Silkworm Genome Informatics Database

Gene

KWMTBOMO06218

Pre Gene Modal

BGIBMGA001650

Annotation

PREDICTED:_leishmanolysin-like_peptidase_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):2631269-2648782 View in EpiBrowser

Full name

Leishmanolysin-like peptidase + More
Phosphoglycerate mutase

Alternative Name

Invadolysin

Location in the cell

Extracellular Reliability : 2.63

CDS

ATGTGTGGAGAGGTTCGTGTACCAGAGGAGCATTTGAATCCTTGCTATGTCTGTAATAGCACCGGCCACGACTGCCGGGCGCTACCTCGCTACCAGCCCCCTCCGGATGATGAACCAGCTACAGAAGTCAGCGAGAACAATCTCGACGAACGAAGCGATGTTATCGATGAGGATTCGGAGCCGGTCGGCGTGAAGGATACTGACTTCATGCTCTACGTCAGCGCCGTGGAGACGGAGAGATGCCGGCGGGGTCTCACGGTGGCCTACGCGTCACACTGCCAACAGGAGTCGGCTTTGGACAGGCCGGTGGCTGGTCACGCGAATTTCTGTCCGGCCGAACTGTCGACCAAATACCGCGACTTACCGTCGGTCCTTTCGACCGTCAAACACGAGATGCTGCACGCTCTGGGCTTCAGTGTGTCTCTGTTCGCGTTTTACAGAGACGACAACGGCGAGCCCCTGACCGAAAGAAGACCTGACACCGGGAATCCACCATTGGATGAGGAGCTGCAGATACACAAGTGGTCTGATAGAGTGGTCAGGAACGTGACGCGAAAGAATTGGATGATCAGAGGTGGATATATGGAGAGGACCTTCCACATGATGGTCACTCCGAGGGTTGTTAAAGAGGTACGCGAACACTTCAACTGCTCAGAGCTGGAGGGGGCAGAGTTGGAGGATCAGGGTGGCGACGGCACCGCCATGACCCACTGGGAGAAGAGAGTCTTTGAGAACGAGGCCATGACCGGCACCCACACCCAGAACTCGGTCTTCAGCAGGATAACCCTCGCGATGATGGAGGACACCGGCTGGTACAGGGCGGACTACTCCCACGCGACACCCCTGGACTGGGGGAAGGGACTGGGCTGTAAATTCGCCATGTCCTCGTGCAAGCAGTGGATGAACCTGCAAAGACGCAGAAATCCGGCGCCGTTTTGCGAGAGGATAAAGGGGAATCCCTTGAGGACAGAGTGCTCCCCGAGGAGGTCGGCAGTCGTCCTCTGCAACCTGGTCCGCCACGACAACCTACTGCCGAGAGCCTACCAGCATTTCGACATACTGCCCAACGTTCCACCAGGGCAGGAAGCGTACTATGGCGGCTCCGTGTCCCTCGCGGACTACTGCCCCTACCTTCAGGAGTTCACTTGGAGACACAAGAGCGTACTCATCAGGGGAAGTCGATGCTCCTACGAGGAGAATACTCCGAAGATCGATCTGAACTTCGCCCTTGAGAACTACGGGCAGCACTCGAAGTGTTTCGAGCACAGCGACAAGGTCTGGGAGCAGAAGTCATGCAGACAGATCCGCGAATGGCAACACTGGGGCTCCGGTTGCTACAAATACAAATGCGACAGCGGTCGTCTGCATATCGTGGTGGGTAATTACACGTACACGTGCTTTCACGCCGGTCAACTGCTGCACATAAGGATCATAAAGAACGGCTGGCTTCACAGGGGGGGCGTGGTCTGTCCCCCCTGCAGGCAAGTGTGCGGCGCTGAGTTCGCTGCGAGAAGCGAATACTGTAAGCCGGGTGAGGAGCCTCTACCCCCGAATTTGTATCCCAACGATTTTCTAGCTTGTAGAGCGTCGGTTATCCGACCCGCCATCTTGTGGACGGCGGCCATCTTGTATTCGCTGTCATAA

Protein

MCGEVRVPEEHLNPCYVCNSTGHDCRALPRYQPPPDDEPATEVSENNLDERSDVIDEDSEPVGVKDTDFMLYVSAVETERCRRGLTVAYASHCQQESALDRPVAGHANFCPAELSTKYRDLPSVLSTVKHEMLHALGFSVSLFAFYRDDNGEPLTERRPDTGNPPLDEELQIHKWSDRVVRNVTRKNWMIRGGYMERTFHMMVTPRVVKEVREHFNCSELEGAELEDQGGDGTAMTHWEKRVFENEAMTGTHTQNSVFSRITLAMMEDTGWYRADYSHATPLDWGKGLGCKFAMSSCKQWMNLQRRRNPAPFCERIKGNPLRTECSPRRSAVVLCNLVRHDNLLPRAYQHFDILPNVPPGQEAYYGGSVSLADYCPYLQEFTWRHKSVLIRGSRCSYEENTPKIDLNFALENYGQHSKCFEHSDKVWEQKSCRQIREWQHWGSGCYKYKCDSGRLHIVVGNYTYTCFHAGQLLHIRIIKNGWLHRGGVVCPPCRQVCGAEFAARSEYCKPGEEPLPPNLYPNDFLACRASVIRPAILWTAAILYSLS

Description

Essential for the coordination of mitotic progression, and also plays a role in cell migration.

Catalytic Activity

(2R)-2-phosphoglycerate = 3-phospho-D-glycerate
3-phospho-D-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M8 family.
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Keywords

Cell cycle Cell division Complete proteome Cytoplasm Hydrolase Metal-binding Metalloprotease Mitosis Protease Reference proteome Zinc

Feature

chain Leishmanolysin-like peptidase

Uniprot

H9IWL8 A0A2A4JF72 A0A194Q4N7 A0A1S4FEB7 Q175B5 B4K792 + More
E2AB53 A0A1Q3FUE2 A0A1B0C987 A0A1W4UK25 A0A026VZ23 B4QVA8 A0A3L8DZB7 B3P4K5 B4PKL9 B4M424 Q9VH19 A0A182GDL9 B4NIZ8 E2BRA8 W8ACI8 B4G6G5 A0A0R3NLH2 Q29AK2 A0A1Y1MW84 B3LW16 A0A1W4W9F5 B4JSJ0 A0A1I8N2V8 A0A3B0K087 A0A182FPP9 A0A3B0KPD3 A0A151WK81 A0A195FGG9 A0A0A1WGE6 A0A151ISG8 A0A0M3QY80 T1PIR7 F4W9L1 A0A195BRN4 D6W703 A0A0A1XPI5 A0A2M4CJJ6 W5JHV0 A0A336M4P9 A0A0K8VNN0 A0A084VEG8 A0A0C9QQZ6 A0A0K8ULK9 A0A034VRT6 A0A182JPW5 A0A182HU12 A0A182WRR7 A0A034VV80 A0A0M9ADB2 A0A182UIU6 N6UDW5 A0A151ICR6 A0A182V1P8 A0A182JMK7 Q7QD48 A0A182P6M3 A0A0L0CH49 A0A0L7QNR1 A0A182RNC1 E0VYP7 A0A1B6E3E1 A0A154NZ92 A0A182XWB9 A0A2P8XF71 A0A182VYK7 A0A182MA94 A0A182NDX6 A0A1I8P0D7 A0A1J1HGT9 A0A310SNH9 A0A1B6FAY9 A0A1A9Y4J7 K7J267 A0A1B0AHG5 A0A1B0GDZ8 A0A1A9VM31 A0A232FMG7 A0A2A3EJE5 A0A067QUB0 A0A0T6AVU7 A0A158NCB3 A0A1A9W2N6 A0A2S2Q2P6 A0A0J7KM73 A0A2H8TVJ3 A0A2S2PPE2 A0A182LG15 J9K1Y3 A0A1B6C3F0 B0WA37 A0A3Q0J9U1 A0A1D2NG41 E9H0K4 A0A0A9WRW0

EC Number

3.4.24.-
5.4.2.11
5.4.2.4

Pubmed

19121390 26354079 17510324 17994087 18057021 20798317 + More
24508170 30249741 17550304 15557119 10731132 12537572 12537569 26483478 24495485 15632085 28004739 25315136 25830018 21719571 18362917 19820115 20920257 23761445 24438588 25348373 23537049 12364791 14747013 17210077 26108605 20566863 25244985 29403074 20075255 28648823 24845553 21347285 20966253 27289101 21292972 25401762

EMBL

BABH01021211 NWSH01001683 PCG70426.1 KQ459463 KPJ00507.1 CH477403 + More
EAT41672.1 CH933806 EDW16405.1 KRG02098.1 GL438234 EFN69329.1 GFDL01003804 JAV31241.1 AJWK01002053 AJWK01002054 AJWK01002055 AJWK01002056 AJWK01002057 AJWK01002058 AJWK01002059 KK107555 EZA49022.1 CM000364 EDX13514.1 QOIP01000002 RLU25465.1 CH954181 EDV49658.1 CM000160 EDW96778.1 CH940652 EDW59385.1 AF234630 AE014297 BT001861 JXUM01056215 JXUM01056216 JXUM01056217 KQ561901 KXJ77219.1 CH964272 EDW84900.1 GL449942 EFN81771.1 GAMC01020945 JAB85610.1 CH479179 EDW23884.1 CM000070 KRS99967.1 GEZM01025001 JAV87647.1 CH902617 EDV41549.1 CH916373 EDV94730.1 OUUW01000013 SPP87725.1 SPP87726.1 KQ983012 KYQ48246.1 KQ981606 KYN39476.1 GBXI01016198 JAC98093.1 KQ981071 KYN09812.1 CP012526 ALC47213.1 KA648666 AFP63295.1 GL888033 EGI68997.1 KQ976423 KYM88879.1 KQ971307 EFA11490.2 GBXI01001460 JAD12832.1 GGFL01001237 MBW65415.1 ADMH02001205 ETN63696.1 UFQS01000554 UFQT01000554 SSX04872.1 SSX25235.1 GDHF01020896 GDHF01011827 JAI31418.1 JAI40487.1 ATLV01012277 KE524778 KFB36362.1 GBYB01006149 JAG75916.1 GDHF01024715 JAI27599.1 GAKP01012926 GAKP01012921 JAC46026.1 APCN01000599 GAKP01012925 JAC46027.1 KQ435694 KOX80933.1 APGK01039132 APGK01039133 APGK01039134 KB740967 ENN76852.1 KQ978004 KYM98201.1 AAAB01008859 EAA07618.4 JRES01000409 KNC31527.1 KQ414845 KOC60260.1 DS235845 EEB18503.1 GEDC01004867 JAS32431.1 KQ434785 KZC04996.1 PYGN01002373 PSN30625.1 AXCM01002121 CVRI01000003 CRK87091.1 KQ762805 OAD55473.1 GECZ01022417 JAS47352.1 CCAG010012076 NNAY01000024 OXU31845.1 KZ288227 PBC31857.1 KK853419 KDR07722.1 LJIG01022716 KRT79085.1 ADTU01000559 ADTU01000560 ADTU01000561 ADTU01000562 GGMS01002698 MBY71901.1 LBMM01005602 KMQ91392.1 GFXV01006016 MBW17821.1 GGMR01018722 MBY31341.1 ABLF02039931 ABLF02039936 GEDC01029281 JAS08017.1 DS231868 EDS40770.1 LJIJ01000051 ODN04209.1 GL732581 EFX74736.1 GBHO01032422 JAG11182.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000008820 UP000009192 UP000000311 + More
UP000092461 UP000192221 UP000053097 UP000000304 UP000279307 UP000008711 UP000002282 UP000008792 UP000000803 UP000069940 UP000249989 UP000007798 UP000008237 UP000008744 UP000001819 UP000007801 UP000192223 UP000001070 UP000095301 UP000268350 UP000069272 UP000075809 UP000078541 UP000078492 UP000092553 UP000007755 UP000078540 UP000007266 UP000000673 UP000030765 UP000075881 UP000075840 UP000076407 UP000053105 UP000075902 UP000019118 UP000078542 UP000075903 UP000075880 UP000007062 UP000075885 UP000037069 UP000053825 UP000075900 UP000009046 UP000076502 UP000076408 UP000245037 UP000075920 UP000075883 UP000075884 UP000095300 UP000183832 UP000092443 UP000002358 UP000092445 UP000092444 UP000078200 UP000215335 UP000242457 UP000027135 UP000005205 UP000091820 UP000036403 UP000075882 UP000007819 UP000002320 UP000079169 UP000094527 UP000000305

PRIDE

H9IWL8 Q9VH19

Pfam

PF01457 Peptidase_M8 + More
PF00300 His_Phos_1

Interpro

IPR001577   Peptidase_M8        + More
IPR029033   His_PPase_superfam
IPR005952   Phosphogly_mut1
IPR013078   His_Pase_superF_clade-1
IPR001345   PG/BPGM_mutase_AS

SUPFAM

SSF53254 SSF53254

Gene 3D

3.40.50.1240

CDD

cd07067 HP_PGM_like

ProteinModelPortal

H9IWL8 A0A2A4JF72 A0A194Q4N7 A0A1S4FEB7 Q175B5 B4K792 + More
E2AB53 A0A1Q3FUE2 A0A1B0C987 A0A1W4UK25 A0A026VZ23 B4QVA8 A0A3L8DZB7 B3P4K5 B4PKL9 B4M424 Q9VH19 A0A182GDL9 B4NIZ8 E2BRA8 W8ACI8 B4G6G5 A0A0R3NLH2 Q29AK2 A0A1Y1MW84 B3LW16 A0A1W4W9F5 B4JSJ0 A0A1I8N2V8 A0A3B0K087 A0A182FPP9 A0A3B0KPD3 A0A151WK81 A0A195FGG9 A0A0A1WGE6 A0A151ISG8 A0A0M3QY80 T1PIR7 F4W9L1 A0A195BRN4 D6W703 A0A0A1XPI5 A0A2M4CJJ6 W5JHV0 A0A336M4P9 A0A0K8VNN0 A0A084VEG8 A0A0C9QQZ6 A0A0K8ULK9 A0A034VRT6 A0A182JPW5 A0A182HU12 A0A182WRR7 A0A034VV80 A0A0M9ADB2 A0A182UIU6 N6UDW5 A0A151ICR6 A0A182V1P8 A0A182JMK7 Q7QD48 A0A182P6M3 A0A0L0CH49 A0A0L7QNR1 A0A182RNC1 E0VYP7 A0A1B6E3E1 A0A154NZ92 A0A182XWB9 A0A2P8XF71 A0A182VYK7 A0A182MA94 A0A182NDX6 A0A1I8P0D7 A0A1J1HGT9 A0A310SNH9 A0A1B6FAY9 A0A1A9Y4J7 K7J267 A0A1B0AHG5 A0A1B0GDZ8 A0A1A9VM31 A0A232FMG7 A0A2A3EJE5 A0A067QUB0 A0A0T6AVU7 A0A158NCB3 A0A1A9W2N6 A0A2S2Q2P6 A0A0J7KM73 A0A2H8TVJ3 A0A2S2PPE2 A0A182LG15 J9K1Y3 A0A1B6C3F0 B0WA37 A0A3Q0J9U1 A0A1D2NG41 E9H0K4 A0A0A9WRW0

PDB

1LML E-value=5.09322e-27, Score=302

KEGG

101743621 K13539 leishmanolysin-like peptidase [EC:3.4.24.-] | (RefSeq) leishmanolysin-like peptidase

GO

GO:0016020 GO:0004222 GO:0007155 GO:0016021 GO:0007052 GO:0008406 GO:0007076 GO:0007100 GO:0005737 GO:0008354 GO:0007444 GO:1902769 GO:0007420 GO:0051298 GO:0006338 GO:0019915 GO:0045842 GO:0022900 GO:0031252 GO:0008233 GO:0046872 GO:0051301 GO:0004619 GO:0006096 GO:0004082 GO:0006508 GO:0022857 GO:0004559 GO:0006013 GO:0015923 GO:0005634 GO:0006260

PANTHER

PTHR10942 PTHR11931

Subcellular location

Cytoplasm Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells. With evidence from 3 publications.

Length:

547

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.35128

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00131

outside

1 - 547

Pi

209.093649

Theta

152.028559

Tajima's D

1.32481

CLR

10.775044

CSRT

0.744112794360282

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics