Gene

KWMTBOMO06168  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001670

Annotation

PREDICTED:_cytoplasmic_FMR1-interacting_protein_[Papilio_xuthus]

Location

Bomo_Chr11(-):1832712-1858010      View in EpiBrowser

Full name

Cytoplasmic FMR1-interacting protein      

Alternative Name

Specifically Rac1-associated protein 1

Location in the cell

Nuclear   Reliability : 1.914

CDS

ATGTCTGTAAGTGAAAAAGTGTCGTTATCGGATGCTCTGAGCAACGTAGATGTGTTGGATGAGCTGACTTTGCCGGATGAACAGCCATGTATCGAAGCAGCACCTTGCTCGATCCTGTATCAAGCTAATTTCGATACTAACTTTGAAGACCGCAATGGGTTCATCACCGGTATCGCAAAGTACATAGAGGAAGCGACCGTCCACGCCAACTTGAACGAGCTCCTGGAAGAAGGGAACGCCCACGCTGTCATGCTGTACACGTGGCGTTGCTGCAGCCGTGCCATACCTCAGCCCAGGTCCAATGAACAACCAGACCGGGTTCACATATACGAGAGGACCGTTCAAGTGCTGGCTCCTGAGGTTGATAAGCTCTTGCAGTTCATGTATTTCCAGCGCAAGGCCATAGAAAGGTTCTGTGCTGAAGTGCGTCGGCTGTGCCACGCGGAGAAGAGGAGGGACTTCGTCTCCGAAGCCTACCTCCTGACCCTCGGCAAGTTCGTGAACATGTTCGCGGTCCTCGACGAGCTGAAGAACATGAAGAGTTCGGTCAAGAATGATTACTCGACTTACAGAAGGGCGGCGCAATTCCTGAAGGTGATGTCCGACAGTCAGAGCCTGCAGGAGTCTCAGAACCTGTCCATGTTCCTCGCGACCCAGAACAAGATCAGAGACACGGTCAAGGATGCCCTAGAGAAAATTAACGGTTACGAAGACTTGTTGGCTGATGTGGTCAATATATGCGTGCACATGTTCGAGACAAGAATGTATTTGACTCCATGCGAGAAACACATGCTCGTGAAGGTTATGGGCTTCGGACTCTTCCTCATGGACTCAGAGGTGTGCAACATCAATCGTTTGGATCAGAAGAAGAAGATACGTCTGGACCGCATCGACAGGATCTTCAAGAACCTCGAAGTGGTTCCACTGTTTGGCGACATGCAAATAGCTCCTTTCAATTACATCAAGAGATCGAAACACTATGATCCGAATAAGTGGCCCCTGTCCTCGAGCCCCAACCCGCCCTCGCCGCAGGCCGACCTGATGGTCCACCTGCCCCAGATCCGGGAGGAGCACCAGAACTACATATCCGAGCTGGCCCGGTACAGCAACGAGGTGACGACCACTTTCAAAGAGGCGGGTTCGGACTCCGAGAACAAGGCGGTGACGGAGCTCTGTCTGCGCGGCCTGCAGCTGCTGTCCTCCTGGTGCTCGGTGCTCACGGAGCTGTGCTCGTGGAAGCTGCTCCACCCGACGGACCACACCATCAACGCGCGGTGTCCCCCCGAAGCCGAGGAGTACGAGAGGGCGACGCGTTACAACTACACGTCCGAGGAGAAGTTCGCCATGATCGAGGTGATCGCGATGATAAAGGGCCTCCAGGTCCTGATGGCGCGGATGGAGACCGTGTTCGCGGACGCGGCCAGGAGGTCCATATACGCGGAGCTGCAGGACTTCGTGCAGCTCGTCCTGCGGGAGCCCCTGAGGAAGGCCATCAAGAACAAGAAGGACCTCATCCGGAGCATAATAGTGTCGGTTCGGGAGACGTGTGGTGACTGGGCGCGCGGCTGCGAGCCTCAGCAGGACCCGGCGCTCAAGGGGAAGAAGGACGGCGAAGCCAGCTTCACCATCAAGGTGCCCAGAAGGAATGTCGGTCCCTCATCGACCCAGCTCTACATGGTGAGAACGCAGCTTGAGGCCCTCATATCGGACAAGTCCGGAGGCCGGCGGACTCTTCGGAAAGACCTGGACGCAGCCACCCTGCATCAGATCGAAAGCTTCCACAGAACCAGCTTTTATTGGTCCTACCTGCTGAACTTACCTGATTCCCTGCAGAAGTGCTGCGATCTGTCTCAACTCTGGTATAGAGAGTTTTATCTCGAAATGACAATGGGAAAGAAAGTTAATAAATGCATGGTGCGTCATCAGCACAACGAGGAGTGCAACGACCTGGTCACGATGGAGAAGCGGATACAGTTCCCCATCGAGATGTCCATGCCATGGATATTGACCGAGCACATATTAAGGACCAAAGAACCGGCGATGATGGAATACGTCCTGTACCCGCTGGACCTGTACAACGACTCGGCCCAGTACGCGCTGACCGTCTTCAAGAAGCAGTTCCTCTACGACGAGGTGGAGGCGGAAGTCAACCTCTGCTTCGATCAGTTCGTGTACAAGCTCTCCGAGCAGGTCTACGCGTACTACAAGCAGCTGGCCGCGAGCATGCTGCTGGATAAGCGCTACCGTGCCGAGTGCTTGTCGCGAGGCGCGGGCGTCGGTGTCGGTCCAGGCCGGTACGCCTCCTTACTCAAGCAGAGGCACGTGGCTCTACTGGGACGGCACGTCGACCTCTGCGCGCTGGTGGCGCAGCGTATCAACTCGGACATGCACCGCGCTCTGGACGCGGCCATCGCGAAGTTCGAGGCCGGGGACATCACCGGCGTGGTGGAGCTGGAGGGGCTGATCGCGGTGAACCGTCTCTGCCACAAGCTGCTCAGCCGCTACCTGACCTTGGACGACTTCGAGGCGGTGCTGCGGGAGTCGGACCACGGCGTGCTGGCCCCGTACGGCAGGGTCACGCTGCACGTCTTCTGGGAGCTCAACTACGACTTCCTGCCGAACTACTGCTACAACGCTGCGACAGCGCGGTTCGTGAAGTGTCGCGGGATCCAGTTCGCGGCCAACGTGCAGCGGGAGCGCCCGCAACAGTACGGGCACGCGCTGCTGTGGGGCTCCAAGCAGCTCAGCCTCGTGTACTCCGCGCAGTACACGCAGTACAACGGGTTCGTGGGGGCGGCGCACCTGCACGCGCTGGTCCGGCTGCTGGGCTACCAGGGCGTGGCCGTGGTCGTGGGCGAGCTGCTGGGTGTGGCCCGTGGACTGCTGCACGGCTCGCTGGCGCAGTTCACGCGGGCCCTGCTCGCCGCGCTGCCGCGACACTGCCGCCTGCCCAGATACGACTACGGCTCCAATGGCGTGCTGGGCTACTACCACGCGCAGCTGACGGACATCGTGCAGTACCCCGACGCGAAGACGGAACTCTTCCACGCCTTCAGGGAGCTCGGGAACATCATCCTGTTCTGCATGCTGATCGAGCAGGCTTTAAGCCAAGAGGAGGTGACGGATCTGCTCCACGCGGCGCCCTTCCAGAACATTCTGCCGCGTCCCTACAGCACAGTTGCAGACGGTGATAAGCCCGAATCAAAACAAAAACGTCTGGAGGCCAAGTACGCGTCCCTACAGATCGTCCATAATGTCGACAAGTACGGCACCGCCAAGCAAGGTCAGCTGTCCCGCGAGGGCGACCTGCTGACCCGCGAGCGGCTGTGCTGCGGCCTGTCGCTGTTCGGCGTGGTGCTGCGGCGGCTGCGCACCTGCCTCGCCGCGCCCGCCTGGCCCGCGCCCCCCGCCGCGCACCACGCGCACACCGACGACACCAACGAGTTCCACAGATTGTGGTCAGCCCTGCAGTTCCTGTACTGCATTCCGGTCGGCGACACCCAGTTTACCGTCGAGGAACTGTTCGGCGAGGGTCTCCATTGGGCCGGCTGCACCATCATCGCTCTCCTGGGGCAGCAGAGGAGGTTCGAGGCGCTGGACTTCTGCTACCACATCCTGAGGGTGCAGAGGGTCGACGGAAAGGATGAACTGGTCAAAGGCATTCCCCTCAAGCGGATGGTGGACCGCATCAGGCGGTTCCAAGTGCTGAACTCGCAGATCTTCGGCGTGCTGTCCAGGCAGCTGTCCGCGGACGACGCGGCCGGCGTCGAGCACGTGCGCTGCTTCCCGCCCCCGCAGGCGCCGCTTACGCTCAACTGA

Protein

MSVSEKVSLSDALSNVDVLDELTLPDEQPCIEAAPCSILYQANFDTNFEDRNGFITGIAKYIEEATVHANLNELLEEGNAHAVMLYTWRCCSRAIPQPRSNEQPDRVHIYERTVQVLAPEVDKLLQFMYFQRKAIERFCAEVRRLCHAEKRRDFVSEAYLLTLGKFVNMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMSDSQSLQESQNLSMFLATQNKIRDTVKDALEKINGYEDLLADVVNICVHMFETRMYLTPCEKHMLVKVMGFGLFLMDSEVCNINRLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHYDPNKWPLSSSPNPPSPQADLMVHLPQIREEHQNYISELARYSNEVTTTFKEAGSDSENKAVTELCLRGLQLLSSWCSVLTELCSWKLLHPTDHTINARCPPEAEEYERATRYNYTSEEKFAMIEVIAMIKGLQVLMARMETVFADAARRSIYAELQDFVQLVLREPLRKAIKNKKDLIRSIIVSVRETCGDWARGCEPQQDPALKGKKDGEASFTIKVPRRNVGPSSTQLYMVRTQLEALISDKSGGRRTLRKDLDAATLHQIESFHRTSFYWSYLLNLPDSLQKCCDLSQLWYREFYLEMTMGKKVNKCMVRHQHNEECNDLVTMEKRIQFPIEMSMPWILTEHILRTKEPAMMEYVLYPLDLYNDSAQYALTVFKKQFLYDEVEAEVNLCFDQFVYKLSEQVYAYYKQLAASMLLDKRYRAECLSRGAGVGVGPGRYASLLKQRHVALLGRHVDLCALVAQRINSDMHRALDAAIAKFEAGDITGVVELEGLIAVNRLCHKLLSRYLTLDDFEAVLRESDHGVLAPYGRVTLHVFWELNYDFLPNYCYNAATARFVKCRGIQFAANVQRERPQQYGHALLWGSKQLSLVYSAQYTQYNGFVGAAHLHALVRLLGYQGVAVVVGELLGVARGLLHGSLAQFTRALLAALPRHCRLPRYDYGSNGVLGYYHAQLTDIVQYPDAKTELFHAFRELGNIILFCMLIEQALSQEEVTDLLHAAPFQNILPRPYSTVADGDKPESKQKRLEAKYASLQIVHNVDKYGTAKQGQLSREGDLLTRERLCCGLSLFGVVLRRLRTCLAAPAWPAPPAAHHAHTDDTNEFHRLWSALQFLYCIPVGDTQFTVEELFGEGLHWAGCTIIALLGQQRRFEALDFCYHILRVQRVDGKDELVKGIPLKRMVDRIRRFQVLNSQIFGVLSRQLSADDAAGVEHVRCFPPPQAPLTLN

Description

Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development (By similarity).
Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development.

Subunit

Interacts with Fmr1 and Rac1. Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds through its C-terminus directly to Hem (By similarity).
Interacts with Fmr1 and Rac1. Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds through its C-terminus directly to Hem.

Similarity

Belongs to the CYFIP family.

Keywords

Cell shape   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Neurogenesis   Reference proteome  

Feature

chain  Cytoplasmic FMR1-interacting protein

Uniprot

A0A212FEB2   H9IWN8   A0A1Y1LBS7   A0A1W4X9U0   A0A1W4X0D3   A0A0A9YMY3   + More
A0A154PF73   A0A067QJN8   A0A087ZRN0   D6W6N5   A0A023F4Y3   A0A0M9A438   A0A2H8TTY5   J9JL00   A0A2S2PGC3   A0A069DZS4   A0A195BYR5   A0A195FLC5   A0A0C9RNX2   A0A026VST8   A0A195ENV3   F4WRU2   A0A195BVS2   A0A158NEL8   A0A3L8DDD8   E2AEJ6   A0A151XIS4   E9IJB2   T1I0M5   A0A0A9YLG4   E0VKF3   A0A182IU35   A0A1I8P265   E2BT38   A0A1L8DJK9   A0A0L0CRE7   A0A182FK33   A0A182W4Z5   W5JMR6   T1PGJ9   A0A182K353   A0A182P7I9   A0A1A9VLJ8   A0A1A9ZN40   A0A182V303   Q7QEX4   U5EXQ3   U4UVP4   A0A182MF32   A0A182R7H8   A0A182N1K0   A0A182Q9W1   B4N7Y7   A0A1A9X2J4   A0A182GY71   B4G548   B4HDX6   B3P0V0   Q299G2   Q9VF87   A0A182YQ59   A0A3B0KPH8   U3PXB4   A0A1Q3FXC0   W8AKB2   Q16ZZ3   A0A1W4VEF2   B4MBK0   B4KCY0   A0A0K8VKF5   B4PS48   A0A034VU41   A0A0M4EPP6   N6U0N1   A0A310SRG8   B3MSU9   A0A0A1X1G2   A0A084WPX5   A0A3S2MA46   B4JS07   A0A182HIB1   A0A3B0K0E4   A0A336KRU0   K7IU01   A0A1B6IXR2   A0A1J1IGB3   A0A0P5JWY7   E9G9J2   A0A0P4Z605   A0A0P6A2V9   W8B750   A0A0P5YDJ2   A0A0P5MU60   A0A1B6J2I2   A0A0P5JIL9   A0A226E545   A0A2J7R5M9   B4QYJ2   A0A0P4YFE5   A0A182X808  

Pubmed

22118469    19121390    28004739    25401762    26823975    24845553    + More
18362917    19820115    25474469    26334808    24508170    21719571    21347285    30249741    20798317    21282665    20566863    26108605    20920257    23761445    25315136    12364791    14747013    17210077    23537049    17994087    26483478    15632085    11438699    10731132    12537572    12537569    14588242    12818175    15385157    15269173    25244985    24495485    17510324    17550304    25348373    25830018    24438588    20075255    21292972   

EMBL

AGBW02008966    OWR52053.1    BABH01021128    BABH01021129    BABH01021130    BABH01021131    + More
BABH01021132    BABH01021133    GEZM01060282    JAV71122.1    GBHO01011146    GDHC01017156    JAG32458.1    JAQ01473.1    KQ434886    KZC10094.1    KK853265    KDR09197.1    KQ971307    EFA10974.1    GBBI01002156    JAC16556.1    KQ435740    KOX76825.1    GFXV01005918    MBW17723.1    ABLF02026358    GGMR01015860    MBY28479.1    GBGD01000135    JAC88754.1    KQ978501    KYM93455.1    KQ981490    KYN41213.1    GBYB01010140    JAG79907.1    KK108171    EZA46838.1    KQ978625    KYN29579.1    GL888292    EGI63099.1    KQ976401    KYM92370.1    ADTU01013497    QOIP01000009    RLU18467.1    GL438862    EFN68153.1    KQ982080    KYQ60306.1    GL763764    EFZ19330.1    ACPB03016920    ACPB03016921    ACPB03016922    ACPB03016923    GBHO01011148    JAG32456.1    DS235243    EEB13869.1    GL450325    EFN81168.1    GFDF01007529    JAV06555.1    JRES01000007    KNC34935.1    ADMH02000604    ETN65677.1    KA647906    AFP62535.1    AAAB01008846    EAA06404.3    GANO01000835    JAB59036.1    KB632384    ERL94290.1    AXCM01000253    AXCN02002442    CH964232    EDW81238.1    JXUM01096983    JXUM01096984    JXUM01096985    JXUM01096986    KQ564307    KXJ72452.1    CH479179    EDW24714.1    CH480815    EDW42068.1    CH954181    EDV48998.1    CM000070    EAL27741.1    AY017343    AY029211    AE014297    BT011115    AY122203    AAF55173.1    AAG61254.1    AAK31584.1    AAM52715.1    AAR82782.1    OUUW01000013    SPP87776.1    BT150379    AGW52189.1    GFDL01002801    JAV32244.1    GAMC01017505    JAB89050.1    CH477480    EAT40231.1    CH940656    EDW58471.1    CH933806    EDW17002.1    GDHF01027818    GDHF01013264    JAI24496.1    JAI39050.1    CM000160    EDW97468.2    GAKP01013894    JAC45058.1    CP012526    ALC47790.1    APGK01047141    KB741077    ENN74156.1    KQ759874    OAD62357.1    CH902623    EDV30339.1    GBXI01009360    JAD04932.1    ATLV01025136    KE525369    KFB52269.1    RSAL01000002    RVE54909.1    CH916373    EDV94547.1    APCN01003925    SPP87777.1    UFQS01000761    UFQS01000777    UFQT01000761    UFQT01000777    SSX06699.1    SSX06812.1    SSX27045.1    GECU01015979    JAS91727.1    CVRI01000050    CRK99285.1    GDIQ01197841    GDIQ01027653    JAK53884.1    GL732536    EFX83871.1    GDIP01229363    JAI94038.1    GDIP01036484    JAM67231.1    GAMC01017504    JAB89051.1    GDIP01059232    JAM44483.1    GDIQ01159253    JAK92472.1    GECU01014312    JAS93394.1    GDIQ01197842    JAK53883.1    LNIX01000006    OXA52418.1    NEVH01006991    PNF36132.1    CM000364    EDX12837.1    GDIP01229364    JAI94037.1   

Proteomes

UP000007151    UP000005204    UP000192223    UP000076502    UP000027135    UP000005203    + More
UP000007266    UP000053105    UP000007819    UP000078542    UP000078541    UP000053097    UP000078492    UP000007755    UP000078540    UP000005205    UP000279307    UP000000311    UP000075809    UP000015103    UP000009046    UP000075880    UP000095300    UP000008237    UP000037069    UP000069272    UP000075920    UP000000673    UP000095301    UP000075881    UP000075885    UP000078200    UP000092445    UP000075903    UP000007062    UP000030742    UP000075883    UP000075900    UP000075884    UP000075886    UP000007798    UP000091820    UP000069940    UP000249989    UP000008744    UP000001292    UP000008711    UP000001819    UP000000803    UP000076408    UP000268350    UP000008820    UP000192221    UP000008792    UP000009192    UP000002282    UP000092553    UP000019118    UP000007801    UP000030765    UP000283053    UP000001070    UP000075840    UP000002358    UP000183832    UP000000305    UP000198287    UP000235965    UP000000304    UP000076407   

PRIDE

H9IWN8    Q299G2    Q9VF87    U3PXB4   

Pfam

PF07159   DUF1394        + More
PF05994   FragX_IP
PF00096   zf-C2H2
PF00069   Pkinase

Interpro

IPR008081   Cytoplasmic_FMR1-int        + More
IPR009828   DUF1394       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       
IPR000719   Prot_kinase_dom       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF57667   SSF57667        + More
SSF56112   SSF56112       

ProteinModelPortal

A0A212FEB2   H9IWN8   A0A1Y1LBS7   A0A1W4X9U0   A0A1W4X0D3   A0A0A9YMY3   + More
A0A154PF73   A0A067QJN8   A0A087ZRN0   D6W6N5   A0A023F4Y3   A0A0M9A438   A0A2H8TTY5   J9JL00   A0A2S2PGC3   A0A069DZS4   A0A195BYR5   A0A195FLC5   A0A0C9RNX2   A0A026VST8   A0A195ENV3   F4WRU2   A0A195BVS2   A0A158NEL8   A0A3L8DDD8   E2AEJ6   A0A151XIS4   E9IJB2   T1I0M5   A0A0A9YLG4   E0VKF3   A0A182IU35   A0A1I8P265   E2BT38   A0A1L8DJK9   A0A0L0CRE7   A0A182FK33   A0A182W4Z5   W5JMR6   T1PGJ9   A0A182K353   A0A182P7I9   A0A1A9VLJ8   A0A1A9ZN40   A0A182V303   Q7QEX4   U5EXQ3   U4UVP4   A0A182MF32   A0A182R7H8   A0A182N1K0   A0A182Q9W1   B4N7Y7   A0A1A9X2J4   A0A182GY71   B4G548   B4HDX6   B3P0V0   Q299G2   Q9VF87   A0A182YQ59   A0A3B0KPH8   U3PXB4   A0A1Q3FXC0   W8AKB2   Q16ZZ3   A0A1W4VEF2   B4MBK0   B4KCY0   A0A0K8VKF5   B4PS48   A0A034VU41   A0A0M4EPP6   N6U0N1   A0A310SRG8   B3MSU9   A0A0A1X1G2   A0A084WPX5   A0A3S2MA46   B4JS07   A0A182HIB1   A0A3B0K0E4   A0A336KRU0   K7IU01   A0A1B6IXR2   A0A1J1IGB3   A0A0P5JWY7   E9G9J2   A0A0P4Z605   A0A0P6A2V9   W8B750   A0A0P5YDJ2   A0A0P5MU60   A0A1B6J2I2   A0A0P5JIL9   A0A226E545   A0A2J7R5M9   B4QYJ2   A0A0P4YFE5   A0A182X808  

PDB

4N78     E-value=0,     Score=4076

KEGG

101735854    K05749 cytoplasmic FMR1 interacting protein | (RefSeq) cytoplasmic FMR1-interacting protein

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0003676   GO:0000902   GO:0031209   GO:0043005   GO:0007411   GO:0000340   GO:0045202   GO:0006417   GO:0030031   GO:0030866   GO:0060269   GO:0033627   GO:0008360   GO:0051491   GO:0001745   GO:0045177   GO:0050807   GO:0022416   GO:0004672   GO:0005524  

PANTHER

PTHR12195  

Subcellular location

Cytoplasm   Accumulates in central axons and motor neuron terminals.   With evidence from 1 publications.

Length:

1272

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.150020000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00453

outside

1  -  1272

 

 

Pi

199.741292

Theta

160.597015

Tajima's D

0.876079

CLR

0.419724

CSRT

0.625668716564172

Interpretation

Uncertain