Gene

KWMTBOMO06148  Validated by peptides from experiments

Annotation

PREDICTED:_gelsolin-like_[Amyelois_transitella]

Location

Bomo_Chr11(+):1383394-1395188      View in EpiBrowser

Full name

Gelsolin      

Location in the cell

Cytoplasmic   Reliability : 2.152

CDS

ATGCCTGAAGTACACCAAGCATTCGCGGATGCCGGCAGGAAGCCGGGTCTCGAAATATGGAGGATTGAGAACTTCGAACCGGTCGCCGTTCCGAAGACTCAGTTTGGTCTCTTCTACTCTGGGGACTCCTATATTGTACTGAACACCACAGGCGATAAGGACCGTCTAACATGGGACATCCACTTCTGGCTCGGCTCAAGGACCAGCCAGGACGAAGCCGGCGCGGCGGCCATCCTCACGGTGAACTTGGACGACGAACAATTCCAGGGATCAGCGGTACAGCACCGAGAGGTCCAATATTACGAGTCCAAGGAGTTCCTGGAATATTTCTCGCCAGCCATCCGCTACTTAAAAGGCGGACACGCCTCAGGCTTCAGCCACGTGACGATCAATGAGGGAACAGAGAAACGACTCTTCCAGATCAAGGGTAAAAGAAACGTCCGCGTTAAGCAGACACAGTCCTCTGCAGCTCTGTACTGA

Protein

MPEVHQAFADAGRKPGLEIWRIENFEPVAVPKTQFGLFYSGDSYIVLNTTGDKDRLTWDIHFWLGSRTSQDEAGAAAILTVNLDDEQFQGSAVQHREVQYYESKEFLEYFSPAIRYLKGGHASGFSHVTINEGTEKRLFQIKGKRNVRVKQTQSSAALY

Description

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Subunit

Binds to actin and to fibronectin.

Similarity

Belongs to the villin/gelsolin family.

Keywords

Actin-binding   Alternative splicing   Calcium   Complete proteome   Cytoplasm   Cytoskeleton   Metal-binding   Phosphoprotein   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  Gelsolin
splice variant  In isoform 2.

Uniprot

H9IWX1   A0A0N0PA91   A0A2W1B6C1   S4P8F1   A0A0A9X3I0   A0A0K8SZI1   + More
A0A1A9XMX0   A0A1B0A8V6   A0A1A9UQ65   A0A0A9Z2C4   A0A1B0FCE4   A0A034V9E0   A0A2W1BDE5   A0A0K8SZE6   A0A0K8VYB1   W8B6S7   A0A0K8WEL2   A0A1A9WIF6   A0A336MY83   A0A336MRC3   A0A336MF08   W8BFB5   A0A1I8NXC0   A0A1I8NXE8   A0A0N1I6N5   A0A2A4JSL9   A0A0L0CJJ3   B3P1X4   B4QUY4   A0A0A1X561   A0A2H1X307   B4I3K2   A0A3B0K219   A0A0N8P1H5   B3LXY4   T1PDD6   A0A1I8NCV8   A0A0M3QXF2   B4PTP4   A0A0R1DZS5   B4GM71   A0A0K8WH15   A0A034VMT8   I5APK8   A0A034VNT3   A0A0A1XCB7   A0A0K8VEK4   Q295D4   A0A0N1PF90   I4DKR3   A0A084WAH3   B4KCW4   A0A0Q9XFV1   A0A0Q9XDT7   A0A1W4VZL6   A0A1W4VLN5   A0A1J1HKI1   A0A0C4DHG2   Q07171   B4NFJ3   B4MBI4   A0A0Q9WBU6   Q07171-2   A0A0C4DHG6   Q07171-6   A0A2W1BN17   B4JS24   A0A1L8E5M0   A0A1L8E5G4   A0A1L8E5D0   A0A1L8E606   A0A1L8E5B4   A0A1L8E5N5   A0A1B6IRD1   A0A1B6CL01   A0A2M3ZET1   A0A161MIR2   U5ETK7   A0A182JHU4   A0A224XQJ4   A0A2M3YY40   A0A2M3YY66   A0A2M4BQS3   A0A2M4BRN4   A0A2M4A063   A0A0P4VVN5   W5JSX6   A0A1S4FCK2   A0A2J7RA50   Q177L3   Q177K9   A0A023ER95   A0A2J7RA31   A0A2J7RA37   A0A023ESF2   A0A1S4H7D0   A0A182KHE3   U4UCC7   N6UGY5  

Pubmed

19121390    26354079    28756777    23622113    25401762    25348373    + More
24495485    26108605    17994087    25830018    25315136    17550304    15632085    22651552    24438588    18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8386771    8175883    12537569    27129103    20920257    23761445    17510324    24945155    12364791    23537049   

EMBL

BABH01021068    KQ458725    KPJ05340.1    KZ150657    PZC70405.1    GAIX01009520    + More
JAA83040.1    GBHO01033317    GBHO01031979    JAG10287.1    JAG11625.1    GBRD01007159    JAG58662.1    GBHO01005588    JAG38016.1    CCAG010002582    CCAG010002583    GAKP01020261    GAKP01020260    JAC38692.1    KZ150427    PZC70920.1    GBRD01007158    JAG58663.1    GDHF01008411    JAI43903.1    GAMC01012223    JAB94332.1    GDHF01002830    JAI49484.1    UFQT01001498    SSX30818.1    SSX30817.1    UFQS01001020    UFQT01001020    SSX08604.1    SSX28520.1    GAMC01006570    JAB99985.1    KQ460736    KPJ12596.1    NWSH01000756    PCG74392.1    JRES01000310    KNC32416.1    CH954181    EDV47747.1    CM000364    EDX11565.1    GBXI01017400    GBXI01008256    JAC96891.1    JAD06036.1    ODYU01013020    SOQ59632.1    CH480821    EDW54795.1    OUUW01000014    SPP88317.1    CH902617    KPU79940.1    EDV42840.1    KA646135    AFP60764.1    CP012526    ALC45823.1    CM000160    EDW95627.1    KRK02572.1    CH479185    EDW37945.1    GDHF01032030    GDHF01001868    JAI20284.1    JAI50446.1    GAKP01015189    GAKP01015188    JAC43764.1    CM000070    EIM52893.1    GAKP01015191    GAKP01015190    JAC43762.1    GBXI01005705    JAD08587.1    GDHF01015067    GDHF01010278    JAI37247.1    JAI42036.1    EAL28778.1    KPJ05342.1    AK401881    BAM18503.1    ATLV01022193    KE525329    KFB47217.1    CH933806    EDW16986.1    KRG02434.1    KRG02435.1    KRG02433.1    CVRI01000008    CRK88567.1    AE014297    AAO41509.3    L08794    X75629    X75630    AY119662    BT031288    AAF52163.1    CH964251    EDW83060.2    CH940656    EDW58455.1    KRF78299.1    ABI31119.2    KZ149957    PZC76449.1    CH916373    EDV94564.1    GFDF01000140    JAV13944.1    GFDF01000141    JAV13943.1    GFDF01000143    JAV13941.1    GFDF01000142    JAV13942.1    GFDF01000144    JAV13940.1    GFDF01000145    JAV13939.1    GECU01018237    JAS89469.1    GEDC01023154    JAS14144.1    GGFM01006237    MBW26988.1    GEMB01001542    JAS01616.1    GANO01002735    JAB57136.1    GFTR01005706    JAW10720.1    GGFM01000420    MBW21171.1    GGFM01000444    MBW21195.1    GGFJ01006296    MBW55437.1    GGFJ01006297    MBW55438.1    GGFK01000866    MBW34187.1    GDKW01002904    JAI53691.1    ADMH02000569    ETN65859.1    NEVH01006578    PNF37694.1    CH477374    EAT42353.1    EAT42357.1    GAPW01001920    JAC11678.1    PNF37691.1    PNF37692.1    GAPW01001912    JAC11686.1    AAAB01008966    KB632195    ERL89958.1    APGK01026644    KB740635    ENN79901.1   

Proteomes

UP000005204    UP000053268    UP000092443    UP000092445    UP000078200    UP000092444    + More
UP000091820    UP000095300    UP000053240    UP000218220    UP000037069    UP000008711    UP000000304    UP000001292    UP000268350    UP000007801    UP000095301    UP000092553    UP000002282    UP000008744    UP000001819    UP000030765    UP000009192    UP000192221    UP000183832    UP000000803    UP000007798    UP000008792    UP000001070    UP000075880    UP000000673    UP000235965    UP000008820    UP000075881    UP000030742    UP000019118   

PRIDE

H9IWX1    Q07171   

Pfam

PF00626   Gelsolin        + More
PF00098   zf-CCHC
PF13961   DUF4219
PF13976   gag_pre-integrs

Interpro

IPR007122   Villin/Gelsolin        + More
IPR036180   Gelsolin-like_dom_sf       
IPR029006   ADF-H/Gelsolin-like_dom_sf       
IPR007123   Gelsolin-like_dom       
IPR030004   Gelsolin       
IPR001878   Znf_CCHC       
IPR036875   Znf_CCHC_sf       
IPR025314   DUF4219       
IPR025724   GAG-pre-integrase_dom       

SUPFAM

SSF82754   SSF82754        + More
SSF57756   SSF57756       

Gene 3D

3.40.20.10    

ProteinModelPortal

H9IWX1   A0A0N0PA91   A0A2W1B6C1   S4P8F1   A0A0A9X3I0   A0A0K8SZI1   + More
A0A1A9XMX0   A0A1B0A8V6   A0A1A9UQ65   A0A0A9Z2C4   A0A1B0FCE4   A0A034V9E0   A0A2W1BDE5   A0A0K8SZE6   A0A0K8VYB1   W8B6S7   A0A0K8WEL2   A0A1A9WIF6   A0A336MY83   A0A336MRC3   A0A336MF08   W8BFB5   A0A1I8NXC0   A0A1I8NXE8   A0A0N1I6N5   A0A2A4JSL9   A0A0L0CJJ3   B3P1X4   B4QUY4   A0A0A1X561   A0A2H1X307   B4I3K2   A0A3B0K219   A0A0N8P1H5   B3LXY4   T1PDD6   A0A1I8NCV8   A0A0M3QXF2   B4PTP4   A0A0R1DZS5   B4GM71   A0A0K8WH15   A0A034VMT8   I5APK8   A0A034VNT3   A0A0A1XCB7   A0A0K8VEK4   Q295D4   A0A0N1PF90   I4DKR3   A0A084WAH3   B4KCW4   A0A0Q9XFV1   A0A0Q9XDT7   A0A1W4VZL6   A0A1W4VLN5   A0A1J1HKI1   A0A0C4DHG2   Q07171   B4NFJ3   B4MBI4   A0A0Q9WBU6   Q07171-2   A0A0C4DHG6   Q07171-6   A0A2W1BN17   B4JS24   A0A1L8E5M0   A0A1L8E5G4   A0A1L8E5D0   A0A1L8E606   A0A1L8E5B4   A0A1L8E5N5   A0A1B6IRD1   A0A1B6CL01   A0A2M3ZET1   A0A161MIR2   U5ETK7   A0A182JHU4   A0A224XQJ4   A0A2M3YY40   A0A2M3YY66   A0A2M4BQS3   A0A2M4BRN4   A0A2M4A063   A0A0P4VVN5   W5JSX6   A0A1S4FCK2   A0A2J7RA50   Q177L3   Q177K9   A0A023ER95   A0A2J7RA31   A0A2J7RA37   A0A023ESF2   A0A1S4H7D0   A0A182KHE3   U4UCC7   N6UGY5  

PDB

3FFK     E-value=9.45637e-40,     Score=405

KEGG

101746366    K05768 gelsolin | (RefSeq) gelsolin-like

GO

GO:0051015   GO:0005509   GO:0051016   GO:0045010   GO:0051014   GO:0005829   GO:0005884   GO:0005576   GO:0030041   GO:0003779   GO:0046872   GO:0003676   GO:0008270   GO:0016705   GO:0020037   GO:0005874   GO:0007017   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR11977   PTHR11977:SF29  

Subcellular location

  
Secreted  

Length:

159

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00519

Exp number, first 60 AAs:

0.00478

Total prob of N-in:

0.07726

outside

1  -  159

 

 

Pi

21.32126

Theta

21.197858

Tajima's D

0.192316

CLR

0.262904

CSRT

0.424578771061447

Interpretation

Uncertain