Gene

KWMTBOMO06147

Pre Gene Modal

BGIBMGA001753

Annotation

cytochrome_P450_[Bombyx_mori]

Location

Bomo_Chr11(+):1357184-1359002      View in EpiBrowser

Full name

Cytochrome P450 307a1      

Alternative Name

CYPCCCVIIA1
Protein spook

Location in the cell

Nuclear   Reliability : 2.181

CDS

ATGTTAATGTCCATAGGGGACTTTTTGGCGGGAACGCGAGGAGTGAAGTTGTCTCTGGCCCTGTGCGACTGGTCCAATCTTCAGCTGCGCAGGAGGAACCTGGCGAGGCGGCACTGCGGTCCCAAACAGCACACCGACTCCCACGCCAGAATCGGCACCGTCGGCACCTTTGAATCTGTCGAGCTAATTCAAACCCTCAAAGGATTGACCAGCAGATCGGACGCCAGCATCGATCTGAAGCCGATACTGATGAAGTCCGCCATGAACATGTTCTCAAACTACATGTGTAGCGTCCGTTTTGATGACGAGGACCTCGAATTCCAGAAGATTGTCGATCACTTCGACGAGATATTCTGGGAGATCAACCAGGGCTACGCTGTCGATTTTCTGCCGTGGCTGGCGCCGTTCTACAAAAAGCACATGGAAAAGCTCTCCAACTGGTCCCAGGACATCCGATCCTTCATCTTATCGAGGATCGTGGAGCAACGCGAAATAAACTTAGACACGGAAGCTCCGGAGAAGGACTTTCTGGACGGCCTCCTCAGGGTACTACACGAAGACCCGACCATGGACAGGAACACTATTATCTTTATGCTCGAAGACTTCCTGGGGGGGCATTCGTCTGTTGGTAACTTAGTCATGCTGTGTCTGACCGCAGTCGCCAGAGACCCGGAGGTCGGCAGAAAGATTCGTCAGGAAATCGACGCGGTGACCAGAGGCAAAAGACCCGTAGGTCTCACCGACCGCAGCCATTTGCCGTACACCGAGGCCACCATCTTGGAATGTCTGCGGTACGCGTCCTCGCCCATCGTGCCCCACGTGGCCACCGAGAACGCCAACATATCCGGGTACGGAATCGAAAAGGGTACTGTCGTTTTTATCAACAACTACGTTCTGAACAATTCCGAACAGTACTGGTCCGAGCCGGAGAAATTCGATCCGAGCCGTTTCCTGGAGAAGACCAGGGTCAGGACGAGACGCAACTCCCAGTGTGACTCCGGCCTGGAGTCCGACTCGGAGAGAGCGCCCGTCGGCAAGCCTGACGTCGAGAGGGAGATGCTTTCCGTGAAAAAGAACATACCCCACTTCATACCCTTCAGCATTGGTAAGAGAACGTGTATCGGTCAAACTATGGTCACGTCGATGTCTTTCACGATGTTCGCGAACATCATGCAGTCCTTTGAGGTCGGCGTCGAGAACATCAACGACCTCAAACAGAAGCCGGCGTGCGTGGCCCTACCCAAAAACACATACAAAATGCATTTGATACCTAGGAAGTAG

Protein

MLMSIGDFLAGTRGVKLSLALCDWSNLQLRRRNLARRHCGPKQHTDSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLESDSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPKNTYKMHLIPRK

Description

Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.

Cofactor

heme

Miscellaneous

Member of the Halloween gene group.

Similarity

Belongs to the cytochrome P450 family.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase   Phosphoprotein   Reference proteome  

Feature

chain  Cytochrome P450 307a1

Uniprot

H9IWX0   C0SPF8   Q3C2E4   Q09HR8   D1GJ59   A0A248QJ56   + More
S6BJ74   A0A2A4K2P7   A0A068EWM1   A0A2W1BBI6   A0A0Q6B317   A0A0Q6L2B6   A0A194Q627   A0A212ESX1   A0A194QTB2   A0A286MXN4   X5DQP1   A0A0U4EQD6   A0A0C5CGV2   A0A1V0D9G4   A0A0L7KRL6   A0A2H1WQP7   A0A0T0M2C9   L0N744   A0A336MIA1   B0WH44   B3M3P2   A0A182ME71   A0A182TDV7   A0A182W4V4   B4PIV0   A0A182J253   A0A182FIM0   A0A182S4L5   A0A182PYX5   A0A182Y512   A0A0L0BU33   A0A182II18   F5HJ41   W5JX32   A0A182X2C8   A0A182V6M6   A0A182KVQ9   Q16UX0   A0A0M4E2Z0   A0A0M3QU55   B3NC69   A0A084WF45   A0A182KHH4   B4NBP6   A0A0J9RQX1   A0A1W4UHF5   A0A182R0D0   A0A3B0JN80   A0A1B0CC32   B4HUG8   Q5TW91   A0A182SBE1   B4NZD8   A0A1A9ZZ64   Q2LZM9   A0A182N8Z5   A0A0J9TU78   A0A1B0FI99   A0A3B0K4Z7   B3NJ63   D3TPV8   H8F4V5   Q9VRM7   A0A1A9Z3Z5   B4K4F2   A0A0J9R619   A0A1B0FF53   A0A0J9R5X4   B4JRP7   A8Y592   A0A1A9YT07   A0A1B0B3B9   A0A0Q9WK74   A0A1A9VUS2   A0A0L0CGQ3   B4GE74   B4H3D5   A0A0R3P1X6   A0A1A9XM14   B3MWZ4   B4MLR1   B4K737   A0A1B6CB76   B4M0C8   A0A1A9WV93   A0A1I8Q4J4   A0A1I8N7J6   A0A1A9WYN5   A0A1I8Q764   A0A0K8VMR7   E0VV52   N6TG67   A0A0M5JTI9   A0A1W4X2L3  

EC Number

1.14.-.-

Pubmed

19121390    16188237    16949568    19682519    28881445    28756777    + More
26354079    22118469    19954531    25299618    24361403    26227816    26633631    17994087    17550304    25244985    26108605    12364791    14747013    17210077    20920257    23761445    20966253    17510324    24438588    22936249    24324583    15632085    20353571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    10328928    18327897    25315136    20566863    23537049    26319543   

EMBL

BABH01021064    AB124841    AK289330    BAH47267.1    BAM73857.1    AB206555    + More
BAE46798.1    DQ899315    ABI74778.1    FJ981602    ACY92457.1    KX443456    ASO98031.1    AB649120    BAN66314.2    NWSH01000195    PCG78517.1    KM016704    AID54856.1    KZ150489    PZC70697.1    LMQS01000007    KQT36897.1    LMRU01000003    KQU61630.1    KQ459463    KPJ00460.1    AGBW02012703    OWR44577.1    KQ461137    KPJ08763.1    MF684352    ASX93986.1    KF701128    AHW57298.1    KU160493    RSAL01000002    ALX37958.1    RVE54889.1    KP001122    AJN91167.1    KY212067    ARA91631.1    JTDY01006737    KOB65735.1    ODYU01010309    SOQ55327.1    LMQH01000016    KQS88552.1    AK289329    BAM73856.1    UFQT01001315    SSX29996.1    DS231932    EDS27495.1    CH902618    EDV40335.1    AXCM01004323    CM000159    EDW93520.1    AXCP01008102    JRES01001339    KNC23557.1    APCN01004835    APCN01004836    AAAB01008811    EGK96302.1    ADMH02000116    ETN67789.1    CH477612    EAT38335.2    CP012523    ALC40078.1    ALC40073.1    CH954178    EDV51027.1    ATLV01023299    KE525342    KFB48839.1    CH964232    EDW81210.1    CM002912    KMY97759.1    AXCN02001399    OUUW01000002    SPP76940.1    AJWK01006100    CH480817    EDW50589.1    KF656700    AHB59617.1    EAL41693.4    CM000157    EDW89851.2    CH379069    EAL29478.2    CM002911    KMY91725.1    CCAG010001331    OUUW01000014    SPP88373.1    EDV52846.2    EZ423460    ADD19736.1    BT133345    AE014296    AFF57510.1    AHN57968.1    AF484415    AY071053    CH933806    EDW13904.2    KMY91558.1    CCAG010023255    KMY91503.1    CH916373    EDV94437.1    AE014297    EDP28053.2    JXJN01007808    CH940657    KRF80949.1    JRES01000422    KNC31415.1    CH479182    EDW33909.1    CH479206    EDW30875.1    CH475481    KRT05509.1    CH902627    EDV33974.2    CH963847    EDW72987.1    EDW16350.2    GEDC01026560    JAS10738.1    CH940650    EDW67290.2    GDHF01012132    JAI40182.1    DS235802    EEB17258.1    APGK01039038    KB740967    KB632399    ENN76763.1    ERL94749.1    KR012818    ALD15893.1   

Proteomes

UP000005204    UP000218220    UP000050891    UP000051502    UP000053268    UP000007151    + More
UP000053240    UP000283053    UP000037510    UP000051822    UP000002320    UP000007801    UP000075883    UP000075902    UP000075920    UP000002282    UP000075880    UP000069272    UP000075900    UP000075885    UP000076408    UP000037069    UP000075840    UP000007062    UP000000673    UP000076407    UP000075903    UP000075882    UP000008820    UP000092553    UP000008711    UP000030765    UP000075881    UP000007798    UP000192221    UP000075886    UP000268350    UP000092461    UP000001292    UP000075901    UP000092445    UP000001819    UP000075884    UP000092444    UP000000803    UP000009192    UP000001070    UP000092443    UP000092460    UP000008792    UP000078200    UP000008744    UP000091820    UP000095300    UP000095301    UP000009046    UP000019118    UP000030742    UP000192223   

PRIDE

H9IWX0    C0SPF8    Q3C2E4    L0N744    H8F4V5    Q9VRM7    + More

Pfam

PF00067   p450        + More
PF00355   Rieske

Interpro

IPR002401   Cyt_P450_E_grp-I        + More
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR036396   Cyt_P450_sf       
IPR017941   Rieske_2Fe-2S       
IPR036922   Rieske_2Fe-2S_sf       

SUPFAM

SSF48264   SSF48264        + More
SSF50022   SSF50022       

Gene 3D

1.10.630.10     2.102.10.10    

ProteinModelPortal

H9IWX0   C0SPF8   Q3C2E4   Q09HR8   D1GJ59   A0A248QJ56   + More
S6BJ74   A0A2A4K2P7   A0A068EWM1   A0A2W1BBI6   A0A0Q6B317   A0A0Q6L2B6   A0A194Q627   A0A212ESX1   A0A194QTB2   A0A286MXN4   X5DQP1   A0A0U4EQD6   A0A0C5CGV2   A0A1V0D9G4   A0A0L7KRL6   A0A2H1WQP7   A0A0T0M2C9   L0N744   A0A336MIA1   B0WH44   B3M3P2   A0A182ME71   A0A182TDV7   A0A182W4V4   B4PIV0   A0A182J253   A0A182FIM0   A0A182S4L5   A0A182PYX5   A0A182Y512   A0A0L0BU33   A0A182II18   F5HJ41   W5JX32   A0A182X2C8   A0A182V6M6   A0A182KVQ9   Q16UX0   A0A0M4E2Z0   A0A0M3QU55   B3NC69   A0A084WF45   A0A182KHH4   B4NBP6   A0A0J9RQX1   A0A1W4UHF5   A0A182R0D0   A0A3B0JN80   A0A1B0CC32   B4HUG8   Q5TW91   A0A182SBE1   B4NZD8   A0A1A9ZZ64   Q2LZM9   A0A182N8Z5   A0A0J9TU78   A0A1B0FI99   A0A3B0K4Z7   B3NJ63   D3TPV8   H8F4V5   Q9VRM7   A0A1A9Z3Z5   B4K4F2   A0A0J9R619   A0A1B0FF53   A0A0J9R5X4   B4JRP7   A8Y592   A0A1A9YT07   A0A1B0B3B9   A0A0Q9WK74   A0A1A9VUS2   A0A0L0CGQ3   B4GE74   B4H3D5   A0A0R3P1X6   A0A1A9XM14   B3MWZ4   B4MLR1   B4K737   A0A1B6CB76   B4M0C8   A0A1A9WV93   A0A1I8Q4J4   A0A1I8N7J6   A0A1A9WYN5   A0A1I8Q764   A0A0K8VMR7   E0VV52   N6TG67   A0A0M5JTI9   A0A1W4X2L3  

PDB

4R1Z     E-value=9.53392e-32,     Score=342

KEGG

100127052    K14939 cytochrome P450 family 307 subfamily A | (RefSeq) Cyp307a1, P450, spook; cytochrome P450

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0004497   GO:0020037   GO:0016705   GO:0005506   GO:0016021   GO:0007417   GO:0008258   GO:0007494   GO:0005783   GO:0048477   GO:0007391   GO:0042335   GO:0006697   GO:0048566   GO:0016491   GO:0001700   GO:0005789   GO:0007591   GO:0051537   GO:0070330   GO:0005874   GO:0007017   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260   GO:0055114  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

426

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27402

Exp number, first 60 AAs:

0.0018

Total prob of N-in:

0.00176

outside

1  -  426

 

 

Pi

198.418648

Theta

188.042112

Tajima's D

0.262976

CLR

0.005969

CSRT

0.44162791860407

Interpretation

Uncertain