoporphyrin IX.

Catalytic Activity

2 H(+) + heme b = Fe(2+) + protoporphyrin IX

Cofactor

[2Fe-2S] cluster

Similarity

Belongs to the ferrochelatase family.

Keywords

2Fe-2S   Alternative splicing   Complete proteome   Heme biosynthesis   Iron   Iron-sulfur   Lyase   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Porphyrin biosynthesis   Reference proteome   Transit peptide  

Feature

chain  Ferrochelatase
splice variant  In isoform B.

Uniprot

H9IWL6   A0A194Q673   A0A2A4K1G5   A0A0N0PDD9   A0A1I8NIE5   A0A0A1WJI0   + More
A0A0L0CEU2   A0A1I8Q922   A0A0K8VXJ2   A0A0K8UYX0   W8C3L1   A0A034WXW5   A0A1L8DZM4   A0A1I8JVS6   A0A1L8DZL5   A0A182VEE7   A0A182I916   A0A232EQE6   A0A182UDS9   A0A0M4F540   A0A182LAZ9   Q7QG25   A0A0C9R3D5   K7J6F4   A0A3F2YU13   A0A1B6JBC8   B3LVE6   A0A0K8TL18   A0A182PQQ9   B4K856   A0A182QRZ2   A0A2M3ZGE4   A0A1Q3FF29   B4LY79   B4N956   A0A2M3Z273   A0A182JCM4   A0A340TBF9   T1PJ01   B0WMV1   A0A2Y9D1F0   A0A182HDH9   A0A154P178   A0A2J7RC77   A0A084WR17   Q17A56   A0A182GMR7   A0A2M4ACE0   A0A2J7RC80   B4JTR5   A0A182M850   A0A182S4U9   A0A2M4ACD1   Q967G9   B4PP36   B3P4Z2   A0A2Y9D0I2   A0A3B0K9N3   A0A0R1EBB5   A0A1B0DQV8   A0A1W4VYK9   A0A1W4VZG1   W5JKR8   A0A1B6KI31   B4QTA8   E2BRA4   B4IJ43   E9IFZ2   B4G340   Q297V9   A0A0P4VTD1   A0A336N1E7   Q9V9S8   A0A2M4BR17   E2AB59   C4WVX3   A0A2W1B7B1   A0A1J1J4S4   A0A336MYP4   A0A0A9WFE4   T1DUG1   A0A2S2NQ52   A0A151ICQ7   T1HSU2   A0A151WKA4   A0A195BS91   A0A158NY65   A0A1A9Y931   A0A087ZU01   A0A1B0B6R7   A0A2A3EKZ1   A0A1B0FL77   A0A1B6C2V0   A0A1B6DFR4   A0A182YJM0   A0A310SRK1   A0A067RJX2   A0A1B0AGK9   A0A151ISJ6   F4W9L3  

EC Number

4.99.1.1

Pubmed

19121390    26354079    25315136    25830018    26108605    24495485    + More
25348373    28648823    20966253    12364791    14747013    17210077    20075255    17994087    26369729    26483478    24438588    17510324    15532727    17550304    20920257    23761445    20798317    21282665    15632085    27129103    9712849    10731132    12537572    12537569    28756777    25401762    26823975    21347285    25244985    24845553    21719571   

EMBL

BABH01021223    BABH01021224    KQ459463    KPJ00505.1    NWSH01000270    PCG77866.1    + More
KQ460393    KPJ15385.1    GBXI01015083    JAC99208.1    JRES01000501    KNC30737.1    GDHF01009074    JAI43240.1    GDHF01020586    JAI31728.1    GAMC01006017    GAMC01006014    JAC00542.1    GAKP01000324    JAC58628.1    GFDF01002207    JAV11877.1    GFDF01002208    JAV11876.1    APCN01003158    NNAY01002784    OXU20568.1    CP012526    ALC46582.1    AAAB01008844    EAA05967.3    GBYB01010777    GBYB01010779    JAG80544.1    JAG80546.1    GECU01011373    JAS96333.1    CH902617    EDV41474.1    GDAI01002531    JAI15072.1    CH933806    EDW15410.2    AXCN02001183    GGFM01006838    MBW27589.1    GFDL01008892    JAV26153.1    CH940650    EDW67967.1    CH964232    EDW81603.1    GGFM01001886    MBW22637.1    KA647893    AFP62522.1    DS232003    EDS31343.1    JXUM01035014    KQ561044    KXJ79910.1    KQ434785    KZC04998.1    NEVH01005885    PNF38444.1    ATLV01025887    KE525402    KFB52661.1    CH477340    EAT43108.1    JXUM01075026    KQ562865    KXJ74971.1    GGFK01005099    MBW38420.1    PNF38442.1    CH916374    EDV91494.1    AXCM01003114    GGFK01005133    MBW38454.1    AY033074    AAK52337.1    CM000160    EDW99272.1    CH954182    EDV52906.1    OUUW01000005    SPP80258.1    KRK04753.1    AJVK01019411    ADMH02001252    ETN63495.1    GEBQ01028865    JAT11112.1    CM000364    EDX15170.1    GL449942    EFN81767.1    CH480846    EDW50996.1    GL762905    EFZ20501.1    CH479179    EDW24235.1    CM000070    EAL28096.2    GDKW01002391    JAI54204.1    UFQT01001903    SSX32118.1    AF076220    AE014297    AY058251    BT001392    BT001878    GGFJ01006282    MBW55423.1    GL438234    EFN69335.1    ABLF02022108    AK341726    BAH72043.1    KZ150251    PZC71819.1    CVRI01000070    CRL07413.1    UFQT01002445    SSX33477.1    GBHO01037508    GBHO01037507    GDHC01010348    GDHC01008234    JAG06096.1    JAG06097.1    JAQ08281.1    JAQ10395.1    GAMD01000064    JAB01527.1    GGMR01006473    MBY19092.1    KQ978004    KYM98194.1    ACPB03016665    KQ983012    KYQ48251.1    KQ976423    KYM88872.1    ADTU01000590    JXJN01009222    KZ288227    PBC31856.1    CCAG010015535    GEDC01029450    JAS07848.1    GEDC01012781    JAS24517.1    KQ761221    OAD57965.1    KK852636    KDR19726.1    KQ981071    KYN09804.1    GL888033    EGI68999.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000095301    UP000037069    + More
UP000095300    UP000076407    UP000075903    UP000075840    UP000215335    UP000075902    UP000092553    UP000075882    UP000007062    UP000002358    UP000075881    UP000007801    UP000075885    UP000009192    UP000075886    UP000008792    UP000007798    UP000075880    UP000075920    UP000002320    UP000075884    UP000069940    UP000249989    UP000076502    UP000235965    UP000030765    UP000008820    UP000001070    UP000075883    UP000075900    UP000002282    UP000008711    UP000069272    UP000268350    UP000092462    UP000192221    UP000000673    UP000000304    UP000008237    UP000001292    UP000008744    UP000001819    UP000000803    UP000000311    UP000007819    UP000183832    UP000078542    UP000015103    UP000075809    UP000078540    UP000005205    UP000092443    UP000005203    UP000092460    UP000242457    UP000092444    UP000076408    UP000027135    UP000092445    UP000078492    UP000007755   

PRIDE

H9IWL6    Q9V9S8   

Pfam

PF00762   Ferrochelatase        + More
PF00191   Annexin

Interpro

IPR033659   Ferrochelatase_N        + More
IPR019772   Ferrochelatase_AS       
IPR001015   Ferrochelatase       
IPR033644   Ferrochelatase_C       
IPR037104   Annexin_sf       
IPR018502   Annexin_repeat       
IPR013032   EGF-like_CS       

Gene 3D

1.10.220.10    

CDD

cd00419  Ferrochelatase_C
cd03411  Ferrochelatase_N

ProteinModelPortal

H9IWL6   A0A194Q673   A0A2A4K1G5   A0A0N0PDD9   A0A1I8NIE5   A0A0A1WJI0   + More
A0A0L0CEU2   A0A1I8Q922   A0A0K8VXJ2   A0A0K8UYX0   W8C3L1   A0A034WXW5   A0A1L8DZM4   A0A1I8JVS6   A0A1L8DZL5   A0A182VEE7   A0A182I916   A0A232EQE6   A0A182UDS9   A0A0M4F540   A0A182LAZ9   Q7QG25   A0A0C9R3D5   K7J6F4   A0A3F2YU13   A0A1B6JBC8   B3LVE6   A0A0K8TL18   A0A182PQQ9   B4K856   A0A182QRZ2   A0A2M3ZGE4   A0A1Q3FF29   B4LY79   B4N956   A0A2M3Z273   A0A182JCM4   A0A340TBF9   T1PJ01   B0WMV1   A0A2Y9D1F0   A0A182HDH9   A0A154P178   A0A2J7RC77   A0A084WR17   Q17A56   A0A182GMR7   A0A2M4ACE0   A0A2J7RC80   B4JTR5   A0A182M850   A0A182S4U9   A0A2M4ACD1   Q967G9   B4PP36   B3P4Z2   A0A2Y9D0I2   A0A3B0K9N3   A0A0R1EBB5   A0A1B0DQV8   A0A1W4VYK9   A0A1W4VZG1   W5JKR8   A0A1B6KI31   B4QTA8   E2BRA4   B4IJ43   E9IFZ2   B4G340   Q297V9   A0A0P4VTD1   A0A336N1E7   Q9V9S8   A0A2M4BR17   E2AB59   C4WVX3   A0A2W1B7B1   A0A1J1J4S4   A0A336MYP4   A0A0A9WFE4   T1DUG1   A0A2S2NQ52   A0A151ICQ7   T1HSU2   A0A151WKA4   A0A195BS91   A0A158NY65   A0A1A9Y931   A0A087ZU01   A0A1B0B6R7   A0A2A3EKZ1   A0A1B0FL77   A0A1B6C2V0   A0A1B6DFR4   A0A182YJM0   A0A310SRK1   A0A067RJX2   A0A1B0AGK9   A0A151ISJ6   F4W9L3  

PDB

2PO7     E-value=1.25143e-108,     Score=1005

KEGG

101743914    K01772 protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9] | (RefSeq) ferrochelatase

PATHWAY

00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006783   GO:0004325   GO:0005739   GO:0005544   GO:0005509   GO:0051537   GO:0046872   GO:0005743   GO:0006782   GO:0007155   GO:0016020   GO:0022857   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11108  

Subcellular location

Mitochondrion inner membrane  

Length:

396

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03744

Exp number, first 60 AAs:

0.01922

Total prob of N-in:

0.01601

outside

1  -  396

 

 

Pi

244.497541

Theta

169.302214

Tajima's D

1.562248

CLR

0.272688

CSRT

0.798410079496025

Interpretation

Uncertain