Gene

KWMTBOMO06144

Pre Gene Modal

BGIBMGA001750

Annotation

FKBP6_BOMMO_RecName:_Full%3DInactive_peptidyl-prolyl_cis-trans_isomerase_shutdown

Location

Bomo_Chr11(+):1221754-1233156      View in EpiBrowser

Full name

Inactive peptidyl-prolyl cis-trans isomerase shutdown       + More
Peptidylprolyl isomerase      

Location in the cell

Cytoplasmic   Reliability : 3.938

CDS

ATGGAGCAAGTATTTCAAGAACCCGTTCAACTGTCTAAAGGAATAAATCTGAGAGAGCTCACTTCAGAAATGGAGTTTCAGATTGATGTGGACTTTCAAAACAGAAAAACGGAGATGTTCATCAACGGTGATGACGATTTGTTTCCTGAAATGGGTGACGAGGATGACAGTGATGGAGAGGATACACTCAGGAATATTGAGGAGACAACCAAAAAGATGATGCTGGCCTCACCAGATTACTTGTCTTTTGAGGAGTTGGGCGCCAATATGATAGACTGCATGAGCACTGGTGACGTGAAAATGCTCATCATAGAAGAAGGTAAAGGACCTCTGGTGCCCGTTGATTCAGAAGTGACGATACATTACGCGGCTTACTGGGAGAAAGCTGTGATACCGTTTGATTCTACTTTAACCATGAATATGGGCGCACCAAAGCGTCTGCGTTTAGGAACAGGGAAAATAATACCCGGTCTGGAGATAGGTTTGACTATGGTCAAAGGGCCACAGGCGCGTCTCAACTTGCTGGTGCAACCGGCGGCCGCGTGGGGTCCGCGCGGGGTCCCGCCCAGGATCAGACCGGAGCCCGCGCTCTTCGTCATCGTCTTGTATGACGTCAAAGACAACTACGCGGCCACCAGATTTAACGATCTACCAATGGCGGAGCAGACTAAATACGAGGTCACATTGCGTACCGTCAACGCCTTACGCGCTGACGCCAAAGAGCTATACAAGAAAAAGAAATATGTGAAGGCCATTAAGAATTATCAGCAGGCCATCTCGGTTTTGCGTCTATCGCGTCCTGGTACGGCCGACGAGGAGTTAGACATAAAAAACAATAAAGTTAACGCGTACTTAAATTTGGCAGTCTGCTATTACAAGACGAACAAGCCTAAACACGTTCTGAACATGTGCGAATGCTTGGACAGACTTATTGACACCGAAAAGCACTGCAAAGCGCTTTACTACTATGGGAAAGCTCACGAAATGCTCGGCAAAACGGAAATGGCGATTAAATATTACAAGAAAGCTTTAAAATTGGAGCCGAAAAATAAAGAGATTGGCAAGATATTGGCGGATTTAGATACGAAGACGAAGGATTTTGCGGTCAACGAGAAGGCTATGTGGCTGAAGGCGTTTAACGTCGAGGTCCCCGCGACGAACGCGGTCTATGACGTTGACGCGACTTTCCAAAGTGACGTGTTGGACATGTGTCAAAGTTTGGCGGGAAGGTCGGAGTTTGCGAAATTCGATCTGCCCGTCGGGCTGACGAAAAACGAGGTGGATTGCATCAAGGGTATTGTGAGCGATTTCGGGTGCCTCTCAGTGGACGTCAGCGGTGAAGGTAGAAATAAAAAAGTTTGTATCGTTAAGAAGATCGTCTGA

Protein

MEQVFQEPVQLSKGINLRELTSEMEFQIDVDFQNRKTEMFINGDDDLFPEMGDEDDSDGEDTLRNIEETTKKMMLASPDYLSFEELGANMIDCMSTGDVKMLIIEEGKGPLVPVDSEVTIHYAAYWEKAVIPFDSTLTMNMGAPKRLRLGTGKIIPGLEIGLTMVKGPQARLNLLVQPAAAWGPRGVPPRIRPEPALFVIVLYDVKDNYAATRFNDLPMAEQTKYEVTLRTVNALRADAKELYKKKKYVKAIKNYQQAISVLRLSRPGTADEELDIKNNKVNAYLNLAVCYYKTNKPKHVLNMCECLDRLIDTEKHCKALYYYGKAHEMLGKTEMAIKYYKKALKLEPKNKEIGKILADLDTKTKDFAVNEKAMWLKAFNVEVPATNAVYDVDATFQSDVLDMCQSLAGRSEFAKFDLPVGLTKNEVDCIKGIVSDFGCLSVDVSGEGRNKKVCIVKKIV

Description

Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations (By similarity).

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Interacts with Hsp83.

Similarity

Belongs to the FKBP6 family.
Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Complete proteome   Cytoplasm   Differentiation   Meiosis   Oogenesis   Reference proteome   Repeat   RNA-mediated gene silencing   TPR repeat  

Feature

chain  Inactive peptidyl-prolyl cis-trans isomerase shutdown

Uniprot

H9IWW7   A0A2W1B4N3   A0A0N1I7G7   A0A2A4JPU8   A0A0L7L198   E2A4Y8   + More
A0A3L8DXT2   A0A026X467   A0A1Y9H221   A0A1X7V8C2   A0A310SIH5   A0A0L0C9J3   T1PHG5   A0A1I8NAG1   F4WY20   A0A0A1XP56   A0A154PEE0   A0A195AYQ9   A0A158NYL1   A0A195DEB8   A0A0J7L1A3   F4X2D5   A0A151WU13   A0A0L7QY84   A0A1B0BNJ8   A0A1A9Y0M9   A0A195FTK4   A0A0K8WCQ6   W8CDP5   A0A0M9A1A3   A0A1A9WIQ6   A0A1I8NY75   A0A2A3EFJ9   A0A034WCL6   A0A182Q1X1   A0A151IEV6   A0A182G8A7   A0A1Q3F193   A0A084VZE6   A0A1A9ZWD6   A0A1B0G7Q4   A0A240PJX4   A0A182R8Q0   A0A182VMP2   E9JDF4   Q16PH6   A0A1S4FTS0   A0A182WF59   A0A1A9V8D6   B0WGW1   U5ENS3   W5JRX6   A0A182JWF1   A0A084VV77   A0A182XCA1   T2MIQ4   A0A182LPI6   A0A182FTD7   E2C0E2   A0A182MGT8   A0A182P9C6   A0A182HNK2   A0A182TN62   A0NFE6   A0A084VU23   A0A2M4BRI7   A0A182T071   A0A146LVU3   A0A182YPF5   B4PA75   A0A194R279   A0A0A9YHD0   A0A0P4W9F9   A0A2L2YF89   A0A1B6F1X8   A0A2B4RN23   A0A023GMQ0   A0A336LDM3   A0A336L5J2   A0A069DYT9  

EC Number

5.2.1.8

Pubmed

19121390    22902560    28756777    26354079    26227816    20798317    + More
30249741    24508170    26108605    25315136    21719571    25830018    21347285    24495485    25348373    26483478    24438588    21282665    17510324    20920257    23761445    24065732    20966253    12364791    26823975    25244985    17994087    17550304    25401762    26561354    26334808   

EMBL

KZ150331    PZC71352.1    KQ460596    KPJ13908.1    NWSH01000868    PCG73786.1    + More
JTDY01003724    KOB69091.1    GL436770    EFN71505.1    QOIP01000003    RLU25102.1    KK107013    EZA62898.1    KQ759870    OAD62431.1    JRES01000819    KNC28119.1    KA648211    AFP62840.1    GL888434    EGI60945.1    GBXI01001622    JAD12670.1    KQ434875    KZC09784.1    KQ976701    KYM77373.1    ADTU01004020    KQ980953    KYN11177.1    LBMM01001374    KMQ96426.1    GL888577    EGI59395.1    KQ982748    KYQ51324.1    KQ414697    KOC63519.1    JXJN01017416    KQ981276    KYN43793.1    GDHF01003679    GDHF01002901    JAI48635.1    JAI49413.1    GAMC01001586    JAC04970.1    KQ435765    KOX75315.1    KZ288269    PBC29989.1    GAKP01005651    JAC53301.1    AXCN02002114    KQ977854    KYM99352.1    JXUM01151776    KQ571296    KXJ68208.1    GFDL01013731    JAV21314.1    ATLV01018748    KE525248    KFB43340.1    CCAG010016890    GL771866    EFZ09302.1    CH477781    EAT36272.1    DS231930    EDS27255.1    GANO01003957    JAB55914.1    ADMH02000540    ETN66048.1    ATLV01017157    KE525157    KFB41871.1    HAAD01005570    CDG71802.1    GL451770    EFN78601.1    AXCM01000254    APCN01001938    AAAB01008966    EAU76262.2    ATLV01016628    KE525098    KFB41467.1    GGFJ01006491    MBW55632.1    GDHC01006821    JAQ11808.1    CM000158    EDW92401.1    KQ460855    KPJ11893.1    GBHO01014659    GBRD01017776    JAG28945.1    JAG48051.1    GDRN01070793    GDRN01070791    JAI63809.1    IAAA01022285    IAAA01022286    LAA06687.1    GECZ01025595    JAS44174.1    LSMT01000381    PFX19011.1    GBBM01001273    JAC34145.1    UFQS01003771    UFQT01003771    SSX15928.1    SSX35270.1    UFQS01001911    UFQT01001911    SSX12694.1    SSX32137.1    GBGD01001810    JAC87079.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000037510    UP000000311    UP000279307    + More
UP000053097    UP000075884    UP000007879    UP000037069    UP000095301    UP000007755    UP000076502    UP000078540    UP000005205    UP000078492    UP000036403    UP000075809    UP000053825    UP000092460    UP000092443    UP000078541    UP000053105    UP000091820    UP000095300    UP000242457    UP000075886    UP000078542    UP000069940    UP000249989    UP000030765    UP000092445    UP000092444    UP000075880    UP000075900    UP000075903    UP000008820    UP000075920    UP000078200    UP000002320    UP000000673    UP000075881    UP000076407    UP000075882    UP000069272    UP000008237    UP000075883    UP000075885    UP000075840    UP000075902    UP000007062    UP000075901    UP000076408    UP000002282    UP000225706   

PRIDE

H9IWW7   

Pfam

PF07719   TPR_2        + More
PF00254   FKBP_C
PF13499   EF-hand_7
PF00151   Lipase
PF02949   7tm_6
PF13181   TPR_8
PF00027   cNMP_binding
PF00520   Ion_trans
PF00515   TPR_1
PF04148   Erv26

Interpro

IPR019734   TPR_repeat        + More
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR042282   FKBP6/shu       
IPR013105   TPR_2       
IPR001179   PPIase_FKBP_dom       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       
IPR018247   EF_Hand_1_Ca_BS       
IPR000734   TAG_lipase       
IPR029058   AB_hydrolase       
IPR004117   7tm6_olfct_rcpt       
IPR013818   Lipase/vitellogenin       
IPR033906   Lipase_N       
IPR000595   cNMP-bd_dom       
IPR018488   cNMP-bd_CS       
IPR005821   Ion_trans_dom       
IPR014710   RmlC-like_jellyroll       
IPR018490   cNMP-bd-like       
IPR001440   TPR_1       
IPR007277   Svp26/Tex261       
IPR036867   R3H_dom_sf       

SUPFAM

SSF48452   SSF48452        + More
SSF47473   SSF47473       
SSF53474   SSF53474       
SSF51206   SSF51206       

Gene 3D

1.25.40.10     3.40.50.1820     2.60.120.10     3.30.1370.50    

CDD

cd00707  Pancreat_lipase_like
cd00038  CAP_ED

ProteinModelPortal

H9IWW7   A0A2W1B4N3   A0A0N1I7G7   A0A2A4JPU8   A0A0L7L198   E2A4Y8   + More
A0A3L8DXT2   A0A026X467   A0A1Y9H221   A0A1X7V8C2   A0A310SIH5   A0A0L0C9J3   T1PHG5   A0A1I8NAG1   F4WY20   A0A0A1XP56   A0A154PEE0   A0A195AYQ9   A0A158NYL1   A0A195DEB8   A0A0J7L1A3   F4X2D5   A0A151WU13   A0A0L7QY84   A0A1B0BNJ8   A0A1A9Y0M9   A0A195FTK4   A0A0K8WCQ6   W8CDP5   A0A0M9A1A3   A0A1A9WIQ6   A0A1I8NY75   A0A2A3EFJ9   A0A034WCL6   A0A182Q1X1   A0A151IEV6   A0A182G8A7   A0A1Q3F193   A0A084VZE6   A0A1A9ZWD6   A0A1B0G7Q4   A0A240PJX4   A0A182R8Q0   A0A182VMP2   E9JDF4   Q16PH6   A0A1S4FTS0   A0A182WF59   A0A1A9V8D6   B0WGW1   U5ENS3   W5JRX6   A0A182JWF1   A0A084VV77   A0A182XCA1   T2MIQ4   A0A182LPI6   A0A182FTD7   E2C0E2   A0A182MGT8   A0A182P9C6   A0A182HNK2   A0A182TN62   A0NFE6   A0A084VU23   A0A2M4BRI7   A0A182T071   A0A146LVU3   A0A182YPF5   B4PA75   A0A194R279   A0A0A9YHD0   A0A0P4W9F9   A0A2L2YF89   A0A1B6F1X8   A0A2B4RN23   A0A023GMQ0   A0A336LDM3   A0A336L5J2   A0A069DYT9  

PDB

3B7X     E-value=3.01061e-10,     Score=157

KEGG

101745988    K09572 FK506-binding protein 6 [EC:5.2.1.8] | (RefSeq) inactive peptidyl-prolyl cis-trans isomerase

GO

GO:0051879   GO:0051321   GO:0005737   GO:0048477   GO:0031047   GO:0003755   GO:0005509   GO:0016853   GO:0005576   GO:0005549   GO:0006629   GO:0052689   GO:0016021   GO:0004984   GO:0005216   GO:0003676   GO:0070725   GO:0043186   GO:0034587   GO:0005515   GO:0006457   GO:0005525   GO:0005874   GO:0007017   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

PANTHER

PTHR46674   PTHR11610  

Subcellular location

Cytoplasm  
Secreted  

Length:

460

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00345

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00277

outside

1  -  460

 

 

Pi

155.025519

Theta

129.643366

Tajima's D

1.176768

CLR

0.518831

CSRT

0.705014749262537

Interpretation

Uncertain