SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO06135  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA001683
Annotation
PREDICTED:_tubulin_beta_chain-like_[Papilio_xuthus]
Full name
Tubulin beta chain       + More
Tubulin beta-1 chain      
Alternative Name
Beta-1-tubulin
Location in the cell
Cytoplasmic   Reliability : 3.014
 

Sequence

CDS
ATGCGTGAAATAGTCCACGTGCAAGCCGGCCAATGCGGGAATCAGATAGGATCGAAGTTTTGGGAGATAATCTCAGACGAGCATGGCGTCGACACGACCGGAGTTTACAAAGGGGAGAGCGACCTGCAGCTCGACAGAATAAACGTTTACTACAATGAGGCATCTAGTGGTAAATACGTCCCCCGTGCCGTTCTCGTGGATCTGGAGCCGGGCACTATGGACGCGGTCAGATCAGGACCCTACGGAATGCTGTTCCGGCCCGATAACTTTGTCTTCGGTCAGAGCGGCGCTGGCAACAATTGGGCCAAAGGACATTACACAGAGGGCGCTGAGCTAGTCGATTCTGTACTGGACGTGATCAGAAAAGAAGCTGAAAGCTGTGATTGTCTCCAAGGGTTCCAGTTGACCCACTCGCTGGGCGGCGGCACTGGATCCGGCATGGGCACTCTGCTGCTCAGCAAGATCCGGGAGGAATACCCGGACAGAATCATGAATACATTCAGCGTTGTACCCTCGCCTAAGGTGAGCGAAGTCGTTTTGGAGCCCTACAACGCGACGCTGTCCGTGCACCAGCTGGTCGAGAACACGGATATGTCCTTCTGCATCGACAACGAAGCGTTATACAACATCTGCTTCAAGACGCTGAGACTCAGCAGTCCTAGTTACGGCGACCTTAACCACCTCATATCTCTGACCATGTCCGGGGTGACGACCTGCCTCCGGTTCCCGGGACAGCTGAACGCGGATCTGAGGAAGCTGGCCGTCAACATGGTGCCATTCCCGAGGCTCCACTTCTTCATGCCGGGCTTCGCACCGCTGACCGCGCGAAATTCATTCAACTATCGCCCTCAGACTGTCTCCGAGCTCATGAGTCAAATGTTCAACTCCGGTAACATGATGACCGCCGCCGATCCTCGCCACGGAAGATACCTGACCGTTGCCACCATATTCAGAGGCCGCATGTCCATGAGGGAGGTCGACGACCAGATCCTCGCCATACAGAACAAGAACTCGAGCTACTTCGTGGAGTGGATCCCGAACAACCTAAAGGTGGCCGTGTGCGACATCCCGCCGCGCGGCCTCAAGATGTCCGCCACGTTCATCGGTAACTCGACGGCCATACAGGAGATCTTCAAGCGCATCTCCGAGCAGTTCACCGCCATGTTCCGGAGGAGGGCCTTCCTCCATTGGTACACGGGTGAAGGAATGGATGAGATGGAGTTCACTGAAGCGGCCAGTAACATGGCCGACCTCATTTCAGAATATCAGCAGTATCAGGAGGCAACTCTGGAAGACGATGATGCAGTGTTCGATGAAGAAGAGGAATTGGCGCAGGAGGAGGACCCGCCGGTTCAAATACAAATGTATTGA
Protein
MREIVHVQAGQCGNQIGSKFWEIISDEHGVDTTGVYKGESDLQLDRINVYYNEASSGKYVPRAVLVDLEPGTMDAVRSGPYGMLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVIRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIMNTFSVVPSPKVSEVVLEPYNATLSVHQLVENTDMSFCIDNEALYNICFKTLRLSSPSYGDLNHLISLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARNSFNYRPQTVSELMSQMFNSGNMMTAADPRHGRYLTVATIFRGRMSMREVDDQILAIQNKNSSYFVEWIPNNLKVAVCDIPPRGLKMSATFIGNSTAIQEIFKRISEQFTAMFRRRAFLHWYTGEGMDEMEFTEAASNMADLISEYQQYQEATLEDDDAVFDEEEELAQEEDPPVQIQMY

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with mgr and Vhl.
Similarity
Belongs to the tubulin family.
Keywords
Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Complete proteome   Phosphoprotein   Reference proteome  
Feature
chain  Tubulin beta-1 chain
EMBL
BABH01021023    BABH01021024    GAIX01005113    JAA87447.1    ODYU01004760    SOQ44984.1    + More
RSAL01000098    RVE47652.1    KQ460152    KPJ17359.1    KQ459593    KPI96367.1    CP026247    AWP01106.1    GAPW01001430    JAC12168.1    GALA01001146    JAA93706.1    GFDL01016207    JAV18838.1    GANO01001316    JAB58555.1    KQ435824    KOX72161.1    GDIQ01047153    GDIQ01002074    JAN47584.1    UFQT01000630    UFQT01000929    SSX25891.1    SSX28043.1    CH477254    EAT45945.1    GEZM01080243    JAV62278.1    BT128131    AEE63092.1    CH940648    EDW61137.1    GAMC01001610    JAC04946.1    EZ423882    ADD20158.1    CH933808    EDW09833.1    KR133399    AKM70869.1    GDHF01016881    JAI35433.1    JXJN01002474    CH674335    EDY71630.1    CH479183    EDW36350.1    CM000158    EDW91493.1    CP012524    ALC42690.1    CH902619    EDV35701.1    CH963850    EDW74799.1    CH480816    EDW48605.1    CH916367    EDW01883.1    CH954179    EDV55213.2    GBXI01014311    JAC99980.1    GFDG01000517    JAV18282.1    GDAI01000029    JAI17574.1    CM000362    CM002911    EDX07818.1    KMY95122.1    JRES01001535    JRES01000890    KNC22195.1    KNC27524.1    KA647387    AFP62016.1    AF030547    DQ377071    M20419    AE013599    BT003242    LNIX01000001    OXA63748.1    KU194643    ALP82107.1    GFAC01002138    JAT97050.1    GDIQ01040660    GDIQ01003233    JAN91504.1    GCES01166490    JAQ19832.1    AF255554    AAG15316.1    BT120510    ADD24150.1    HACA01027819    CDW45180.1    GFDF01000155    JAV13929.1    GL888122    EGI66955.1    KQ976681    KYM78155.1    KZ288269    PBC29959.1    JR049240    AEY60906.1    ADTU01004210    ADTU01004211    GL441846    EFN64123.1    KK107151    QOIP01000003    EZA57342.1    RLU24488.1    AF255553    AAG15315.1    AF255954    AAG15328.1    GFDF01000126    JAV13958.1    AK402544    BAM19166.1    GALX01001232    JAB67234.1    RSAL01000012    RVE53452.1    JN029962    AEJ84083.1    GADI01002870    JAA70938.1    GAMD01003291    JAA98299.1    EU373305    ABY66392.1    KQ971352    EFA06663.1    GDQN01000168    JAT90886.1    GDQN01009594    JAT81460.1    KK852686    KDR18435.1    AK401197    BAM17819.1    GGFM01006525    MBW27276.1    GGFK01000957    MBW34278.1    EU980443    ACL36826.1    BABH01035358    AB072308    BAB86853.1    AXCN02002037    AXCN02002038    GGFL01004205    MBW68383.1    ATLV01022298    KE525331    KFB47391.1    AXCP01003904    AXCP01003905    AAAB01008823    EAA05547.5    APCN01001414    FR906120    CDQ83152.1   
Pfam
PF00091   Tubulin        + More
PF03953   Tubulin_C
PF00612   IQ
PF00307   CH
PF03836   RasGAP_C
PF00616   RasGAP
PF10294   Methyltransf_16
Interpro
IPR017975   Tubulin_CS        + More
IPR002453   Beta_tubulin       
IPR037103   Tubulin/FtsZ_C_sf       
IPR023123   Tubulin_C       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR013838   Beta-tubulin_BS       
IPR036872   CH_dom_sf       
IPR001715   CH-domain       
IPR000048   IQ_motif_EF-hand-BS       
IPR008936   Rho_GTPase_activation_prot       
IPR023152   RasGAP_CS       
IPR027417   P-loop_NTPase       
IPR000593   RasGAP_C       
IPR001202   WW_dom       
IPR001936   RasGAP_dom       
IPR019410   Methyltransf_16       
IPR029063   SAM-dependent_MTases       
SUPFAM
SSF52490   SSF52490        + More
SSF55307   SSF55307       
SSF52540   SSF52540       
SSF47576   SSF47576       
SSF48350   SSF48350       
SSF53335   SSF53335       
PDB
5ZXH     E-value=0,     Score=1886

Ontologies

Topology

Subcellular location
  
Length:
456
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01952
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00677
outside
1  -  456
 
 

Population Genetic Test Statistics

Pi
193.336582
Theta
176.239388
Tajima's D
0.696968
CLR
0.039369
CSRT
0.574721263936803
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 SGPYGMLFRPDNFVFGQSGAGNNWAK 100.00 8e-13
28556443 SGPYGMLFR 100.00 8e-13
28556443 NSSYFVEWIPNNLK 100.00 8e-13
28556443 LHFFMPGFAPLTAR 100.00 1e-11
28556443 LSSPSYGDLNHLISLTMSGVTTCLR 100.00 8e-10
28556443 LFRPDNFVFGQSGAGNNWAK 100.00 4e-09
28556443 IREEYPDR 100.00 4e-09
28556443 LAVNMVPFPR 100.00 4e-09
28556443 INVYYNEASSGK 100.00 4e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 5e-09
28556443 NMMAACDPR 100.00 5e-09
26822097 EVDDQIIAIQNK 100.00 1e-07
28556443 FVEWIPNNLK 100.00 1e-07
28556443 EVDDQILAIQNK 100.00 1e-07
26822097 MREIVHIQAGQCGNQIGAK 100.00 6e-07
28467696 PDIDNAVIVR 100.00 6e-07
28556443 GHYTEGAELVDSVLDVIR 100.00 2e-06
28556443 GHYTEGAELVDSVLDVIR 100.00 2e-06
28556443 GGGTGSGMGTLLLSK 100.00 2e-06
28556443 FWEIISDEHGVDTTGVYK 100.00 2e-06
26822097 FDTEVDITYFK 100.00 3e-06
26280517 EIVFPISSDWQVDYESYDWK 100.00 3e-06
28556443 AVLVDLEPGTMDAVR 100.00 3e-06
28556443 YLTVATIFR 100.00 5e-06
28556443 TAVCDIPPK 100.00 5e-05
28556443 TFIGNSTAIQEIFK 100.00 5e-05
28556443 INVYYNEASGGKYVPR 100.00 5e-05
25044914 MREEGFMSGSDDVR 100.00 9e-05
28467696 MSAIDQIK 100.00 9e-05
28556443 MSATFIGNSTAIQEIFK 100.00 9e-05
28556443 MSATFIGNSTAIQEIFK 100.00 9e-05
28556443 MSATFIGNSTAIQEIFK 100.00 9e-05
28556443 LHFFMPGFAPLTAR 100.00 9e-05
28556443 LHFFMPGFAPLTAR 100.00 2e-04
28556443 LHFFMPGFAPLTA 100.00 2e-04
28556443 LFRPDNFVFGQSGAGNNWAK 100.00 2e-04
28556443 MSATFIGNSTAIQEIFK 100.00 4e-04
28556443 MLFRPDNFVFGQSGAGNNWAK 100.00 4e-04
28556443 AVLVDLEPGTMDAVR 100.00 5e-04
28556443 AVLVDLEPGTMDAVR 100.00 5e-04
28556443 AVLVDLEPGTMDAVR 100.00 5e-04
28556443 AVLVDLEPGTMDAVR 100.00 5e-04
28556443 AFLHWY 100.00 5e-04
28556443 VAVVNQLAR 100.00 5e-04
28556443 TTCLRFPGQLNADLR 100.00 0.001
28556443 VDLEPGTMDAVR 100.00 0.001
28556443 NMMAACDPR 100.00 0.001
28556443 LHFFMPGFAPLTA 100.00 0.001
28556443 LHFFMPGFAPLT 100.00 0.001
28556443 GESDLQLDR 100.00 0.001
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