Gene

KWMTBOMO06113

Pre Gene Modal

BGIBMGA001734

Annotation

PREDICTED:_MIP18_family_protein_CG7949_[Amyelois_transitella]

Location

Bomo_Chr11(+):626745-628109      View in EpiBrowser

Full name

MIP18 family protein galla-2       + More
Cytosolic iron-sulfur assembly component 2B      

Alternative Name

Mitotic spindle-associated MMXD complex subunit MIP18

Location in the cell

Nuclear   Reliability : 2.531

CDS

ATGACCAAAACAGCGGATAACATCAACCCTCACATTTACGAGAAGGGTTCAGAACGGGAGATCACTTCTTCGGAACGCGACGAAGACTTGCAAGATGAATTTGATGATCGCGAAATATTTGATTTAATACGAAATATAAATGATCCTGAACACCCATTGACACTCGAGGAGCTCAGGGTGGTGGAAGAGAAGAATATAATCGTTAATAACGATGATAGTACTGTATTAGTCAATTTTACACCGACAATTCCCCATTGCAGTATGGCGACTCTGATAGGTCTTTCAATACGAGTTCAACTACTCCGAGCTCTGCCAAGCCGTTTCAAAGTGACCGTACAAGTATCGGAGGGCTCTCACGCTTCCGAACATGCGGTCAACAAACAGTTAGCGGACAAGGAAAGAGTTGCTGCAGCTTTAGAGAACAATAATCTACTGCAAATCATCAATCAATGCATAGCTGTTTAA

Protein

MTKTADNINPHIYEKGSEREITSSERDEDLQDEFDDREIFDLIRNINDPEHPLTLEELRVVEEKNIIVNNDDSTVLVNFTPTIPHCSMATLIGLSIRVQLLRALPSRFKVTVQVSEGSHASEHAVNKQLADKERVAAALENNNLLQIINQCIAV

Description

Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex.
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.

Subunit

Component of the CGX complex composed of crb, galla (galla-1 or galla-2) and Xpd. Interacts with crb (via intracellular domain). Also able to interact with Xpd in the absence of crb.
Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO1, ERCC2 and MMS19; the interactions are direct.

Miscellaneous

The name 'galla' means splitting in Korean and is derived from its role in chromosome segregation.

Similarity

Belongs to the MIP18 family.

Keywords

Cell cycle   Cell division   Chromosome partition   Complete proteome   Mitosis   Reference proteome   Cytoplasm   Cytoskeleton   Nucleus  

Feature

chain  MIP18 family protein galla-2

Uniprot

H9IWV1   A0A0N1IND0   A0A212EHY4   A0A0N1IEE1   A0A1E1W0H3   S4NXG2   + More
I4DRD1   A0A2A4JTB8   A0A2H1VX78   A0A1A9X342   A0A195CYB3   E9ICX1   A0A151XK94   A0A1A9ZS50   A0A1A9UQK3   A0A1B0FBZ6   A0A195FUJ0   A0A1A9YH04   A0A1B0BC60   E2AHN5   A0A151J8G1   F4W6S7   A0A1I8Q5M7   B3M5L7   A0A0L0C6H4   A0A195BRS8   A0A158NS96   A0A1L8DCL1   A0A210QES1   A0A1B0CMI5   B4LHL0   Q2LZY0   E2C1Z8   B4PEI0   B4H6R9   A0A0M3QWG3   Q174X2   A0A0L7R315   A0A3B0JV96   A0A0J7NXR9   A0A182NMD0   A0A182QFT3   A0A1I8MTD1   B5DET6   A0A026X3S7   A0A023EFM8   Q5HZC8   A0A182JV17   B3NCN7   A0A1B6JBL3   A0A182RC24   B4N699   A0A3B3B6D4   A0A2A3EIM9   A0A1L8G0Z5   A0A1S2ZDQ3   A0A1B2AL76   Q9VTC4   B4QP99   A0A1B6LBT9   A0A1W4W3J1   A0A2C9GTP4   A0A182V6L3   A0A182TJN9   A0A182XCV9   Q7Q798   A0A182HM88   A0A0P4VVL2   R4G418   A0A2K6FBU9   A0A0K8UEI5   B4HDS2   A0A250XVH3   Q29QJ3   B4IZI6   B4KWB5   A0A1U7QGY1   Q9D187   D3Z8Q7   A0A034VH64   Q5M9B8   V4AM69   A0A1S3EUY3   E1BWV0   G3I775   A0A1J1J8P4   A0A340XDT9   K9IQK6   F7DB83   A0A2Y9K218   A0A3Q7UQ40   A0A341AEM7   A0A2Y9FL20   A0A2Y9P1U0   A0A384BEH1   A0A224XYQ2   Q05AU2   M3WPZ0   I3MAK7   A0A3Q7QR67  

Pubmed

19121390    26354079    22118469    23622113    22651552    21282665    + More
20798317    21719571    17994087    26108605    21347285    28812685    15632085    17550304    17510324    25315136    24508170    30249741    24945155    29451363    27762356    10731132    12537572    25065591    22936249    20966253    12364791    14747013    17210077    27129103    28087693    18057021    16141072    15489334    21183079    15057822    25348373    23254933    15592404    21804562    19892987    17975172   

EMBL

BABH01020984    KQ458725    KPJ05364.1    AGBW02014764    OWR41087.1    KQ460546    + More
KPJ14048.1    GDQN01010566    JAT80488.1    GAIX01014210    JAA78350.1    AK405069    BAM20471.1    NWSH01000719    PCG74632.1    ODYU01004997    SOQ45435.1    KQ977171    KYN05134.1    GL762419    EFZ21581.1    KQ982045    KYQ60751.1    CCAG010008857    KQ981241    KYN44305.1    JXJN01011858    GL439566    EFN67069.1    KQ979602    KYN20531.1    GL887726    EGI70089.1    CH902618    EDV40651.1    JRES01000828    KNC27998.1    KQ976421    KYM89067.1    ADTU01024725    GFDF01010024    JAV04060.1    NEDP02004027    OWF47151.1    AJWK01018774    CH940647    EDW69563.1    CH379069    EAL31157.1    GL452030    EFN78035.1    CM000159    EDW94046.1    CH479215    EDW33507.1    CP012525    ALC44099.1    CH477404    EAT41660.1    EAT41661.1    KQ414664    KOC65166.1    OUUW01000009    SPP84983.1    LBMM01000921    KMQ97210.1    AXCN02000934    BC168797    AAI68797.1    KK107019    QOIP01000007    EZA62738.1    RLU21071.1    GAPW01005375    GAPW01005374    JAC08223.1    BC089077    AAH89077.1    CH954178    EDV51334.1    GECU01011090    JAS96616.1    CH964154    EDW79888.1    KZ288250    PBC31059.1    CM004475    OCT77526.1    KX532107    ANY27917.1    AE014296    CM000363    CM002912    EDX09997.1    KMY98888.1    GEBQ01018983    JAT20994.1    AAAB01008960    EAA11936.3    APCN01004380    GDKW01001824    JAI54771.1    ACPB03009066    GAHY01001730    JAA75780.1    GDHF01027849    GDHF01027321    JAI24465.1    JAI24993.1    CH480815    EDW41012.1    GFFV01004581    JAV35364.1    BT024397    ABC86459.1    CH916366    CH916846    EDV97761.1    EDW05094.1    CH933809    EDW18522.1    AK003830    BC055880    AABR07042638    GAKP01017848    GAKP01017846    GAKP01017844    GAKP01017842    JAC41110.1    BC087289    CM004474    AAH87289.1    OCT79498.1    KB201262    ESO98237.1    AADN05000558    JH001411    EGW11238.1    CVRI01000075    CRL08338.1    GABZ01002815    JAA50710.1    GFTR01002714    JAW13712.1    BC123354    AAI23355.1    AANG04002512    AGTP01009761   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000218220    UP000091820    + More
UP000078542    UP000075809    UP000092445    UP000078200    UP000092444    UP000078541    UP000092443    UP000092460    UP000000311    UP000078492    UP000007755    UP000095300    UP000007801    UP000037069    UP000078540    UP000005205    UP000242188    UP000092461    UP000008792    UP000001819    UP000008237    UP000002282    UP000008744    UP000092553    UP000008820    UP000053825    UP000268350    UP000036403    UP000075884    UP000075886    UP000095301    UP000053097    UP000279307    UP000075881    UP000008711    UP000075900    UP000007798    UP000261560    UP000242457    UP000186698    UP000079721    UP000000803    UP000000304    UP000192221    UP000075882    UP000075903    UP000075902    UP000076407    UP000007062    UP000075840    UP000015103    UP000233160    UP000001292    UP000001070    UP000009192    UP000189706    UP000000589    UP000002494    UP000030746    UP000081671    UP000000539    UP000001075    UP000183832    UP000265300    UP000002281    UP000248482    UP000286642    UP000252040    UP000248484    UP000248483    UP000261681    UP000011712    UP000005215    UP000286641   

PRIDE

H9IWV1    Q9VTC4    Q29QJ3    Q9D187    D3Z8Q7   

Pfam

PF01883   FeS_assembly_P

Interpro

IPR002744   MIP18-like        + More
IPR034904   FSCA_dom_sf       
IPR039796   MIP18       

SUPFAM

SSF117916   SSF117916       

Gene 3D

3.30.300.130    

ProteinModelPortal

H9IWV1   A0A0N1IND0   A0A212EHY4   A0A0N1IEE1   A0A1E1W0H3   S4NXG2   + More
I4DRD1   A0A2A4JTB8   A0A2H1VX78   A0A1A9X342   A0A195CYB3   E9ICX1   A0A151XK94   A0A1A9ZS50   A0A1A9UQK3   A0A1B0FBZ6   A0A195FUJ0   A0A1A9YH04   A0A1B0BC60   E2AHN5   A0A151J8G1   F4W6S7   A0A1I8Q5M7   B3M5L7   A0A0L0C6H4   A0A195BRS8   A0A158NS96   A0A1L8DCL1   A0A210QES1   A0A1B0CMI5   B4LHL0   Q2LZY0   E2C1Z8   B4PEI0   B4H6R9   A0A0M3QWG3   Q174X2   A0A0L7R315   A0A3B0JV96   A0A0J7NXR9   A0A182NMD0   A0A182QFT3   A0A1I8MTD1   B5DET6   A0A026X3S7   A0A023EFM8   Q5HZC8   A0A182JV17   B3NCN7   A0A1B6JBL3   A0A182RC24   B4N699   A0A3B3B6D4   A0A2A3EIM9   A0A1L8G0Z5   A0A1S2ZDQ3   A0A1B2AL76   Q9VTC4   B4QP99   A0A1B6LBT9   A0A1W4W3J1   A0A2C9GTP4   A0A182V6L3   A0A182TJN9   A0A182XCV9   Q7Q798   A0A182HM88   A0A0P4VVL2   R4G418   A0A2K6FBU9   A0A0K8UEI5   B4HDS2   A0A250XVH3   Q29QJ3   B4IZI6   B4KWB5   A0A1U7QGY1   Q9D187   D3Z8Q7   A0A034VH64   Q5M9B8   V4AM69   A0A1S3EUY3   E1BWV0   G3I775   A0A1J1J8P4   A0A340XDT9   K9IQK6   F7DB83   A0A2Y9K218   A0A3Q7UQ40   A0A341AEM7   A0A2Y9FL20   A0A2Y9P1U0   A0A384BEH1   A0A224XYQ2   Q05AU2   M3WPZ0   I3MAK7   A0A3Q7QR67  

PDB

3UX3     E-value=1.76757e-22,     Score=256

KEGG

101742241    no KO assigned | (RefSeq) MIP18 family protein CG7949

GO

GO:0106035   GO:0097361   GO:0016226   GO:0051301   GO:0007049   GO:0007059   GO:0016021   GO:0005654   GO:0071817   GO:0005737   GO:0005819   GO:0005829   GO:0005634   GO:0097428  

PANTHER

PTHR12377  

Subcellular location

Nucleus  
Cytoplasm  
Cytoskeleton  
Spindle  

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.8223

Exp number, first 60 AAs:

0

Total prob of N-in:

0.40170

outside

1  -  154

 

 

Pi

237.519795

Theta

225.301967

Tajima's D

0.170769

CLR

0.96694

CSRT

0.421078946052697

Interpretation

Uncertain