Gene

KWMTBOMO06122

Pre Gene Modal

BGIBMGA001688

Annotation

PREDICTED:_dynein_light_chain_1?_axonemal-like_[Papilio_xuthus]

Location

Bomo_Chr11(-):727156-729374      View in EpiBrowser

Full name

Dynein light chain 1, axonemal      

Location in the cell

Cytoplasmic   Reliability : 1.065 Mitochondrial   Reliability : 1.18

CDS

ATGGCGAAAGCTACGACAATTAAAGAAGCAATAAAAAAATGGGAAGAAAAAACTGGCCTACACGCCGCAACAGCCACAGAAGTGAATTTAATATTTCAATGGCCGCCAATTGAAAAAATGGATAATTCGTTAGCTTCTTTAGTTAATTGCGAAAAACTTAGCTTATCCACGAACATGATAGAAAAGGTAACGGGATTGAATAGCTTAAAAAAGCTCCGAATTCTTTCACTTGGACGAAATTATATCAAATCTTTCGCCGGTATGGAATCACTGGGAGACACCTTAGAAGAGTTATGGGTCTCTTACAATCTAATAGAGAAACTAAAGGGCGTTCACGTTTTGAGGAACCTGAGAGTGTTATATATGAGCAACAATTTGGTAAAAGAGTGGAGTGAATTCAATAAGCTACAGGTCTGTGTTCGCGGTGGCGAGAGACTTTTTTTTTCTACCTAA

Protein

MAKATTIKEAIKKWEEKTGLHAATATEVNLIFQWPPIEKMDNSLASLVNCEKLSLSTNMIEKVTGLNSLKKLRILSLGRNYIKSFAGMESLGDTLEELWVSYNLIEKLKGVHVLRNLRVLYMSNNLVKEWSEFNKLQVCVRGGERLFFST

Description

Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity).

Subunit

Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.
Interacts with ZMYND10 (via C-terminus) (By similarity). Interacts with DNAH5, a outer arm dynein heavy chain (PubMed:21496787). Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner (PubMed:21496787).

Miscellaneous

Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.

Similarity

Belongs to the dynein light chain LC1-type family.

Keywords

Cell projection   Complete proteome   Cytoplasm   Cytoskeleton   Dynein   Leucine-rich repeat   Microtubule   Motor protein   Reference proteome   Repeat   Acetylation   Phosphoprotein  

Feature

chain  Dynein light chain 1, axonemal

Uniprot

A0A3S2LXD1   A0A0N1IAX3   A0A0N1PK27   A0A2A4IUC3   A0A2H1V0U4   A0A2W1BGJ5   + More
A0A2J7PR94   E0W4A5   A0A232F431   A0A067RJ51   K7IUE2   A0A310SAV3   A0A026VWJ1   A0A0L7R2X4   E2AP37   A0A0L7QNN7   A0A087ZZH0   A0A2A3EP63   A0A195D8M2   D6WR95   A0A1B6H9S6   F4WBH0   A0A158P121   A0A1B6FSZ3   E9IBZ7   A0A195FQA0   A0A1B6L624   A0A0J7L1K8   A0A1W4WJC0   A0A151WWD0   A0A1Y1KR48   A0A087ZUP2   A0A1A9YBJ8   A0A1B0GQJ4   A0A1B0B6H1   A0A195B3N5   A0A2A3E6K9   A0A195C3N9   A0A195FVH0   A0A310SRH2   A0A195ELT7   A0A151XK78   A0A3N0Z538   A0A2A4JI11   A0A3S2LT45   K7IQF1   A0A1I8M3I4   A0A195DKJ8   F4WCG6   A0A194QT50   A0A0B8RXW1   A0A1Y1M986   A0A182NB45   B1WB18   Q28G94   A0A195B6J8   B0WNF7   A0A2D4LQ20   A0A2D4ILY2   B0JZ03   E0W184   A0A2G9P0E6   A0A2D4LQ92   A0A2D4IM61   A0A1Y1M8L2   A0A3B1J6A7   T1HVM5   A0A336L7V8   A0A1A8U3L7   A0A2U9CMN9   A0A1A8KWC8   A0A084VBE2   A0A182X186   J3JWL3   Q6DHB1   A0A3Q1JTW4   A0A2K5DUV6   F7GW85   A0A1L8FAF5   Q641R9   A0A2K5DUQ4   U3EVK6   A0A1U7TZH8   F6PIE4   A0A1U7R5L2   G5C1N9   A0A182Y8G8   A0A1A9WA46   C1LFH9   E3TDT8   A0A096MJZ0   U4UCQ5   A0A151MVD2   A0A2H1WJF6   A0A2D0RLD6   A0A3Q0E0W7   A0A2D4KVF4   G1SSQ9   W5N9U4  

Pubmed

26354079    28756777    20566863    28648823    24845553    20075255    + More
24508170    20798317    18362917    19820115    21719571    21347285    21282665    28004739    25315136    25476704    25329095    24438588    22516182    27762356    25243066    18464734    21993625    25244985    20634964    15057822    21496787    22673903    23537049    22293439    21993624   

EMBL

RSAL01000131    RVE46425.1    KQ458725    KPJ05372.1    LADJ01064520    KPJ21653.1    + More
NWSH01007082    PCG63096.1    ODYU01000153    SOQ34439.1    KZ150196    PZC72327.1    NEVH01022633    PNF18839.1    DS235886    EEB20461.1    NNAY01001004    OXU25521.1    KK852653    KDR19353.1    AAZX01013097    KQ761906    OAD56454.1    KK107921    EZA47204.1    KQ414663    KOC65227.1    GL441439    EFN64869.1    KQ414855    KOC60101.1    KZ288212    PBC32821.1    KQ976749    KYN08774.1    KQ971354    EFA07038.1    GECU01036324    JAS71382.1    GL888063    EGI68449.1    ADTU01006080    GECZ01016464    GECZ01016180    JAS53305.1    JAS53589.1    GL762140    EFZ21910.1    KQ981305    KYN42765.1    GEBQ01020867    JAT19110.1    LBMM01001340    KMQ96483.1    KQ982691    KYQ52212.1    GEZM01076286    JAV63784.1    AJVK01017152    JXJN01009096    KQ976641    KYM78809.1    KZ288351    PBC27348.1    KQ978292    KYM95479.1    KQ981272    KYN43859.1    KQ761246    OAD57931.1    KQ978739    KYN28844.1    KQ982052    KYQ60688.1    RJVU01008125    ROL53586.1    NWSH01001323    PCG71697.1    RSAL01000266    RVE43266.1    KQ980765    KYN13362.1    GL888070    EGI68146.1    KQ461195    KPJ06716.1    GBSH01000918    JAG68107.1    GEZM01037151    JAV82131.1    BC161581    BC170910    BC170912    AAI61581.1    AAI70910.1    CR761486    KQ976582    KYM79809.1    DS232010    EDS31611.1    IACM01040010    LAB23009.1    IACK01103932    LAA85245.1    BC158985    AAI58986.1    DS235866    EEB19390.1    KV922779    PIN96816.1    IACM01040009    LAB23006.1    IACK01103933    LAA85246.1    GEZM01037152    JAV82129.1    ACPB03010729    UFQS01001948    UFQT01000542    UFQT01001948    SSX12767.1    SSX25108.1    HAEJ01002228    SBS42685.1    CP026259    AWP16996.1    HAEE01015894    SBR35944.1    ATLV01006574    KE524368    KFB35286.1    BT127631    AEE62593.1    BC076064    CM004480    OCT68571.1    BC082218    GAMS01008208    GAMR01008017    GAMQ01007421    GAMP01010352    JAB14928.1    JAB25915.1    JAB34430.1    JAB42403.1    JH172853    EHB15450.1    FN317727    CAX73457.1    GU588518    ADO28474.1    AC094055    KB632299    ERL91739.1    AKHW03004924    KYO28444.1    ODYU01009058    SOQ53201.1    IACL01089406    LAB12716.1    AAGW02049260    AHAT01022185   

Proteomes

UP000283053    UP000053268    UP000053240    UP000218220    UP000235965    UP000009046    + More
UP000215335    UP000027135    UP000002358    UP000053097    UP000053825    UP000000311    UP000005203    UP000242457    UP000078542    UP000007266    UP000007755    UP000005205    UP000078541    UP000036403    UP000192223    UP000075809    UP000092443    UP000092462    UP000092460    UP000078540    UP000078492    UP000095301    UP000075884    UP000008143    UP000002320    UP000018467    UP000015103    UP000246464    UP000030765    UP000076407    UP000000437    UP000265040    UP000233020    UP000008225    UP000186698    UP000189704    UP000002279    UP000189706    UP000006813    UP000076408    UP000091820    UP000221080    UP000002494    UP000030742    UP000050525    UP000001811    UP000018468   

PRIDE

Q28G94    Q6DHB1    Q641R9   

Pfam

PF12799   LRR_4        + More
PF00071   Ras

Interpro

IPR001611   Leu-rich_rpt        + More
IPR032675   LRR_dom_sf       
IPR025875   Leu-rich_rpt_4       
IPR020849   Small_GTPase_Ras-type       
IPR027417   P-loop_NTPase       
IPR001806   Small_GTPase       

SUPFAM

SSF52540   SSF52540       

Gene 3D

3.80.10.10    

ProteinModelPortal

A0A3S2LXD1   A0A0N1IAX3   A0A0N1PK27   A0A2A4IUC3   A0A2H1V0U4   A0A2W1BGJ5   + More
A0A2J7PR94   E0W4A5   A0A232F431   A0A067RJ51   K7IUE2   A0A310SAV3   A0A026VWJ1   A0A0L7R2X4   E2AP37   A0A0L7QNN7   A0A087ZZH0   A0A2A3EP63   A0A195D8M2   D6WR95   A0A1B6H9S6   F4WBH0   A0A158P121   A0A1B6FSZ3   E9IBZ7   A0A195FQA0   A0A1B6L624   A0A0J7L1K8   A0A1W4WJC0   A0A151WWD0   A0A1Y1KR48   A0A087ZUP2   A0A1A9YBJ8   A0A1B0GQJ4   A0A1B0B6H1   A0A195B3N5   A0A2A3E6K9   A0A195C3N9   A0A195FVH0   A0A310SRH2   A0A195ELT7   A0A151XK78   A0A3N0Z538   A0A2A4JI11   A0A3S2LT45   K7IQF1   A0A1I8M3I4   A0A195DKJ8   F4WCG6   A0A194QT50   A0A0B8RXW1   A0A1Y1M986   A0A182NB45   B1WB18   Q28G94   A0A195B6J8   B0WNF7   A0A2D4LQ20   A0A2D4ILY2   B0JZ03   E0W184   A0A2G9P0E6   A0A2D4LQ92   A0A2D4IM61   A0A1Y1M8L2   A0A3B1J6A7   T1HVM5   A0A336L7V8   A0A1A8U3L7   A0A2U9CMN9   A0A1A8KWC8   A0A084VBE2   A0A182X186   J3JWL3   Q6DHB1   A0A3Q1JTW4   A0A2K5DUV6   F7GW85   A0A1L8FAF5   Q641R9   A0A2K5DUQ4   U3EVK6   A0A1U7TZH8   F6PIE4   A0A1U7R5L2   G5C1N9   A0A182Y8G8   A0A1A9WA46   C1LFH9   E3TDT8   A0A096MJZ0   U4UCQ5   A0A151MVD2   A0A2H1WJF6   A0A2D0RLD6   A0A3Q0E0W7   A0A2D4KVF4   G1SSQ9   W5N9U4  

PDB

5YXM     E-value=8.97277e-29,     Score=310

KEGG

101743484    K10411 dynein light chain 1, axonemal | (RefSeq) dynein light chain 1, axonemal-like

GO

GO:0045504   GO:0005737   GO:0003774   GO:0043014   GO:0036158   GO:0007165   GO:0003924   GO:0005525   GO:0016020   GO:0016021   GO:0030286   GO:0005874   GO:0042995   GO:0005515   GO:0008270   GO:0016567   GO:0005975   GO:0030246   GO:0004559   GO:0006013   GO:0015923   GO:0005634   GO:0006260  

Subcellular location

  

Length:

150

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02872

Exp number, first 60 AAs:

0.02787

Total prob of N-in:

0.44913

outside

1  -  150

 

 

Pi

207.947986

Theta

158.744226

Tajima's D

1.108726

CLR

0

CSRT

0.684615769211539

Interpretation

Uncertain