Gene

KWMTBOMO06152  Validated by peptides from experiments

Annotation

yellow-fa_precursor_[Bombyx_mori]

Location

Bomo_Chr11(+):1454464-1473941      View in EpiBrowser

Full name

L-dopachrome tautomerase yellow-f2       + More
L-dopachrome tautomerase yellow-f      

Location in the cell

PlasmaMembrane   Reliability : 1.604

CDS

ATGAAGGTTTTCCTGTTGTTTTTGCTGCTCGCCGTCACTGCTTCCGGTCAGTTGATGAGCAGGAAAGTCGGGAAATTAACCGAAGTGTTCGCCTGGAAGCAACTGACTTATAACATACAAGGAAACCTGTTTTTAGAAGATCGATTCGCTACTGACACTGACAGAAGGAGGAGACAAACTGACAGCGGATTCAGACAAGACAATCGGAATCAGCTATCAAATCGCGGAGATCTACCCCTCAGGCCGAGTTGGAATCTATTCAGACCCGAAATCGTGAGACCATTCGTGAAGCCTGTCGAGAACGAAACAGGAAGATTCTTCGTTCAATATAACAATGTGCCAATGGGCGTTGAAAAGGTTGGCGACAGATTGTTCATTACAGTCCCTAGACGGAGATATGGTATACCATCCACGTTAAATTACGTAGATCTAACGACGGACTCCAACACACGGTCGCCGGCTTTGAGACCTTACCCTAGCCTGAGGGAGGGTAGTTCTCTGGTGTCTGTTTATAGAACAAGAGCTGATGAATGCGGCAGACTCTGGATGGTGGATACTGGAAGACTGGAGATACCTGACAATCACCAGCAAGTACAGCCACCGGCGATCGTGGTCTTCGATTTGAATACCGACAGAGAATTATTCAGATACCAGTTCAAAAGCTCTGACATACCGGCCGAGAACACTCCAACAGGACTGGCATCGATAACGATCGACACGAAGTCGGGCTGCGATACGGCTCACGCTTACGTCCCGGACCTGACCACATACGGCATCATCGTGTACTCGTTGAGGGACAACGACAGCTGGAGAATATCGCACAGCTACTTCCATTTCAATCCGATAGCGGGCAACTTGAACATCGCCGGCCAGTCGTTCCAATGGAGCGACGGAATATTCAGTCTGACTATAAAGAAGACGGAAGACAGATGCGACACGGCCTACTTCCATCCTTTGATCAGCACGCACGAGTTCGCTGTCTCCACGTGCCTCCTGAATAACCGCACCGCGTCCTCAGACAGCGACTACTGGACCAGATACTCAATAGTCGGTGAACGCGGCCCAAACAGTCAATCTACCATGCATGCCCATGACGCGGAGACCAACGTAATGTTTTACGCCGAAGTCGGCCGGGACGCCTTCTCCTGCTGGAACACTGCGAAGCCCCTGACGCCGAGCAACGTGGAAATACTAGCCAAAGACGCCATAAGGCTGAGCTATCCTTCAGATCTTCACATAACAGACGGCGAGGTGTGGTTAATGGCGAATTCGTTGCCGCGCTTCGGTTATGCTAGGCTCGACACGAACGAATATAACTTCTTTATTTACAGGGCGAACATTAGAGACGCTATTTACGGGACAACATGCAGCGGACGTTAG

Protein

MKVFLLFLLLAVTASGQLMSRKVGKLTEVFAWKQLTYNIQGNLFLEDRFATDTDRRRRQTDSGFRQDNRNQLSNRGDLPLRPSWNLFRPEIVRPFVKPVENETGRFFVQYNNVPMGVEKVGDRLFITVPRRRYGIPSTLNYVDLTTDSNTRSPALRPYPSLREGSSLVSVYRTRADECGRLWMVDTGRLEIPDNHQQVQPPAIVVFDLNTDRELFRYQFKSSDIPAENTPTGLASITIDTKSGCDTAHAYVPDLTTYGIIVYSLRDNDSWRISHSYFHFNPIAGNLNIAGQSFQWSDGIFSLTIKKTEDRCDTAYFHPLISTHEFAVSTCLLNNRTASSDSDYWTRYSIVGERGPNSQSTMHAHDAETNVMFYAEVGRDAFSCWNTAKPLTPSNVEILAKDAIRLSYPSDLHITDGEVWLMANSLPRFGYARLDTNEYNFFIYRANIRDAIYGTTCSGR

Description

Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages.
Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages.

Catalytic Activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

Biophysicochemical Properties

0.11 mM for L-dopachrome
0.31 mM for dopamine chrome
0.33 mM for L-dopachrome
0.29 mM for dopamine chrome

Similarity

Belongs to the major royal jelly protein family.

Keywords

Complete proteome   Glycoprotein   Isomerase   Melanin biosynthesis   Reference proteome   Secreted   Signal   Alternative initiation  

Feature

chain  L-dopachrome tautomerase yellow-f2
splice variant  In isoform 2.

Uniprot

Q2HZG5   A4GR70   H9B422   I4DLT0   S4PXQ8   D5LPU0   + More
A0A2W1B8N9   A0A2A4JYP7   A0A2H1VW15   A0A0N1I452   A0A1B0C0W0   I4DJY5   A0A1A9UFP7   A0A1A9ZA11   D3TNF5   A0A1B0GFL4   A0A1A9XRG8   A0A336MSU8   H9B423   A0A336KNV0   A0A336KJG6   A0A0A1X3L0   W8BA62   Q2HZG3   A0A212EU30   B4R1Y4   A0A0K8VKB6   B3P1A2   B4HGD1   Q9VG08   A0A1I8NG88   A0A0K8UHM5   A0A0M4EQV5   B4PPG8   A0A1W4U7Z4   A0A034W6M6   A0A034W5G2   B4G5K1   A0A0L0CBQ0   A0A1W4ULJ1   B3LW54   A0A3B0K3U0   A0A212EPC1   B5DXV3   Q9VG09   B4M3V3   Q9VG09-2   A0A0B4KGZ1   B4K8J0   A0A0B4KHA3   A0A0K8WCT9   B3P1A3   B4PPG7   A0A0K8VHY4   B4JEX3   A0A1A9WET6   B4HGD2   B4R1Y5   B0W604   A0A2P8ZJN1   A0A1B0GFH7   A0A1A9UIS0   A0A1Y1LCH2   B4N9W6   A0A3G1T1A9   A0A1Q3FQT7   A0A1I8PA66   B4N9X9   A0A212FLY1   A0A1Q3F1W3   A0A182RAF3   A0A0P4VLE7   R4FP61   A0A224XLY0   A0A2S2NRW5   A0A182VSS2   A0A182S4V5   F1AAN7   A0A336M1H6   A0A182M6M4   W5JJL4   A0A1S4H3I8   B0W605   A0A1S4FGJ8   Q172J0   A0A1C7CZU5   A0A182F8W1   A0NDC3   A0A2W1BZK1   A0A1Q3G2K4   F1AAM9   S4PE83   A0A182M7Q4   F1AAN0   T1PG39   A0A1I8JW38   A0A182XPW5   A0A1I8MIB3  

EC Number

5.3.3.12

Pubmed

16884544    22651552    23622113    28756777    26354079    20353571    + More
25830018    24495485    22118469    17994087    10731132    12537572    12537569    12164780    25315136    17550304    25348373    26108605    15632085    12537568    12537573    12537574    16110336    17569856    17569867    29403074    28004739    27129103    20920257    23761445    12364791    17510324    20966253    14747013    17210077   

EMBL

DQ358080    ABC96695.1    EF383145    ABO26383.1    JN977507    AFC87787.1    + More
AK402248    BAM18870.1    GAIX01004613    JAA87947.1    GU953230    ADF43214.1    KZ150547    PZC70564.1    NWSH01000417    PCG76540.1    ODYU01004481    SOQ44394.1    KQ458725    KPJ05345.1    JXJN01023775    AK401603    BAM18225.1    EZ422957    ADD19233.1    CCAG010023921    UFQS01002523    UFQT01002523    SSX14209.1    SSX33624.1    JN977508    AFC87788.1    UFQS01000574    UFQT01000574    SSX05055.1    SSX25417.1    SSX05054.1    SSX25416.1    GBXI01008585    JAD05707.1    GAMC01016596    GAMC01016594    JAB89961.1    DQ358082    ABC96697.1    AGBW02012516    OWR44954.1    CM000364    EDX13136.1    GDHF01013000    JAI39314.1    CH954181    EDV49291.1    CH480815    EDW42379.1    AE014297    AY060728    AAL28276.1    GDHF01026140    JAI26174.1    CP012526    ALC47451.1    CM000160    EDW97174.1    GAKP01008990    JAC49962.1    GAKP01008988    JAC49964.1    CH479179    EDW24867.1    JRES01000641    KNC29686.1    CH902617    EDV42632.1    OUUW01000013    SPP87943.1    AGBW02013493    OWR43338.1    CM000070    EDY67920.1    BT003613    AAO39616.1    CH940652    EDW59314.1    AGB95899.1    CH933806    EDW14389.2    AGB95898.1    GDHF01003649    JAI48665.1    EDV49292.1    EDW97173.1    GDHF01013800    JAI38514.1    CH916369    EDV93254.1    EDW42380.1    EDX13137.1    DS231845    EDS35991.1    PYGN01000035    PSN56703.1    CCAG010008538    GEZM01061260    JAV70598.1    CH964232    EDW81721.1    MG846918    AXY94770.1    GFDL01005075    JAV29970.1    EDW81734.2    AGBW02007691    OWR54736.1    GFDL01013514    JAV21531.1    GDKW01000657    JAI55938.1    ACPB03019756    GAHY01001044    JAA76466.1    GFTR01005598    JAW10828.1    GGMR01006877    MBY19496.1    GU063836    ADX87356.1    UFQT01000415    SSX24095.1    AXCM01000163    ADMH02001341    ETN62954.1    AAAB01008980    EDS35992.1    CH477436    EAT40936.1    AAAB01008879    EAU77002.3    KZ149892    PZC79024.1    GFDL01001034    JAV34011.1    GU063828    ADX87348.1    GAIX01004647    JAA87913.1    AXCM01005162    GU063829    ADX87349.1    KA647726    AFP62355.1   

Proteomes

UP000218220    UP000053268    UP000092460    UP000078200    UP000092445    UP000092444    + More
UP000092443    UP000007151    UP000000304    UP000008711    UP000001292    UP000000803    UP000095301    UP000092553    UP000002282    UP000192221    UP000008744    UP000037069    UP000007801    UP000268350    UP000001819    UP000008792    UP000009192    UP000001070    UP000091820    UP000002320    UP000245037    UP000007798    UP000095300    UP000075900    UP000015103    UP000075920    UP000075883    UP000000673    UP000008820    UP000075882    UP000069272    UP000007062    UP000076407   

PRIDE

Q2HZG5    A4GR70    H9B422    H9B423    Q2HZG3    Q9VG08    + More
Q9VG09   

Pfam

PF03022   MRJP

Interpro

IPR017996   Royal_jelly/protein_yellow        + More
IPR011042   6-blade_b-propeller_TolB-like       

Gene 3D

2.120.10.30    

ProteinModelPortal

Q2HZG5   A4GR70   H9B422   I4DLT0   S4PXQ8   D5LPU0   + More
A0A2W1B8N9   A0A2A4JYP7   A0A2H1VW15   A0A0N1I452   A0A1B0C0W0   I4DJY5   A0A1A9UFP7   A0A1A9ZA11   D3TNF5   A0A1B0GFL4   A0A1A9XRG8   A0A336MSU8   H9B423   A0A336KNV0   A0A336KJG6   A0A0A1X3L0   W8BA62   Q2HZG3   A0A212EU30   B4R1Y4   A0A0K8VKB6   B3P1A2   B4HGD1   Q9VG08   A0A1I8NG88   A0A0K8UHM5   A0A0M4EQV5   B4PPG8   A0A1W4U7Z4   A0A034W6M6   A0A034W5G2   B4G5K1   A0A0L0CBQ0   A0A1W4ULJ1   B3LW54   A0A3B0K3U0   A0A212EPC1   B5DXV3   Q9VG09   B4M3V3   Q9VG09-2   A0A0B4KGZ1   B4K8J0   A0A0B4KHA3   A0A0K8WCT9   B3P1A3   B4PPG7   A0A0K8VHY4   B4JEX3   A0A1A9WET6   B4HGD2   B4R1Y5   B0W604   A0A2P8ZJN1   A0A1B0GFH7   A0A1A9UIS0   A0A1Y1LCH2   B4N9W6   A0A3G1T1A9   A0A1Q3FQT7   A0A1I8PA66   B4N9X9   A0A212FLY1   A0A1Q3F1W3   A0A182RAF3   A0A0P4VLE7   R4FP61   A0A224XLY0   A0A2S2NRW5   A0A182VSS2   A0A182S4V5   F1AAN7   A0A336M1H6   A0A182M6M4   W5JJL4   A0A1S4H3I8   B0W605   A0A1S4FGJ8   Q172J0   A0A1C7CZU5   A0A182F8W1   A0NDC3   A0A2W1BZK1   A0A1Q3G2K4   F1AAM9   S4PE83   A0A182M7Q4   F1AAN0   T1PG39   A0A1I8JW38   A0A182XPW5   A0A1I8MIB3  

PDB

3Q6T     E-value=1.29575e-30,     Score=333

KEGG

693000    K22203 dopachrome tautomerase [EC:5.3.3.12] | (RefSeq) Y-fa; yellow-fa

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004167   GO:0042435   GO:0005576   GO:0048066   GO:0042438   GO:0048067   GO:0006583   GO:0016853  

PANTHER

PTHR10009  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.996931

 

 

Length:

459

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.371760000000001

Exp number, first 60 AAs:

0.36944

Total prob of N-in:

0.02062

outside

1  -  459

 

 

Pi

29.857585

Theta

161.587199

Tajima's D

2.893855

CLR

0.53824

CSRT

0.975351232438378

Interpretation

Uncertain