Gene

KWMTBOMO06170

Pre Gene Modal

BGIBMGA001766

Annotation

Phosphatidylserine_decarboxylase_[Operophtera_brumata]

Location

Bomo_Chr11(+):1868531-1869578      View in EpiBrowser

Full name

Phosphatidylserine decarboxylase proenzyme, mitochondrial      

Location in the cell

Mitochondrial   Reliability : 1.407 PlasmaMembrane   Reliability : 1.779

CDS

ATGTTCCCCTTCCGGGTGACCAGTCGATTGTGGGGGAAAATGGCGGCCTGCGAAATCCCGGTGTCCCTCCGCAGCTTCGTCTACGGCACGTACATAAGAATGTTCAGCGTGAACCTAAATGATGCAGCAGTCACCGACCTGAAATACTACAAAAGCTTATCAGCGTTCTTCACCAGGCCGCTCAGGGATGGCGCGAGATACATATCAGCAGCGCCCTGCGTATCGCCCTGTGACGGAGTAGTCTTGAACTGTGGCCCAGCTGATACCGATAAGATTGAACAGGTAAAAGGTGTGACATACAGCCTTGAGGAATTCCTCGGTGAAAACAAATGGCTAAAAAGGAAAGATGAGAGCTATTACAACTCCTTACTAAAGAATAAAGAGAATATATTACATCAGTGCATAATATATTTAGCGCCCGGGGATTATCACCGCTTTCATGCTCCTTGTGATTGGACTGCTACATTCAGGAGACATTTCTCAGGGAAATTGCTCTCTGTAAATCCTTGGTTGGCGAAACTAATACCTGGATTGTTCACTGTCAACGAAAGAGCTGTGTACGTCGGAGAATGGGAGTATGGCTTCTTCAGCATGACAGCCGTCGGAGCGACAAATGTGGGATCTATAGAAATATTCAAAGATCCAGAATTAAGAACGAACACTAAAGGTAAACGGAATCGTGTGAACGAACTCGAATTAGGGCAGGTATGCATGAGCAAAGGTGAACTCTTCGGTCAGTTCAATATGGGAAGTACTATCATACTGCTCTTTGAGGCCCCAAAGGACTTCAAATTTGATATGGCTGCTGGAGATAAAGTATTAGTTGGACAATCATTAACGAAAGTAACCAGACAAATGACGAGATGA

Protein

MFPFRVTSRLWGKMAACEIPVSLRSFVYGTYIRMFSVNLNDAAVTDLKYYKSLSAFFTRPLRDGARYISAAPCVSPCDGVVLNCGPADTDKIEQVKGVTYSLEEFLGENKWLKRKDESYYNSLLKNKENILHQCIIYLAPGDYHRFHAPCDWTATFRRHFSGKLLSVNPWLAKLIPGLFTVNERAVYVGEWEYGFFSMTAVGATNVGSIEIFKDPELRTNTKGKRNRVNELELGQVCMSKGELFGQFNMGSTIILLFEAPKDFKFDMAAGDKVLVGQSLTKVTRQMTR

Description

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

Catalytic Activity

1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2

Cofactor

pyruvate

Subunit

Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.

Similarity

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.

Feature

chain  Phosphatidylserine decarboxylase proenzyme, mitochondrial

Uniprot

H9IWY3   A0A2A4JCW4   A0A2W1BHW7   A0A0L7L7K7   A0A2H1WC49   A0A212FE93   + More
A0A0N0PC89   A0A194QAI4   A0A1B0G858   A0A0L0CLH3   B3M2S6   A0A067R9S4   A0A1Y1LCI2   A0A1A9XI27   A0A1B0BJP7   A0A0M4EP02   A0A1I8NB19   T1PGF3   J3JWY2   U4UMN9   A0A084W044   U5ES05   B4NBP0   A0A1A9VR18   A0A3B0K428   Q298L0   A0A1I8PGN0   B4G433   A0A023EQ94   A0A182J586   W8AZA7   A0A1Q3FWK8   A0A1Q3FW75   A0A1Q3FW18   A0A1Q3FVW1   B4K5A4   A0A034WFZ6   Q16TJ5   B4QSF4   B4PL28   A0A336LR80   A0A1A9X1B4   B4MBZ9   A0A1J1IQ26   A0A1W4V4T4   A0A1S4FPW9   K7IMK1   A0A2M3Z8T6   W5J6W7   A0A182PRT9   Q9VCE0   A0A0K8WII1   A0A182GM50   B4HGH0   B3P7A3   A0A232EWZ2   A0A182M5N0   A0A182QSB2   V5I9R0   A0A0A1WFB6   A0A182NQQ8   C6TPB6   A0A139WNM4   A0A2M4AT34   B4JIH6   Q7PX64   A0A182X9E5   A0A182RSB8   A0A182VHL7   A0A182TKY9   A0A087ZIK7   A0A182FS14   A0A182YHY5   A0A1Y9IXW8   A0A182HKD1   A0A182L8L6   A0A182JUS1   A0A1B0CIY5   A0A2J7R5S6   A0A0P6GF40   A0A0P5NGP9   A0A1L8DZ44   T1K3B0   A0A0P5MRD9   A0A0P5ZC79   A0A0P5JXN8   A0A0P5MJB2   A0A0P5XLG0   A0A0P5MBV6   A0A0P5TN97   A0A0P5M1H6   A0A0N8BYV3   A0A0P5DE76   A0A0N8CEY7   A0A0P5LPF9   A0A0N8EC00   A0A0N8C7Q2   A0A0P6DLD2   A0A1L8DY97   A0A1L8DY52  

EC Number

4.1.1.65

Pubmed

19121390    28756777    26227816    22118469    26354079    26108605    + More
17994087    24845553    28004739    25315136    22516182    23537049    24438588    15632085    24945155    24495485    25348373    17510324    17550304    20075255    20920257    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26483478    28648823    25830018    18362917    19820115    12364791    14747013    17210077    25244985    20966253   

EMBL

BABH01021133    NWSH01002066    PCG69262.1    KZ150350    PZC71263.1    JTDY01002484    + More
KOB71324.1    ODYU01007549    SOQ50412.1    AGBW02008966    OWR52051.1    KQ460736    KPJ12601.1    KQ459463    KPJ00426.1    CCAG010000199    JRES01000321    KNC32294.1    CH902617    EDV42397.1    KK852832    KDR15313.1    GEZM01061243    JAV70608.1    JXJN01015477    CP012526    ALC47440.1    KA647220    AFP61849.1    APGK01039349    APGK01039350    BT127750    KB740970    AEE62712.1    ENN76643.1    KB632388    ERL94372.1    ATLV01019085    KE525262    KFB43588.1    GANO01003475    JAB56396.1    CH964232    EDW81204.1    OUUW01000007    SPP82730.1    CM000070    EAL27945.1    CH479179    EDW24444.1    GAPW01002363    JAC11235.1    GAMC01014978    JAB91577.1    GFDL01003242    JAV31803.1    GFDL01003240    JAV31805.1    GFDL01003300    JAV31745.1    GFDL01003306    JAV31739.1    CH933806    EDW15104.1    GAKP01004441    JAC54511.1    CH477648    EAT37827.1    CM000364    EDX14153.1    CM000160    EDW99013.1    UFQS01000083    UFQT01000083    SSW99069.1    SSX19451.1    CH940656    EDW58620.1    CVRI01000057    CRL02264.1    GGFM01004149    MBW24900.1    ADMH02002101    ETN59143.1    AE014297    AY121648    AAF56228.1    AAM51975.1    GDHF01001353    JAI50961.1    JXUM01073817    JXUM01073818    JXUM01073819    KQ562796    KXJ75113.1    CH480815    EDW43423.1    CH954182    EDV53923.1    NNAY01001807    OXU22866.1    AXCM01002705    AXCN02001502    GALX01002500    JAB65966.1    GBXI01017117    JAC97174.1    BT099602    ACU45755.1    KQ971311    KYB29477.1    GGFK01010561    MBW43882.1    CH916369    EDV93057.1    AAAB01008987    EAA01787.4    EGK97628.1    APCN01000826    AJWK01013903    NEVH01006990    PNF36186.1    GDIQ01033973    JAN60764.1    GDIQ01153078    JAK98647.1    GFDF01002532    JAV11552.1    CAEY01001378    GDIQ01153079    JAK98646.1    GDIP01058605    JAM45110.1    GDIQ01218256    JAK33469.1    GDIQ01155777    JAK95948.1    GDIP01070609    JAM33106.1    GDIQ01157919    JAK93806.1    GDIP01124006    JAL79708.1    GDIQ01170919    JAK80806.1    GDIQ01131435    JAL20291.1    GDIP01158836    JAJ64566.1    GDIP01138351    JAL65363.1    GDIQ01167071    JAK84654.1    GDIQ01041668    JAN53069.1    GDIQ01106643    JAL45083.1    GDIQ01090646    JAN04091.1    GFDF01002705    JAV11379.1    GFDF01002706    JAV11378.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000053240    UP000053268    + More
UP000092444    UP000037069    UP000007801    UP000027135    UP000092443    UP000092460    UP000092553    UP000095301    UP000019118    UP000030742    UP000030765    UP000007798    UP000078200    UP000268350    UP000001819    UP000095300    UP000008744    UP000075880    UP000009192    UP000008820    UP000000304    UP000002282    UP000091820    UP000008792    UP000183832    UP000192221    UP000002358    UP000000673    UP000075885    UP000000803    UP000069940    UP000249989    UP000001292    UP000008711    UP000215335    UP000075883    UP000075886    UP000075884    UP000007266    UP000001070    UP000007062    UP000076407    UP000075900    UP000075903    UP000075902    UP000069272    UP000076408    UP000075840    UP000075882    UP000075881    UP000092461    UP000235965    UP000015104   

PRIDE

H9IWY3    Q9VCE0    C6TPB6   

Pfam

PF02666   PS_Dcarbxylase        + More
PF00581   Rhodanese
PF02225   PA

Interpro

IPR033177   PSD        + More
IPR003817   PS_Dcarbxylase       
IPR033661   PSD_type1_euk       
IPR036873   Rhodanese-like_dom_sf       
IPR001763   Rhodanese-like_dom       
IPR037323   PRADC1-like_PA       
IPR003137   PA_domain       

SUPFAM

SSF52821   SSF52821       

Gene 3D

3.40.250.10    

CDD

cd02127  PA_hPAP21_like

ProteinModelPortal

H9IWY3   A0A2A4JCW4   A0A2W1BHW7   A0A0L7L7K7   A0A2H1WC49   A0A212FE93   + More
A0A0N0PC89   A0A194QAI4   A0A1B0G858   A0A0L0CLH3   B3M2S6   A0A067R9S4   A0A1Y1LCI2   A0A1A9XI27   A0A1B0BJP7   A0A0M4EP02   A0A1I8NB19   T1PGF3   J3JWY2   U4UMN9   A0A084W044   U5ES05   B4NBP0   A0A1A9VR18   A0A3B0K428   Q298L0   A0A1I8PGN0   B4G433   A0A023EQ94   A0A182J586   W8AZA7   A0A1Q3FWK8   A0A1Q3FW75   A0A1Q3FW18   A0A1Q3FVW1   B4K5A4   A0A034WFZ6   Q16TJ5   B4QSF4   B4PL28   A0A336LR80   A0A1A9X1B4   B4MBZ9   A0A1J1IQ26   A0A1W4V4T4   A0A1S4FPW9   K7IMK1   A0A2M3Z8T6   W5J6W7   A0A182PRT9   Q9VCE0   A0A0K8WII1   A0A182GM50   B4HGH0   B3P7A3   A0A232EWZ2   A0A182M5N0   A0A182QSB2   V5I9R0   A0A0A1WFB6   A0A182NQQ8   C6TPB6   A0A139WNM4   A0A2M4AT34   B4JIH6   Q7PX64   A0A182X9E5   A0A182RSB8   A0A182VHL7   A0A182TKY9   A0A087ZIK7   A0A182FS14   A0A182YHY5   A0A1Y9IXW8   A0A182HKD1   A0A182L8L6   A0A182JUS1   A0A1B0CIY5   A0A2J7R5S6   A0A0P6GF40   A0A0P5NGP9   A0A1L8DZ44   T1K3B0   A0A0P5MRD9   A0A0P5ZC79   A0A0P5JXN8   A0A0P5MJB2   A0A0P5XLG0   A0A0P5MBV6   A0A0P5TN97   A0A0P5M1H6   A0A0N8BYV3   A0A0P5DE76   A0A0N8CEY7   A0A0P5LPF9   A0A0N8EC00   A0A0N8C7Q2   A0A0P6DLD2   A0A1L8DY97   A0A1L8DY52  

KEGG

101736119    K01613 phosphatidylserine decarboxylase [EC:4.1.1.65] | (RefSeq) phosphatidylserine decarboxylase pr

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008654   GO:0004609   GO:0031305   GO:0006646   GO:0016540   GO:0005739   GO:0016021   GO:0006355   GO:0003700   GO:0043565   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR10067  

Subcellular location

Mitochondrion inner membrane   Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.   With evidence from 1 publications.

Length:

288

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.26677

Exp number, first 60 AAs:

0.07917

Total prob of N-in:

0.03807

outside

1  -  288

 

 

Pi

149.950233

Theta

146.648618

Tajima's D

-0.646739

CLR

154.788129

CSRT

0.205339733013349

Interpretation

Uncertain