Silkworm Genome Informatics Database

Gene

KWMTBOMO06209

Pre Gene Modal

BGIBMGA001790

Annotation

cyclin_g_[Danaus_plexippus]

Location

Bomo_Chr11(+):2416321-2445811 View in EpiBrowser

Full name

Cyclin G

Location in the cell

Cytoplasmic Reliability : 1.095 Mitochondrial Reliability : 1.079 Nuclear Reliability : 1.326

CDS

ATGTTGAGAGCGGGCGCGAGGCACCCGGATGCTGCTGAGTGTCGTTCGCCGGTCGCGTCCACGTCACGTGACGACGTCGACTCGGCCCAGCAACTGTACGCTACGCTCAACGAGTACCTGCTCCTCGAGCAAAAGTCTCAGCCGAAACTGCGCTTGCCCGCGGAGTCTGAGAGCGGCGAAGTGACGACCGGCGCTAGGGATGGCGCAGCGCACGTGTTGCGCTGTCTCAAAGTCTGGTTCGATCTACCCGCGGACGTGCTCATCGGGGCCATCAATCTGTTCGACAGGTTTCTGACCAAGATGAAGGTGAGGCCGTGTCATGTGCCGTGCATTACTGTCTCCTGCATGAACATATCCATAGACGAGTATGCGGCTAGGACCAACATAAAAAGGACAGTGTCAATAGAGGAGCTGGTGTCTATCTCACAATCGGCCTGCACCGCTGGCGACGTGTCCAGGATGTCTCGAGTCATTCAGGACAAGCTGGGATTGGCACGAGGAACTGTCAGCGTGACGGCTCTGCACTGGCTCAGACTGTATCGGAAGCTGTTGCTGATGCATGCTGACGCCGGAGACGTACTGGCGCAGGAAAGCGAGCTGGTGAATCTACTGGAGATAGCCGTGTGCGACGCCACCTGCGCCAACGCTCGGACCAGCGAACTGGCACTCGTCTTACTCTTCCATAAACTAGAAAAACAACTCGTCGAATGGTCTGAAAAAGGAATGACTGTCCCGGAAAAGGTTTTCTACATGTACGACTTTGCCAGGCAACTGCAAATTCATTGTCATATGTCGGACGCTTCCCTGAGCGGCGTCGGCGGCGCCGTGCGCGGCGTGGTGCAGCGCTACGAGTCGCGCAGCGCGCAGCCGCTCCGGCAGCGACTCGTCTGGAGACTCTCCGAGAGAACCCTCAAGGTGCTCCGCCCTACCGATCGCCTCACATCCCTGCTGCCCACCATTGAGGAACAGCACTTCGCGGTCGAGGCGACGCCCACAAGAACCAGATCTGGAAGCGAAAGTAGTGTAAGCGAAGAGACATCGGATTGGCCCAGAAGTCCGTTGCTGCCGGTTTATTGTGACAATTGA

Protein

MLRAGARHPDAAECRSPVASTSRDDVDSAQQLYATLNEYLLLEQKSQPKLRLPAESESGEVTTGARDGAAHVLRCLKVWFDLPADVLIGAINLFDRFLTKMKVRPCHVPCITVSCMNISIDEYAARTNIKRTVSIEELVSISQSACTAGDVSRMSRVIQDKLGLARGTVSVTALHWLRLYRKLLLMHADAGDVLAQESELVNLLEIAVCDATCANARTSELALVLLFHKLEKQLVEWSEKGMTVPEKVFYMYDFARQLQIHCHMSDASLSGVGGAVRGVVQRYESRSAQPLRQRLVWRLSERTLKVLRPTDRLTSLLPTIEEQHFAVEATPTRTRSGSESSVSEETSDWPRSPLLPVYCDN

Description

Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism (PubMed:18667003, PubMed:18286205, PubMed:21311225, PubMed:22976300, PubMed:25995770, PubMed:26274446). Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium (PubMed:18667003, PubMed:18286205). Involved in the transcriptional repression of the homeotic genes Scr and Ubx (PubMed:25995770). Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells (PubMed:23121330, PubMed:22976300). Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism (PubMed:26274446). Required for the formation of bilateral symmetry (PubMed:21998598). Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression (PubMed:21311225).

Subunit

Interacts with corto (PubMed:18286205). Interacts with the cyclin-dependent kinases Cdk2 and Cdk4 (PubMed:21311225). Interacts with Brca2 and Rad9 (PubMed:22976300). Interacts with polycomb protein Asx (PubMed:25995770). Interacts with protein phosphatase 2A subunit wdb (PubMed:26274446).

Similarity

Belongs to the cyclin family.
Belongs to the cyclin family. Cyclin G subfamily.

Keywords

Cell cycle Cell division Chromosome Complete proteome Cyclin Developmental protein DNA damage DNA repair DNA-binding Growth regulation Meiosis Reference proteome Transcription Transcription regulation

Feature

chain Cyclin G

Uniprot

H9IX07 A0A2W1BDE2 A0A3S2LG75 A0A1E1WDR3 A0A212F8G9 A0A2H1WUL3 + More
A0A194Q4P7 A0A0L7LND9 T1E208 Q17BQ6 A0A0K8TQ84 A0A1Q3FDI0 A0A1Q3FDG0 B0W6E3 U5ESQ7 A0A023ESV2 A0A2M4BTE2 A0A2M4BSI0 A0A2M4CPJ1 A0A2M3YY14 A0A2M4A175 A0A2M4BJU7 A0A2M4BJW4 A0A2M4BKM3 A0A2M4BJX1 A0A232F0S4 A0A182QXR1 K7J9W8 A0A182Y3U3 A0A182LA52 A0A182HLP9 A0A182WSU6 Q7PY34 A0A182MEB0 A0A310SNC5 A0A182H3V3 W5J9G5 A0A154P9W4 A0A088ARU4 A0A2A3EK19 V9IHM8 A0A0P6FZP1 A0A1B6LIQ7 A0A0M8ZZE2 A0A182FPW6 A0A2J7PIA8 A0A182VZN4 A0A182NRS5 E2BQG8 A0A182KEG7 A0A067RHR0 A0A0L7RDJ5 A0A182TQ29 A0A1L8DL84 A0A1B6DLX3 A0A0C9QCR6 A0A182PSH6 A0A1B6I6G6 A0A1B6FGZ6 A0A1B0GKW4 A0A1J1IWT7 E0W2X2 D3TRJ8 A0A146LPB4 A0A0A9YVM9 A0A1L8E742 A0A1A9VDH3 A0A1A9Z870 A0A1L8E882 A0A0L0C8Z9 A0A1L8E955 W8B0L6 A0A1I8Q460 A0A0V0GBS8 A0A0N7Z8V8 A0A1L8ED57 A0A1B0D304 A0A1A9WPT8 A0A1B0GEQ6 A0A1A9XM45 B4PNF4 Q29AE9 A0A3B0JDQ3 T1PGL2 A0A1I8MR57 A0A0M5J1R1 B4IJ09 Q95TJ9 B4K7Y6 A0A023EZM6 B3P526 A0A1W4W6Z4 B3MSZ0 A0A034VBJ3 B4NAI1 B4M100 A0A158NKL4

Pubmed

19121390 28756777 22118469 26354079 26227816 24330624 + More
17510324 26369729 24945155 28648823 20075255 25244985 20966253 12364791 14747013 17210077 26483478 20920257 23761445 20798317 24845553 20566863 20353571 26823975 25401762 26108605 24495485 27129103 17994087 17550304 15632085 23185243 25315136 10731132 12537572 12537569 18667003 18286205 21311225 21998598 23121330 22976300 25995770 26274446 25474469 18057021 25348373 21347285

EMBL

BABH01021192 KZ150332 PZC71347.1 RSAL01000142 RVE46024.1 GDQN01010950 + More
GDQN01005931 JAT80104.1 JAT85123.1 AGBW02009730 OWR50021.1 ODYU01010788 SOQ56104.1 KQ459463 KPJ00517.1 JTDY01000484 KOB76967.1 GALA01001174 JAA93678.1 CH477318 EAT43711.1 GDAI01001553 JAI16050.1 GFDL01009442 JAV25603.1 GFDL01009455 JAV25590.1 DS231848 EDS36617.1 GANO01003149 JAB56722.1 GAPW01001231 JAC12367.1 GGFJ01006897 MBW56038.1 GGFJ01006878 MBW56019.1 GGFL01003011 MBW67189.1 GGFM01000377 MBW21128.1 GGFK01001243 MBW34564.1 GGFJ01004208 MBW53349.1 GGFJ01004209 MBW53350.1 GGFJ01004207 MBW53348.1 GGFJ01004206 MBW53347.1 NNAY01001351 OXU24274.1 AXCN02001149 AAZX01002312 APCN01000910 AAAB01008987 EAA01373.5 AXCM01000028 KQ760869 OAD58761.1 JXUM01024901 JXUM01024902 JXUM01024903 JXUM01024904 JXUM01024905 JXUM01024906 KQ560705 KXJ81212.1 ADMH02001998 ETN60048.1 KQ434856 KZC08726.1 KZ288222 PBC32115.1 JR046204 AEY60152.1 GDIQ01040702 JAN54035.1 GEBQ01016503 JAT23474.1 KQ435814 KOX72669.1 NEVH01025127 PNF16087.1 GL449769 EFN82026.1 KK852463 KDR23337.1 KQ414614 KOC68855.1 GFDF01006851 JAV07233.1 GEDC01019266 GEDC01010615 JAS18032.1 JAS26683.1 GBYB01001113 GBYB01001114 JAG70880.1 JAG70881.1 GECU01037692 GECU01025187 JAS70014.1 JAS82519.1 GECZ01031514 GECZ01020287 GECZ01019145 GECZ01018287 GECZ01013263 GECZ01004190 GECZ01003753 GECZ01001916 GECZ01001115 JAS38255.1 JAS49482.1 JAS50624.1 JAS51482.1 JAS56506.1 JAS65579.1 JAS66016.1 JAS67853.1 JAS68654.1 AJWK01033867 AJWK01033868 AJWK01033869 AJWK01033870 CVRI01000059 CRL03017.1 DS235880 EEB19978.1 EZ424050 ADD20326.1 GDHC01008876 JAQ09753.1 GBHO01007923 GBRD01007644 GBRD01007355 GDHC01020898 JAG35681.1 JAG58177.1 JAP97730.1 GFDG01004303 JAV14496.1 GFDG01003984 JAV14815.1 JRES01000752 KNC28756.1 GFDG01003683 JAV15116.1 GAMC01019769 JAB86786.1 GECL01000758 JAP05366.1 GDKW01002267 JAI54328.1 GFDG01002286 JAV16513.1 AJVK01010812 CCAG010012544 CCAG010012545 CCAG010012546 CCAG010012547 CCAG010012548 CCAG010012549 CCAG010012550 CCAG010012551 CCAG010012552 CCAG010012553 CM000160 EDW99236.1 KRK04739.1 KRK04740.1 CM000070 EAL27401.2 EIM52472.1 EIM52473.1 OUUW01000005 SPP80514.1 KA647280 AFP61909.1 CP012526 ALC45574.1 CH480846 EDW50962.1 AE014297 AY058720 AAL13949.1 CH933806 EDW14320.2 GBBI01004471 JAC14241.1 CH954182 EDV52940.1 CH902623 EDV30380.1 KPU72819.1 GAKP01019475 JAC39477.1 CH964232 EDW80795.2 CH940650 EDW67411.1 KRF83283.1 ADTU01018882

Proteomes

UP000005204 UP000283053 UP000007151 UP000053268 UP000037510 UP000008820 + More
UP000002320 UP000215335 UP000075886 UP000002358 UP000076408 UP000075882 UP000075840 UP000076407 UP000007062 UP000075883 UP000069940 UP000249989 UP000000673 UP000076502 UP000005203 UP000242457 UP000053105 UP000069272 UP000235965 UP000075920 UP000075884 UP000008237 UP000075881 UP000027135 UP000053825 UP000075902 UP000075885 UP000092461 UP000183832 UP000009046 UP000078200 UP000092445 UP000037069 UP000095300 UP000092462 UP000091820 UP000092444 UP000092443 UP000002282 UP000001819 UP000268350 UP000095301 UP000092553 UP000001292 UP000000803 UP000009192 UP000008711 UP000192221 UP000007801 UP000007798 UP000008792 UP000005205

PRIDE

H9IX07 Q95TJ9

Pfam

PF00134   Cyclin_N        + More
PF00096   zf-C2H2
PF00432   Prenyltrans

Interpro

IPR028895   CCNG2        + More
IPR039361   Cyclin
IPR006671   Cyclin_N
IPR013763   Cyclin-like
IPR036915   Cyclin-like_sf
IPR013087   Znf_C2H2_type
IPR036236   Znf_C2H2_sf
IPR001330   PFTB_repeat
IPR026872   FTB
IPR008930   Terpenoid_cyclase/PrenylTrfase

SUPFAM

SSF47954   SSF47954        + More
SSF57667   SSF57667
SSF48239   SSF48239

CDD

cd00043 CYCLIN
cd02893 FTase

ProteinModelPortal