Gene

KWMTBOMO06150  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001755

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_gelsolin-like_[Bombyx_mori]

Location

Bomo_Chr11(+):1409724-1428399      View in EpiBrowser

Full name

Gelsolin      

Location in the cell

Extracellular   Reliability : 1.084

CDS

ATGAAGATCATTTTTTCGTGTCTCCTTTTTGTTTTGCTGGGATCCGTCTGGGCACGGACGGCGACCAAGCCTCAGGAGATAAGCGGGCCGATCACATCGCTGTCAGATAAAAACGCCCGTGACAAAGCTAAGGTCCACCCGGCTTTTGCCAATGTCGGCAGAACAGCCGGTGTGCAAATATGGAGAATACAGAACTTCGAACCAATACCCGTTGCTCAGAAGGACATAGGAAAATTCTACAAAGGAGATTCATACATCATTTTACGGACGACCTCGGACAATCGCAACAATCTGTCATGGGACATCCACTACTGGATCGGTCGGGAGTCGACGCAAGACGAATCAGGAGCCGCCGCCATCCTCACCGTCGGCCTGGACGACAAGTTCGGGGGCGCCGCGGTCCAGCACCGAGAGACCATGGGTCACGAAAGCGCTTTGTTCCTATCATATTTCCAGACACCCTTGAACTATTTGGAGGGAGGGAATCCGTCCGGTTTTAACCACGTCGTCACGAACGCGGGAGCCCAGAAACGAATGTTCCAGGTCAAGGGGAAGCGAGATGTCCGCGTTAGACAAGTCGATCCGCAGATAGCTTCGATGAACAAAGGCGACGTCTTCGTTCTTGATCTAGACAACGACATCTATGTCTTTGTCGGCGAGAAAGCTAAAAACGTTGAGAAGCTTAAAGCGATTTCGTTCGCCAATCAAGTACGGGATCAGGATCATCACGGACGCGGAAGAGTCGATATTGTGGACAAGTACTCGAGCGATGTGGACGTTCAGAAATTCTTCACGGCTCTTGGTTCAGGAGTTAAGGATCTGGTGCCGGATGAGAGCACCGGCGGAGACGACCAGGAGTTCGAAAGGAATGAAGCTAGCAACGTGATTCTCTCTGAAGTGTCAGACGCCACGGGAAAGATCAAAGTGACGCCACTATCGAAGCCTTTCAAGCAAGAGAACTTGAGTCCACAGAACGCGTATATTTTGGACACCATATCTGGCAACATTTACGTTTGGATCGGGAAGCAGGCTACCGCAAACGAGAAATCTCAGGCCATGACGAAAGCTCAGGAATTGTTGAACGCTAAGAACTATCCTTCGTGGGTGCAAGTGACCAGAGTTCTACAGAACACGGAGCCTGCAGCATTCAAGCAGTACTTCTTCACCTGGCGAGACTTCGGAATGTCTCACTCGCGAGTCATTTAA

Protein

MKIIFSCLLFVLLGSVWARTATKPQEISGPITSLSDKNARDKAKVHPAFANVGRTAGVQIWRIQNFEPIPVAQKDIGKFYKGDSYIILRTTSDNRNNLSWDIHYWIGRESTQDESGAAAILTVGLDDKFGGAAVQHRETMGHESALFLSYFQTPLNYLEGGNPSGFNHVVTNAGAQKRMFQVKGKRDVRVRQVDPQIASMNKGDVFVLDLDNDIYVFVGEKAKNVEKLKAISFANQVRDQDHHGRGRVDIVDKYSSDVDVQKFFTALGSGVKDLVPDESTGGDDQEFERNEASNVILSEVSDATGKIKVTPLSKPFKQENLSPQNAYILDTISGNIYVWIGKQATANEKSQAMTKAQELLNAKNYPSWVQVTRVLQNTEPAAFKQYFFTWRDFGMSHSRVI

Description

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Subunit

Binds to actin and to fibronectin.

Similarity

Belongs to the villin/gelsolin family.

Keywords

Actin-binding   Alternative splicing   Calcium   Complete proteome   Cytoplasm   Cytoskeleton   Metal-binding   Phosphoprotein   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  Gelsolin
splice variant  In isoform 2.

Uniprot

H9IWX2   I4DKR3   A0A2H1X307   A0A0N1PF90   A0A2A4JSL9   A0A2W1BDE5   + More
B4NFJ3   A0A1I8NXC0   A0A0M3QXF2   B4JS24   A0A1I8NXE8   A0A1A9WIF6   A0A0C4DHG2   Q07171   W8BFB5   A0A1L8E606   A0A1L8E5D0   B3P1X4   B4MBI4   A0A1L8E5B4   B4PTP4   B3LXY4   A0A1L8E5N5   B4QUY4   U5ETK7   A0A0K8VYB1   A0A0Q9XDT7   A0A0N8P1H5   Q07171-6   Q295D4   T1PDD6   A0A0Q9XFV1   A0A0Q9WBU6   B4GM71   A0A0K8WEL2   B4KCW4   A0A0A1X561   A0A1W4VZL6   A0A034V9E0   A0A1I8NCV8   Q07171-2   A0A0C4DHG6   A0A0R1DZS5   A0A1W4VLN5   A0A336MY83   A0A336MRC3   A0A1L8E5M0   A0A3B0K219   I5APK8   A0A1L8E5G4   A0A1B0FCE4   A0A1J1HKI1   B4I3K2   A0A336MF08   A0A0L0CJJ3   A0A182JHU4   A0A2M4A063   A0A0N1I6N5   A0A1B0A8V6   A0A1A9UQ65   Q177K9   Q177L3   A0A084WAH3   A0A2M4A0T5   A0A0T6ATX5   A0A182KHE3   A0A1A9XMX0   A0A1S4FCK2   A0A2M4ARI5   A0A034VMT8   W5JSX6   A0A034VNT3   A0A2M3YY66   A0A2M4BQS3   A0A2M4BRN4   A0A1S4H7D0   A0A2M3ZET1   A0A0A1XCB7   A0A023ESF2   A0A182MCE7   A0A1Q3FPV9   A0A0K8WH15   A0A0K8VEK4   A0A0K8SZE6   A0A1Q3FQ94   A0A1Q3FQS9   A0A023ER95   B0WBT0   A0A182LQA0   A0A084WAH4   W5JRC5   A0A1S4HE98   A0A1Q3FQM8   A0A182JFK4   A0A182U2B6   A0A1Q3FQD7   A0A1Q3FQB1   D6W686   A0A1Q3FQ87   A0A2M3YY40  

Pubmed

19121390    22651552    26354079    28756777    17994087    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    8386771    8175883    12537569    24495485    17550304    15632085    18057021    25830018    25348373    25315136    26108605    17510324    24438588    20920257    23761445    12364791    24945155    20966253    18362917    19820115   

EMBL

BABH01021070    BABH01021071    BABH01021072    AK401881    BAM18503.1    ODYU01013020    + More
SOQ59632.1    KQ458725    KPJ05342.1    NWSH01000756    PCG74392.1    KZ150427    PZC70920.1    CH964251    EDW83060.2    CP012526    ALC45823.1    CH916373    EDV94564.1    AE014297    AAO41509.3    L08794    X75629    X75630    AY119662    BT031288    AAF52163.1    GAMC01006570    JAB99985.1    GFDF01000142    JAV13942.1    GFDF01000143    JAV13941.1    CH954181    EDV47747.1    CH940656    EDW58455.1    GFDF01000144    JAV13940.1    CM000160    EDW95627.1    CH902617    EDV42840.1    GFDF01000145    JAV13939.1    CM000364    EDX11565.1    GANO01002735    JAB57136.1    GDHF01008411    JAI43903.1    CH933806    KRG02433.1    KPU79940.1    CM000070    EAL28778.1    KA646135    AFP60764.1    KRG02435.1    KRF78299.1    CH479185    EDW37945.1    GDHF01002830    JAI49484.1    EDW16986.1    KRG02434.1    GBXI01017400    GBXI01008256    JAC96891.1    JAD06036.1    GAKP01020261    GAKP01020260    JAC38692.1    ABI31119.2    KRK02572.1    UFQT01001498    SSX30818.1    SSX30817.1    GFDF01000140    JAV13944.1    OUUW01000014    SPP88317.1    EIM52893.1    GFDF01000141    JAV13943.1    CCAG010002582    CCAG010002583    CVRI01000008    CRK88567.1    CH480821    EDW54795.1    UFQS01001020    UFQT01001020    SSX08604.1    SSX28520.1    JRES01000310    KNC32416.1    GGFK01000866    MBW34187.1    KQ460736    KPJ12596.1    CH477374    EAT42357.1    EAT42353.1    ATLV01022193    KE525329    KFB47217.1    GGFK01000927    MBW34248.1    LJIG01022826    KRT78520.1    GGFK01010059    MBW43380.1    GAKP01015189    GAKP01015188    JAC43764.1    ADMH02000569    ETN65859.1    GAKP01015191    GAKP01015190    JAC43762.1    GGFM01000444    MBW21195.1    GGFJ01006296    MBW55437.1    GGFJ01006297    MBW55438.1    AAAB01008966    GGFM01006237    MBW26988.1    GBXI01005705    JAD08587.1    GAPW01001912    JAC11686.1    AXCM01010666    GFDL01005406    JAV29639.1    GDHF01032030    GDHF01001868    JAI20284.1    JAI50446.1    GDHF01015067    GDHF01010278    JAI37247.1    JAI42036.1    GBRD01007158    JAG58663.1    GFDL01005264    JAV29781.1    GFDL01005187    JAV29858.1    GAPW01001920    JAC11678.1    DS231882    EDS42860.1    KFB47218.1    ETN65858.1    GFDL01005237    JAV29808.1    GFDL01005226    JAV29819.1    GFDL01005244    JAV29801.1    KQ971306    EFA11080.2    GFDL01005341    JAV29704.1    GGFM01000420    MBW21171.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007798    UP000095300    UP000092553    + More
UP000001070    UP000091820    UP000000803    UP000008711    UP000008792    UP000002282    UP000007801    UP000000304    UP000009192    UP000001819    UP000008744    UP000192221    UP000095301    UP000268350    UP000092444    UP000183832    UP000001292    UP000037069    UP000075880    UP000053240    UP000092445    UP000078200    UP000008820    UP000030765    UP000075881    UP000092443    UP000000673    UP000075883    UP000002320    UP000075882    UP000075902    UP000007266   

PRIDE

H9IWX2    Q07171   

Pfam

PF00626   Gelsolin        + More
PF00878   CIMR

Interpro

IPR029006   ADF-H/Gelsolin-like_dom_sf        + More
IPR007123   Gelsolin-like_dom       
IPR007122   Villin/Gelsolin       
IPR030004   Gelsolin       
IPR000479   CIMR       
IPR009011   Man6P_isomerase_rcpt-bd_dom_sf       

Gene 3D

3.40.20.10     2.70.130.10    

ProteinModelPortal

H9IWX2   I4DKR3   A0A2H1X307   A0A0N1PF90   A0A2A4JSL9   A0A2W1BDE5   + More
B4NFJ3   A0A1I8NXC0   A0A0M3QXF2   B4JS24   A0A1I8NXE8   A0A1A9WIF6   A0A0C4DHG2   Q07171   W8BFB5   A0A1L8E606   A0A1L8E5D0   B3P1X4   B4MBI4   A0A1L8E5B4   B4PTP4   B3LXY4   A0A1L8E5N5   B4QUY4   U5ETK7   A0A0K8VYB1   A0A0Q9XDT7   A0A0N8P1H5   Q07171-6   Q295D4   T1PDD6   A0A0Q9XFV1   A0A0Q9WBU6   B4GM71   A0A0K8WEL2   B4KCW4   A0A0A1X561   A0A1W4VZL6   A0A034V9E0   A0A1I8NCV8   Q07171-2   A0A0C4DHG6   A0A0R1DZS5   A0A1W4VLN5   A0A336MY83   A0A336MRC3   A0A1L8E5M0   A0A3B0K219   I5APK8   A0A1L8E5G4   A0A1B0FCE4   A0A1J1HKI1   B4I3K2   A0A336MF08   A0A0L0CJJ3   A0A182JHU4   A0A2M4A063   A0A0N1I6N5   A0A1B0A8V6   A0A1A9UQ65   Q177K9   Q177L3   A0A084WAH3   A0A2M4A0T5   A0A0T6ATX5   A0A182KHE3   A0A1A9XMX0   A0A1S4FCK2   A0A2M4ARI5   A0A034VMT8   W5JSX6   A0A034VNT3   A0A2M3YY66   A0A2M4BQS3   A0A2M4BRN4   A0A1S4H7D0   A0A2M3ZET1   A0A0A1XCB7   A0A023ESF2   A0A182MCE7   A0A1Q3FPV9   A0A0K8WH15   A0A0K8VEK4   A0A0K8SZE6   A0A1Q3FQ94   A0A1Q3FQS9   A0A023ER95   B0WBT0   A0A182LQA0   A0A084WAH4   W5JRC5   A0A1S4HE98   A0A1Q3FQM8   A0A182JFK4   A0A182U2B6   A0A1Q3FQD7   A0A1Q3FQB1   D6W686   A0A1Q3FQ87   A0A2M3YY40  

PDB

3FFK     E-value=2.4895e-69,     Score=666

KEGG

101746507    K05768 gelsolin | (RefSeq) gelsolin-like

GO

GO:0051015   GO:0005576   GO:0005884   GO:0005829   GO:0030041   GO:0003779   GO:0046872   GO:0005509   GO:0051016   GO:0045010   GO:0051014   GO:0007041   GO:0051219   GO:0038023   GO:0016705   GO:0020037   GO:0005874   GO:0007017   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11977   PTHR11977:SF29  

Subcellular location

  
Secreted  

SignalP

Position:   1 - 18,         Likelihood:  0.998369

 

 

Length:

401

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.621669999999999

Exp number, first 60 AAs:

0.611469999999999

Total prob of N-in:

0.03415

outside

1  -  401

 

 

Pi

221.511488

Theta

36.888137

Tajima's D

1.680194

CLR

1.023259

CSRT

0.822858857057147

Interpretation

Uncertain