Gene

KWMTBOMO06149  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001754

Annotation

PREDICTED:_gelsolin-like_[Amyelois_transitella]

Location

Bomo_Chr11(+):1396034-1401784      View in EpiBrowser

Full name

Gelsolin      

Location in the cell

Cytoplasmic   Reliability : 2.27

CDS

ATGAAAGCCATCACCGTAGCCAACCAGATTAAAGACCAGGATCACAATGGAAGGGCTGATATCGAAGTGGTCGACTCCGAAGCGCACGATGGAATCTTCGACAGGTTCTTCGATGCCCTCGGCTCCGGCAACAAGGAGGCCATCGCTGATGCCGAAGAAGGGGGCGACGATCAAGAGTTCGAACGCGTCGTCACGAAGGAGGTGTCCCTGAGTGAGATCTCCGATAAGACTGGCAGCATCAGGATAACGAGACTCCCCGCGCCACTTAAGAAGGAGCAACTGAACACCGATGAATGCTACGTGCTTGATACCGGAAGTTACAGCGGCATCTATGTGTGGGTCGGGCGCGGCTCGAACCTAAAGGAGAAAGCCGAAGCGATGAATAGAGCTGAGCAATACCTGAAATACCACGACTATCCGGCTTGGGTCCACGTGTCGAAGGTTCCGGAAGGCGCTGAACCGATACCCTTCAAGCAATACTTCGAGGATTGGAACTGA

Protein

MKAITVANQIKDQDHNGRADIEVVDSEAHDGIFDRFFDALGSGNKEAIADAEEGGDDQEFERVVTKEVSLSEISDKTGSIRITRLPAPLKKEQLNTDECYVLDTGSYSGIYVWVGRGSNLKEKAEAMNRAEQYLKYHDYPAWVHVSKVPEGAEPIPFKQYFEDWN

Description

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Subunit

Binds to actin and to fibronectin.

Similarity

Belongs to the villin/gelsolin family.

Keywords

Actin-binding   Alternative splicing   Calcium   Complete proteome   Cytoplasm   Cytoskeleton   Metal-binding   Phosphoprotein   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  Gelsolin
splice variant  In isoform 2.

Uniprot

H9IWX1   A0A2W1BN17   A0A2H1WKP3   A0A0N0PA91   A0A2A4JQW7   A0A2H1X307   + More
A0A2A4JSL9   A0A0N1PF90   I4DKR3   A0A0N1I6N5   E5L9L1   A0A2K8JM62   T1HKR8   A0A1S4E792   B4NFJ3   A0A224XF20   A0A0M3QXF2   A0A161MIR2   Q07171-2   A0A0C4DHG6   A0A0C4DHG2   Q07171   A0A224XQJ4   Q07171-6   A0A1A9WIF6   B4QUY4   A0A1I8NCV8   T1PDD6   B4JS24   A0A069DYQ6   I5APK8   A0A1I8NXE8   A0A1I8NXC0   Q295D4   B4GM71   A0A0Q9XFV1   A0A0Q9XDT7   B4KCW4   A0A1W4VZL6   A0A0P4VVN5   A0A0R1DZS5   A0A3B0K219   B4PTP4   A0A1W4VLN5   A0A0N8P1H5   A0A0Q9WBU6   A0A171A3J0   B4MBI4   B3LXY4   A0A0K8VYB1   A0A336MRC3   A0A1B0FCE4   A0A336MY83   U5ETK7   A0A0A1X561   A0A1J1HKI1   A0A0K8WEL2   A0A2K8JW66   D6W686   A0A034VAZ1   A0A0T6ATX5   J9K5M7   A0A034V9E0   A0A293LI79   A0A0A1XCB7   A0A0K8SZE6   A0A2R5L4E0   A0A2S2PJ12   A0A2H8U180   W8BFB5   A0A1L8E5G4   A0A1L8E5M0   A0A1L8E606   A0A1L8E5B4   A0A1L8E5D0   A0A1L8E5N5   A0A0K8WH15   A0A0K8VEK4   B3P1X4   A0A336MF08   L7MCZ6   A0A224YQ72   A0A1E1XM95   A0A224YNC3   A0A1B0BZ83   A0A1Z5L535   A0A034VNT3   A0A034VMT8   B7PVR6   A0A131XHX0   A0A131YKS1   A0A1E1XAG7   A0A0L0CJJ3   W8B6S7   A0A1E1W458   A0A0A9WEB4   V5HJ32   A0A2J7RA32   A0A1A9UQ65   A0A1B6CL01  

Pubmed

19121390    28756777    26354079    22651552    20978910    17994087    + More
8386771    8175883    10731132    12537572    12537569    12537568    12537573    12537574    16110336    17569856    17569867    25315136    26334808    15632085    18057021    27129103    17550304    25830018    18362917    19820115    25348373    24495485    25576852    28797301    29209593    28528879    28049606    26830274    28503490    26108605    25401762    25765539   

EMBL

BABH01021068    KZ149957    PZC76449.1    ODYU01009215    SOQ53482.1    KQ458725    + More
KPJ05340.1    NWSH01000756    PCG74391.1    ODYU01013020    SOQ59632.1    PCG74392.1    KPJ05342.1    AK401881    BAM18503.1    KQ460736    KPJ12596.1    HQ383992    ADQ64485.1    KY030980    ATU82731.1    ACPB03022068    CH964251    EDW83060.2    GFTR01005349    JAW11077.1    CP012526    ALC45823.1    GEMB01001542    JAS01616.1    L08794    X75629    X75630    AE014297    AY119662    BT031288    AAF52163.1    ABI31119.2    AAO41509.3    GFTR01005706    JAW10720.1    CM000364    EDX11565.1    KA646135    AFP60764.1    CH916373    EDV94564.1    GBGD01001975    JAC86914.1    CM000070    EIM52893.1    EAL28778.1    CH479185    EDW37945.1    CH933806    KRG02435.1    KRG02433.1    EDW16986.1    KRG02434.1    GDKW01002904    JAI53691.1    CM000160    KRK02572.1    OUUW01000014    SPP88317.1    EDW95627.1    CH902617    KPU79940.1    CH940656    KRF78299.1    GEMB01001541    JAS01617.1    EDW58455.1    EDV42840.1    GDHF01008411    JAI43903.1    UFQT01001498    SSX30817.1    CCAG010002582    CCAG010002583    SSX30818.1    GANO01002735    JAB57136.1    GBXI01017400    GBXI01008256    JAC96891.1    JAD06036.1    CVRI01000008    CRK88567.1    GDHF01002830    JAI49484.1    MF683379    ATU82520.1    KQ971306    EFA11080.2    GAKP01020259    JAC38693.1    LJIG01022826    KRT78520.1    ABLF02022767    GAKP01020261    GAKP01020260    JAC38692.1    GFWV01008468    MAA33197.1    GBXI01005705    JAD08587.1    GBRD01007158    JAG58663.1    GGLE01000184    MBY04310.1    GGMR01016820    MBY29439.1    GFXV01007996    MBW19801.1    GAMC01006570    JAB99985.1    GFDF01000141    JAV13943.1    GFDF01000140    JAV13944.1    GFDF01000142    JAV13942.1    GFDF01000144    JAV13940.1    GFDF01000143    JAV13941.1    GFDF01000145    JAV13939.1    GDHF01032030    GDHF01001868    JAI20284.1    JAI50446.1    GDHF01015067    GDHF01010278    JAI37247.1    JAI42036.1    CH954181    EDV47747.1    UFQS01001020    UFQT01001020    SSX08604.1    SSX28520.1    GACK01002948    JAA62086.1    GFPF01007949    MAA19095.1    GFAA01003228    JAU00207.1    GFPF01007950    MAA19096.1    JXJN01023019    JXJN01023020    GFJQ02004488    JAW02482.1    GAKP01015191    GAKP01015190    JAC43762.1    GAKP01015189    GAKP01015188    JAC43764.1    ABJB010273219    ABJB010277958    ABJB010343362    ABJB010707454    ABJB011053052    DS801915    EEC10688.1    GEFH01002776    JAP65805.1    GEDV01009010    JAP79547.1    GFAC01002976    JAT96212.1    JRES01000310    KNC32416.1    GAMC01012223    JAB94332.1    GDQN01009286    JAT81768.1    GBHO01036802    JAG06802.1    GANP01006869    JAB77599.1    NEVH01006578    PNF37693.1    GEDC01023154    JAS14144.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000015103    UP000079169    + More
UP000007798    UP000092553    UP000000803    UP000091820    UP000000304    UP000095301    UP000001070    UP000001819    UP000095300    UP000008744    UP000009192    UP000192221    UP000002282    UP000268350    UP000007801    UP000008792    UP000092444    UP000183832    UP000007266    UP000007819    UP000008711    UP000092460    UP000001555    UP000037069    UP000235965    UP000078200   

PRIDE

H9IWX1    Q07171   

Pfam

PF00626   Gelsolin        + More
PF00098   zf-CCHC
PF13961   DUF4219
PF13976   gag_pre-integrs
PF00878   CIMR

Interpro

IPR007122   Villin/Gelsolin        + More
IPR036180   Gelsolin-like_dom_sf       
IPR029006   ADF-H/Gelsolin-like_dom_sf       
IPR007123   Gelsolin-like_dom       
IPR001878   Znf_CCHC       
IPR036875   Znf_CCHC_sf       
IPR025314   DUF4219       
IPR025724   GAG-pre-integrase_dom       
IPR000479   CIMR       
IPR009011   Man6P_isomerase_rcpt-bd_dom_sf       

SUPFAM

SSF82754   SSF82754        + More
SSF57756   SSF57756       

Gene 3D

3.40.20.10     2.70.130.10    

ProteinModelPortal

H9IWX1   A0A2W1BN17   A0A2H1WKP3   A0A0N0PA91   A0A2A4JQW7   A0A2H1X307   + More
A0A2A4JSL9   A0A0N1PF90   I4DKR3   A0A0N1I6N5   E5L9L1   A0A2K8JM62   T1HKR8   A0A1S4E792   B4NFJ3   A0A224XF20   A0A0M3QXF2   A0A161MIR2   Q07171-2   A0A0C4DHG6   A0A0C4DHG2   Q07171   A0A224XQJ4   Q07171-6   A0A1A9WIF6   B4QUY4   A0A1I8NCV8   T1PDD6   B4JS24   A0A069DYQ6   I5APK8   A0A1I8NXE8   A0A1I8NXC0   Q295D4   B4GM71   A0A0Q9XFV1   A0A0Q9XDT7   B4KCW4   A0A1W4VZL6   A0A0P4VVN5   A0A0R1DZS5   A0A3B0K219   B4PTP4   A0A1W4VLN5   A0A0N8P1H5   A0A0Q9WBU6   A0A171A3J0   B4MBI4   B3LXY4   A0A0K8VYB1   A0A336MRC3   A0A1B0FCE4   A0A336MY83   U5ETK7   A0A0A1X561   A0A1J1HKI1   A0A0K8WEL2   A0A2K8JW66   D6W686   A0A034VAZ1   A0A0T6ATX5   J9K5M7   A0A034V9E0   A0A293LI79   A0A0A1XCB7   A0A0K8SZE6   A0A2R5L4E0   A0A2S2PJ12   A0A2H8U180   W8BFB5   A0A1L8E5G4   A0A1L8E5M0   A0A1L8E606   A0A1L8E5B4   A0A1L8E5D0   A0A1L8E5N5   A0A0K8WH15   A0A0K8VEK4   B3P1X4   A0A336MF08   L7MCZ6   A0A224YQ72   A0A1E1XM95   A0A224YNC3   A0A1B0BZ83   A0A1Z5L535   A0A034VNT3   A0A034VMT8   B7PVR6   A0A131XHX0   A0A131YKS1   A0A1E1XAG7   A0A0L0CJJ3   W8B6S7   A0A1E1W458   A0A0A9WEB4   V5HJ32   A0A2J7RA32   A0A1A9UQ65   A0A1B6CL01  

PDB

1J72     E-value=1.46472e-15,     Score=197

KEGG

101746366    K05768 gelsolin | (RefSeq) gelsolin-like

GO

GO:0051015   GO:0003676   GO:0008270   GO:0005576   GO:0005884   GO:0005829   GO:0003779   GO:0046872   GO:0030041   GO:0051014   GO:0045010   GO:0051016   GO:0005509   GO:0007041   GO:0051219   GO:0038023   GO:0016705   GO:0020037   GO:0005874   GO:0007017   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11977  

Subcellular location

  
Secreted  

Length:

165

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01131

Exp number, first 60 AAs:

0

Total prob of N-in:

0.33296

outside

1  -  165

 

 

Pi

23.525135

Theta

148.975249

Tajima's D

1.625539

CLR

0.248001

CSRT

0.814309284535773

Interpretation

Uncertain